In‐depth immune profiling of peripheral blood mononuclear cells in patients with pancreatic ductal adenocarcinoma reveals discriminative immune subpopulations von Rodriguez, Ernesto, Zwart, Eline S., Affandi, Alsya A., Verhoeff, Jan, Kok, Mike, Boyd, Lenka N. C., Meijer, Laura L., Le Large, Tessa Y. S., Olesek, Katarzyna, Giovannetti, Elisa, García‐Vallejo, Juan J., Mebius, Reina E., Kooyk, Yvette, Kazemier, Geert

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Editorial: Novel Platform for Antigen Delivery to Dendritic Cells for Immunotherapy von Plantinga, Maud, Affandi, Alsya J

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Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis von Stifano, Giuseppina, Affandi, Alsya J, Mathes, Allison L, Rice, Lisa M, Nakerakanti, Sashidhar, Nazari, Banafsheh, Lee, Jungeun, Christmann, Romy B, Lafyatis, Robert

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CD169 + Macrophages Capture and Dendritic Cells Instruct: The Interplay of the Gatekeeper and the General of the Immune System von Grabowska, Joanna, Lopez-Venegas, Miguel A, Affandi, Alsya J, den Haan, Joke M M

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Selective tumor antigen vaccine delivery to human CD169+ antigen-presenting cells using ganglioside-liposomes von Affandi, Alsya J., Grabowska, Joanna, Olesek, Katarzyna, Venegas, Miguel Lopez, Barbaria, Arnaud, Rodríguez, Ernesto, Mulder, Patrick P. G., Pijffers, Helen J., Ambrosini, Martino, Kalay, Hakan, O’Toole, Tom, Zwart, Eline S., Kazemier, Geert, Nazmi, Kamran, Bikker, Floris J., Stöckl, Johannes, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D., Storm, Gert, van Kooyk, Yvette, den Haan, Joke M. M.

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Proteome-wide Analysis and CXCL4 as a Biomarker in Systemic Sclerosis von van Bon, Lenny, Affandi, Alsya J, Broen, Jasper, Christmann, Romy B, Marijnissen, Renoud J, Stawski, Lukasz, Farina, Giuseppina A, Stifano, Giuseppina, Mathes, Allison L, Cossu, Marta, York, Michael, Collins, Cindy, Wenink, Mark, Huijbens, Richard, Hesselstrand, Roger, Saxne, Tore, DiMarzio, Mike, Wuttge, Dirk, Agarwal, Sandeep K, Reveille, John D, Assassi, Shervin, Mayes, Maureen, Deng, Yanhui, Drenth, Joost P.H, de Graaf, Jacqueline, den Heijer, Martin, Kallenberg, Cees G.M, Bijl, Marc, Loof, Arnoud, van den Berg, Wim B, Joosten, Leo A.B, Smith, Vanessa, de Keyser, Filip, Scorza, Rafaella, Lunardi, Claudio, van Riel, Piet L.C.M, Vonk, Madelon, van Heerde, Waander, Meller, Stephan, Homey, Bernhard, Beretta, Lorenzo, Roest, Mark, Trojanowska, Maria, Lafyatis, Robert, Radstake, Timothy R.D.J

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CD169 Defines Activated CD14(+) Monocytes With Enhanced CD8(+) T Cell Activation Capacity von Affandi, Alsya J., Olesek, Katarzyna, Grabowska, Joanna, Twilhaar, Maarten K. Nijen, Rodriguez, Ernesto, Saris, Anno, Zwart, Eline S., Nossent, Esther J., Kalay, Hakan, de Kok, Michael, Kazemier, Geert, Stockl, Johannes, van den Eertwegh, Alfons J. M., de Gruijl, Tanja D., Garcia-Vallejo, Juan J., Storm, Gert, van Kooyk, Yvette, den Haan, Joke M. M.

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Interferon and alternative activation of monocyte/macrophages in systemic sclerosis–associated pulmonary arterial hypertension von Christmann, Romy B., Hayes, Everett, Pendergrass, Sarah, Padilla, Cristina, Farina, Giuseppina, Affandi, Alsya J., Whitfield, Michael L., Farber, Harrison W., Lafyatis, Robert

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Dendritic cells in systemic sclerosis: Advances from human and mice studies von Affandi, Alsya J., Carvalheiro, Tiago, Radstake, Timothy R.D.J., Marut, Wioleta

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Induction of Inflammation and Fibrosis by Semaphorin 4A in Systemic Sclerosis von Carvalheiro, Tiago, Affandi, Alsya J., Malvar‐Fernández, Beatriz, Dullemond, Ilse, Cossu, Marta, Ottria, Andrea, Mertens, Jorre S., Giovannone, Barbara, Bonte‐Mineur, Femke, Kok, Marc R., Marut, Wioleta, Reedquist, Kris A., Radstake, Timothy R., García, Samuel

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Platelets interact with CD169 + macrophages and cDC1 and enhance liposome-induced CD8 + T cell responses von Grabowska, Joanna, Léopold, Valentine, Olesek, Katarzyna, Nijen Twilhaar, Maarten K, Affandi, Alsya J, Brouwer, Mieke C, Jongerius, Ilse, Verschoor, Admar, van Kooten, Cees, van Kooyk, Yvette, Storm, Gert, van 't Veer, Cornelis, den Haan, Joke M M

