Genome-wide association studies of metabolites in Finnish men identify disease-relevant loci von Yin, Xianyong, Chan, Lap Sum, Bose, Debraj, Jackson, Anne U., VandeHaar, Peter, Locke, Adam E., Fuchsberger, Christian, Stringham, Heather M., Welch, Ryan, Yu, Ketian, Fernandes Silva, Lilian, Service, Susan K., Zhang, Daiwei, Hector, Emily C., Young, Erica, Ganel, Liron, Das, Indraniel, Abel, Haley, Erdos, Michael R., Bonnycastle, Lori L., Kuusisto, Johanna, Stitziel, Nathan O., Hall, Ira M., Wagner, Gregory R., Kang, Jian, Morrison, Jean, Burant, Charles F., Collins, Francis S., Ripatti, Samuli, Palotie, Aarno, Freimer, Nelson B., Mohlke, Karen L., Scott, Laura J., Wen, Xiaoquan, Fauman, Eric B., Laakso, Markku, Boehnke, Michael

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Systematic comparison of family history and polygenic risk across 24 common diseases von Mars, Nina, Lindbohm, Joni V., della Briotta Parolo, Pietro, Widén, Elisabeth, Kaprio, Jaakko, Palotie, Aarno, Ripatti, Samuli

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Polygenic and clinical risk scores and their impact on age at onset and prediction of cardiometabolic diseases and common cancers von Mars, Nina, Koskela, Jukka T., Ripatti, Pietari, Kiiskinen, Tuomo T. J., Havulinna, Aki S., Lindbohm, Joni V., Ahola-Olli, Ari, Kurki, Mitja, Karjalainen, Juha, Palta, Priit, Neale, Benjamin M., Daly, Mark, Salomaa, Veikko, Palotie, Aarno, Widén, Elisabeth, Ripatti, Samuli

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Genomic prediction of coronary heart disease von Abraham, Gad, Havulinna, Aki S, Bhalala, Oneil G, Byars, Sean G, De Livera, Alysha M, Yetukuri, Laxman, Tikkanen, Emmi, Perola, Markus, Schunkert, Heribert, Sijbrands, Eric J, Palotie, Aarno, Samani, Nilesh J, Salomaa, Veikko, Ripatti, Samuli, Inouye, Michael

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Genetic Risk Prediction and a 2-Stage Risk Screening Strategy for Coronary Heart Disease von Tikkanen, Emmi, Havulinna, Aki S., Palotie, Aarno, Salomaa, Veikko, Ripatti, Samuli

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Whole exome sequencing study identifies novel rare and common Alzheimer’s-Associated variants involved in immune response and transcriptional regulation von Bis, Joshua C., Jian, Xueqiu, Kunkle, Brian W., Chen, Yuning, Hamilton-Nelson, Kara L., Bush, William S., Salerno, William J., Lancour, Daniel, Ma, Yiyi, Renton, Alan E., Marcora, Edoardo, Farrell, John J., Zhao, Yi, Qu, Liming, Ahmad, Shahzad, Amin, Najaf, Amouyel, Philippe, Beecham, Gary W., Below, Jennifer E., Campion, Dominique, Cantwell, Laura, Charbonnier, Camille, Chung, Jaeyoon, Crane, Paul K., Cruchaga, Carlos, Cupples, L. Adrienne, Dartigues, Jean-François, Debette, Stéphanie, Deleuze, Jean-François, Fulton, Lucinda, Gabriel, Stacey B., Genin, Emmanuelle, Gibbs, Richard A., Goate, Alison, Grenier-Boley, Benjamin, Gupta, Namrata, Haines, Jonathan L., Havulinna, Aki S., Helisalmi, Seppo, Hiltunen, Mikko, Howrigan, Daniel P., Ikram, M. Arfan, Kaprio, Jaakko, Konrad, Jan, Kuzma, Amanda, Lander, Eric S., Lathrop, Mark, Lehtimäki, Terho, Lin, Honghuang, Mattila, Kari, Mayeux, Richard, Muzny, Donna M., Nasser, Waleed, Neale, Benjamin, Nho, Kwangsik, Nicolas, Gaël, Patel, Devanshi, Pericak-Vance, Margaret A., Perola, Markus, Psaty, Bruce M., Quenez, Olivier, Rajabli, Farid, Redon, Richard, Reitz, Christiane, Remes, Anne M., Salomaa, Veikko, Sarnowski, Chloe, Schmidt, Helena, Schmidt, Michael, Schmidt, Reinhold, Soininen, Hilkka, Thornton, Timothy A., Tosto, Giuseppe, Tzourio, Christophe, van der Lee, Sven J., van Duijn, Cornelia M., Valladares, Otto, Vardarajan, Badri, Wang, Li-San, Wang, Weixin, Wijsman, Ellen, Wilson, Richard K., Witten, Daniela, Worley, Kim C., Zhang, Xiaoling, Bellenguez, Celine, Lambert, Jean-Charles, Kurki, Mitja I., Palotie, Aarno, Daly, Mark, Boerwinkle, Eric, Lunetta, Kathryn L., Destefano, Anita L., Dupuis, Josée, Martin, Eden R., Schellenberg, Gerard D., Seshadri, Sudha, Naj, Adam C., Fornage, Myriam, Farrer, Lindsay A.

