Activation of 4-1BB on Liver Myeloid Cells Triggers Hepatitis via an Interleukin-27-Dependent Pathway von Bartkowiak, Todd, Jaiswal, Ashvin R, Ager, Casey R, Chin, Renee, Chen, Chao-Hsien, Budhani, Pratha, Ai, Midan, Reilley, Matthew J, Sebastian, Manu M, Hong, David S, Curran, Michael A

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Unique potential of 4-1BB agonist antibody to promote durable regression of HPV⁺ tumors when combined with an E6/E7 peptide vaccine von Bartkowiak, Todd, Singh, Shailbala, Yang, Guojun, Galvan, Gloria, Haria, Dhwani, Ai, Midan, Allison, James P., Sastry, K. Jagannadha, Curran, Michael A.

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Selective Induction of Tumor Cell Apoptosis by a Novel P450-mediated Reactive Oxygen Species (ROS) Inducer Methyl 3-(4-Nitrophenyl) Propiolate von Sun, Xiaoxiao, Ai, Midan, Wang, Ying, Shen, Shensi, Gu, Yuan, Jin, Yi, Zhou, Zuyu, Long, Yaqiu, Yu, Qiang

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Abstract IA11: Reversal of immunotherapy resistance through hypoxia reduction von Jayaprakash, Priyamvada, Ai, Midan, Curran, Michael A.

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Abstract 1233: A triad of Brk, HER2 and STAT3 in regulating epithelial and mesenchymal transition and survival of breast cancer cells von Ai, Midan

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Targeted hypoxia reduction restores T cell infiltration and sensitizes prostate cancer to immunotherapy von Jayaprakash, Priyamvada, Ai, Midan, Liu, Arthur, Budhani, Pratha, Bartkowiak, Todd, Sheng, Jie, Ager, Casey, Nicholas, Courtney, Jaiswal, Ashvin R, Sun, Yanqiu, Shah, Krishna, Balasubramanyam, Sadhana, Li, Nan, Wang, Guocan, Ning, Jing, Zal, Anna, Zal, Tomasz, Curran, Michael A

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Tumor hypoxia drives immune suppression and immunotherapy resistance von Ai, Midan, Budhani, Pratha, Sheng, Jie, Balasubramanyam, Sadhana, Bartkowiak, Todd, Jaiswal, Ashvin R, Ager, Casey R, Haria, Dhwani D, Curran, Michael A

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Immune checkpoint combinations from mouse to man von Ai, Midan, Curran, Michael A.

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A novel synthetic analog of 5, 8-disubstituted quinazolines blocks mitosis and induces apoptosis of tumor cells by inhibiting microtubule polymerization von Tian, Wei, Qin, Lili, Song, Qiaoling, He, Li, Ai, Midan, Jin, Yi, Zhou, Zuyu, You, Song, Long, Yaqiu, Yu, Qiang

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HSV-tk/GCV gene therapy mediated by EBV-LMP1 for EBV-associated cancer von Lifang, Yang, Min, Tang, Midan, Ai, Ya, Cao

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Brk/PTK6 cooperates with HER2 and Src in regulating breast cancer cell survival and epithelial-to-mesenchymal transition von Ai, Midan, Liang, Ke, Lu, Yang, Qiu, Songbo, Fan, Zhen

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HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain von Ai, Midan, Qiu, Songbo, Lu, Yang, Fan, Zhen

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Despite KLRG1 expression, highly cytotoxic ThEO/TcEO polarized T cells efficiently establish immunologic memory (LYM5P.662) von Bartkowiak, Todd, Ai, Midan, Ager, Casey, Curran, Michael

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Abstract 4799: Inhibition of STAT3 in pancreatic ductal adenocarcinoma and immunotherapeutic implications von Zielinski, Rafal, Fokt, Izabela, Skora, Stanislaw, Felix, Edward, Grela, Krzysztof, Arumugam, Jayakumar, Venugopal, Radj, Ai, Midan, Hartley, Genevieve, Curran, Michael, Priebe, Waldemar

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Channelrhodopsin-2-expressed dorsal root ganglion neurons activates calcium channel currents and increases action potential in spinal cord von Zhang, Yi, Yue, Jing, Ai, Midan, Ji, Zhigang, Liu, Zhiguo, Cao, Xuehong, Li, Li

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Mechanisms underlying 4-1BB agonist antibody mediated hepatotoxicity von Bartkowiak, Todd, Jaiswal, Ashvin R, Ai, Midan, Budhani, Pratha, Ager, Casey, Curran, Michael A

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Despite KLRG1 expression, highly cytotoxic ThEO/TcEO polarized T cells efficiently establish immunologic memory von Bartkowiak, Todd, Jaiswal, Ashvin R, Ai, Midan, Budhani, Pratha, Ager, Casey, Curran, Michael A

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Abstract 5011: Targeting hypoxia-induced immune suppression to overcome immunotherapy resistance in prostate cancer von Jayaprakash, Priyamvada, Ai, Midan, Liu, Arthur, Budhani, Pratha, Bartkowiak, Todd, Sheng, Jie, Ager, Casey, Nicholas, Courtney, Jaiswal, Ashvin, Sun, Yanqiu, Shah, Krishna, Balasubramanyam, Sadhana, Li, Nan, Wang, Guocan, Ning, Jing, Zal, Anna, Zal, Tomasz, Curran, Michael

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Abstract PR003: Hypoxia is an essential driver of immune suppression in the tumor microenvironment von Ai, Midan, Budhani, Pratha, Curran, Michael A.

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Identifying mechanisms of acquired resistance to immunotherapy (TUM2P.1025) von Jaiswal, Ashvin, Ager, Casey, Ai, Midan, Bartkowiak, Todd, Budhani, Pratha, Curran, Michael

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