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Incorporation of Toll-Like Receptor Ligands and Inflammasome Stimuli in GM3 Liposomes to Induce Dendritic Cell Maturation and T Cell Responses von Nijen Twilhaar, Maarten K, Czentner, Lucas, Bouma, Rianne G, Olesek, Katarzyna, Grabowska, Joanna, Wang, Aru Zeling, Affandi, Alsya J, Belt, Saskia C, Kalay, Hakan, van Nostrum, Cornelus F, van Kooyk, Yvette, Storm, Gert, den Haan, Joke M M

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Update on biomarkers in systemic sclerosis: tools for diagnosis and treatment von Affandi, Alsya J., Radstake, Timothy R. D. J., Marut, Wioleta

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CXCL4 drives fibrosis by promoting several key cellular and molecular processes von Affandi, Alsya J, Carvalheiro, Tiago, Ottria, Andrea, de Haan, Judith J, Brans, Maike A D, Brandt, Maarten M, Tieland, Ralph G, Lopes, Ana P, Fernández, Beatriz Malvar, Bekker, Cornelis P J, van der Linden, Maarten, Zimmermann, Maili, Giovannone, Barbara, Wichers, Catharina G K, Garcia, Samuel, de Kok, Michael, Stifano, Giuseppina, Xu, Yan Juan, Kowalska, M Anna, Waasdorp, Maaike, Cheng, Caroline, Gibbs, Susan, de Jager, Saskia C A, van Roon, Joel A G, Radstake, Timothy R D J, Marut, Wioleta

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Association of MicroRNA‐618 Expression With Altered Frequency and Activation of Plasmacytoid Dendritic Cells in Patients With Systemic Sclerosis von Rossato, Marzia, Affandi, Alsya J., Thordardottir, Soley, Wichers, Catharina G. K., Cossu, Marta, Broen, Jasper C. A., Moret, Frederique M., Bossini‐Castillo, Lara, Chouri, Eleni, van Bon, Lenny, Wolters, Femke, Marut, Wioleta, van der Kroef, Maarten, Silva‐Cardoso, Sandra, Bekker, Cornelis P. J., Dolstra, Harry, van Laar, Jacob M., Martin, Javier, van Roon, Joel A. G., Reedquist, Kris A., Beretta, Lorenzo, Radstake, Timothy R. D. J.

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Serum microRNA screening and functional studies reveal miR-483-5p as a potential driver of fibrosis in systemic sclerosis von Chouri, Eleni, Servaas, Nila H., Bekker, Cornelis P.J., Affandi, Alsya J., Cossu, Marta, Hillen, Maarten R., Angiolilli, Chiara, Mertens, Jorre S., van den Hoogen, Lucas L., Silva-Cardoso, Sandra, van der Kroef, Maarten, Vazirpanah, Nadia, Wichers, Catharina G.K., Carvalheiro, Tiago, Blokland, Sofie L.M., Giovannone, Barbara, Porretti, Laura, Marut, Wioleta, Vigone, Barbara, van Roon, Joel A.G., Beretta, Lorenzo, Rossato, Marzia, Radstake, Timothy R.D.J.

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CXCL4 Exposure Potentiates TLR-Driven Polarization of Human Monocyte-Derived Dendritic Cells and Increases Stimulation of T Cells von Silva-Cardoso, Sandra C, Affandi, Alsya J, Spel, Lotte, Cossu, Marta, van Roon, Joel A G, Boes, Marianne, Radstake, Timothy R D J

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Development of a Versatile Cancer Vaccine Format Targeting Antigen-Presenting Cells Using Proximity-Based Sortase A-Mediated Ligation of T‑Cell Epitopes von Wang, Aru Z., Brink, Hendrik J., Bouma, Rianne G., Affandi, Alsya J., Nijen Twilhaar, Maarten K., Heijnen, Dijmphna A. M., van Elk, Joelle, Maaskant, Janneke J., Konijn, Veronique A. L., Stolwijk, Joeke G. C., Kalay, Hakan, Olesek, Katarina, van Kooyk, Yvette, van der Schoot, Johan M. S., Bentlage, Arthur E. H., Scheeren, Ferenc A., Verdoes, Martijn, Vidarsson, Gestur, Kuijl, Coenraad P., den Haan, Joke M. M.

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Optimization of Liposomes for Antigen Targeting to Splenic CD169(+) Macrophages von Twilhaar, Maarten K. Nijen, Czentner, Lucas, Grabowska, Joanna, Affandi, Alsya J., Lau, Chun Yin Jerry, Olesek, Katarzyna, Kalay, Hakan, van Nostrum, Cornelus F., van Kooyk, Yvette, Storm, Gert, den Haan, Joke M. M.

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Nuclear Receptor Subfamily 4A Signaling as a Key Disease Pathway of CD1c+ Dendritic Cell Dysregulation in Systemic Sclerosis von Servaas, Nila H., Hiddingh, Sanne, Chouri, Eleni, Wichers, Catharina G. K., Affandi, Alsya J., Ottria, Andrea, Bekker, Cornelis P. J., Cossu, Marta, Silva‐Cardoso, Sandra C., Kroef, Maarten, Hinrichs, Anneline C., Carvalheiro, Tiago, Vazirpanah, Nadia, Beretta, Lorenzo, Rossato, Marzia, Bonte‐Mineur, Femke, Radstake, Timothy R. D. J., Kuiper, Jonas J. W., Boes, Marianne, Pandit, Aridaman

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