Large-scale features and evaluation of the PMIP4-CMIP6 midHolocene simulations von Brierley, Chris M., Zhao, Anni, Harrison, Sandy P., Braconnot, Pascale, Williams, Charles J. R., Thornalley, David J. R., Shi, Xiaoxu, Peterschmitt, Jean-Yves, Ohgaito, Rumi, Kaufman, Darrell S., Kageyama, Masa, Hargreaves, Julia C., Erb, Michael P., Emile-Geay, Julien, Agostino, Roberta D, Chandan, Deepak, Carré, Matthieu, Bartlein, Partrick J., Zheng, Weipeng, Zhang, Zhongshi, Zhang, Qiong, Yang, Hu, Volodin, Evgeny M., Tomas, Robert A., Routson, Cody, Peltier, W. Richard, Otto-Bliesner, Bette, Morozova, Polina A., McKay, Nicholas P., Lohmann, Gerrit, Legrande, Allegra N., Guo, Chuncheng, Cao, Jian, Brady, Esther, Annan, James D., Abe-Ouchi7, Ayako

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Multi-model evidence of future tropical Atlantic precipitation change modulated by AMOC decline von Cerato, Giada, Bellomo, Katinka, Agostino, Roberta D, von Hardenberg, Jost

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Multi-model evidence of future tropical Atlantic precipitation change modulated by AMOC decline von Cerato, Giada, Bellomo, Katinka, Agostino, Roberta D, Jost von Hardenberg

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Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression von Baglio, S Rubina, Lagerweij, Tonny, Pérez-Lanzón, Maria, Ho, Xuan Dung, Léveillé, Nicolas, Melo, Sonia A, Cleton-Jansen, Anne-Marie, Jordanova, Ekaterina S, Roncuzzi, Laura, Greco, Michelina, van Eijndhoven, Monique A J, Grisendi, Giulia, Dominici, Massimo, Bonafede, Roberta, Lougheed, Sinead M, de Gruijl, Tanja D, Zini, Nicoletta, Cervo, Silvia, Steffan, Agostino, Canzonieri, Vincenzo, Martson, Aare, Maasalu, Katre, Köks, Sulev, Wurdinger, Tom, Baldini, Nicola, Pegtel, D Michiel

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P594: THE CXCR4‐LOW/CD5‐HIGH PROLIFERATIVE FRACTION IS ENRICHED IN BTK MUTATIONS AND ANTICIPATES RELAPSE IN IBRUTINIB‐TREATED CLL von Pozzo, Federico, Forestieri, Gabriela, Ianna, Giulia, Vit, Filippo, Tissino, Erika, Bittolo, Tamara, Papotti, Robel, Terzi DI Bergamo, Lodovico, Steffan, Agostino, Laureana, Roberta, Tafuri, Agostino, Chiarenza, Annalisa, DI Raimondo, Francesco, Olivieri, Jacopo, Zaja, Francesco, Laurenti, Luca, Ilaria DEL Principe, Maria, Bomben, Riccardo, Zucchetto, Antonella, Rossi, Davide, Gattei, Valter

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Describing self-care in Italian adults with heart failure and identifying determinants of poor self-care von Cocchieri, Antonello, Riegel, Barbara, D’Agostino, Fabio, Rocco, Gennaro, Fida, Roberta, Alvaro, Rosaria, Vellone, Ercole

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Common, low-frequency, rare, and ultra-rare coding variants contribute to COVID-19 severity von Fallerini, Chiara, Picchiotti, Nicola, Baldassarri, Margherita, Zguro, Kristina, Daga, Sergio, Fava, Francesca, Benetti, Elisa, Amitrano, Sara, Bruttini, Mirella, Palmieri, Maria, Croci, Susanna, Lista, Mirjam, Beligni, Giada, Valentino, Floriana, Meloni, Ilaria, Tanfoni, Marco, Minnai, Francesca, Colombo, Francesca, Cabri, Enrico, Fratelli, Maddalena, Gabbi, Chiara, Mantovani, Stefania, Frullanti, Elisa, Gori, Marco, Crawley, Francis P., Butler-Laporte, Guillaume, Richards, Brent, Zeberg, Hugo, Lipcsey, Miklos, Hultström, Michael, Ludwig, Kerstin U., Schulte, Eva C., Pairo-Castineira, Erola, Baillie, John Kenneth, Schmidt, Axel, Frithiof, Robert, Mari, Francesca, Renieri, Alessandra, Furini, Simone

