Discovery of Epigenetic Regulator I‑BET762: Lead Optimization to Afford a Clinical Candidate Inhibitor of the BET Bromodomains von Mirguet, Olivier, Gosmini, Romain, Toum, Jérôme, Clément, Catherine A, Barnathan, Mélanie, Brusq, Jean-Marie, Mordaunt, Jacqueline E, Grimes, Richard M, Crowe, Miriam, Pineau, Olivier, Ajakane, Myriam, Daugan, Alain, Jeffrey, Phillip, Cutler, Leanne, Haynes, Andrea C, Smithers, Nicholas N, Chung, Chun-wa, Bamborough, Paul, Uings, Iain J, Lewis, Antonia, Witherington, Jason, Parr, Nigel, Prinjha, Rab K, Nicodème, Edwige

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Discovery and Optimization of Potent, Selective, and in Vivo Efficacious 2‑Aryl Benzimidazole BCATm Inhibitors von Deng, Hongfeng, Zhou, Jingye, Sundersingh, Flora, Messer, Jeffrey A, Somers, Donald O, Ajakane, Myriam, Arico-Muendel, Christopher C, Beljean, Arthur, Belyanskaya, Svetlana L, Bingham, Ryan, Blazensky, Emily, Boullay, Anne-Benedicte, Boursier, Eric, Chai, Jing, Carter, Paul, Chung, Chun-Wa, Daugan, Alain, Ding, Yun, Herry, Kenny, Hobbs, Clare, Humphries, Eric, Kollmann, Christopher, Nguyen, Van Loc, Nicodeme, Edwige, Smith, Sarah E, Dodic, Nerina, Ancellin, Nicolas

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Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis von Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D., Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, Cesar, Mackenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F., Fiandor, Jose M., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Miles, Timothy J.

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Identification of 6-amino-1-pyrazolo[3,4-]pyrimidines with efficacy against visceral leishmaniasis von Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D, Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F, Fiandor, Jose M, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H, Miles, Timothy J

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The bisindolylmaleimide GF 109203X is a potent and selective inhibitor of protein kinase C von TOULEC, D, PIANETTI, P, DUHAMEL, L, CHARON, D, KIRILOVSKY, J, COSTE, H, BELLEVERGUE, P, GRAND-PERRET, T, AJAKANE, M, BAUDET, V, BOISIN, P, BOURSIER, E, LORIOLLE, F

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Identification of 6-amino-1H-pyrazolo[3,4-d]pyrimidines with in vivo efficacy against visceral leishmaniasis† †Electronic supplementary information (ESI) available. See DOI: 10.103... von Thomas, Michael G., De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D., Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J., MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R. C., Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F., Fiandor, Jose M., Wyatt, Paul G., Read, Kevin D., Gilbert, Ian H., Miles, Timothy J.

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Identification of 6-amino-1 H -pyrazolo[3,4- d ]pyrimidines with in vivo efficacy against visceral leishmaniasis von Thomas, Michael G, De Rycker, Manu, Ajakane, Myriam, Crouch, Sabrinia D, Campbell, Lorna, Daugan, Alain, Fra, Gloria, Guerrero, César, Mackenzie, Claire J, MacLean, Lorna, Manthri, Sujatha, Martin, Franck, Norval, Suzanne, Osuna-Cabello, Maria, Riley, Jennifer, Shishikura, Yoko, Miguel-Siles, Juan, Simeons, Frederick R C, Stojanovski, Laste, Thomas, John, Thompson, Stephen, Velasco, Raul F, Fiandor, Jose M, Wyatt, Paul G, Read, Kevin D, Gilbert, Ian H, Miles, Timothy J

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