Ambulatory care management of 69 patients with acute severe ulcerative colitis in comparison to 695 inpatients: insights from a multicentre UK cohort study von Sebastian, Shaji, Patel, Kamal V, Segal, Jonathan P, Subramanian, Sreedhar, Conley, Thomas Edward, Gonzalez, Haidee Aleman, Kent, Alexandra J, Saifuddin, Aamir, Hicks, Lucy, Mehta, Shameer, Bhala, Neeraj, Brookes, Matthew J, Lamb, Christopher A, Kennedy, Nicholas A, Walker, Gareth J

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Tu1762 A CORE TRANSCRIPTIONAL RESISTOME, CHARACTERISED BY NEUTROPHIL DEGRANULATION AND EXTRACELLULAR MATRIX DYSREGULATION, PREDICTS RESISTANCE TO MULTIPLE THERAPIES IN UC von Saifuddin, Aamir, Cozzetto, Domenico, Pavlidis, Polychronis, Hart, Ailsa, Powell, Nick

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The Future of Precision Medicine to Predict Outcomes and Control Tissue Remodeling in Inflammatory Bowel Disease von Lamb, Christopher A., Saifuddin, Aamir, Powell, Nick, Rieder, Florian

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Sa1859 EXTRACELLULAR MATRIX DYSREGULATION AND NEUTROPHIL DEGRANULATION ARE CORE PATHWAYS DRIVING TREATMENT RESISTANCE IN ULCERATIVE COLITIS von Saifuddin, Aamir, Cozzetto, Domenico, Pavlidis, Polychronis, Hart, Ailsa, Powell, Nick

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Limitations of poster presentations reporting educational innovations at a major international medical education conference von Gordon, Morris, Darbyshire, Daniel, Saifuddin, Aamir, Vimalesvaran, Kavitha

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Tu1761 GENE CORRELATION NETWORK ANALYSES REVEAL TRANSCRIPT MODULES AND PATHOGENIC MECHANISMS ASSOCIATED WITH RESISTANCE AND RESPONSE TO USTEKINUMAB THERAPY IN ULCERATIVE COLITIS von Saifuddin, Aamir, Cozzetto, Domenico, Olbei, Marton, Pavlidis, Polychronis, Hart, Ailsa, Korcsmaros, Tamas, Powell, Nick

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Tacrolimus therapy in moderate to subacute ulcerative proctocolitis: a large single-centre cohort study von Saifuddin, Aamir, Harris, Adam

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Editorial: the impact of COVID on the management of IBD flares: different care but similar outcomes—authors' reply von Saifuddin, Aamir, Kent, Alexandra J., Mehta, Shameer J., Sebastian, Shaji

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P198 Prepare-IBD: physician responses to flares and patient adaptation in IBD during the COVID-19 pandemic von Saifuddin, Aamir, Kent, Alexandra, Mehta, Shameer, Hicks, Lucy, Gonzalez, Haidee, Patel, Kamal, Lamb, Christopher, Walker, Gareth, Kennedy, Nicholas, Sebastian, Shaji

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COVID-19 vaccine-induced antibody responses in immunosuppressed patients with inflammatory bowel disease (VIP): a multicentre, prospective, case-control study von Alexander, James L, Kennedy, Nicholas A, Ibraheim, Hajir, Anandabaskaran, Sulak, Saifuddin, Aamir, Castro Seoane, Rocio, Liu, Zhigang, Nice, Rachel, Bewshea, Claire, D'Mello, Andrea, Constable, Laura, Jones, Gareth R, Balarajah, Sharmili, Fiorentino, Francesca, Sebastian, Shaji, Irving, Peter M, Hicks, Lucy C, Williams, Horace R T, Kent, Alexandra J, Linger, Rachel, Parkes, Miles, Kok, Klaartje, Patel, Kamal V, Teare, Julian P, Altmann, Daniel M, Boyton, Rosemary J, Goodhand, James R, Hart, Ailsa L, Lees, Charlie W, Ahmad, Tariq, Powell, Nick, Chukwurah, Ijeoma, Haq, Sulaimaan, Shah, Parita, Wilken-Smith, Stephanie, Ramanathan, Anitha, Patel, Mikin, Romanczuk, Lidia, King, Rebecca, Domingo, Jason, Shamtally, Djamila, Mendoza, Vivien, Sanchez, Joanne, Stark, Hannah, Knight, Bridget, Bee, Louise, Estember, Charmaine, Barnes, Anna, Watkins, Darcy, Stone, Sam, Kirkwood, John, Parkinson, Marian, Gardner-Thorpe, Helen, Covil, Kate, Derikx, Lauranne, Gros Alcalde, Beatriz, Lee, Irish, Cipriano, Bessie, Ruocco, Giuseppe, Baden, Manisha, Cooke, Graham, Pollock, Katrina