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Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 a... von Juran, Brian D, Hirschfield, Gideon M, Invernizzi, Pietro, Atkinson, Elizabeth J, Li, Yafang, Xie, Gang, Kosoy, Roman, Ransom, Michael, Sun, Ye, Bianchi, Ilaria, Schlicht, Erik M, Lleo, Ana, Coltescu, Catalina, Bernuzzi, Francesca, Podda, Mauro, Lammert, Craig, Shigeta, Russell, Chan, Landon L, Balschun, Tobias, Marconi, Maurizio, Cusi, Daniele, Heathcote, E Jenny, Mason, Andrew L, Myers, Robert P, Milkiewicz, Piotr, Odin, Joseph A, Luketic, Velimir A, Bacon, Bruce R, Bodenheimer, Jr, Henry C, Liakina, Valentina, Vincent, Catherine, Levy, Cynthia, Franke, Andre, Gregersen, Peter K, Bossa, Fabrizio, Gershwin, M Eric, deAndrade, Mariza, Amos, Christopher I, Lazaridis, Konstantinos N, Seldin, Michael F, Siminovitch, Katherine A

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Recommendations on cutaneous and hematological manifestations of Sjögren's disease by the Brazilian Society of Rheumatology von Pugliesi, Alisson, Egypto, Danielle Christinne Soares do, Duffles, Guilherme, Cantali, Diego Ustárroz, Pasoto, Sandra Gofinet, Oliveira, Fabiola Reis, Valim, Valeria, Lopes, Maria Lucia Lemos, Miyamoto, Samira Tatiyama, Fernandes, Marilena Leal Mesquita Silvestre, Fialho, Sonia Cristina de Magalhães Souza, Pinheiro, Aysa César, Santos, Laura Caldas Dos, Appenzeller, Simone, Ribeiro, Sandra Lucia Euzébio, Libório-Kimura, Tatiana Nayara, Santos, Maria Carmen Lopes Ferreira Silva, Gennari, Juliana D Agostino, Pernanbuco, Roberta, Capobiano, Karina Gatz, Civile, Vinicius Tassoni, Pinto, Ana Carolina Pereira Nunes, Rocha-Filho, César Ramos, Rocha, Aline Pereira da, Trevisani, Virginia Fernandes Moça

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A genome-wide association study for survival from a multi-centre European study identified variants associated with COVID-19 risk of death von Minnai, Francesca, Biscarini, Filippo, Esposito, Martina, Dragani, Tommaso A., Bujanda, Luis, Rahmouni, Souad, Alarcón-Riquelme, Marta E., Bernardo, David, Carnero-Montoro, Elena, Buti, Maria, Zeberg, Hugo, Asselta, Rosanna, Romero-Gómez, Manuel, Fernandez-Cadenas, Israel, Fallerini, Chiara, Zguro, Kristina, Croci, Susanna, Baldassarri, Margherita, Bruttini, Mirella, Furini, Simone, Renieri, Alessandra, Colombo, Francesca

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HCV-unrelated cryoglobulinaemic vasculitis: the results of a prospective observational study by the Italian Group for the Study of Cryoglobulinaemias (GISC) von Galli, Massimo, Oreni, Letizia, Saccardo, Francesco, Castelnovo, Laura, Filippini, Davide, Marson, Piero, Mascia, Maria Teresa, Mazzaro, Cesare, Origgi, Laura, Ossi, Elena, Pietrogrande, Maurizio, Pioltelli, Piero, Quartuccio, Luca, Scarpato, Salvatore, Sollima, Salvatore, Riva, Agostino, Fraticelli, Paolo, Zani, Roberta, Giuggioli, Dilia, Sebastiani, Marco, Sarzi Puttini, Piercarlo, Gabrielli, Armando, Zignego, Anna Linda, Scaini, Patrizia, Ferri, Clodoveo, De Vita, Salvatore, Monti, Giuseppe

