Activation mutations of human c-KIT resistant to imatinib mesylate are sensitive to the tyrosine kinase inhibitor PKC412 von Growney, Joseph D., Clark, Jennifer J., Adelsperger, Jennifer, Stone, Richard, Fabbro, Doriano, Griffin, James D., Gilliland, D. Gary

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FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitors in a Murine Model of Chronic Myelomonocytic Leukemia von Lee, Benjamin H., Tothova, Zuzana, Levine, Ross L., Anderson, Kristina, Buza-Vidas, Natalija, Cullen, Dana E., McDowell, Elizabeth P., Adelsperger, Jennifer, Fröhling, Stefan, Huntly, Brian J.P., Beran, Miloslav, Jacobsen, Sten Eirik, Gilliland, D. Gary

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PKC412 Inhibits the Zinc Finger 198-Fibroblast Growth Factor Receptor 1 Fusion Tyrosine Kinase and Is Active in Treatment of Stem Cell Myeloproliferative Disorder von Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, Duclos, Nicole, Cohen, Sarah, Adelsperger, Jennifer, Okabe, Rachel, Coburn, Allison, Galinsky, Ilene, Huntly, Brian, Cohen, Pamela S., Meyer, Thomas, Fabbro, Doriano, Roesel, Johannes, Banerji, Lolita, Griffin, James D., Xiao, Sheng, Fletcher, Jonathan A., Stone, Richard M., Gilliland, D. Gary, Witte, Owen N.

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Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis von Levine, Ross L., Wadleigh, Martha, Cools, Jan, Ebert, Benjamin L., Wernig, Gerlinde, Huntly, Brian J.P., Boggon, Titus J., Wlodarska, Iwona, Clark, Jennifer J., Moore, Sandra, Adelsperger, Jennifer, Koo, Sumin, Lee, Jeffrey C., Gabriel, Stacey, Mercher, Thomas, D’Andrea, Alan, Fröhling, Stefan, Döhner, Konstanze, Marynen, Peter, Vandenberghe, Peter, Mesa, Ruben A., Tefferi, Ayalew, Griffin, James D., Eck, Michael J., Sellers, William R., Meyerson, Matthew, Golub, Todd R., Lee, Stephanie J., Gilliland, D. Gary

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Loss of Runx1 perturbs adult hematopoiesis and is associated with a myeloproliferative phenotype von Growney, Joseph D., Shigematsu, Hirokazu, Li, Zhe, Lee, Benjamin H., Adelsperger, Jennifer, Rowan, Rebecca, Curley, David P., Kutok, Jeffery L., Akashi, Koichi, Williams, Ifor R., Speck, Nancy A., Gilliland, D. Gary

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The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRβ and FIP1L1-PDGFRα in vitro and in vivo von Stover, Elizabeth H., Chen, Jing, Lee, Benjamin H., Cools, Jan, McDowell, Elizabeth, Adelsperger, Jennifer, Cullen, Dana, Coburn, Allison, Moore, Sandra A., Okabe, Rachel, Fabbro, Doriano, Manley, Paul W., Griffin, James D., Gilliland, D. Gary

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FGFR3 as a therapeutic target of the small molecule inhibitor PKC412 in hematopoietic malignancies von Chen, Jing, Lee, Benjamin H, Williams, Ifor R, Kutok, Jeffery L, Mitsiades, Constantine S, Duclos, Nicole, Cohen, Sarah, Adelsperger, Jennifer, Okabe, Rachel, Coburn, Allison, Moore, Sandra, Huntly, Brian J P, Fabbro, Doriano, Anderson, Kenneth C, Griffin, James D, Gilliland, Dwight Gary

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Leukemogenic FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitor Cells in a Murine Model of Chronic Myelomonocytic Leukemia von Lee, Benjamin H., Tothova, Zuzana, Levine, Ross L., Anderson, Kristina, Buza-Vidas, Natalija, Cullen, Dana E., McDowell, Elizabeth P., Adelsperger, Jennifer, Frohling, Stefan, Huntly, Brian J.P., Beran, Miloslav, Jacobsen, Sten Eirik, Gilliland, D. Gary

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Inhibition of the NPM-ALK Fusion Tyrosine Kinase in Hematopoietic Neoplasia by the Small Molecule Tyrosine Kinase Antagonist TAE684 von Sternberg, David W., Ray, Arghya, Lee, Benjamin H., Adelsperger, Jennifer, Duclos, Nicole, McDowell, Elizabeth, Haq, Naznin, Imbach, Patricia, Ohmori, Osamu, Honda, Toshiyuki, Warmuth, Markus, Fabbro, Doriano, Griffin, James D., Roesel, Johannes

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The small molecule tyrosine kinase inhibitor AMN107 inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in vitro and in vivo von Stover, Elizabeth H, Chen, Jing, Lee, Benjamin H, Cools, Jan, McDowell, Elizabeth, Adelsperger, Jennifer, Cullen, Dana, Coburn, Allison, Moore, Sandra A, Okabe, Rachel, Fabbro, Doriano, Manley, Paul W, Griffin, James D, Gilliland, D Gary

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Loss of Runx1 Perturbs Adult Hematopoiesis and Is Associated with a Myeloproliferative Phenotype von Growney, Joseph D., Shigematsu, Hirokazu, Li, Zhe, Lee, Benjamin H., Adelsperger, Jennifer, Rowan, Rebecca, Curley, David P., Akashi, Koichi, Williams, Ifor R., Speck, Nancy A., Gilliland, D. Gary

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PKC412 Effectively Inhibits Constitutively Activated FGFR3 Mutants in Murine Leukemia Models and t(4;14) Myeloma Cell Lines von Chen, Jing, Lee, Benjamin H., Williams, Ifor R., Kutok, Jeffery L., Duclos, Nicole, Cohen, Sarah, Adelsperger, Jennifer, Okabe, Rachel, Coburn, Allison, Moore, Sandra, Huntly, Brian J.P., Mitsiades, Constantine S., Anderson, Kenneth C., Griffin, James D., Fabbro, Doriano, Gilliland, D. Gary

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PKC412 Inhibits the ZNF198-FGFR1 Fusion Tyrosine Kinase and Is Efficacious in Treatment of t(8;13)(p11;q12) Associated Stem Cell Myeloproliferative Disease von Chen, Jing, DeAngelo, Daniel J., Kutok, Jeffery L., Williams, Ifor R., Lee, Benjamin H., Wadleigh, Martha, Duclos, Nicole, Cohen, Sarah, Adelsperger, Jennifer, Okabe, Rachel, Coburn, Allison, Galinsky, Ilene, Huntly, Brian J.P., Cohen, Pamela, Meyer, Thomas, Fabbro, Doriano, Banerji, Lolita, Griffin, James D., Xiao, Sheng, Fletcher, Jonathan A., Stone, Richard M., Gilliland, D. Gary

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