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Genetic Associations with Gestational Duration and Spontaneous Preterm Birth von Zhang, Ge, Feenstra, Bjarke, Bacelis, Jonas, Liu, Xueping, Muglia, Lisa M, Juodakis, Julius, Miller, Daniel E, Litterman, Nadia, Jiang, Pan-Pan, Russell, Laura, Hinds, David A, Hu, Youna, Weirauch, Matthew T, Chen, Xiaoting, Chavan, Arun R, Wagner, Günter P, Pavličev, Mihaela, Nnamani, Mauris C, Maziarz, Jamie, Karjalainen, Minna K, Rämet, Mika, Sengpiel, Verena, Geller, Frank, Boyd, Heather A, Palotie, Aarno, Momany, Allison, Bedell, Bruce, Ryckman, Kelli K, Huusko, Johanna M, Forney, Carmy R, Kottyan, Leah C, Hallman, Mikko, Teramo, Kari, Nohr, Ellen A, Davey Smith, George, Melbye, Mads, Jacobsson, Bo, Muglia, Louis J

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Geographic Variation and Bias in the Polygenic Scores of Complex Diseases and Traits in Finland von Kerminen, Sini, Martin, Alicia R., Koskela, Jukka, Ruotsalainen, Sanni E., Havulinna, Aki S., Surakka, Ida, Palotie, Aarno, Perola, Markus, Salomaa, Veikko, Daly, Mark J., Ripatti, Samuli, Pirinen, Matti

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Improved imputation accuracy of rare and low-frequency variants using population-specific high-coverage WGS-based imputation reference panel von Mitt, Mario, Kals, Mart, Pärn, Kalle, Gabriel, Stacey B, Lander, Eric S, Palotie, Aarno, Ripatti, Samuli, Morris, Andrew P, Metspalu, Andres, Esko, Tõnu, Mägi, Reedik, Palta, Priit

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Integrating common and rare genetic variation in diverse human populations von Altshuler, David M, Gibbs, Richard A, Peltonen, Leena, Dermitzakis, Emmanouil, Schaffner, Stephen F, Yu, Fuli, Bonnen, Penelope E, de Bakker, Paul I W, Deloukas, Panos, Gabriel, Stacey B, Gwilliam, Rhian, Hunt, Sarah, Inouye, Michael, Jia, Xiaoming, Palotie, Aarno, Parkin, Melissa, Whittaker, Pamela, Chang, Kyle, Hawes, Alicia, Lewis, Lora R, Ren, Yanru, Wheeler, David, Muzny, Donna Marie, Barnes, Chris, Darvishi, Katayoon, Hurles, Matthew, Korn, Joshua M, Kristiansson, Kati, Lee, Charles, McCarrol, Steven A, Nemesh, James, Keinan, Alon, Montgomery, Stephen B, Pollack, Samuela, Price, Alkes L, Soranzo, Nicole, Gonzaga-Jauregui, Claudia, Anttila, Verneri, Brodeur, Wendy, Daly, Mark J, Leslie, Stephen, McVean, Gil, Moutsianas, Loukas, Nguyen, Huy, Zhang, Qingrun, Ghori, Mohammed J R, McGinnis, Ralph, McLaren, William, Takeuchi, Fumihiko, Grossman, Sharon R, Shlyakhter, Ilya, Hostetter, Elizabeth B, Sabeti, Pardis C, Adebamowo, Clement A, Foster, Morris W, Gordon, Deborah R, Licinio, Julio, Manca, Maria Cristina, Marshall, Patricia A, Matsuda, Ichiro, Ngare, Duncan, Wang, Vivian Ota, Reddy, Deepa, Rotimi, Charles N, Royal, Charmaine D, Sharp, Richard R, Zeng, Changqing, Brooks, Lisa D, McEwen, Jean E