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P597: XPO1 MUTATIONS IDENTIFY EARLY STAGE CLL CHARACTERIZED BY SHORTER TIME TO FIRST TREATMENT AND ENHANCED BCR SIGNALING von Talotta, Donatella, Moia, Riccardo, Terzi DI Bergamo, Lodovico, Bomben, Riccardo, Forestieri, Gabriela, Spina, Valeria, Bruscaggin, Alessio, Cosentino, Chiara, Almasri, Mohammad, Dondolin, Riccardo, Bittolo, Tamara, Zucchetto, Antonella, Baldoni, Stefano, Del Giudice, Ilaria, Romana Mauro, Francesca, Maffei, Rossana, Chiarenza, Annalisa, Tafuri, Agostino, Laureana, Roberta, Ilaria Del Principe, Maria, Zaja, Francesco, D’arena, Giovanni, Olivieri, Jacopo, Rasi, Silvia, Mahmoud, Abdurraouf, Al Essa, Wael, Awikeh, Bassel, Kogila, Sreekar, Bellia, Matteo, Mouhssine, Samir, Sportoletti, Paolo, Marasca, Roberto, Scarfò, Lydia, Ghia, Paolo, Gattei, Valter, Foà, Robin, Rossi, Davide, Gaidano, Gianluca

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Impact of COVID-19 on antimicrobial stewardship activities in Italy: a region-wide assessment von Vicentini, Costanza, Corcione, Silvia, Moro, Giuseppina Lo, Mara, Alessandro, De Rosa, Francesco Giuseppe, Zotti, Carla Maria

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Pathway-based analysis of primary biliary cirrhosis genome-wide association studies von Kar, S P, Seldin, M F, Chen, W, Lu, E, Hirschfield, G M, Invernizzi, P, Heathcote, J, Cusi, D, Gershwin, M E, Siminovitch, K A, Amos, C I

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Age, successive waves, immunization, and mortality in elderly COVID-19 hematological patients : EPICOVIDEHA findings von Rossi, Giuseppe, Cattaneo, Chiara, Marchesi, Francesco, Dávila-Valls, Julio, López-García, Alberto, Gomes da Silva, Maria, Marchetti, Monia, Weinbergerová, Barbora, Jaksic, Ozren, Jiménez, Moraima, Bilgin, Yavuz M, Van Doesum, Jaap, Farina, Francesca, Verga, Luisa, Collins, Graham P, Bonuomo, Valentina, Espigado, Ildefonso, Valković, Toni, Čolović, Natasha, Dragonetti, Giulia, Buquicchio, Caterina, Blennow, Ola, Schönlein, Martin, Falces-Romero, Iker, Abu-Zeinah, Ghaith, Adžić-Vukičević, Tatjana, Piukovics, Klára, Stoma, Igor, Szotkowski, Tomáš, González-López, Tomás-José, El-Ashwah, Shaimaa, Sili, Uluhan, Maertens, Johan, Navrátil, Milan, Dargenio, Michelina, Samarkos, Michail, Vena, Antonio, Biernat, Monika M, Merelli, Maria, Wolf, Dominik, Çolak, Gökçe Melis, García-Sanz, Ramón, Emarah, Ziad, Núñez-Martín-Buitrago, Lucía, Nordlander, Anna, Zambrotta, Giovanni Paolo Maria, Ammatuna, Emanuele, Nunes Rodrigues, Raquel, Hersby, Ditte Stampe, Cordoba, Raul, Cornely, Oliver A, Pagano, Livio, HERNÁNDEZ-RIVAS, José-Ángel, GUIDETTI, Anna, STOJANOSKI, Zlate, MELETIADIS, Joseph, DE JONGE, Nick, ANTIĆ, Darko, SERRANO, Laura, PLANTEFEVE, Gaëtan, KHANNA, Nina, HOENIGL, Martin, ČERŇAN, Martin, MIRANDA-CASTILLO, Carolina, DULÉRY, Rémy, AUJAYEB, Avinash, NOVÁK, Jan, SAPIENZA, Giuseppe, REIZINE, Florian, OMRANI, Ali S, DRGOŇA, Ľuboš, COPPOLA, Nicola, BATINIĆ, Josip, AL-KHABORI, Murtadha, PIEDIMONTE, Monica, FOUQUET, Guillemette, FAZZI, Rita, DANION, François, SCHUBERT, Jörg, HOELL-NEUGEBAUER, Baerbel, BAHR, Nathan C, TORRES-ATIENZA, Ana, OMMEN, Hans-Beier, MIKULSKA, Malgorzata, KHOSTELIDI, Sofya, WIN, Sein, GUOLO, Fabio, DELLA PEPA, Roberta, ZDZIARSKI, Przemyslaw, WAI-MAN, Vivien, ORTH, Hans Martin, MALAK, Sandra, KOLDITZ, Martin, HEATH, Christopher H, FUNG, Monica, EGGER, Matthias, CHOWDHURY, Fazle Rabbi, BREHON, Mathias, JIMÉNEZ-LORENZO, María-Josefa, TSIRIGOTIS, Panagiotis

