High concentration formulation developability approaches and considerations von Zarzar, Jonathan, Khan, Tarik, Bhagawati, Maniraj, Weiche, Benjamin, Sydow-Andersen, Jasmin, Sreedhara, Alavattam

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Metal Ion Interactions with mAbs: Part 2. Zinc-Mediated Aggregation of IgG1 Monoclonal Antibodies von Mehta, Shrenik, Flores, Heather, Walters, Benjamin, Sreedhara, Alavattam

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Protein Stability and Photostability under In Vitro Vitreal Conditions – Implications for Long Acting Delivery of Protein Therapeutics for Ocular Disease von Mantha, Neelima, Burra, Shalini, Rajagopal, Karthikan, Sreedhara, Alavattam

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Selective Uptake of Macromolecules to the Brain in Microfluidics and Animal Models Using the HAVN1 Peptide as a Blood-Brain Barrier Modulator von Schwinghamer, Kelly, Line, Stacey, Tesar, Devin B., Miller, Donald W., Sreedhara, Alavattam, Siahaan, Teruna J.

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A Comprehensive Assessment of All-Oleate Polysorbate 80: Free Fatty Acid Particle Formation, Interfacial Protection and Oxidative Degradation von Doshi, Nidhi, Giddings, Jamie, Luis, Lin, Wu, Arthur, Ritchie, Kyle, Liu, Wenqiang, Chan, Wayman, Taing, Rosalynn, Chu, Jeff, Sreedhara, Alavattam, Kannan, Aadithya, Kei, Pervina, Shieh, Ian, Graf, Tobias, Hu, Mark

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A novel in vitro method to model the fate of subcutaneously administered biopharmaceuticals and associated formulation components von Kinnunen, Hanne M., Sharma, Vikas, Contreras-Rojas, Luis Rodrigo, Yu, Yafei, Alleman, Chlöe, Sreedhara, Alavattam, Fischer, Stefan, Khawli, Leslie, Yohe, Stefan T., Bumbaca, Daniela, Patapoff, Thomas W., Daugherty, Ann L., Mrsny, Randall J.

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Effect of ambient light on IgG1 monoclonal antibodies during drug product processing and development von Sreedhara, Alavattam, Yin, Jian, Joyce, Michael, Lau, Kimberly, Wecksler, Aaron T., Deperalta, Galahad, Yi, Li, John Wang, Y., Kabakoff, Bruce, Kishore, Ravuri S.K.

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Photo-oxidation of IgG1 and Model Peptides: Detection and Analysis of Triply Oxidized His and Trp Side Chain Cleavage Products von Bane, Jessica, Mozziconacci, Olivier, Yi, Li, Wang, Y. John, Sreedhara, Alavattam, Schöneich, Christian

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Charge variants in IgG1: Isolation, characterization, in vitro binding properties and pharmacokinetics in rats von Khawli, Leslie A., Goswami, Sirj, Hutchinson, Ryan, Kwong, Zephania W., Yang, Jihong, Wang, Xiangdan, Yao, Zhenling, Sreedhara, Alavattam, Cano, Tony, Tesar, Devin B., Nijem, Ihsan, Allison, David E., Wong, Pin Yee, Kao, Yung-Hsiang, Quan, Cynthia, Joshi, Amita, Harris, Reed J., Motchnik, Paul

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Establishing a Link Between Amino Acid Sequences and Self-Associating and Viscoelastic Behavior of Two Closely Related Monoclonal Antibodies von Yadav, Sandeep, Sreedhara, Alavattam, Kanai, Sonoko, Liu, Jun, Lien, Samantha, Lowman, Henry, Kalonia, Devendra S., Shire, Steven J.

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Physicochemical and biological impact of metal-catalyzed oxidation of IgG1 monoclonal antibodies and antibody-drug conjugates via reactive oxygen species von Glover, Zephania Kwong, Wecksler, Aaron, Aryal, Baikuntha, Mehta, Shrenik, Pegues, Melissa, Chan, Wayman, Lehtimaki, Mari, Luo, Allen, Sreedhara, Alavattam, Rao, V Ashutosh

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Insights into ultra-low affinity lipase-antibody noncovalent complex binding mechanisms von Hecht, Elizabeth Sara, Mehta, Shrenik, Wecksler, Aaron T, Aguilar, Ben, Swanson, Nathaniel, Phung, Wilson, Dubey Kelsoe, Ananya, Benner, W Henry, Tesar, Devin, Kelley, Robert F, Sandoval, Wendy, Sreedhara, Alavattam

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Efficient Inorganic Deoxyribonucleases. Greater than 50-Million-Fold Rate Enhancement in Enzyme-Like DNA Cleavage von Sreedhara, Alavattam, Freed, John D, Cowan, J. A

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Impurity investigations by phases of drug and product development von Olsen, Bernard A., Sreedhara, Alavattam, Baertschi, Steven W.

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Fragmentation of a Monoclonal Antibody by Peroxotungstate von Rathnayaka, Hasitha, Mozziconacci, Olivier, Sreedhara, Alavattam, Schöneich, Christian

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Stress Factors in mAb Drug Substance Production Processes: Critical Assessment of Impact on Product Quality and Control Strategy von Das, Tapan K., Narhi, Linda O., Sreedhara, Alavattam, Menzen, Tim, Grapentin, Christoph, Chou, Danny K., Antochshuk, Valentyn, Filipe, Vasco

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Challenges of Using Closed System Transfer Devices With Biological Drug Products: An Industry Perspective von Sreedhara, Alavattam, Zamiri, Camellia, Goswami, Sumit, Weiser, Sarah, Cram, Michael, Christian, Twinkle R., Jagannathan, Bharat

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Use of Closed System Transfer Devices (CSTDs) with Protein-Based Therapeutic Drugs-A Non-Solution for a Non-Problem? von Fast, Jonas, Christian, Twinkle, Crul, Mirjam, Jiskoot, Wim, Nejadnik, M Reza, Medina, Annette, Radwick, Allison, Sreedhara, Alavattam, Tole, Hugh

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Stress Factors in Protein Drug Product Manufacturing and Their Impact on Product Quality von Das, Tapan K., Sreedhara, Alavattam, Colandene, James D., Chou, Danny K., Filipe, Vasco, Grapentin, Christoph, Searles, Jim, Christian, Twinkle R., Narhi, Linda O., Jiskoot, Wim

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Assessing the Utility of Circular Dichroism and FTIR Spectroscopy in Monoclonal-Antibody Comparability Studies von Lin, Jasper C., Glover, Zephania Kwong, Sreedhara, Alavattam

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