Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth von Zhu, Jiajun, Sammons, Morgan A., Donahue, Greg, Dou, Zhixun, Vedadi, Masoud, Getlik, Matthäus, Barsyte-Lovejoy, Dalia, Al-awar, Rima, Katona, Bryson W., Shilatifard, Ali, Huang, Jing, Hua, Xianxin, Arrowsmith, Cheryl H., Berger, Shelley L.

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Discovery of an MLLT1/3 YEATS Domain Chemical Probe von Moustakim, Moses, Christott, Thomas, Monteiro, Octovia P., Bennett, James, Giroud, Charline, Ward, Jennifer, Rogers, Catherine M., Smith, Paul, Panagakou, Ioanna, Díaz‐Sáez, Laura, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Halidi, Nadia, Heidenreich, David, Chaikuad, Apirat, Knapp, Stefan, Huber, Kilian V. M., Farnie, Gillian, Heer, Jag, Manevski, Nenad, Poda, Gennady, Al‐awar, Rima, Dixon, Darren J., Brennan, Paul E., Fedorov, Oleg

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Combined deletion of Pten and p53 in mammary epithelium accelerates triple‐negative breast cancer with dependency on eEF2K von Liu, Jeff C, Voisin, Veronique, Wang, Sharon, Wang, Dong‐Yu, Jones, Robert A, Datti, Alessandro, Uehling, David, Al‐awar, Rima, Egan, Sean E, Bader, Gary D, Tsao, Ming, Mak, Tak W, Zacksenhaus, Eldad

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Functional characterization of a PROTAC directed against BRAF mutant V600E von Posternak, Ganna, Tang, Xiaojing, Maisonneuve, Pierre, Jin, Ting, Lavoie, Hugo, Daou, Salima, Orlicky, Stephen, Goullet de Rugy, Theo, Caldwell, Lauren, Chan, Kin, Aman, Ahmed, Prakesch, Michael, Poda, Gennady, Mader, Pavel, Wong, Cassandra, Maier, Stefan, Kitaygorodsky, Julia, Larsen, Brett, Colwill, Karen, Yin, Zhe, Ceccarelli, Derek F., Batey, Robert A., Taipale, Mikko, Kurinov, Igor, Uehling, David, Wrana, Jeff, Durocher, Daniel, Gingras, Anne-Claude, Al-Awar, Rima, Therrien, Marc, Sicheri, Frank

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Asymmetric Synthesis of All the Known Phlegmarine Alkaloids von Wolfe, Bradley H, Libby, Adam H, Al-awar, Rima S, Foti, Christopher J, Comins, Daniel L

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Metformin Pharmacokinetics in Mouse Tumors: Implications for Human Therapy von Dowling, Ryan J.O., Lam, Sonya, Bassi, Christian, Mouaaz, Samar, Aman, Ahmed, Kiyota, Taira, Al-awar, Rima, Goodwin, Pamela J., Stambolic, Vuk

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Preclinical evaluation of taxane-binding peptide-modified polymeric micelles loaded with docetaxel in an orthotopic breast cancer mouse model von Logie, Jennifer, Ganesh, Ahil N, Aman, Ahmed M, Al-awar, Rima S, Shoichet, Molly S

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Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response von Szewczyk, Magdalena M., Ishikawa, Yoshinori, Organ, Shawna, Sakai, Nozomu, Li, Fengling, Halabelian, Levon, Ackloo, Suzanne, Couzens, Amber L., Eram, Mohammad, Dilworth, David, Fukushi, Hideto, Harding, Rachel, dela Seña, Carlo C., Sugo, Tsukasa, Hayashi, Kozo, McLeod, David, Zepeda, Carlos, Aman, Ahmed, Sánchez-Osuna, Maria, Bonneil, Eric, Takagi, Shinji, Al-Awar, Rima, Tyers, Mike, Richard, Stephane, Takizawa, Masayuki, Gingras, Anne-Claude, Arrowsmith, Cheryl H., Vedadi, Masoud, Brown, Peter J., Nara, Hiroshi, Barsyte-Lovejoy, Dalia

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(R)-PFI-2 is a potent and selective inhibitor of SETD7 methyltransferase activity in cells von Barsyte-Lovejoy, Dalia, Li, Fengling, Oudhoff, Menno J., Tatlock, John H., Dong, Aiping, Zeng, Hong, Wu, Hong, Freeman, Spencer A., Schapira, Matthieu, Senisterra, Guillermo A., Kuznetsova, Ekaterina, Marcellus, Richard, Allali-Hassani, Abdellah, Kennedy, Steven, Lambert, Jean-Philippe, Couzens, Amber L., Aman, Ahmed, Gingras, Anne-Claude, Al-Awar, Rima, Fish, Paul V., Gerstenberger, Brian S., Roberts, Lee, Benn, Caroline L., Grimley, Rachel L., Braam, Mitchell J. S., Rossi, Fabio M. V., Sudol, Marius, Brown, Peter J., Bunnage, Mark E., Owen, Dafydd R., Zaph, Colby, Vedadi, Masoud, Arrowsmith, Cheryl H.

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High-throughput sensitive screening of small molecule modulators of microexon alternative splicing using dual Nano and Firefly luciferase reporters von Best, Andrew J., Braunschweig, Ulrich, Wu, Mingkun, Farhangmehr, Shaghayegh, Pasculescu, Adrian, Lim, Justin J., Comsa, Lim Caden, Jen, Mark, Wang, Jenny, Datti, Alessandro, Wrana, Jeffrey L., Cordes, Sabine P., Al-awar, Rima, Han, Hong, Blencowe, Benjamin J.