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Synovial tissue myeloid dendritic cell subsets exhibit distinct tissue-niche localization and function in health and rheumatoid arthritis von MacDonald, Lucy, Elmesmari, Aziza, Somma, Domenico, Frew, Jack, Di Mario, Clara, Madhu, Roopa, Paoletti, Audrey, Simakou, Theodoros, Hardy, Olympia M., Tolusso, Barbara, Campobasso, Denise, Perniola, Simone, Gessi, Marco, Gigante, Maria Rita, Petricca, Luca, Bruno, Dario, Coletto, Lavinia Agra, Benvenuto, Roberta, Isaacs, John D., Filby, Andrew, McDonald, David, Sim, Jasmine P.X., Jamieson, Nigel, Wei, Kevin, D’Agostino, Maria Antonietta, Millar, Neal L., Milling, Simon, McSharry, Charles, Gremese, Elisa, Affleck, Karen, Baker, Kenneth F., McInnes, Iain B., Otto, Thomas D., Korsunsky, Ilya, Alivernini, Stefano, Kurowska-Stolarska, Mariola

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Classical HLA-DRB1 and DPB1 alleles account for HLA associations with primary biliary cirrhosis von Invernizzi, P, Ransom, M, Raychaudhuri, S, Kosoy, R, Lleo, A, Shigeta, R, Franke, A, Bossa, F, Amos, C I, Gregersen, P K, Siminovitch, K A, Cusi, D, de Bakker, P I W, Podda, M, Gershwin, M E, Seldin, M F

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A new method for the Characterization of Strain-Specific Conformational Stability of Protease-Sensitive and Protease Resistant PrPSc von Pirisinu, L, Di Bari, M, Marcon, S, Vaccari, G, D'Agostino, C, Fazzi, P, Esposito, E, Cardone, F, Langeveld, J.P.M, Agrimi, U, Nonno, R

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Comparison of past and future simulations of ENSO in CMIP5/PMIP3 and CMIP6/PMIP4 models von Brown, Josephine R., Brierley, Chris M., An, Soon-Il, Guarino, Maria-Vittoria, Stevenson, Samantha, Williams, Charles J. R., Zhang, Qiong, Zhao, Anni, Abe-Ouchi, Ayako, Braconnot, Pascale, Brady, Esther C., Chandan, Deepak, D’Agostino, Roberta, Guo, Chuncheng, Legrande, Allegra N., Lohmann, Gerrit, Morozova, Polina A., Ohgaito, Rumi, O’ishi, Ryouta, Otto-Bliesner, Bette L., Peltier, W. Richard, Shi, Xiaoxu, Sime, Louise, Volodin, Evgeny M., Zhang, Zhongshi, Zheng, Weipeng

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Homozygous mutation in the prokineticin-receptor2 gene (Val274Asp) presenting as reversible Kallmann syndrome and persistent oligozoospermia: Case Report von Sinisi, Antonio Agostino, Asci, Roberta, Bellastella, Giuseppe, Maione, Luigi, Esposito, Dario, Elefante, Andrea, De Bellis, Annamaria, Bellastella, Antonio, Iolascon, Achille

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