Familial Isolated Pituitary Adenomas (FIPA) and the Pituitary Adenoma Predisposition due to Mutations in the Aryl Hydrocarbon Receptor Interacting Protein (AIP) Gene von Beckers, Albert, Aaltonen, Lauri A, Daly, Adrian F, Karhu, Auli

Volltext

Genomics of uterine leiomyomas: insights from high-throughput sequencing von Mehine, Miika, M.Sc, Mäkinen, Netta, M.Sc, Heinonen, Hanna-Riikka, M.B, Aaltonen, Lauri A., M.D., Ph.D, Vahteristo, Pia, Ph.D

Volltext

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer von Dziubańska-Kusibab, Paulina J., Berger, Hilmar, Battistini, Federica, Bouwman, Britta A. M., Iftekhar, Amina, Katainen, Riku, Cajuso, Tatiana, Crosetto, Nicola, Orozco, Modesto, Aaltonen, Lauri A., Meyer, Thomas F.

Volltext

Genetic and Epigenetic Characteristics of Inflammatory Bowel Disease–Associated Colorectal Cancer von Rajamäki, Kristiina, Taira, Aurora, Katainen, Riku, Välimäki, Niko, Kuosmanen, Anna, Plaketti, Roosa-Maria, Seppälä, Toni T., Ahtiainen, Maarit, Wirta, Erkki-Ville, Vartiainen, Emilia, Sulo, Päivi, Ravantti, Janne, Lehtipuro, Suvi, Granberg, Kirsi J., Nykter, Matti, Tanskanen, Tomas, Ristimäki, Ari, Koskensalo, Selja, Renkonen-Sinisalo, Laura, Lepistö, Anna, Böhm, Jan, Taipale, Jussi, Mecklin, Jukka-Pekka, Aavikko, Mervi, Palin, Kimmo, Aaltonen, Lauri A.

Volltext

Exome-wide somatic mutation characterization of small bowel adenocarcinoma von Hänninen, Ulrika A, Katainen, Riku, Tanskanen, Tomas, Plaketti, Roosa-Maria, Laine, Riku, Hamberg, Jiri, Ristimäki, Ari, Pukkala, Eero, Taipale, Minna, Mecklin, Jukka-Pekka, Forsström, Linda M, Pitkänen, Esa, Palin, Kimmo, Välimäki, Niko, Mäkinen, Netta, Aaltonen, Lauri A

Volltext

Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers von Mehine, Miika, Kaasinen, Eevi, Heinonen, Hanna-Riikka, Mäkinen, Netta, Kämpjärvi, Kati, Sarvilinna, Nanna, Aavikko, Mervi, Vähärautio, Anna, Pasanen, Annukka, Bützow, Ralf, Heikinheimo, Oskari, Sjöberg, Jari, Pitkänen, Esa, Vahteristo, Pia, Aaltonen, Lauri A.

Volltext

Characterization of Uterine Leiomyomas by Whole-Genome Sequencing von Mehine, Miika, Kaasinen, Eevi, Mäkinen, Netta, Katainen, Riku, Kämpjärvi, Kati, Pitkänen, Esa, Heinonen, Hanna-Riikka, Bützow, Ralf, Kilpivaara, Outi, Kuosmanen, Anna, Ristolainen, Heikki, Gentile, Massimiliano, Sjöberg, Jari, Vahteristo, Pia, Aaltonen, Lauri A

Volltext

Mutations in BRIP1 confer high risk of ovarian cancer von Rafnar, Thorunn, Stefansson, Kari, Gudbjartsson, Daniel F, Sulem, Patrick, Jonasdottir, Aslaug, Sigurdsson, Asgeir, Jonasdottir, Adalbjorg, Besenbacher, Soren, Lundin, Pär, Stacey, Simon N, Gudmundsson, Julius, Magnusson, Olafur T, le Roux, Louise, Orlygsdottir, Gudbjorg, Helgadottir, Hafdis T, Johannsdottir, Hrefna, Gylfason, Arnaldur, Tryggvadottir, Laufey, Jonasson, Jon G, de Juan, Ana, Ortega, Eugenia, Ramon-Cajal, Jose M, García-Prats, Maria D, Mayordomo, Carlos, Panadero, Angeles, Rivera, Fernando, Aben, Katja K H, van Altena, Anne M, Massuger, Leon F A G, Aavikko, Mervi, Kujala, Paula M, Staff, Synnöve, Aaltonen, Lauri A, Olafsdottir, Kristrun, Bjornsson, Johannes, Kong, Augustine, Salvarsdottir, Anna, Saemundsson, Hafsteinn, Olafsson, Karl, Benediktsdottir, Kristrun R, Gulcher, Jeffrey, Masson, Gisli, Kiemeney, Lambertus A, Mayordomo, Jose I, Thorsteinsdottir, Unnur