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Structure-Based Optimization of a Small Molecule Antagonist of the Interaction Between WD Repeat-Containing Protein 5 (WDR5) and Mixed-Lineage Leukemia 1 (MLL1) von Getlik, Matthäus, Smil, David, Zepeda-Velázquez, Carlos, Bolshan, Yuri, Poda, Gennady, Wu, Hong, Dong, Aiping, Kuznetsova, Ekaterina, Marcellus, Richard, Senisterra, Guillermo, Dombrovski, Ludmila, Hajian, Taraneh, Kiyota, Taira, Schapira, Matthieu, Arrowsmith, Cheryl H, Brown, Peter J, Vedadi, Masoud, Al-awar, Rima

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Small Molecule Kinase Inhibitor Screen Identifies Polo-Like Kinase 1 as a Target for Neuroblastoma Tumor-Initiating Cells von GRINSHTEIN, Natalie, DATTI, Alessandro, FUJITANI, Mayumi, UEHLING, David, PRAKESCH, Michael, ISAAC, Methvin, IRWIN, Meredith S, WRANA, Jeffrey L, AI-AWAR, Rima, KAPLAN, David R

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Antagonists of the serotonin receptor 5A target human breast tumor initiating cells von Gwynne, William D., Shakeel, Mirza S., Girgis-Gabardo, Adele, Kim, Kwang H., Ford, Emily, Dvorkin-Gheva, Anna, Aarts, Craig, Isaac, Methvin, Al-awar, Rima, Hassell, John A.

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Virus-Tumor Interactome Screen Reveals ER Stress Response Can Reprogram Resistant Cancers for Oncolytic Virus-Triggered Caspase-2 Cell Death von Mahoney, Douglas J., Lefebvre, Charles, Allan, Kristina, Brun, Jan, Sanaei, Cina A., Baird, Stephen, Pearce, Nelson, Grönberg, Susanna, Wilson, Brian, Prakesh, Mikael, Aman, Ahmed, Isaac, Methvin, Mamai, Ahmed, Uehling, David, Al-Awar, Rima, Falls, Theresa, Alain, Tommy, Stojdl, David F.

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Amphiphilic micelles of poly(2-methyl-2-carboxytrimethylene carbonate- co - d,l -lactide)- graft -poly(ethylene glycol) for anti-cancer drug delivery to solid tumours von Ho, Karyn S, Aman, Ahmed M, Al-awar, Rima S, Shoichet, Molly S

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An Allosteric Inhibitor of Protein Arginine Methyltransferase 3 von Siarheyeva, Alena, Senisterra, Guillermo, Allali-Hassani, Abdellah, Dong, Aiping, Dobrovetsky, Elena, Wasney, Gregory A., Chau, Irene, Marcellus, Richard, Hajian, Taraneh, Liu, Feng, Korboukh, Ilia, Smil, David, Bolshan, Yuri, Min, Jinrong, Wu, Hong, Zeng, Hong, Loppnau, Peter, Poda, Gennadiy, Griffin, Carly, Aman, Ahmed, Brown, Peter J., Jin, Jian, Al-awar, Rima, Arrowsmith, Cheryl H., Schapira, Matthieu, Vedadi, Masoud

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Interrogation of Functional Cell-Surface Markers Identifies CD151 Dependency in High-Grade Serous Ovarian Cancer von Medrano, Mauricio, Communal, Laudine, Brown, Kevin R., Iwanicki, Marcin, Normand, Josee, Paterson, Joshua, Sircoulomb, Fabrice, Krzyzanowski, Paul, Novak, Marian, Doodnauth, Sasha A., Saiz, Fernando Suarez, Cullis, Jane, Al-awar, Rima, Neel, Benjamin G., McPherson, John, Drapkin, Ronny, Ailles, Laurie, Mes-Massons, Anne-Marie, Rottapel, Robert

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Discovery of a Selective Inhibitor for the YEATS Domains of ENL/AF9 von Christott, Thomas, Bennett, James, Coxon, Carmen, Monteiro, Octovia, Giroud, Charline, Beke, Viktor, Felce, Suet Ling, Gamble, Vicki, Gileadi, Carina, Poda, Gennady, Al-awar, Rima, Farnie, Gillian, Fedorov, Oleg

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A genome-wide CRISPR/Cas9 screen in acute myeloid leukemia cells identifies regulators of TAK-243 sensitivity von Barghout, Samir H., Aman, Ahmed, Nouri, Kazem, Blatman, Zachary, Arevalo, Karen, Thomas, Geethu E., MacLean, Neil, Hurren, Rose, Ketela, Troy, Saini, Mehakpreet, Abohawya, Moustafa, Kiyota, Taira, Al-Awar, Rima, Schimmer, Aaron D.

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Potent Targeting of the STAT3 Protein in Brain Cancer Stem Cells: A Promising Route for Treating Glioblastoma von Haftchenary, Sina, Luchman, H. Artee, Jouk, Andriana O, Veloso, Anthony J, Page, Brent D. G, Cheng, Xin Ran, Dawson, Sean S, Grinshtein, Natalie, Shahani, Vijay M, Kerman, Kagan, Kaplan, David R, Griffin, Carly, Aman, Ahmed M, Al-awar, Rima, Weiss, Samuel, Gunning, Patrick T

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