AP24534, a Pan-BCR-ABL Inhibitor for Chronic Myeloid Leukemia, Potently Inhibits the T315I Mutant and Overcomes Mutation-Based Resistance von O'Hare, Thomas, Shakespeare, William C., Zhu, Xiaotian, Eide, Christopher A., Rivera, Victor M., Wang, Frank, Adrian, Lauren T., Zhou, Tianjun, Huang, Wei-Sheng, Xu, Qihong, Metcalf, Chester A., Tyner, Jeffrey W., Loriaux, Marc M., Corbin, Amie S., Wardwell, Scott, Ning, Yaoyu, Keats, Jeffrey A., Wang, Yihan, Sundaramoorthi, Raji, Thomas, Mathew, Zhou, Dong, Snodgrass, Joseph, Commodore, Lois, Sawyer, Tomi K., Dalgarno, David C., Deininger, Michael W.N., Druker, Brian J., Clackson, Tim

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BCR-ABL1 compound mutations in tyrosine kinase inhibitor–resistant CML: frequency and clonal relationships von Khorashad, Jamshid S., Kelley, Todd W., Szankasi, Philippe, Mason, Clinton C., Soverini, Simona, Adrian, Lauren T., Eide, Christopher A., Zabriskie, Matthew S., Lange, Thoralf, Estrada, Johanna C., Pomicter, Anthony D., Eiring, Anna M., Kraft, Ira L., Anderson, David J., Gu, Zhimin, Alikian, Mary, Reid, Alistair G., Foroni, Letizia, Marin, David, Druker, Brian J., O'Hare, Thomas, Deininger, Michael W.

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Acute dasatinib exposure commits Bcr-Abl–dependent cells to apoptosis von Snead, Jennifer L., O'Hare, Thomas, Adrian, Lauren T., Eide, Christopher A., Lange, Thoralf, Druker, Brian J., Deininger, Michael W.

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The ABL switch control inhibitor DCC-2036 is active against the chronic myeloid leukemia mutant BCR-ABLT315I and exhibits a narrow resistance profile von Eide, Christopher A, Adrian, Lauren T, Tyner, Jeffrey W, Mac Partlin, Mary, Anderson, David J, Wise, Scott C, Smith, Bryan D, Petillo, Peter A, Flynn, Daniel L, Deininger, Michael W N, O'Hare, Thomas, Druker, Brian J

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Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis von O'HARE, Thomas, EIDE, Christopher A, RIDDLE, Steven M, MARKS, Bryan D, VOGEI, Kurt W, KOOP, Dennis R, APGAR, John, TYNER, Jeffrey W, DEININGER, Michael W, DRUKER, Brian J, AGARWAL, Anupriya, ADRIAN, Lauren T, ZABRISKIE, Matthew S, MACKENZIE, Ryan J, LATOCHA, Dorian H, JOHNSON, Kara J, HUIHONG YOU, LUO, Jenny

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The BCR-ABL35INS insertion/truncation mutant is kinase-inactive and does not contribute to tyrosine kinase inhibitor resistance in chronic myeloid leukemia von O'Hare, Thomas, Zabriskie, Matthew S., Eide, Christopher A., Agarwal, Anupriya, Adrian, Lauren T., You, Huihong, Corbin, Amie S., Yang, Fei, Press, Richard D., Rivera, Victor M., Toplin, Julie, Wong, Stephane, Deininger, Michael W., Druker, Brian J.

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Resistance Profiling of BCR-ABL Compound Mutations Linked to Tyrosine Kinase Inhibitor Therapy Failure in Chronic Myeloid Leukemia von Eide, Christopher A., Zabriskie, Matthew S., Adrian, Lauren T., Lange, Thoralf, Deininger, Michael W., Druker, Brian J., O'Hare, Thomas

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Threshold levels of ABL tyrosine kinase inhibitors retained in chronic myeloid leukemia cells define commitment to apoptosis von O’Hare, Thomas, Eide, Christopher A., Agarwal, Anupriya, Adrian, Lauren T., Zabriskie, Matthew S., MacKenzie, Ryan J., LaTocha, Dorian H., Johnson, Kara J., You, Huihong, Luo, Jenny, Riddle, Steven M., Marks, Bryan D., Vogel, Kurt W., Koop, Dennis R., Apgar, John, Tyner, Jeffrey W., Deininger, Michael W., Druker, Brian J.

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Cryptic Intracellular Retention of ABL Tyrosine Kinase Inhibitors within CML Cells Mediates Apoptosis Commitment Following Acute Drug Exposure von O'Hare, Thomas, Eide, Christopher A., Adrian, Lauren T., Agarwal, Anupriya, Zabriskie, Matthew S., MacKenzie, Ryan, LaTocha, Dorian H., You, Huihong, Luo, Jenny, Riddle, Steven M., Marks, Bryan, Koop, Dennis R., Apgar, John, Deininger, Michael W., Druker, Brian J.

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Frequency and Clonality of BCR-ABL Compound Mutations in Chronic Myeloid Leukemia von Khorashad, Jamshid, Kelley, Todd W., Szankasi, Philippe, Adrian, Lauren T., Eide, Christopher A., Zabriskie, Matthew S., Lange, Thoralf, Kraft, Ira L, Eiring, Anna M, O'Hare, Thomas, Deininger, Michael W.

