EP4 Antagonism by E7046 diminishes Myeloid immunosuppression and synergizes with Treg-reducing IL-2-Diphtheria toxin fusion protein in restoring anti-tumor immunity von Albu, Diana I., Wang, Zichun, Huang, Kuan-Chun, Wu, Jiayi, Twine, Natalie, Leacu, Sarah, Ingersoll, Christy, Parent, Lana, Lee, Winnie, Liu, Diana, Wright-Michaud, Renee, Kumar, Namita, Kuznetsov, Galina, Chen, Qian, Zheng, Wanjun, Nomoto, Kenichi, Woodall-Jappe, Mary, Bao, Xingfeng

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A bispecific anti-PD-1 and PD-L1 antibody induces PD-1 cleavage and provides enhanced anti-tumor activity von Albu, Diana I, Wolf, Benjamin J, Qin, Yan, Wang, Xianzhe, Daniel Ulumben, Amy, Su, Mei, Li, Vivian, Ding, Eirene, Angel Gonzalo, Jose, Kong, Jason, Jadhav, Ruturaj, Kuklin, Nelly, Visintin, Alberto, Gong, Bing, Schuetz, Thomas J

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BCL11B is required for positive selection and survival of double-positive thymocytes von Albu, Diana I, Feng, Dongyun, Bhattacharya, Debarati, Jenkins, Nancy A, Copeland, Neal G, Liu, Pentao, Avram, Dorina

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Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes von Albu, Diana I, VanValkenburgh, Jeffrey, Morin, Nicole, Califano, Danielle, Jenkins, Nancy A, Copeland, Neal G, Liu, Pentao, Avram, Dorina

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Critical role of Bcl11b in suppressor function of T regulatory cells and prevention of inflammatory bowel disease von Vanvalkenburgh, Jeffrey, Albu, Diana I, Bapanpally, Chandra, Casanova, Sarah, Califano, Danielle, Jones, David M, Ignatowicz, Leszek, Kawamoto, Shimpei, Fagarasan, Sidonia, Jenkins, Nancy A, Copeland, Neal G, Liu, Pentao, Avram, Dorina

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BCL11B participates in the activation of IL2 gene expression in CD4+ T lymphocytes von Cismasiu, Valeriu B., Ghanta, Sailaja, Duque, Javier, Albu, Diana I., Chen, Hong-Mei, Kasturi, Rohini, Avram, Dorina

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Antigen-specific clonal expansion and cytolytic effector function of CD8+ T lymphocytes depend on the transcription factor Bcl11b von Zhang, Shuning, Rozell, Mike, Verma, Raj K, Albu, Diana I, Califano, Danielle, VanValkenburgh, Jeffrey, Merchant, Akeel, Rangel-Moreno, Javier, Randall, Troy D, Jenkins, Nancy A, Copeland, Neal G, Liu, Pentao, Avram, Dorina

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Flow Cytometry Analysis of Transcription Factors in T Lymphocytes von Albu, Diana I., Califano, Danielle, Avram, Dorina

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Abstract 3431: Dose range finding study in non-human primates confirms the unique mechanism of action of CTX-8371, a novel bispecific antibody blocking PD-1 and PD-L1 von Albu, Diana I., Wang, Xianzhe, Qin, Yan, Li, Vivian, Nanjappa, Purushothama, Ulumben, Amy Daniel, Jadhav, Ruturaj, Kong, Jason, Ablicki, Austin, Schilling, Neal, Schuetz, Thomas, Kalled, Susan, Gong, Bing, Kuklin, Nelly

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Intranasal Vaccination Using Interleukin-12 and Cholera Toxin Subunit B as Adjuvants To Enhance Mucosal and Systemic Immunity to Human Immunodeficiency Virus Type 1 Glycoproteins von Albu, Diana I., Jones-Trower, Agnes, Woron, Amy M., Stellrecht, Kathleen, Broder, Christopher C., Metzger, Dennis W.

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Abstract 5522: Evaluation of eribulin-induced alterations of the intact immune cell landscape in spleens and tumors from tumor-bearing immunocompetent mice von Wu, Haochen, Zhu, Keyi, Tu, Xiaolong, Albu, Diana, Woodall-Jappe, Mary, Littlefield, Bruce A.

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Bispecific anti-PD-1/PD-L1 antibody CTX-8371 to promote cellular clustering and PD-1 shedding, antitumor activity and tolerability von Albu, Diana I., Qin, Yan, Wang, Xianzhe, Li, Vivian, Kim, Taeg, Gong, Bing, Schuetz, Thomas, Kuklin, Nelly

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Abstract 4586: Intratumoral Treg cell depletion by local administration of IL-2-Diphteria toxin fusion protein E7777 induces a therapeutic and memory anti-tumor immune response in... von Albu, Diana I., Ingersoll, Christy, Huang, Kuan-Chun, Woodall-Jappe, Mary, Bao, Xingfeng

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Abstract 4607: Specific inhibition of PGE2-EP4 signaling by E7046 promotes anti-tumor activity of checkpoint blockade agents through boosting cytotoxic T cell activity von Albu, Diana I., Verbel, David, Huang, Yuan, Kolber-Simonds, Donna, Wang, Zichun, Wang, Xulong, Dezso, Zoltan, Ingersoll, Christy, Huang, Kuan-Chun, Hutz, Janna, Woodall-Jappe, Mary, Bao, Xingfeng

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Abstract 1227: Macrophage depletion enhances the anticancer efficacy of eribulin mesylate in mice bearing syngeneic tumors von Albu, Diana I., Littlefield, Bruce A., Woodall-Jappe, Mary

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Abstract 3269: Discovery and characterization of E7766, a novel macrocycle-bridged STING agonist with pan-genotypic and potent antitumor activity through intravesical and intratumo... von Huang, Kuan-Chun, Endo, Atsushi, McGrath, Shannon, Chandra, Dinesh, Wu, Jiayi, Kim, Dae-Shik, Albu, Diana, Ingersoll, Christy, Tendyke, Karen, Loiacono, Kara, Noland, Thomas, Verbel, David, Zhang, Chi, Hao, Ming-Hong, Matijevic, Mark, Dixit, Vaishali, Hukkanen, Renee R., Hutz, Janna, Wang, John, Fang, Frank, Bao, Xingfeng, Kolber-Simonds, Donna, Akram, Muzaffar, Sarwar, Nadeem

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Abstract B198: Pharmacological profile of the PGE2 EP4 receptor antagonist E7046 von Albu, Diana I., Wu, Jiayi, Huang, Kuan-chung, Wright-Michaud, Renee, Xu, Shanqin, Kuznetsov, Galina, Bao, Xingfeng, Woodall-Jappe, Mary

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Abstract 275: ER-886046, an antagonist of PGE2 receptor type-4, induces an effective antitumor immune response in mice by attenuating intratumoral MDSCs and TAMs von Albu, Diana I., Wang, Zichun, Wu, Jiayi, Huang, Kuan-chun, Li, Wei, Liu, Diana, Kuznetsov, Galina, Chen, Qian, Bao, Xingfeng, Woodall-Jappe, Mary

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Abstract B90: Eribulin mesylate alters immune homeostasis in mice bearing syngeneic tumors von Albu, Diana I., Kumar, Namita, Kusnetzov, Galina, Xu, Shanqin, Littlefield, Bruce, Woodall-Jappe, Mary

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Abstract B034: Preclinical immune antitumor activity of myeloid-targeting E7046 and Treg depleting E7777 von Albu, Diana I., Huang, Kuan-Chun, Wu, Jiayi, Bao, Xingfeng, Nomoto, Kenichi, Woodall-Jappe, Mary

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