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P75 Vaccine-induced antibody responses against influenza are diminished in infliximab and tofacitinib-treated IBD patients and correlate with responses to COVID-19 vaccination von Alexander, James, Liu, Zhigang, Eng, Kai Yee, Ibraheim, Hajir, Saifuddin, Aamir, Bewshea, Claire, Balarajah, Sharmili, Sebastian, Shaji, Irving, Peter, Hicks, Lucy, Kent, Alexandra, Parkes, Miles, Kok, Klaartje, Patel, Kamal, Hart, Ailsa, Lees, Charlie, Goodhand, James, Kennedy, Nick, Ahmad, Tariq, Powell, Nick

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P77 Neutralising antibody responses against SARS-CoV-2 Omicron BA.4/5 and wild-type strain in patients with IBD after three doses of COVID-19 vaccine von Liu, Zhigang, Alexander, James, Le, Kaixing, Zhou, Xin, Ibraheim, Hajir, Anandabaskaran, Sulakchanan, Saifuddin, Aamir, Constable, Laura, Bewshea, Claire, Jones, Gareth, Sebastian, Shaji, Irving, Peter, Hart, Ailsa, Lees, Charlie, Boyton, Rosemary, Goodhand, James, Kennedy, Nicholas, Pollock, Katrina, Ahmad, Tariq, Powell, Nick

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Infliximab and Tofacitinib Attenuate Neutralizing Antibody Responses Against SARS-CoV-2 Ancestral and Omicron Variants in Inflammatory Bowel Disease Patients After 3 Doses of COVID... von Liu, Zhigang, Alexander, James L., Lin, Kathy Weitung, Le, Kaixing, Zhou, Xin, Ibraheim, Hajir, Anandabaskaran, Sulak, Saifuddin, Aamir, McFarlane, Leon R., Anand, Nikhil, Constable, Laura, Seoane, Rocio Castro, D’Mello, Andrea, Balarajah, Sharmili, Hicks, Lucy C., Williams, Horace R.T., Lo, Jonathan W., Hart, Ailsa L., Altmann, Daniel M., Boyton, Rosemary J., Teare, Julian P., Nice, Rachel, Bewshea, Claire, Goodhand, James R., Kennedy, Nicholas A., Barnes, Anna, Kirkwood, John, Parkinson, Marian, Gardner-Thorpe, Helen, Lees, Charlie W., Jones, Gareth R., Covil, Kate, Derikx, Lauranne, Fiorentino, Francesca, Irving, Peter M., Parkes, Miles, Linger, Rachel, Kok, Klaartje, Lee, Irish, Cipriano, Bessie, Patel, Kamal V., Sebastian, Shaji, Kent, Alexandra J., Chukwurah, Ijeoma, Haq, Sulaimaan, Shah, Parita, Wilken-Smith, Stephanie, Ramanathan, Anitha, Patel, Mikin, Romanczuk, Lidia, King, Rebecca, Domingo, Jason, Knight, Bridget, Shamtally, Djamila, Mendoza, Vivien, Sanchez, Joanne, Stark, Hannah, Bee, Louise, Estember, Charmaine, Watkins, Darcy, Stone, Sam, Alcalde, Beatriz Gros, Ruocco, Giuseppe, Baden, Manisha, Cooke, Graham, Kourampa, Evgenia, Pasquale, Ciro, Robisco-Diaz, Elena, Bhatti, Suhaylah, Ahmad, Tariq, Pollock, Katrina M., Powell, Nick

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Su1611: POOR RESPONSE TO ANTI-SARS-COV-2 VACCINATION IN IMMUNOSUPPRESSED INFLAMMATORY BOWEL DISEASE PATIENTS IS ASSOCIATED WITH ALTERED GUT MICROBIOTA FUNCTION von Alexander, James L., Mullish, Benjamin H., Danckert, Nathan P., Liu, Zhigang, Saifuddin, Aamir, Torkizadeh, Melissa, Ibraheim, Hajir, Blanco, Jesús Miguéns, Bewshea, Claire M., Nice, Rachel, Lin, Simeng, Prabhudev, Hemanth, Sands, Caroline, Lewis, Matthew, Teare, Julian P., Hart, Ailsa, Kennedy, Nick, Ahmad, Tariq, Marchesi, Julian, Powell, Nick

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Towards excellence in cardiac surgery: experience from a developing country von SAIFUDDIN, AAMIR, SHAHABUDDIN, SYED, PERVEEN, SHAZIA, FURNAZ, SHUMAILA, SHARIF, HASANAT

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Su1485: COVID-19 VACCINE-INDUCED ANTIBODY RESPONSES ARE IMPAIRED IN IBD PATIENTS TREATED WITH INFLIXIMAB, USTEKINUMAB OR TOFACITINIB, BUT NOT THIOPURINES OR VEDOLIZUMAB von Alexander, James L., Kennedy, Nick, Ibraheim, Hajir, Anandabaskaran, Sulak, Saifuddin, Aamir, Seoane, Rocio Castro, Liu, Zhigang, Nice, Rachel, Bewshea, Claire M., D'Mello, Andrea, Constable, Laura E., Jones, Gareth-Rhys, Balarajah, Sharmili, Fiorentino, Francesca, Sebastian, Shaji, Irving, Peter M., Hicks, Lucy C., Williams, Horace R., Kent, Alexandra J., Parkes, Miles, Kok, Klaartje, Patel, Kamal V, Altmann, Daniel, Boyton, Rosemary, Goodhand, James, Hart, Ailsa, Lees, Charlie W., Ahmad, Tariq, Powell, Nick

