Simple and Sensitive Method for Deep Profiling of Host Cell Proteins in Therapeutic Antibodies by Combining Ultra-Low Trypsin Concentration Digestion, Long Chromatographic Gradient... von Nie, Song, Greer, Tyler, O’Brien Johnson, Reid, Zheng, Xiaojing, Torri, Albert, Li, Ning

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Immunogenicity of dupilumab in adult and pediatric patients with atopic dermatitis von Kamal, Mohamed A, Kosloski, Matthew P, Lai, Ching-Ha, Partridge, Michael A, Rajadhyaksha, Manoj, Kanamaluru, Vanaja, Bansal, Ashish, Shabbir, Arsalan, Shumel, Brad, Ardeleanu, Marius, Richards, Susan M, Yan, Hong, Xu, Christine R, Rodríguez-Marco, Ainara, Xiao, Jing, Khokhar, Faisal A, Gherardi, Guy, Babilonia, Elisa, Maloney, Jennifer, Mortensen, Eric, Akinlade, Bolanle, Braunstein, Ned, Stahl, Neil, Torri, Albert, Davis, John D, DiCioccio, A Thomas

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Immunogenicity of Sarilumab Monotherapy in Patients with Rheumatoid Arthritis Who Were Inadequate Responders or Intolerant to Disease-Modifying Antirheumatic Drugs von Wells, Alvin F., Parrino, Janie, Mangan, Erin K., Paccaly, Anne, Lin, Yong, Xu, Christine, Fan, Chunpeng, Graham, Neil M. H., van Hoogstraten, Hubert, Torri, Albert

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2014 White Paper on Recent Issues in Bioanalysis: A Full Immersion in Bioanalysis (Part 2 – Hybrid LBA/LCMS, ELN & Regulatory Agencies’ Input) von Dufield, Dawn, Neubert, Hendrik, Garofolo, Fabio, Kirkovsky, Leo, Stevenson, Lauren, Dumont, Isabelle, Kaur, Surinder, Xu, Keyang, Alley, Stephen C, Szapacs, Matthew, Arnold, Mark, Bansal, Surendra, Haidar, Sam, Welink, Jan, Le Blaye, Olivier, Wakelin-Smith, Jason, Whale, Emma, Ishii-Watabe, Akiko, Bustard, Mark, Katori, Noriko, Amaravadi, Lakshmi, Aubry, Anne-Françoise, Beaver, Chris, Bergeron, Annik, Cai, Xiao-Yan, Cojocaru, Laura, DeSilva, Binodh, Duggan, Jeff, Fluhler, Eric, Gorovits, Boris, Gupta, Swati, Hayes, Roger, Ho, Stacy, Ingelse, Benno, King, Lindsay, Lévesque, Ann, Lowes, Steve, Ma, Mark, Musuku, Adrien, Myler, Heather, Olah, Timothy, Patel, Shefali, Rose, Mark, Schultz, Gary, Smeraglia, John, Swanson, Steven, Torri, Albert, Vazvaei, Faye, Wilson, Amanda, Woolf, Eric, Xue, Li, Yang, Tong-Yuan

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Kinetics of Trisulfide-to-Disulfide Conversion of Therapeutic IgG1 Monoclonal Antibodies Under Physiological Conditions: A Case Study of Casirivimab And Imdevimab von Zhong, Xuefei, Gao, Lucy W., Kleinberg, Andrew, Mao, Yuan, Lawrence, Shawn, Bak, Hanne, Li, Ning, Torri, Albert

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Overcoming multimeric target interference in a bridging immunogenicity assay with soluble target receptor, target immunodepletion and mild acidic assay pH von Chen, Jihua, Kendra, Kimberly, Torri, Albert, Sumner, Giane

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Structure–activity relationships for a series of thiobenzamide influenza fusion inhibitors derived from 1,3,3-Trimethyl-5-hydroxy-cyclohexylmethylamine von Yu, Kuo-Long, Torri, Albert F, Luo, Guangxiang, Cianci, Christopher, Grant-Young, Katharine, Danetz, Stephanie, Tiley, Lawrence, Krystal, Mark, Meanwell, Nicholas A

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Antidrug Antibodies in Patients Treated with Alirocumab von Roth, Eli M, Goldberg, Anne C, Catapano, Alberico L, Torri, Albert, Yancopoulos, George D, Stahl, Neil, Brunet, Aurélie, Lecorps, Guillaume, Colhoun, Helen M

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Anti-VEGF drug interference with VEGF quantitation in the R&D systems human quantikine VEGF ELISA kit von Sumner, Giane, Georgaros, Camille, Rafique, Ashique, DiCioccio, Thomas, Martin, Joel, Papadopoulos, Nicholas, Daly, Thomas, Torri, Albert