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Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons von Fischer, Krista, Kettunen, Johannes, Würtz, Peter, Haller, Toomas, Havulinna, Aki S, Kangas, Antti J, Soininen, Pasi, Esko, Tõnu, Tammesoo, Mari-Liis, Mägi, Reedik, Smit, Steven, Palotie, Aarno, Ripatti, Samuli, Salomaa, Veikko, Ala-Korpela, Mika, Perola, Markus, Metspalu, Andres

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Exome sequencing of Finnish isolates enhances rare-variant association power von Locke, Adam E., Steinberg, Karyn Meltz, Chiang, Charleston W. K., Service, Susan K., Havulinna, Aki S., Stell, Laurel, Pirinen, Matti, Abel, Haley J., Chiang, Colby C., Fulton, Robert S., Jackson, Anne U., Kang, Chul Joo, Kanchi, Krishna L., Koboldt, Daniel C., Larson, David E., Nelson, Joanne, Nicholas, Thomas J., Pietilä, Arto, Ramensky, Vasily, Ray, Debashree, Scott, Laura J., Stringham, Heather M., Vangipurapu, Jagadish, Welch, Ryan, Yajnik, Pranav, Yin, Xianyong, Eriksson, Johan G., Ala-Korpela, Mika, Järvelin, Marjo-Riitta, Männikkö, Minna, Laivuori, Hannele, Dutcher, Susan K., Stitziel, Nathan O., Wilson, Richard K., Hall, Ira M., Sabatti, Chiara, Palotie, Aarno, Salomaa, Veikko, Laakso, Markku, Ripatti, Samuli, Boehnke, Michael, Freimer, Nelson B.

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Phenome-wide association studies across large population cohorts support drug target validation von Diogo, Dorothée, Tian, Chao, Franklin, Christopher S., Alanne-Kinnunen, Mervi, March, Michael, Spencer, Chris C. A., Vangjeli, Ciara, Weale, Michael E., Mattsson, Hannele, Kilpeläinen, Elina, Sleiman, Patrick M. A., Reilly, Dermot F., McElwee, Joshua, Maranville, Joseph C., Chatterjee, Arnaub K., Bhandari, Aman, Nguyen, Khanh-Dung H., Estrada, Karol, Reeve, Mary-Pat, Hutz, Janna, Bing, Nan, John, Sally, MacArthur, Daniel G., Salomaa, Veikko, Ripatti, Samuli, Hakonarson, Hakon, Daly, Mark J., Palotie, Aarno, Hinds, David A., Donnelly, Peter, Fox, Caroline S., Day-Williams, Aaron G., Plenge, Robert M., Runz, Heiko

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De novo loss- or gain-of-function mutations in KCNA2 cause epileptic encephalopathy von Syrbe, Steffen, Hedrich, Ulrike B S, Riesch, Erik, Djémié, Tania, Müller, Stephan, Møller, Rikke S, Maher, Bridget, Hernandez-Hernandez, Laura, Synofzik, Matthis, Caglayan, Hande S, Arslan, Mutluay, Serratosa, José M, Nothnagel, Michael, May, Patrick, Krause, Roland, Löffler, Heidrun, Detert, Katja, Dorn, Thomas, Vogt, Heinrich, Krämer, Günter, Schöls, Ludger, Mullis, Primus E, Linnankivi, Tarja, Lehesjoki, Anna-Elina, Sterbova, Katalin, Craiu, Dana C, Hoffman-Zacharska, Dorota, Korff, Christian M, Weber, Yvonne G, Steinlin, Maja, Gallati, Sabina, Bertsche, Astrid, Bernhard, Matthias K, Merkenschlager, Andreas, Kiess, Wieland, Gonzalez, Michael, Züchner, Stephan, Palotie, Aarno, Suls, Arvid, De Jonghe, Peter, Helbig, Ingo, Biskup, Saskia, Wolff, Markus, Maljevic, Snezana, Schüle, Rebecca, Sisodiya, Sanjay M, Weckhuysen, Sarah, Lerche, Holger, Lemke, Johannes R