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The gut microbiota and metabolome are associated with diminished COVID-19 vaccine-induced antibody responses in immunosuppressed inflammatory bowel disease patients von Alexander, James L., Mullish, Benjamin H., Danckert, Nathan P., Liu, Zhigang, Olbei, Marton L., Saifuddin, Aamir, Torkizadeh, Melissa, Ibraheim, Hajir, Blanco, Jesús Miguéns, Roberts, Lauren A., Bewshea, Claire M., Nice, Rachel, Lin, Simeng, Prabhudev, Hemanth, Sands, Caroline, Horneffer-van der Sluis, Verena, Lewis, Matthew, Sebastian, Shaji, Lees, Charlie W., Teare, Julian P., Hart, Ailsa, Goodhand, James R., Kennedy, Nicholas A., Korcsmaros, Tamas, Marchesi, Julian R., Ahmad, Tariq, Powell, Nick

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Treatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID‐19 pandemic: the PREPARE‐IBD multicentre cohort study von Kent, Alexandra J., Brookes, Matthew J., Patel, Kamal V., Abbesi, Abdulla, Abusrewil, Anwar, Aghimien, Precious, Ali, Amjad, Alkhouri, Jad, Appleby, Richard, Arebi, Naila, Avades, Tamar, Ayubi, Homira, Basit, Abdul, Bayati, Murad, Bishop, Sophia, Borg‐Bartolo, Simon, Botwright, Emma, Bouri, Sonia, Boyle, Stephen, Bradley, Neil, Brailsford, Fiona, Campbell, Roisin, Campbell, Iona, Carter, Josiah, Chandy, Rajiv, Chaudhary, Rakesh, Cole, Alexander, Conley, Thomas, Cook, Johannah, Cooney, Rachel, Critchlow, Tamsin, Cuison, Frederic, Darie, Ana‐Marie, Davwar, Pantong, Disney, Benjamin, Dyall, Lovesh, Elias, Mary, Flanagan, Paul, Fofaria, Rishi, Fong, Steven, Gilroy, Leah, Gonzalez, Haidee Aleman, Good, Larissa, Gueroult, Aurelian, Gwiggner, Markus, Hanna, Mina, Harrison, Wendy, Hawthorne, Barney, Howard, Willow, Irving, Peter, Javed, Anun, Jayasooriya, Nishani, Johnson, Matthew, Kanagasundaram, Cynthia, Karagkouni, Foteini, Kennedy, Nick, Khan, Najeebullah, Khan, Zahid, King, Andy, Kirkham, Beverley, Kuzhiyanjal, Anish John Kuriakose, Lim, Samuel, Lim, Yuen‐Hui, Lisle, Jessica, Lucacui, Laura, MacDonald, Jonathan, Mahgoub, Sara, McCaughan, Hannah, McIlwaine, Stuart, Mehta, Shameer, Morris, Liam, Murray, Charles, Myers, Sally, Navaratnam, Janu, Naylor, Deanna, Nolan, Jonathan, Olabintan, Olaolu, Owen, Hayley, Patel, Kamal, Perkins, Rebecca, Phillips, Frank, Pollok, Richard, Powell, Nick, Quraishi, Mohammed Nabil, Rahmany, Sohail, Ramadan, Hanin, Riggott, Christy, Rosiou, Konstantina, Sabine, Joseph, Serna, Solange, Sherifat, Yousuf, Singh, Updesh, Smith, Philip, Stansfield, Cath, Steed, Helen, Townsend, Tristan, Wen, Susie, Widlak, Monika, Woods, Amy, Younge, Lisa

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COVID-19 vaccine-induced antibody and T-cell responses in immunosuppressed patients with inflammatory bowel disease after the third vaccine dose (VIP): a multicentre, prospective,... von Alexander, James L, Liu, Zhigang, Muñoz Sandoval, Diana, Reynolds, Catherine, Ibraheim, Hajir, Anandabaskaran, Sulak, Saifuddin, Aamir, Castro Seoane, Rocio, Anand, Nikhil, Nice, Rachel, Bewshea, Claire, D'Mello, Andrea, Constable, Laura, Jones, Gareth R, Balarajah, Sharmili, Fiorentino, Francesca, Sebastian, Shaji, Irving, Peter M, Hicks, Lucy C, Williams, Horace R T, Kent, Alexandra J, Linger, Rachel, Parkes, Miles, Kok, Klaartje, Patel, Kamal V, Teare, Julian P, Altmann, Daniel M, Goodhand, James R, Hart, Ailsa L, Lees, Charlie W, Boyton, Rosemary J, Kennedy, Nicholas A, Ahmad, Tariq, Powell, Nick

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Improving the management of patients with acute red eyes in a large London Emergency Department von Saifuddin, Aamir, Brookes, Rachel

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