Systemic immune challenge exacerbates neurodegeneration in a model of neurological lysosomal disease von Mandolfo, Oriana, Parker, Helen, Aguado, Èlia, Ishikawa Learmonth, Yuko, Liao, Ai Yin, O’Leary, Claire, Ellison, Stuart, Forte, Gabriella, Taylor, Jessica, Wood, Shaun, Searle, Rachel, Holley, Rebecca J, Boutin, Hervé, Bigger, Brian W

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MAT2A Inhibition Blocks the Growth of MTAP-Deleted Cancer Cells by Reducing PRMT5-Dependent mRNA Splicing and Inducing DNA Damage von Kalev, Peter, Hyer, Marc L., Gross, Stefan, Konteatis, Zenon, Chen, Chi-Chao, Fletcher, Mark, Lein, Max, Aguado-Fraile, Elia, Frank, Victoria, Barnett, Amelia, Mandley, Everton, Goldford, Joshua, Chen, Yue, Sellers, Katie, Hayes, Sebastian, Lizotte, Kate, Quang, Phong, Tuncay, Yesim, Clasquin, Michelle, Peters, Rachel, Weier, Jaclyn, Simone, Eric, Murtie, Joshua, Liu, Wei, Nagaraja, Raj, Dang, Lenny, Sui, Zhihua, Biller, Scott A., Travins, Jeremy, Marks, Kevin M., Marjon, Katya

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A Pilot Study Identifying a Set of microRNAs As Precise Diagnostic Biomarkers of Acute Kidney Injury von Aguado-Fraile, Elia, Ramos, Edurne, Conde, Elisa, Rodríguez, Macarena, Martín-Gómez, Laura, Lietor, Aurora, Candela, Ángel, Ponte, Belen, Liaño, Fernando, García-Bermejo, María Laura

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Hypoxia inducible factor 1-alpha (HIF-1 alpha) is induced during reperfusion after renal ischemia and is critical for proximal tubule cell survival von Conde, Elisa, Alegre, Laura, Blanco-Sánchez, Ignacio, Sáenz-Morales, David, Aguado-Fraile, Elia, Ponte, Belén, Ramos, Edurne, Sáiz, Ana, Jiménez, Carlos, Ordoñez, Angel, López-Cabrera, Manuel, del Peso, Luis, de Landázuri, Manuel O, Liaño, Fernando, Selgas, Rafael, Sanchez-Tomero, Jose Antonio, García-Bermejo, María Laura

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miR-127 protects proximal tubule cells against ischemia/reperfusion: identification of kinesin family member 3B as miR-127 target von Aguado-Fraile, Elia, Ramos, Edurne, Sáenz-Morales, David, Conde, Elisa, Blanco-Sánchez, Ignacio, Stamatakis, Konstantinos, del Peso, Luis, Cuppen, Edwin, Brüne, Bernhard, Bermejo, María Laura García

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Interaction between intestinal dendritic cells and bacteria translocated from the gut in rats with cirrhosis von Muñoz, Leticia, José Borrero, María, Ubeda, María, Lario, Margaret, Díaz, David, Francés, Rubén, Monserrat, Jorge, Pastor, Óscar, Aguado-Fraile, Elia, Such, José, Álvarez-Mon, Melchor, Albillos, Agustín

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Mutual regulation of hypoxic and retinoic acid related signalling in tubular proximal cells von Fernández-Martínez, Ana Belén, Jiménez, María Isabel Arenas, Hernández, Irene Sánchez, García-Bermejo, María Laura, Manzano, Victoria Moreno, Fraile, Elia Aguado, de Lucio-Cazaña, Francisco Javier

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IDH1 mutation detection in plasma circulating tumor DNA (ctDNA) and association with clinical response in patients with advanced intrahepatic cholangiocarcinoma (IHC) from the phas... von Aguado, Elia, Abou-Alfa, Ghassan K., Zhu, Andrew X., Macarulla, Teresa, Fan, Bin, Nejad, Parham, Choe, Sung, Jiang, Liewen, Gliser, Camelia, Pandya, Shuchi Sumant, Wu, Bin

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EXTH-59. THE IDH1 MUTANT INHIBITOR AG-120 SHOWS STRONG INHIBITION OF 2-HG PRODUCTION IN AN ORTHOTOPIC IDH1 MUTANT GLIOMA MODEL IN VIVO von Nicolay, Brandon, Narayanaswamy, Rohini, Aguado, Elia, Nagaraja, Raj, Murtie, Josh, Liu, Guowen, Ishii, Yuko

