What doesn’t kill you makes you stronger – bcl-2 promotes survival independent of proliferation von Schimmer, Aaron D.

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Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Human Acute Myeloid Leukemia von Škrtić, Marko, Sriskanthadevan, Shrivani, Jhas, Bozhena, Gebbia, Marinella, Wang, Xiaoming, Wang, Zezhou, Hurren, Rose, Jitkova, Yulia, Gronda, Marcela, Maclean, Neil, Lai, Courteney K., Eberhard, Yanina, Bartoszko, Justyna, Spagnuolo, Paul, Rutledge, Angela C., Datti, Alessandro, Ketela, Troy, Moffat, Jason, Robinson, Brian H., Cameron, Jessie H., Wrana, Jeffery, Eaves, Connie J., Minden, Mark D., Wang, Jean C.Y., Dick, John E., Humphries, Keith, Nislow, Corey, Giaever, Guri, Schimmer, Aaron D.

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Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality von Ishizawa, Jo, Zarabi, Sarah F., Davis, R. Eric, Halgas, Ondrej, Nii, Takenobu, Jitkova, Yulia, Zhao, Ran, St-Germain, Jonathan, Heese, Lauren E., Egan, Grace, Ruvolo, Vivian R., Barghout, Samir H., Nishida, Yuki, Hurren, Rose, Ma, Wencai, Gronda, Marcela, Link, Todd, Wong, Keith, Mabanglo, Mark, Kojima, Kensuke, Borthakur, Gautam, MacLean, Neil, Ma, Man Chun John, Leber, Andrew B., Minden, Mark D., Houry, Walid, Kantarjian, Hagop, Stogniew, Martin, Raught, Brian, Pai, Emil F., Schimmer, Aaron D., Andreeff, Michael

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Very long chain fatty acid metabolism is required in acute myeloid leukemia von Tcheng, Matthew, Roma, Alessia, Ahmed, Nawaz, Smith, Richard W., Jayanth, Preethi, Minden, Mark D., Schimmer, Aaron D., Hess, David A., Hope, Kristin, Rea, Kevin A., Akhtar, Tariq A., Bohrnsen, Eric, D'Alessandro, Angelo, Mohsen, Al-Walid, Vockley, Jerry, Spagnuolo, Paul A.

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Novel Proteasome Inhibitors to Overcome Bortezomib Resistance von Ruschak, Amy M., Slassi, Malik, Kay, Lewis E., Schimmer, Aaron D.

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Inhibition of the Mitochondrial Protease ClpP as a Therapeutic Strategy for Human Acute Myeloid Leukemia von Cole, Alicia, Wang, Zezhou, Coyaud, Etienne, Voisin, Veronique, Gronda, Marcela, Jitkova, Yulia, Mattson, Rachel, Hurren, Rose, Babovic, Sonja, Maclean, Neil, Restall, Ian, Wang, Xiaoming, Jeyaraju, Danny V., Sukhai, Mahadeo A., Prabha, Swayam, Bashir, Shaheena, Ramakrishnan, Ashwin, Leung, Elisa, Qia, Yi Hua, Zhang, Nianxian, Combes, Kevin R., Ketela, Troy, Lin, Fengshu, Houry, Walid A., Aman, Ahmed, Al-awar, Rima, Zheng, Wei, Wienholds, Erno, Xu, Chang Jiang, Dick, John, Wang, Jean C.Y., Moffat, Jason, Minden, Mark D., Eaves, Connie J., Bader, Gary D., Hao, Zhenyue, Kornblau, Steven M., Raught, Brian, Schimmer, Aaron D.

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Mitochondrial and Metabolic Pathways Regulate Nuclear Gene Expression to Control Differentiation, Stem Cell Function, and Immune Response in Leukemia von Egan, Grace, Khan, Dilshad H, Lee, Jong Bok, Mirali, Sara, Zhang, Li, Schimmer, Aaron D

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MTCH2-mediated mitochondrial fusion drives exit from naïve pluripotency in embryonic stem cells von Bahat, Amir, Goldman, Andres, Zaltsman, Yehudit, Khan, Dilshad H., Halperin, Coral, Amzallag, Emmanuel, Krupalnik, Vladislav, Mullokandov, Michael, Silberman, Alon, Erez, Ayelet, Schimmer, Aaron D., Hanna, Jacob H., Gross, Atan

