Mycobacterial cell wall biosynthesis: a multifaceted antibiotic target von ABRAHAMS, KATHERINE A., BESRA, GURDYAL S.

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Synthesis and recycling of the mycobacterial cell envelope von Abrahams, Katherine A, Besra, Gurdyal S

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Identification of novel imidazo[1,2-a]pyridine inhibitors targeting M. tuberculosis QcrB von Abrahams, Katherine A, Cox, Jonathan A G, Spivey, Vickey L, Loman, Nicholas J, Pallen, Mark J, Constantinidou, Chrystala, Fernández, Raquel, Alemparte, Carlos, Remuiñán, Modesto J, Barros, David, Ballell, Lluis, Besra, Gurdyal S

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DprE2 is a molecular target of the anti-tubercular nitroimidazole compounds pretomanid and delamanid von Abrahams, Katherine A., Batt, Sarah M., Gurcha, Sudagar S., Veerapen, Natacha, Bashiri, Ghader, Besra, Gurdyal S.

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Mycobacterial drug discovery von Abrahams, Katherine A, Besra, Gurdyal S

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Inhibiting mycobacterial tryptophan synthase by targeting the inter-subunit interface von Abrahams, Katherine A., Cox, Jonathan A. G., Fütterer, Klaus, Rullas, Joaquín, Ortega-Muro, Fátima, Loman, Nicholas J., Moynihan, Patrick J., Pérez-Herrán, Esther, Jiménez, Elena, Esquivias, Jorge, Barros, David, Ballell, Lluís, Alemparte, Carlos, Besra, Gurdyal S.

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Top five unanswered questions in bacterial cell wall research von Batt, Sarah M., Abrahams, Katherine A., Besra, Gurdyal S.

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Assay development and inhibition of the Mt -DprE2 essential reductase from Mycobacterium tuberculosis von Batt, Sarah M, Toth, Szilvi, Rodriguez, Beatriz, Abrahams, Katherine A, Veerapen, Natacha, Chiodarelli, Giacomo, Cox, Liam R, Moynihan, Patrick J, Lelievre, Joel, Fütterer, Klaus, Besra, Gurdyal S

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Modular Synthesis of Diverse Natural Product‐Like Macrocycles: Discovery of Hits with Antimycobacterial Activity von Dow, Mark, Marchetti, Francesco, Abrahams, Katherine A., Vaz, Luis, Besra, Gurdyal S., Warriner, Stuart, Nelson, Adam

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GSK2556286 Is a Novel Antitubercular Drug Candidate Effective In Vivo with the Potential To Shorten Tuberculosis Treatment von Nuermberger, Eric L, Martínez-Martínez, Maria Santos, Sanz, Olalla, Urones, Beatriz, Esquivias, Jorge, Soni, Heena, Tasneen, Rokeya, Tyagi, Sandeep, Li, Si-Yang, Converse, Paul J, Boshoff, Helena I, Robertson, Gregory T, Besra, Gurdyal S, Abrahams, Katherine A, Upton, Anna M, Mdluli, Khisimuzi, Boyle, Gary W, Turner, Sam, Fotouhi, Nader, Cammack, Nicholas C, Siles, Juan Miguel, Alonso, Marta, Escribano, Jaime, Lelievre, Joel, Rullas-Trincado, Joaquin, Pérez-Herrán, Esther, Bates, Robert H, Maher-Edwards, Gareth, Barros, David, Ballell, Lluís, Jiménez, Elena

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Identification of KasA as the cellular target of an anti-tubercular scaffold von Abrahams, Katherine A., Chung, Chun-wa, Ghidelli-Disse, Sonja, Rullas, Joaquín, Rebollo-López, María José, Gurcha, Sudagar S., Cox, Jonathan A. G., Mendoza, Alfonso, Jiménez-Navarro, Elena, Martínez-Martínez, María Santos, Neu, Margarete, Shillings, Anthony, Homes, Paul, Argyrou, Argyrides, Casanueva, Ruth, Loman, Nicholas J., Moynihan, Patrick J., Lelièvre, Joël, Selenski, Carolyn, Axtman, Matthew, Kremer, Laurent, Bantscheff, Marcus, Angulo-Barturen, Iñigo, Izquierdo, Mónica Cacho, Cammack, Nicholas C., Drewes, Gerard, Ballell, Lluis, Barros, David, Besra, Gurdyal S., Bates, Robert H.