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Drug Removal Strategies in Competitive Ligand Binding Neutralizing Antibody (NAb) Assays: Highly Drug-Tolerant Methods and Interpreting Immunogenicity Data von Partridge, Michael A., Karayusuf, Elif Kabuloglu, Shyu, Gary, Georgaros, Camille, Torri, Albert, Sumner, Giane

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Assessment of clinically relevant immunogenicity for mAbs; are we over reporting ADA? von Hassanein, Mohamed, A Partridge, Michael, Shao, Weiping, Torri, Albert

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Isotyping and Semi-Quantitation of Monkey Anti-Drug Antibodies by Immunocapture Liquid Chromatography-Mass Spectrometry von Huang, Xiaoxiao, Xu, Xiaobin, Partridge, Michael A., Chen, Jihua, Koehler-Stec, Ellen, Sumner, Giane, Qiu, Haibo, Torri, Albert, Li, Ning

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Statistical Approaches for Establishing Appropriate Immunogenicity Assay Cut Points: Impact of Sample Distribution, Sample Size, and Outlier Removal von Garlits, John, McAfee, Sean, Taylor, Jessica-Ann, Shum, Enoch, Yang, Qi, Nunez, Emily, Kameron, Kristina, Fenech, Keilah, Rodriguez, Jacqueline, Torri, Albert, Chen, Jihua, Sumner, Giane, Partridge, Michael A.

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Liquid Chromatography-Multiple Reaction Monitoring-Mass Spectrometry Assay for Quantitative Measurement of Therapeutic Antibody Cocktail REGEN-COV Concentrations in COVID-19 Patien... von Zhong, Xuefei, Nayak, Shruti, Guo, Lili, Raidas, Shivkumar, Zhao, Yunlong, Weiss, Rachel, Andisik, Matthew, Elango, Chinnasamy, Sumner, Giane, Irvin, Susan C, Partridge, Michael A, Yan, Hong, E, Sook Yen, Qiu, Haibo, Mao, Yuan, Torri, Albert, Li, Ning

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Challenging the Standard Immunogenicity Assessment Approach: 1-Tiered ADA Testing Strategy in Clinical Trials von Lai, Ching-Ha, Chen, Mu, Fraser, Sasha, Wang, Jessica, McAfee, Sean, Speaks, Emma, Simeone, Nicholas, Rodriguez, Jacqueline, Stefan, Colin, DeStefano, Lisa, Elango, Chinnasamy, Andisik, Matthew D., Sumner, Giane, Zhao, An, Irvin, Susan C., Torri, Albert, Partridge, Michael A.

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Immunogenicity of Cemiplimab: Low Incidence of Antidrug Antibodies and Cut-Point Suitability Across Tumor Types von Valentine, Jenny L, Dengler, Andrew, Zhao, An, Truong, Tiffany, McAfee, Sean, Hassanein, Mohamed, Irvin, Susan C, Chen, Jihua, Meng, Xiao, Yan, Hong, Torri, Albert, Sumner, Giane, Andisik, Matthew D, Paccaly, Anne, Partridge, Michael A

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Pre-existing Reactivity to an IgG4 Fc-Epitope: Characterization and Mitigation of Interference in a Bridging Anti-drug Antibody Assay von Partridge, Michael A., Chen, Jihua, Karayusuf, Elif Kabuloglu, Sirimanne, Thanoja, Stefan, Colin, Lai, Ching Ha, Gathani, Meghna, DeStefano, Lisa, Rozanski, Michal, McAfee, Sean, Rajadhyaksha, Manoj, Andisik, Matthew D., Torri, Albert, Sumner, Giane

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Interference in a Neutralizing Antibody Assay for Odronextamab, a CD20xCD3 Bispecific mAb, from Prior Rituximab Therapy and Possible Mitigation Strategy von Irvin, Susan C., D’Orvilliers, Amanda, Bloch, Nicolin, Boccio, Kayla, Pennucci, Jason, Brouwer-Visser, Jurriaan, Ullman, Erica, Rajadhyaksha, Manoj, Hassanein, Mohamed, Potocky, Terra, Torri, Albert, Hermann, Aynur, Partridge, Michael A.

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Mitigating target interference in bridging immunogenicity assay with target-blocking reagents and mild basic pH von Chen, Jihua, Garlits, John, Dhulipala, Gangadhar, Sirimanne, Thanoja, Xu, Colleen, Lu, Kun, Palackal, Nisha, Pyles, Erica, Torri, Albert, Sumner, Giane

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Open-label therapy with alirocumab in patients with heterozygous familial hypercholesterolemia: Results from three years of treatment von Dufour, Robert, Bergeron, Jean, Gaudet, Daniel, Weiss, Robert, Hovingh, G. Kees, Qing, Zhizhi, Yang, Feng, Andisik, Matthew, Torri, Albert, Pordy, Robert, Gipe, Daniel A

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