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RB1 status in triple negative breast cancer cells dictates response to radiation treatment and selective therapeutic drugs von Robinson, Tyler J W, Liu, Jeff C, Vizeacoumar, Frederick, Sun, Thomas, Maclean, Neil, Egan, Sean E, Schimmer, Aaron D, Datti, Alessandro, Zacksenhaus, Eldad

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Targeting p53 via JNK pathway: a novel role of RITA for apoptotic signaling in multiple myeloma von Saha, Manujendra N, Jiang, Hua, Yang, Yijun, Zhu, Xiaoyun, Wang, Xiaoming, Schimmer, Aaron D, Qiu, Lugui, Chang, Hong

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A multicenter phase I/II study of obatoclax mesylate administered as a 3- or 24-hour infusion in older patients with previously untreated acute myeloid leukemia von Schimmer, Aaron D, Raza, Azra, Carter, Thomas H, Claxton, David, Erba, Harry, DeAngelo, Daniel J, Tallman, Martin S, Goard, Carolyn, Borthakur, Gautam

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Preclinical evaluation of the selective small-molecule UBA1 inhibitor, TAK-243, in acute myeloid leukemia von Barghout, Samir H., Patel, Parasvi S., Wang, Xiaoming, Xu, G. Wei, Kavanagh, Simon, Halgas, Ondrej, Zarabi, Sara F., Gronda, Marcela, Hurren, Rose, Jeyaraju, Danny V., MacLean, Neil, Brennan, Shawn, Hyer, Marc L., Berger, Allison, Traore, Tary, Milhollen, Michael, Smith, Adam C., Minden, Mark D., Pai, Emil F., Hakem, Razq, Schimmer, Aaron D.

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Biological and therapeutic implications of a unique subtype of NPM1 mutated AML von Mer, Arvind Singh, Heath, Emily M., Madani Tonekaboni, Seyed Ali, Dogan-Artun, Nergiz, Nair, Sisira Kadambat, Murison, Alex, Garcia-Prat, Laura, Shlush, Liran, Hurren, Rose, Voisin, Veronique, Bader, Gary D., Nislow, Corey, Rantalainen, Mattias, Lehmann, Soren, Gower, Mark, Guidos, Cynthia J., Lupien, Mathieu, Dick, John E., Minden, Mark D., Schimmer, Aaron D., Haibe-Kains, Benjamin

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Targeting nuclear import and export in hematological malignancies von Nachmias, Boaz, Schimmer, Aaron D.

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Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy von Nouri, Kazem, Feng, Yue, Schimmer, Aaron D.

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Correction: The Natural Pesticide Dihydrorotenone Induces Human Plasma Cell Apoptosis by Triggering Endoplasmic Reticulum Stress and Activating p38 Signaling Pathway von Zhang, Jieyu, Tang, Juan, Cao, Biyin, Zhang, Zubin, Li, Jie, Schimmer, Aaron D, He, Sudan, Mao, Xinliang

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ZDHHC21: a mitochondrial vulnerability in AML von Schimmer, Aaron D.

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The ubiquitin-activating enzyme, UBA1, as a novel therapeutic target for AML von Barghout, Samir H, Schimmer, Aaron D

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Extended exposure to low doses of azacitidine induces differentiation of leukemic stem cells through activation of myeloperoxidase von Jeyaraju, Danny V, Alapa, Maryam, Polonskaia, Ann, Risueño, Alberto, Subramanyam, Prakash, Anand, Amit, Ghosh, Kaushik, Kyriakopoulos, Charalampos, Hemerich, Daiane, Hurren, Rose, Wang, Xiaoming, Gronda, Marcela, Ahsan, Aarif, Chiu, Hsiling, Thomas, Geethu, Lind, Evan F, Menezes, Daniel L, Schimmer, Aaron D, Hagner, Patrick R, Gandhi, Anita, Thakurta, Anjan G

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Acute myeloid leukemia drug tolerant persister cells survive chemotherapy by transiently increasing plasma membrane rigidity, that also increases their sensitivity to immune cell k... von Morgenstern, Yael, Lee, JongBok, Na, Yoosu, Lieng, Brandon Y, Ly, Nicholas S, Gwynne, William D, Hurren, Rose, Ma, Li, Ling, Dakai, Gronda, Marcela, Arruda, Andrea, Frisch, Avraham, Zuckerman, Tsila, Ofran, Yishai, Minden, Mark D, Zhang, Li, O'Brien, Catherine, Quaile, Andrew T, Montenegro-Burke, J Rafael, Schimmer, Aaron D

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