Recent advances in the discovery and development of factor XI/XIa inhibitors von Al‐Horani, Rami A., Afosah, Daniel K.

Volltext

Lignosulfonic Acid Sodium Is a Noncompetitive Inhibitor of Human Factor XIa von Kar, Srabani, Bankston, Page, Afosah, Daniel K, Al-Horani, Rami A

Volltext

Allosteric Inhibition of Factor XIIIa. Non-Saccharide Glycosaminoglycan Mimetics, but Not Glycosaminoglycans, Exhibit Promising Inhibition Profile von Al-Horani, Rami A, Karuturi, Rajesh, Lee, Michael, Afosah, Daniel K, Desai, Umesh R

Volltext

New Triazole-Based Potent Inhibitors of Human Factor XIIa as Anticoagulants von Woodland, Ma’Lik D., Thompson, Anthony, Lipford, Amanda, Goyal, Navneet, Schexnaildre, John C., Mottamal, Madhusoodanan, Afosah, Daniel K., Al-Horani, Rami A.

Volltext

Discovery of Heparin Mimetic, Potent, and Selective Inhibitors of Human Clotting Factor XIIIa von Vu, Kayla T., Kar, Srabani, Goyal, Navneet, Mottamal, Madhusoodanan, Afosah, Daniel K., Al-Horani, Rami A.

Volltext

Investigation of the anticoagulant activity of cyclic sulfated glycosaminoglycan mimetics von Chiles, Raquel, Afosah, Daniel K., Al-Horani, Rami A.

Volltext

Homogeneous, Synthetic, Non-Saccharide Glycosaminoglycan Mimetics as Potent Inhibitors of Human Cathepsin G von Afosah, Daniel K, Fayyad, Rawan M, Puliafico, Valerie R, Merrell, Spencer, Langmia, Eltice K, Diagne, Sophie R, Al-Horani, Rami A, Desai, Umesh R

Volltext

Designing Smaller, Synthetic, Functional Mimetics of Sulfated Glycosaminoglycans as Allosteric Modulators of Coagulation Factors von Abdelfadiel, Elsamani I., Gunta, Rama, Villuri, Bharath Kumar, Afosah, Daniel K., Sankaranarayanan, Nehru Viji, Desai, Umesh R.

Volltext

Discovery of a new lead molecule to develop a novel class of human factor XIIa inhibitors von Dumas, Anthony, Goyal, Navneet, Mottamal, Madhusoodanan, Afosah, Daniel K., Al-Horani, Rami A.

Volltext

Potent, Selective, Allosteric Inhibition of Human Plasmin by Sulfated Non-Saccharide Glycosaminoglycan Mimetics von Afosah, Daniel K, Al-Horani, Rami A, Sankaranarayanan, Nehru Viji, Desai, Umesh R

Volltext

Designing Synthetic, Sulfated Glycosaminoglycan Mimetics That Are Orally Bioavailable and Exhibiting In Vivo Anticancer Activity von Morla, Shravan, Ravikumar, Ongolu, O’Hara, Connor, Boothello, Rio, Vera, Alberto, Abdelfadiel, Elsamani I., Fayyad, Rawan, Afosah, Daniel K., Sharon, Chetna, Fernandez, Leopoldo, Shah, Syed Ammer, Patel, Bhaumik B., Desai, Umesh R.

Volltext

Molecular principles for heparin oligosaccharide–based inhibition of neutrophil elastase in cystic fibrosis von Kummarapurugu, Apparao B., Afosah, Daniel K., Sankaranarayanan, Nehru Viji, Navaz Gangji, Rahaman, Zheng, Shuo, Kennedy, Thomas, Rubin, Bruce K., Voynow, Judith A., Desai, Umesh R.

Volltext

Glycan Modulation of Insulin‐like Growth Factor‐1 Receptor von Boothello, Rio S., Sankaranarayanan, Nehru Viji, Sistla, Jyothi C., Nagarajan, Balaji, Sharon, Chetna, Chittum, John E., Niyaz, Rabiya Y., Roy, Swarnali, Nandi, Aditi, O'Hara, Connor P., Gangji, Rahaman Navaz, Afosah, Daniel K., Ongolu, Ravikumar, Patel, Bhaumik B., Desai, Umesh R.

Volltext

On the Process of Discovering Leads That Target the Heparin-Binding Site of Neutrophil Elastase in the Sputum of Cystic Fibrosis Patients von Morla, Shravan, Sankaranarayanan, Nehru Viji, Afosah, Daniel K, Kumar, Megh, Kummarapurugu, Apparao B, Voynow, Judith A, Desai, Umesh R

Volltext

A synthetic heparin mimetic that allosterically inhibits factor XIa and reduces thrombosis in vivo without enhanced risk of bleeding von Al‐Horani, Rami A., Abdelfadiel, Elsamani I., Afosah, Daniel K., Morla, Shravan, Sistla, Jyothi C., Mohammed, Bassem, Martin, Erika J., Sakagami, Masahiro, Brophy, Donald F., Desai, Umesh R.

Volltext

Dual Targeting of the PDZ1 and PDZ2 Domains of MDA-9/Syntenin Inhibits Melanoma Metastasis von Pradhan, Anjan K, Modi, Jinkal, Maji, Santanu, Kumar, Amit, Bhoopathi, Praveen, Mannangatti, Padmanabhan, Guo, Chunqing, Afosah, Daniel K, Mochel, Mark C, Mukhopadhyay, Nitai D, Kirkwood, John M, Wang, Xiang-Yang, Desai, Umesh R, Sarkar, Devanand, Emdad, Luni, Das, Swadesh K, Fisher, Paul B

Volltext

Studies on fragment-based design of allosteric inhibitors of human factor XIa von Boothello, Rio S., Sankaranarayanan, Nehru Viji, Afosah, Daniel K., Karuturi, Rajesh, Al-Horani, Rami A., Desai, Umesh R.

Volltext

A small group of sulfated benzofurans induces steady-state submaximal inhibition of thrombin von Afosah, Daniel K., Verespy, Stephen, Al-Horani, Rami A., Boothello, Rio S., Karuturi, Rajesh, Desai, Umesh R.

Volltext

2-O, 3-O Desulfated Heparin Blocks High Mobility Group Box 1 Release by Inhibition of p300 Acetyltransferase Activity von Zheng, Shuo, Kummarapurugu, Apparao B, Afosah, Daniel K, Sankaranarayanan, Nehru Viji, Boothello, Rio S, Desai, Umesh R, Kennedy, Thomas, Voynow, Judith A

Volltext

Inhibition of Herpes Simplex Virus‑1 Entry into Human Cells by Nonsaccharide Glycosaminoglycan Mimetics von Gangji, Rahaman Navaz, Sankaranarayanan, Nehru Viji, Elste, James, Al-Horani, Rami A, Afosah, Daniel K, Joshi, Rachel, Tiwari, Vaibhav, Desai, Umesh R

Volltext