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The ABL Switch Control Inhibitor DCC-2036 Is Active against the Chronic Myeloid Leukemia Mutant BCR-ABLT3151 and Exhibits a Narrow Resistance Profile von EIDE, Christopher A, ADRIAN, Lauren T, O'HARE, Thomas, DRUKER, Brian J, TYNER, Jeffrey W, MAC PARTLIN, Mary, ANDERSON, David J, WISE, Scott C, SMITH, Bryan D, PETILLO, Peter A, FLYNN, Daniel L, DEININGER, Michael W. N

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Complete Suppression of in Vitro Resistance by AP24534, a Pan-BCR-ABL Inhibitor von O'Hare, Thomas, Eide, Christopher A., Adrian, Lauren T., Rivera, Victor M., Shakespeare, William C., Clackson, Tim, Deininger, Michael W.N., Druker, Brian J.

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Macrosystems ecology: understanding ecological patterns and processes at continental scales von Heffernan, James B, Soranno, Patricia A, Angilletta, Michael J, Buckley, Lauren B, Gruner, Daniel S, Keitt, Tim H, Kellner, James R, Kominoski, John S, Rocha, Adrian V, Xiao, Jingfeng, Harms, Tamara K, Goring, Simon J, Koenig, Lauren E, McDowell, William H, Powell, Heather, Richardson, Andrew D, Stow, Craig A, Vargas, Rodrigo, Weathers, Kathleen C

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Aged skeletal stem cells generate an inflammatory degenerative niche von Ambrosi, Thomas H., Marecic, Owen, McArdle, Adrian, Sinha, Rahul, Gulati, Gunsagar S., Tong, Xinming, Wang, Yuting, Steininger, Holly M., Hoover, Malachia Y., Koepke, Lauren S., Murphy, Matthew P., Sokol, Jan, Seo, Eun Young, Tevlin, Ruth, Lopez, Michael, Brewer, Rachel E., Mascharak, Shamik, Lu, Laura, Ajanaku, Oyinkansola, Conley, Stephanie D., Seita, Jun, Morri, Maurizio, Neff, Norma F., Sahoo, Debashis, Yang, Fan, Weissman, Irving L., Longaker, Michael T., Chan, Charles K. F.

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Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysi... von Cortese, Samuele, Adamo, Nicoletta, Del Giovane, Cinzia, Mohr-Jensen, Christina, Hayes, Adrian J, Carucci, Sara, Atkinson, Lauren Z, Tessari, Luca, Banaschewski, Tobias, Coghill, David, Hollis, Chris, Simonoff, Emily, Zuddas, Alessandro, Barbui, Corrado, Purgato, Marianna, Steinhausen, Hans-Christoph, Shokraneh, Farhad, Xia, Jun, Cipriani, Andrea

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Genome Sequencing of Sewage Detects Regionally Prevalent SARS-CoV-2 Variants von Crits-Christoph, Alexander, Kantor, Rose S., Olm, Matthew R., Whitney, Oscar N., Al-Shayeb, Basem, Lou, Yue Clare, Flamholz, Avi, Kennedy, Lauren C., Greenwald, Hannah, Hinkle, Adrian, Hetzel, Jonathan, Spitzer, Sara, Koble, Jeffery, Tan, Asako, Hyde, Fred, Schroth, Gary, Kuersten, Scott, Banfield, Jillian F., Nelson, Kara L.

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The Non-Dereliction in Evolution: Trophic Specialisation Drives Convergence in the Radiation of Red Devil Spiders (Araneae: Dysderidae) in the Canary Islands von Bellvert, Adrià, Adrián-Serrano, Silvia, Macías-Hernández, Nuria, Toft, Søren, Kaliontzopoulou, Antigoni, Arnedo, Miquel A

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Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data von Jolliffe, David A, Greenberg, Lauren, Hooper, Richard L, Griffiths, Christopher J, Camargo, Carlos A, Kerley, Conor P, Jensen, Megan E, Mauger, David, Stelmach, Iwona, Urashima, Mitsuyoshi, Martineau, Adrian R

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Quantifying the chameleonic properties of macrocycles and other high-molecular-weight drugs von Whitty, Adrian, Zhong, Mengqi, Viarengo, Lauren, Beglov, Dmitri, Hall, David R., Vajda, Sandor

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Tools for interpretation of wastewater SARS-CoV-2 temporal and spatial trends demonstrated with data collected in the San Francisco Bay Area von Greenwald, Hannah D., Kennedy, Lauren C., Hinkle, Adrian, Whitney, Oscar N., Fan, Vinson B., Crits-Christoph, Alexander, Harris-Lovett, Sasha, Flamholz, Avi I., Al-Shayeb, Basem, Liao, Lauren D., Beyers, Matt, Brown, Daniel, Chakrabarti, Alicia R., Dow, Jason, Frost, Dan, Koekemoer, Mark, Lynch, Chris, Sarkar, Payal, White, Eileen, Kantor, Rose, Nelson, Kara L.

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