Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni von Vijayaraghavan, Jagamya, Kumar, Vijay, Krishnan, Nikhil P, Kaufhold, Ross T, Zeng, Ximin, Lin, Jun, van den Akker, Focco

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Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds von Kumar, Vijay, Boorman, Jacob, Greenlee, William J., Zeng, Ximin, Lin, Jun, van den Akker, Focco

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Exploring Additional Dimensions of Complexity in Inhibitor Design for Serine β-Lactamases: Mechanistic and Intra- and Inter-molecular Chemistry Approaches von van den Akker, Focco, Bonomo, Robert A

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NO and CO differentially activate soluble guanylyl cyclase via a heme pivot-bend mechanism von Ma, Xiaolei, Sayed, Nazish, Beuve, Annie, van den Akker, Focco

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Ligand-Dependent Disorder of the Ω Loop Observed in Extended-Spectrum SHV-Type β-Lactamase von SAMPSON, Jared M, WEI KE, BETHEL, Christopher R, PAGADALA, S. R. R, NOTTINGHAM, Michael D, BONOMO, Robert A, BUYNAK, John D, VAN DEN AKKER, Focco

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Desensitization of soluble guanylyl cyclase, the NO receptor, by S-nitrosylation von Sayed, Nazish, Baskaran, Padmamalini, Ma, Xiaolei, van den Akker, Focco, Beuve, Annie

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Inhibition of Klebsiella β-Lactamases (SHV-1 and KPC-2) by Avibactam: A Structural Study von Krishnan, Nikhil P, Nguyen, Nhu Q, Papp-Wallace, Krisztina M, Bonomo, Robert A, van den Akker, Focco

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Mutations in the mitochondrial ribosomal protein MRPS22 lead to primary ovarian insufficiency von Chen, Anlu, Tiosano, Dov, Guran, Tulay, Baris, Hagit N, Bayram, Yavuz, Mory, Adi, Shapiro-Kulnane, Laura, Hodges, Craig A, Akdemir, Zeynep C, Turan, Serap, Jhangiani, Shalini N, van den Akker, Focco, Hoppel, Charles L, Salz, Helen K, Lupski, James R, Buchner, David A

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Structural analysis of the boronic acid β-lactamase inhibitor vaborbactam binding to Pseudomonas aeruginosa penicillin-binding protein 3 von Kumar, Vijay, Viviani, Samantha L., Ismail, Jeeda, Agarwal, Shreya, Bonomo, Robert A., van den Akker, Focco

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Structural Characterization of Diazabicyclooctane β-Lactam "Enhancers" in Complex with Penicillin-Binding Proteins PBP2 and PBP3 of Pseudomonas aeruginosa von Rajavel, Malligarjunan, Kumar, Vijay, Nguyen, Ha, Wyatt, Jacob, Marshall, Steven H, Papp-Wallace, Krisztina M, Deshpande, Prasad, Bhavsar, Satish, Yeole, Ravindra, Bhagwat, Sachin, Patel, Mahesh, Bonomo, Robert A, van den Akker, Focco

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Insights into BAY 60-2770 Activation and S‑Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H‑NOX Domain Complexes... von Kumar, Vijay, Martin, Faye, Hahn, Michael G, Schaefer, Martina, Stamler, Jonathan S, Stasch, Johannes-Peter, van den Akker, Focco

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A reinterpretation of the dimerization interface of the N‐terminal Domains of STATs von Chen, Xiaomin, Bhandari, Rashna, Vinkemeier, Uwe, van den Akker, Focco, Darnell, James E., Kuriyan, John

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PAS-mediated Dimerization of Soluble Guanylyl Cyclase Revealed by Signal Transduction Histidine Kinase Domain Crystal Structure von Ma, Xiaolei, Sayed, Nazish, Baskaran, Padmamalini, Beuve, Annie, van den Akker, Focco

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Is Nostoc H-NOX a NO Sensor or Redox Switch? von Tsai, Ah-Lim, Berka, Vladimir, Martin, Faye, Ma, Xiaolei, van den Akker, Focco, Fabian, Marian, Olson, John S

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Crystal structure of the signaling helix coiled-coil domain of the β1 subunit of the soluble guanylyl cyclase von Ma, Xiaolei, Beuve, Annie, van den Akker, Focco

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Crystal Structures of KPC-2 β-Lactamase in Complex with 3-Nitrophenyl Boronic Acid and the Penam Sulfone PSR-3-226 von Ke, Wei, Bethel, Christopher R, Papp-Wallace, Krisztina M, Pagadala, Sundar Ram Reddy, Nottingham, Micheal, Fernandez, Daniel, Buynak, John D, Bonomo, Robert A, van den Akker, Focco

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Mutations in the Transmembrane Natriuretic Peptide Receptor NPR-B Impair Skeletal Growth and Cause Acromesomelic Dysplasia, Type Maroteaux von Bartels, Cynthia F., Bükülmez, Hülya, Padayatti, Pius, Rhee, David K., van Ravenswaaij-Arts, Conny, Pauli, Richard M., Mundlos, Stefan, Chitayat, David, Shih, Ling-Yu, Al-Gazali, Lihadh I., Kant, Sarina, Cole, Trevor, Morton, Jenny, Cormier-Daire, Valérie, Faivre, Laurence, Lees, Melissa, Kirk, Jeremy, Mortier, Geert R., Leroy, Jules, Zabel, Bernhard, Kim, Chong Ae, Crow, Yanick, Braverman, Nancy E., van den Akker, Focco, Warman, Matthew L.

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Identification of residues in the heme domain of soluble guanylyl cyclase that are important for basal and stimulated catalytic activity von Baskaran, Padmamalini, Heckler, Erin J, van den Akker, Focco, Beuve, Annie

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Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem von Papp-Wallace, Krisztina M, Kumar, Vijay, Zeiser, Elise T, Becka, Scott A, van den Akker, Focco

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Penam sulfones and β-lactamase inhibition: SA2-13 and the importance of the C2 side chain length and composition von Rodkey, Elizabeth A, Winkler, Marisa L, Bethel, Christopher R, Pagadala, Sundar Ram Reddy, Buynak, John D, Bonomo, Robert A, van den Akker, Focco

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