Tumor Heterogeneity and Lesion-Specific Response to Targeted Therapy in Colorectal Cancer von Russo, Mariangela, Siravegna, Giulia, Blaszkowsky, Lawrence S, Corti, Giorgio, Crisafulli, Giovanni, Ahronian, Leanne G, Mussolin, Benedetta, Kwak, Eunice L, Buscarino, Michela, Lazzari, Luca, Valtorta, Emanuele, Truini, Mauro, Jessop, Nicholas A, Robinson, Hayley E, Hong, Theodore S, Mino-Kenudson, Mari, Di Nicolantonio, Federica, Thabet, Ashraf, Sartore-Bianchi, Andrea, Siena, Salvatore, Iafrate, A John, Bardelli, Alberto, Corcoran, Ryan B

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Strategies for monitoring and combating resistance to combination kinase inhibitors for cancer therapy von Ahronian, Leanne G, Corcoran, Ryan B

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Clinical Acquired Resistance to RAF Inhibitor Combinations in BRAF-Mutant Colorectal Cancer through MAPK Pathway Alterations von Ahronian, Leanne G, Sennott, Erin M, Van Allen, Eliezer M, Wagle, Nikhil, Kwak, Eunice L, Faris, Jason E, Godfrey, Jason T, Nishimura, Koki, Lynch, Kerry D, Mermel, Craig H, Lockerman, Elizabeth L, Kalsy, Anuj, Gurski, Jr, Joseph M, Bahl, Samira, Anderka, Kristin, Green, Lisa M, Lennon, Niall J, Huynh, Tiffany G, Mino-Kenudson, Mari, Getz, Gad, Dias-Santagata, Dora, Iafrate, A John, Engelman, Jeffrey A, Garraway, Levi A, Corcoran, Ryan B

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Functional activity of RLIM/Rnf12 is regulated by phosphorylation-dependent nucleocytoplasmic shuttling von Jiao, Baowei, Taniguchi-Ishigaki, Naoko, Güngör, Cenap, Peters, Marvin A, Chen, Ya-Wen, Riethdorf, Sabine, Drung, Alexander, Ahronian, Leanne G, Shin, Jongdae, Pagnis, Rachna, Pantel, Klaus, Tachibana, Taro, Lewis, Brian C, Johnsen, Steven A, Bach, Ingolf

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Genomic Landscape of Cell-Free DNA in Patients with Colorectal Cancer von Strickler, John H, Loree, Jonathan M, Ahronian, Leanne G, Parikh, Aparna R, Niedzwiecki, Donna, Pereira, Allan Andresson Lima, McKinney, Matthew, Korn, W Michael, Atreya, Chloe E, Banks, Kimberly C, Nagy, Rebecca J, Meric-Bernstam, Funda, Lanman, Richard B, Talasaz, AmirAli, Tsigelny, Igor F, Corcoran, Ryan B, Kopetz, Scott

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Polyclonal Secondary FGFR2 Mutations Drive Acquired Resistance to FGFR Inhibition in Patients with FGFR2 Fusion-Positive Cholangiocarcinoma von Goyal, Lipika, Saha, Supriya K, Liu, Leah Y, Siravegna, Giulia, Leshchiner, Ignaty, Ahronian, Leanne G, Lennerz, Jochen K, Vu, Phuong, Deshpande, Vikram, Kambadakone, Avinash, Mussolin, Benedetta, Reyes, Stephanie, Henderson, Laura, Sun, Jiaoyuan Elisabeth, Van Seventer, Emily E, Gurski, Jr, Joseph M, Baltschukat, Sabrina, Schacher-Engstler, Barbara, Barys, Louise, Stamm, Christelle, Furet, Pascal, Ryan, David P, Stone, James R, Iafrate, A John, Getz, Gad, Porta, Diana Graus, Tiedt, Ralph, Bardelli, Alberto, Juric, Dejan, Corcoran, Ryan B, Bardeesy, Nabeel, Zhu, Andrew X

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The p53R172H mutant does not enhance hepatocellular carcinoma development and progression von Ahronian, Leanne G, Driscoll, David R, Klimstra, David S, Lewis, Brian C

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Molecular Heterogeneity and Receptor Coamplification Drive Resistance to Targeted Therapy in MET-Amplified Esophagogastric Cancer von Kwak, Eunice L, Ahronian, Leanne G, Siravegna, Giulia, Mussolin, Benedetta, Borger, Darrell R, Godfrey, Jason T, Jessop, Nicholas A, Clark, Jeffrey W, Blaszkowsky, Lawrence S, Ryan, David P, Lennerz, Jochen K, Iafrate, A John, Bardelli, Alberto, Hong, Theodore S, Corcoran, Ryan B

