A Synthetic Lethal Therapeutic Approach: Poly(ADP) Ribose Polymerase Inhibitors for the Treatment of Cancers Deficient in DNA Double-Strand Break Repair von ASHWORTH, Alan

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Marked for death: targeting epigenetic changes in cancer von Pfister, Sophia Xiao, Ashworth, Alan

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PARP inhibitors: Synthetic lethality in the clinic von Lord, Christopher J., Ashworth, Alan

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Synthetic lethal therapies for cancer: what’s next after PARP inhibitors? von Ashworth, Alan, Lord, Christopher J.

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Synthetic lethality as an engine for cancer drug target discovery von Huang, Alan, Garraway, Levi A., Ashworth, Alan, Weber, Barbara

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Drug Resistance Caused by Reversion Mutation von ASHWORTH, Alan

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Mechanisms of resistance to therapies targeting BRCA-mutant cancers von Lord, Christopher J, Ashworth, Alan

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Time for new guidelines to focus specifically on cardiac arrest in the peri‐operative period? von Harrison, Stephanie, Ashworth, Alan D.

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Transcription-Associated Cyclin-Dependent Kinases as Targets and Biomarkers for Cancer Therapy von Chou, Jonathan, Quigley, David A, Robinson, Troy M, Feng, Felix Y, Ashworth, Alan

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Synthetic Lethality and Cancer Therapy: Lessons Learned from the Development of PARP Inhibitors von Lord, Christopher J, Tutt, Andrew N.J, Ashworth, Alan

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Inherited cylindromas: lessons from a rare tumour von Rajan, Neil, Dr, Ashworth, Alan, Prof

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Tankyrase-targeted therapeutics: expanding opportunities in the PARP family von Riffell, Jenna L., Lord, Christopher J., Ashworth, Alan

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Smoking and risk of breast cancer in the Generations Study cohort von Jones, Michael E, Schoemaker, Minouk J, Wright, Lauren B, Ashworth, Alan, Swerdlow, Anthony J

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Hallmarks of 'BRCAness' in sporadic cancers von Turner, Nicholas, Tutt, Andrew, Ashworth, Alan

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Carboplatin in BRCA1/2-mutated and triple-negative breast cancer BRCAness subgroups: the TNT Trial von Tutt, Andrew, Tovey, Holly, Cheang, Maggie Chon U., Kernaghan, Sarah, Kilburn, Lucy, Gazinska, Patrycja, Owen, Julie, Abraham, Jacinta, Barrett, Sophie, Barrett-Lee, Peter, Brown, Robert, Chan, Stephen, Dowsett, Mitchell, Flanagan, James M, Fox, Lisa, Grigoriadis, Anita, Gutin, Alexander, Harper-Wynne, Catherine, Hatton, Matthew Q., Hoadley, Katherine A., Parikh, Jyoti, Parker, Peter, Perou, Charles M., Roylance, Rebecca, Shah, Vandna, Shaw, Adam, Smith, Ian E., Timms, Kirsten M., Wardley, Andrew M., Wilson, Gregory, Gillett, Cheryl, Lanchbury, Jerry S., Ashworth, Alan, Rahman, Nazneen, Harries, Mark, Ellis, Paul, Pinder, Sarah E., Bliss, Judith M.

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A requirement for STAG2 in replication fork progression creates a targetable synthetic lethality in cohesin-mutant cancers von Mondal, Gourish, Stevers, Meredith, Goode, Benjamin, Ashworth, Alan, Solomon, David A.

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PARP inhibition enhances tumor cell-intrinsic immunity in ERCC1-deficient non-small cell lung cancer von Chabanon, Roman M, Muirhead, Gareth, Krastev, Dragomir B, Adam, Julien, Morel, Daphné, Garrido, Marlène, Lamb, Andrew, Hénon, Clémence, Dorvault, Nicolas, Rouanne, Mathieu, Marlow, Rebecca, Bajrami, Ilirjana, Cardeñosa, Marta Llorca, Konde, Asha, Besse, Benjamin, Ashworth, Alan, Pettitt, Stephen J, Haider, Syed, Marabelle, Aurélien, Tutt, Andrew Nj, Soria, Jean-Charles, Lord, Christopher J, Postel-Vinay, Sophie

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Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance von Pettitt, Stephen J., Krastev, Dragomir B., Brandsma, Inger, Dréan, Amy, Song, Feifei, Aleksandrov, Radoslav, Harrell, Maria I., Menon, Malini, Brough, Rachel, Campbell, James, Frankum, Jessica, Ranes, Michael, Pemberton, Helen N., Rafiq, Rumana, Fenwick, Kerry, Swain, Amanda, Guettler, Sebastian, Lee, Jung-Min, Swisher, Elizabeth M., Stoynov, Stoyno, Yusa, Kosuke, Ashworth, Alan, Lord, Christopher J.

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Detection of early stage pancreatic cancer using 5-hydroxymethylcytosine signatures in circulating cell free DNA von Guler, Gulfem D., Ning, Yuhong, Ku, Chin-Jen, Phillips, Tierney, McCarthy, Erin, Ellison, Christopher K., Bergamaschi, Anna, Collin, Francois, Lloyd, Paul, Scott, Aaron, Antoine, Michael, Wang, Wendy, Chau, Kim, Ashworth, Alan, Quake, Stephen R., Levy, Samuel

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ATR inhibitors as a synthetic lethal therapy for tumours deficient in ARID1A von Williamson, Chris T., Miller, Rowan, Pemberton, Helen N., Jones, Samuel E., Campbell, James, Konde, Asha, Badham, Nicholas, Rafiq, Rumana, Brough, Rachel, Gulati, Aditi, Ryan, Colm J., Francis, Jeff, Vermulen, Peter B., Reynolds, Andrew R., Reaper, Philip M., Pollard, John R., Ashworth, Alan, Lord, Christopher J.

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