Design and optimisation of orally active TLR7 agonists for the treatment of hepatitis C virus infection von Tran, Thien-Duc, Pryde, David C., Jones, Peter, Adam, Fiona M., Benson, Neil, Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Gardner, Iain, Jones, Hannah M., Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy

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Discovery of a highly potent series of TLR7 agonists von Jones, Peter, Pryde, David C., Tran, Thien-Duc, Adam, Fiona M., Bish, Gerwyn, Calo, Frederick, Ciaramella, Guiseppe, Dixon, Rachel, Duckworth, Jonathan, Fox, David N.A., Hay, Duncan A., Hitchin, James, Horscroft, Nigel, Howard, Martin, Laxton, Carl, Parkinson, Tanya, Parsons, Gemma, Proctor, Katie, Smith, Mya C., Smith, Nicholas, Thomas, Amy

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A flexible synthesis of C-6 and N-1 analogues of a 4-amino-1,3-dihydroimidazo[4,5- c]pyridin-2-one core von Hay, Duncan A., Adam, Fiona M., Bish, Gerwyn, Calo, Frederick, Dixon, Rachel, Fray, M. Jonathan, Hitchin, James, Jones, Peter, Paradowski, Michael, Parsons, Gemma C., Proctor, Katie J.W., Pryde, David C., Smith, Nicholas N., Tran, Thien-Duc

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Development of a Practical Synthesis of Toll-like Receptor Agonist PF-4171455: 4-Amino-1-benzyl-6-trifluoromethyl-1,3-dihydroimidazo [4,5-c] pyridin-2-one von Adam, Fiona M, Bish, Gerwyn, Calo, Frederick, Carr, Christopher L, Castro, Nieves, Hay, Duncan, Hodgson, Paul B, Jones, Peter, Knight, Craig J, Paradowski, Michael, Parsons, Gemma C, Proctor, Katie J. W, Pryde, David C, Rota, Filippo, Smith, Mya C, Smith, Nicholas, Tran, Thien-Duc, Hitchin, James, Dixon, Rachel

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Design and optimisation of potent gp120-CD4 inhibitors von Tran, Thien-Duc, Adam, Fiona M., Calo, Frederick, Fenwick, David R., Fok-Seang, Juin, Gardner, Iain, Hay, Duncan A., Perros, Manos, Rawal, Jaiessh, Middleton, Donald S., Parkinson, Tanya, Pickford, Christopher, Platts, Michelle, Randall, Amy, Stephenson, Peter T., Vuong, Hannah, Williams, David H.

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The discovery of a novel prototype small molecule TLR7 agonist for the treatment of hepatitis C virus infection von Pryde, David C., Tran, Thien-Duc, Jones, Peter, Parsons, Gemma C., Bish, Gerwyn, Adam, Fiona M., Smith, Mya C., Middleton, Donald S., Smith, Nick N., Calo, Frederick, Hay, Duncan, Paradowski, Michael, Proctor, Katie J. W., Parkinson, Tanya, Laxton, Carl, Fox, David N. A., Horscroft, Nigel J., Ciaramella, Giuseppe, Jones, Hannah M., Duckworth, Jonathan, Benson, Neil, Harrison, Anthony, Webster, Rob

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Novel syntheses of the amino-1,2,4-triazine GW356194: identification of a synthesis amenable to scale up von Adam, Fiona M., Burton, Andrew J., Cardwell, Kevin S., Cox, Richard A., Henson, Richard A., Mills, Keith, Prodger, Jeremy C., Schilling, Mark B., Tape, Daniel T.

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Seroprevalence of pertussis in The Netherlands: evidence for increased circulation of Bordetella pertussis von de Greeff, Sabine C, de Melker, Hester E, van Gageldonk, Pieter G M, Schellekens, Joop F P, van der Klis, Fiona R M, Mollema, Liesbeth, Mooi, Frits R, Berbers, Guy A M

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Persistent fatigue following SARS-CoV-2 infection is common and independent of severity of initial infection von Townsend, Liam, Dyer, Adam H, Jones, Karen, Dunne, Jean, Mooney, Aoife, Gaffney, Fiona, O'Connor, Laura, Leavy, Deirdre, O'Brien, Kate, Dowds, Joanne, Sugrue, Jamie A, Hopkins, David, Martin-Loeches, Ignacio, Ni Cheallaigh, Cliona, Nadarajan, Parthiban, McLaughlin, Anne Marie, Bourke, Nollaig M, Bergin, Colm, O'Farrelly, Cliona, Bannan, Ciaran, Conlon, Niall

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Crystallization by particle attachment in synthetic, biogenic, and geologic environments von De Yoreo, James J., Gilbert, Pupa U. P. A., Sommerdijk, Nico A. J. M., Penn, R. Lee, Whitelam, Stephen, Joester, Derk, Zhang, Hengzhong, Rimer, Jeffrey D., Navrotsky, Alexandra, Banfield, Jillian F., Wallace, Adam F., Michel, F. Marc, Meldrum, Fiona C., Cölfen, Helmut, Dove, Patricia M.