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EXTH-34. COMBINED USE OF THE PAN-IDH MUTANT INHIBITOR AG-881 WITH RADIATION THERAPY SHOWS ADDED BENEFIT IN AN ORTHOTOPIC IDH1 MUTANT GLIOMA MODEL IN VIVO von Nicolay, Brandon, Narayanaswamy, Rohini, Amatangelo, Michael D, Aguado, Elia, Nagaraja, Raj, Murtie, Josh, Liu, Guowen, Ishii, Yuko

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Abstract 5650: RP-6306, a novel PKMYT1 inhibitor, demonstrates synthetic lethality as monotherapy and in combination with gemcitabine in CCNE1 amplified cancer cells von Fourtounis, Jimmy, Martino, John, Stocco, Rino, Baruah, Prasamit, Duffy, Nicole, Gallo, David, Fournier, Sarah, Li, JingJing, Li, Li, Aguado, Elia, Petrone, Adam, Roulston, Anne, Mamane, Yael, Morris, Stephen, Szychowski, Janek, Papp, Robert, Zinda, Mike, Marshall, C. Gary

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Safety and activity of ivosidenib in patients with IDH1-mutant advanced cholangiocarcinoma: a phase 1 study von Lowery, Maeve A, Burris, Howard A, Janku, Filip, Shroff, Rachna T, Cleary, James M, Azad, Nilofer S, Goyal, Lipika, Maher, Elizabeth A, Gore, Lia, Hollebecque, Antoine, Beeram, Muralidhar, Trent, Jonathan C, Jiang, Liewen, Fan, Bin, Aguado-Fraile, Elia, Choe, Sung, Wu, Bin, Gliser, Camelia, Agresta, Samuel V, Pandya, Shuchi S, Zhu, Andrew X, Abou-Alfa, Ghassan K

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Abstract 3510: IDH1-R132H tumor cells are not robustly sensitive to PARP inhibition in a 2-HG dependent manner von Aguado-Fraile, Elia, Hudson, Christine, Sleger, Taryn, Ronseaux, Sebastien, Narayanaswamy, Rohini, Choe, Sung, Wu, Bin, Kalev, Peter, Nicolay, Brandon

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HIF-1α induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p von Conde, Elisa, Giménez-Moyano, Sara, Martín-Gómez, Laura, Rodríguez, Macarena, Ramos, M. Edurne, Aguado-Fraile, Elia, Blanco-Sanchez, Ignacio, Saiz, Ana, García-Bermejo, María Laura

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Molecular and morphological changes induced by ivosidenib correlate with efficacy in mutant-IDH1 cholangiocarcinoma von Aguado-Fraile, Elia, Tassinari, Ania, Ishii, Yuko, Sigel, Carlie, Lowery, Maeve A., Goyal, Lipika, Gliser, Camelia, Jiang, Liewen, Pandya, Shuchi S., Wu, Bin, Bardeesy, Nabeel, Choe, Sung, Deshpande, Vikram

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Abstract 2275: Detection of IDH1 mutations in plasma cell-free circulating tumor DNA (ctDNA) from patients with cholangiocarcinoma von Aguado-Fraile, Elia, Choe, Sung, Gliser, Camelia, Steelman, Lori, Jiang, Liewen, Fan, Bin, Le, Kha, Lowery, Maeve A., Pandya, Susan, Wu, Bin

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Abstract 2714: Targeting MAT2A in CDKN2A/MTAP-deleted cancers von Marjon, Katya, Kalev, Peter, Hyer, Marc, Fletcher, Mark, Zhang, Peili, Aguado-Fraile, Elia, Mandley, Everton, Konteatis, Zenon, Travins, Jeremy, Marks, Kevin

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Abstract B115: Mitotic defects induced by MAT2A inhibitors guides translational drug combination strategies with AG-270 and taxanes von Kalev, Peter, Hyer, Marc L, Fletcher, Mark, Zhang, Peili, Aguado-Fraile, Elia, Mandley, Everton, Tuncay, Yesim, Konteatis, Zenon, Travins, Jeremy, Marks, Kevin M, Marjon, Katya

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The combination of TPL2 knockdown and TNFα causes synthetic lethality via caspase-8 activation in human carcinoma cell lines von Serebrennikova, Oksana B., Paraskevopoulou, Maria D., Aguado-Fraile, Elia, Taraslia, Vasiliki, Ren, Wenying, Thapa, Geeta, Roper, Jatin, Du, Keyong, Croce, Carlo M., Tsichlis, Philip N.

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Abstract 3090: The MAT2A inhibitor, AG-270, combines with both taxanes and gemcitabine to yield enhanced anti-tumor activity in patient-derived xenograft models von Hyer, Marc L., Kalev, Peter, Fletcher, Mark, Chen, Chi-Chao, Aguado-Fraile, Elia, Mandley, Everton, Newhouse, Sheila, Lein, Max, Nagaraja, Raj, Tuncay, Yesim, Murtie, Josh, Marks, Kevin M., Marjon, Katya

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