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ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease von Helkkula, Pyry, Kiiskinen, Tuomo, Havulinna, Aki S, Karjalainen, Juha, Koskinen, Seppo, Salomaa, Veikko, Daly, Mark J, Palotie, Aarno, Surakka, Ida, Ripatti, Samuli

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A genetic study of Wilson's disease in the United Kingdom von COFFEY, Alison J, DURKIE, Miranda, MIELI-VERGANI, Giorgina, KIRK, Richard, ELIZABETH ALLEN, K, NICHOLL, David, WONG, Siew, GRIFFITHS, William, SMITHSON, Sarah, GIFFIN, Nicola, TAHA, Ali, CONNOLLY, Sally, HAGUE, Stephen, GILLETT, Godfrey T, TANNER, Stuart, BONHAM, Jim, SHARRACK, Basil, PALOTIE, Aarno, RATTRAY, Magnus, DALTON, Ann, BANDMANN, Oliver, MCLAY, Kirsten, EMMERSON, Jennifer, LO, Christine, KLAFFKE, Stefanie, JOYCE, Christopher J, DHAWAN, Anil, HADZIC, Nedim

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Identification of pathogenic variant enriched regions across genes and gene families von Pérez-Palma, Eduardo, May, Patrick, Iqbal, Sumaiya, Niestroj, Lisa-Marie, Du, Juanjiangmeng, Heyne, Henrike O, Castrillon, Jessica A, O'Donnell-Luria, Anne, Nürnberg, Peter, Palotie, Aarno, Daly, Mark, Lal, Dennis

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Polygenic risk scores as a marker for epilepsy risk across lifetime and after unspecified seizure events von Heyne, Henrike O., Pajuste, Fanny-Dhelia, Wanner, Julian, Daniel Onwuchekwa, Jennifer I., Mägi, Reedik, Palotie, Aarno, Kälviainen, Reetta, Daly, Mark J.

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Genome-wide association analysis identifies susceptibility loci for migraine without aura von Freilinger, Tobias, Anttila, Verneri, de Vries, Boukje, Malik, Rainer, Kallela, Mikko, Terwindt, Gisela M, Pozo-Rosich, Patricia, Winsvold, Bendik, Nyholt, Dale R, van Oosterhout, Willebrordus P J, Artto, Ville, Todt, Unda, Hämäläinen, Eija, Fernández-Morales, Jèssica, Louter, Mark A, Kaunisto, Mari A, Schoenen, Jean, Raitakari, Olli, Lehtimäki, Terho, Vila-Pueyo, Marta, Göbel, Hartmut, Wichmann, Erich, Sintas, Cèlia, Uitterlinden, Andre G, Hofman, Albert, Rivadeneira, Fernando, Heinze, Axel, Tronvik, Erling, van Duijn, Cornelia M, Kaprio, Jaakko, Cormand, Bru, Wessman, Maija, Frants, Rune R, Meitinger, Thomas, Müller-Myhsok, Bertram, Zwart, John-Anker, Färkkilä, Markus, Macaya, Alfons, Ferrari, Michel D, Kubisch, Christian, Palotie, Aarno, Dichgans, Martin, van den Maagdenberg, Arn M J M

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Genome-wide association study indicates novel associations of annexin A13 to secretory and GAS2L2 with mucous otitis media von Bizaki-Vallaskangas, Argyro, Rämö, Joel, Sliz, Eeva, Kivekäs, Ilkka, Willberg, Tytti, Saarentaus, Elmo, Toppila-Salmi, Sanna, Dietz, Aarno, Haapaniemi, Teppo, Hytönen, Vesa P., Toivola, Sari, Palotie, Aarno, Mäkitie, Antti, Kettunen, Johannes

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