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Prioritization of cancer therapeutic targets using CRISPR–Cas9 screens von Behan, Fiona M., Iorio, Francesco, Picco, Gabriele, Gonçalves, Emanuel, Beaver, Charlotte M., Migliardi, Giorgia, Santos, Rita, Rao, Yanhua, Sassi, Francesco, Pinnelli, Marika, Ansari, Rizwan, Harper, Sarah, Jackson, David Adam, McRae, Rebecca, Pooley, Rachel, Wilkinson, Piers, van der Meer, Dieudonne, Dow, David, Buser-Doepner, Carolyn, Bertotti, Andrea, Trusolino, Livio, Stronach, Euan A., Saez-Rodriguez, Julio, Yusa, Kosuke, Garnett, Mathew J.

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Low temperature plasmas as emerging cancer therapeutics: the state of play and thoughts for the future von Hirst, Adam M., Frame, Fiona M., Arya, Manit, Maitland, Norman J., O’Connell, Deborah

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A map of transcriptional heterogeneity and regulatory variation in human microglia von Young, Adam M. H., Kumasaka, Natsuhiko, Calvert, Fiona, Hammond, Timothy R., Knights, Andrew, Panousis, Nikolaos, Park, Jun Sung, Schwartzentruber, Jeremy, Liu, Jimmy, Kundu, Kousik, Segel, Michael, Murphy, Natalia A., McMurran, Christopher E., Bulstrode, Harry, Correia, Jason, Budohoski, Karol P., Joannides, Alexis, Guilfoyle, Mathew R., Trivedi, Rikin, Kirollos, Ramez, Morris, Robert, Garnett, Matthew R., Timofeev, Ivan, Jalloh, Ibrahim, Holland, Katherine, Mannion, Richard, Mair, Richard, Watts, Colin, Price, Stephen J., Kirkpatrick, Peter J., Santarius, Thomas, Mountjoy, Edward, Ghoussaini, Maya, Soranzo, Nicole, Bayraktar, Omer A., Stevens, Beth, Hutchinson, Peter J., Franklin, Robin J. M., Gaffney, Daniel J.

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The mechanical and electrical properties of direct-spun carbon nanotube mat-epoxy composites von Tan, Wei, Stallard, Joe C., Smail, Fiona R., Boies, Adam M., Fleck, Norman A.

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Mapping the parameter space for direct-spun carbon nanotube aerogels von Weller, Lee, Smail, Fiona R., Elliott, James A., Windle, Alan H., Boies, Adam M., Hochgreb, Simone

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A joint NCBI and EMBL-EBI transcript set for clinical genomics and research von Morales, Joannella, Pujar, Shashikant, Loveland, Jane E., Astashyn, Alex, Bennett, Ruth, Berry, Andrew, Cox, Eric, Davidson, Claire, Ermolaeva, Olga, Farrell, Catherine M., Fatima, Reham, Gil, Laurent, Goldfarb, Tamara, Gonzalez, Jose M., Haddad, Diana, Hardy, Matthew, Hunt, Toby, Jackson, John, Joardar, Vinita S., Kay, Michael, Kodali, Vamsi K., McGarvey, Kelly M., McMahon, Aoife, Mudge, Jonathan M., Murphy, Daniel N., Murphy, Michael R., Rajput, Bhanu, Rangwala, Sanjida H., Riddick, Lillian D., Thibaud-Nissen, Françoise, Threadgold, Glen, Vatsan, Anjana R., Wallin, Craig, Webb, David, Flicek, Paul, Birney, Ewan, Pruitt, Kim D., Frankish, Adam, Cunningham, Fiona, Murphy, Terence D.

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Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion von Vergari, Elisa, Knudsen, Jakob G., Ramracheya, Reshma, Salehi, Albert, Zhang, Quan, Adam, Julie, Asterholm, Ingrid Wernstedt, Benrick, Anna, Briant, Linford J. B., Chibalina, Margarita V., Gribble, Fiona M., Hamilton, Alexander, Hastoy, Benoit, Reimann, Frank, Rorsman, Nils J. G., Spiliotis, Ioannis I., Tarasov, Andrei, Wu, Yanling, Ashcroft, Frances M., Rorsman, Patrik

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Additive manufactured biodegradable poly(glycerol sebacate methacrylate) nerve guidance conduits von Singh, Dharaminder, Harding, Adam J., Albadawi, Emad, Boissonade, Fiona M., Haycock, John W., Claeyssens, Frederik

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Feasibility of controlling COVID-19 outbreaks by isolation of cases and contacts von Hellewell, Joel, Abbott, Sam, Gimma, Amy, Bosse, Nikos I, Jarvis, Christopher I, Russell, Timothy W, Munday, James D, Kucharski, Adam J, Edmunds, W John, Sun, Fiona, Flasche, Stefan, Quilty, Billy J, Davies, Nicholas, Liu, Yang, Clifford, Samuel, Klepac, Petra, Jit, Mark, Diamond, Charlie, Gibbs, Hamish, van Zandvoort, Kevin, Funk, Sebastian, Eggo, Rosalind M

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Macrophages acquire a TNF-dependent inflammatory memory in allergic asthma von Lechner, Antonie, Henkel, Fiona D.R., Hartung, Franziska, Bohnacker, Sina, Alessandrini, Francesca, Gubernatorova, Ekaterina O., Drutskaya, Marina S., Angioni, Carlo, Schreiber, Yannick, Haimerl, Pascal, Ge, Yan, Thomas, Dominique, Kabat, Agnieszka M., Pearce, Edward J., Ohnmacht, Caspar, Nedospasov, Sergei A., Murray, Peter J., Chaker, Adam M., Schmidt-Weber, Carsten B., Esser-von Bieren, Julia

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