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Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAFV600E Colorectal Cancer von Hazar-Rethinam, Mehlika, Kleyman, Marianna, Han, G Celine, Liu, David, Ahronian, Leanne G, Shahzade, Heather A, Chen, Lifeng, Parikh, Aparna R, Allen, Jill N, Clark, Jeffrey W, Kwak, Eunice L, Faris, Jason E, Murphy, Janet E, Hong, Theodore S, Van Seventer, Emily E, Nadres, Brandon, Hong, Catriona B, Gurski, Joseph M, Jessop, Nicholas A, Dias-Santagata, Dora, Iafrate, A John, Van Allen, Eliezer M, Corcoran, Ryan B

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KRAS(G12D)- and BRAF(V600E)-induced transformation of murine pancreatic epithelial cells requires MEK/ERK-stimulated IGF1R signaling von Appleman, Victoria A, Ahronian, Leanne G, Cai, JiuFeng, Klimstra, David S, Lewis, Brian C

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Effective MAPK Inhibition is critical for therapeutic responses in colorectal cancer with BRAF mutations von Ahronian, Leanne G., Corcoran, Ryan B.

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Convergent Therapeutic Strategies to Overcome the Heterogeneity of Acquired Resistance in BRAF V600E Colorectal Cancer von Hazar-Rethinam, Mehlika, Kleyman, Marianna, Han, G Celine, Liu, David, Ahronian, Leanne G, Shahzade, Heather A, Chen, Lifeng, Parikh, Aparna R, Allen, Jill N, Clark, Jeffrey W, Kwak, Eunice L, Faris, Jason E, Murphy, Janet E, Hong, Theodore S, Van Seventer, Emily E, Nadres, Brandon, Hong, Catriona B, Gurski, Jr, Joseph M, Jessop, Nicholas A, Dias-Santagata, Dora, Iafrate, A John, Van Allen, Eliezer M, Corcoran, Ryan B

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A novel KLF6-Rho GTPase axis regulates hepatocellular carcinoma cell migration and dissemination von Ahronian, L G, Zhu, L J, Chen, Y-W, Chu, H-C, Klimstra, D S, Lewis, B C

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Abstract P146: Loss of HS2ST1 cooperates with MAPK inhibition to impair growth of mesenchymal KRAS mutant NSCLC von Ahronian, Leanne G., Fenoglio, Silvia, Das, Nikitha, Aird, Daniel, Guerin, David, Whittington, Douglas, Jahic, Haris, Brophy, Erin, McCarren, Patrick, McMillan, Brian, Tepper, James, Mentzer, Michaela, Li, Fang, Zhang, Hongxiang, Pan, Xuewen, Maxwell, John, Andersen, Jannik, Huang, Alan, Sjin, Robert Tjin Tham

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Abstract B50: ERK MAPK inhibition enhances the immunogenicity of KRAS-mutant colorectal cancer von Ryan, Meagan B., Fece de la Cruz, Ferran, Ahronian, Leanne G., Phat, Sarah, Myers, David T., Shahzade, Heather A., Hong, Catriona, Corcoran, Ryan B.

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Abstract P183: CRISPR screens identify sensitizers to trametinib in KRAS mutant cancer cell lines von Fenoglio, Silvia, Cristo, Aileen M., Tepper, James, Teng, Teng, Meier, Samuel R., Choi, Ashley, Zhang, Hongxiang, Zhao, Shan-chuan, Liu, Shangtao, Ahronian, Leanne G., Aird, Daniel, Das, Nikitha M., Yu, Yi, Sjin, Robert Tjin Tham, Andersen, Jannik N., Huang, Alan, Li, Fang, Pan, Xuewen

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Abstract 101: Adaptive feedback reactivates MAPK signaling in KRAS-mutant cancers with inhibition of MEK, but not ERK von Ahronian, Leanne G., Misale, Sandra, Godfrey, Jason T., Nishimura, Koki, Chen, Lifeng, Engelman, Jeffrey A., Corcoran, Ryan B.

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Abstract 1175: The tumor-associated p53 R172H mutation does not display gain-of-function properties in hepatocellular carcinoma von Ahronian, Leanne G., Lewis, Brian C.

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KRASG12D- and BRAFV600E-Induced Transformation of Murine Pancreatic Epithelial Cells Requires MEK/ERK-Stimulated IGF1R Signaling von Appleman, Victoria A., Ahronian, Leanne G., Cai, JiuFeng, Klimstra, David S., Lewis, Brian C.

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The p53.sup.R172H Mutant Does Not Enhance Hepatocellular Carcinoma Development and Progression von Ahronian, Leanne G, Driscoll, David R, Klimstra, David S, Lewis, Brian C

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