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In vitro Reconstitution of Peptidoglycan Assembly from the Gram-Positive Pathogen Streptococcus pneumoniae von Zapun, André, Philippe, Jules, Abrahams, Katherine A, Signor, Luca, Roper, David I, Breukink, Eefjan, Vernet, Thierry

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Mycobacterial dihydrofolate reductase inhibitors identified using chemogenomic methods and in vitro validation von Mugumbate, Grace, Abrahams, Katherine A, Cox, Jonathan A G, Papadatos, George, van Westen, Gerard, Lelièvre, Joël, Calus, Szymon T, Loman, Nicholas J, Ballell, Lluis, Barros, David, Overington, John P, Besra, Gurdyal S

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Two‐way regulation of protein expression for identification and validation of on‐target inhibitors of Mycobacterium tuberculosis von Grover, Shipra, Engelhart, Curtis A., Perez‐Herran, Esther, Tiwari, Divya, Li, Wei, Abrahams, Katherine A., Papavinasasundaram, Kadamba, Bean, James M., Sassetti, Christopher M., Mendoza‐Losana, Alfonso, Besra, Gurdyal S., Jackson, Mary, Aldrich, Courtney, Schnappinger, Dirk

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Biochemical and structural characterization of mycobacterial aspartyl-tRNA synthetase AspS, a promising TB drug target von Gurcha, Sudagar S, Usha, Veeraraghavan, Cox, Jonathan A G, Fütterer, Klaus, Abrahams, Katherine A, Bhatt, Apoorva, Alderwick, Luke J, Reynolds, Robert C, Loman, Nicholas J, Nataraj, VijayaShankar, Alemparte, Carlos, Barros, David, Lloyd, Adrian J, Ballell, Lluis, Hobrath, Judith V, Besra, Gurdyal S

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Novel inhibitors of Mycobacterium tuberculosis GuaB2 identified by a target based high-throughput phenotypic screen von Cox, Jonathan A. G., Mugumbate, Grace, Del Peral, Laura Vela-Glez, Jankute, Monika, Abrahams, Katherine A., Jervis, Peter, Jackenkroll, Stefan, Perez, Arancha, Alemparte, Carlos, Esquivias, Jorge, Lelièvre, Joël, Ramon, Fernando, Barros, David, Ballell, Lluis, Besra, Gurdyal S.

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NSC19723, a Thiacetazone-Like Benzaldehyde Thiosemicarbazone Improves the Efficacy of TB Drugs In Vitro and In Vivo von Singh, Padam, Rawat, Srishti, Agrahari, Ashish Kumar, Singh, Manisha, Chugh, Saurabh, Gurcha, Sudagar, Singh, Albel, Abrahams, Katherine, Besra, Gurdyal S, Asthana, Shailendra, Rawat, Diwan S, Singh, Ramandeep

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Anti-tubercular derivatives of rhein require activation by the monoglyceride lipase Rv0183 von Abrahams, Katherine A., Hu, Wei, Li, Gang, Lu, Yu, Richardson, Emily J., Loman, Nicholas J., Huang, Haihong, Besra, Gurdyal S.

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Two-Way Regulation of MmpL3 Expression Identifies and Validates Inhibitors of MmpL3 Function in Mycobacterium tuberculosis von Grover, Shipra, Engelhart, Curtis A, Pérez-Herrán, Esther, Li, Wei, Abrahams, Katherine A, Papavinasasundaram, Kadamba, Bean, James M, Sassetti, Christopher M, Mendoza-Losana, Alfonso, Besra, Gurdyal S, Jackson, Mary, Schnappinger, Dirk

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Development of a whole‐cell high‐throughput phenotypic screen to identify inhibitors of mycobacterial amino acid biosynthesis von Burke, Christopher, Abrahams, Katherine A., Richardson, Emily J., Loman, Nicholas J., Alemparte, Carlos, Lelievre, Joel, Besra, Gurdyal S.

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