Influence of macrolide maintenance therapy and bacterial colonisation on exacerbation frequency and progression of COPD (COLUMBUS): study protocol for a randomised controlled trial von Uzun, Sevim, Djamin, Remco S, Kluytmans, Janajw, Van't Veer, Nils E, Ermens, Anton A M, Pelle, Aline J, Mulder, Paul, van der Eerden, Menno M, Aerts, Joachimgjv

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