Volltext

Ten Years After Mutation Testing for Lynch Syndrome: Cancer Incidence and Outcome in Mutation-Positive and Mutation-Negative Family Members von Järvinen, Heikki J., Renkonen-Sinisalo, Laura, Aktán-Collán, Katja, Peltomäki, Päivi, Aaltonen, Lauri A., Mecklin, Jukka-Pekka

Volltext

Metastasis-Associated Gene Expression Changes Predict Poor Outcomes in Patients with Dukes Stage B and C Colorectal Cancer von JORISSEN, Robert N, GIBBS, Peter, ØRNTOFT, Torben F, LINDBJERG ANDERSEN, Claus, GRUIDL, Mike, KAMATH, Vidya P, ESCHRICH, Steven, YEATMAN, Timothy J, SIEBER, Oliver M, CHRISTIE, Michael, PRAKASH, Saurabh, LIPTON, Lara, DESAI, Jayesh, KERR, David, AALTONEN, Lauri A, ARANGO, Diego, KRUHØFFER, Mogens

Volltext

Uterine Leiomyoma-Linked MED12 Mutations Disrupt Mediator-Associated CDK Activity von Turunen, Mikko, Spaeth, Jason M., Keskitalo, Salla, Park, Min Ju, Kivioja, Teemu, Clark, Alison D., Mäkinen, Netta, Gao, Fangjian, Palin, Kimmo, Nurkkala, Helka, Vähärautio, Anna, Aavikko, Mervi, Kämpjärvi, Kati, Vahteristo, Pia, Kim, Chongwoo A., Aaltonen, Lauri A., Varjosalo, Markku, Taipale, Jussi, Boyer, Thomas G.

Volltext

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival von Cajuso, Tatiana, Sulo, Päivi, Tanskanen, Tomas, Katainen, Riku, Taira, Aurora, Hänninen, Ulrika A., Kondelin, Johanna, Forsström, Linda, Välimäki, Niko, Aavikko, Mervi, Kaasinen, Eevi, Ristimäki, Ari, Koskensalo, Selja, Lepistö, Anna, Renkonen-Sinisalo, Laura, Seppälä, Toni, Kuopio, Teijo, Böhm, Jan, Mecklin, Jukka-Pekka, Kilpivaara, Outi, Pitkänen, Esa, Palin, Kimmo, Aaltonen, Lauri A.

Volltext

The common colorectal cancer predisposition SNP rs6983267 at chromosome 8q24 confers potential to enhanced Wnt signaling von Taipale, Jussi, Aaltonen, Lauri A, Tuupanen, Sari, Turunen, Mikko, Lehtonen, Rainer, Hallikas, Outi, Vanharanta, Sakari, Kivioja, Teemu, Björklund, Mikael, Wei, Gonghong, Yan, Jian, Niittymäki, Iina, Mecklin, Jukka-Pekka, Järvinen, Heikki, Ristimäki, Ari, Di-Bernardo, Mariachiara, East, Phil, Carvajal-Carmona, Luis, Houlston, Richard S, Tomlinson, Ian, Palin, Kimmo, Ukkonen, Esko, Karhu, Auli

Volltext

Cancer incidence following non-neoplastic medical conditions: a prospective population-based cohort study von Sipilä, Lauri J., Tanskanen, Tomas, Heikkinen, Sanna, Seppä, Karri, Aavikko, Mervi, Ravantti, Janne, Aaltonen, Lauri A., Pitkäniemi, Janne

Volltext

Loss of SUFU Function in Familial Multiple Meningioma von Aavikko, Mervi, Li, Song-Ping, Saarinen, Silva, Alhopuro, Pia, Kaasinen, Eevi, Morgunova, Ekaterina, Li, Yilong, Vesanen, Kari, Smith, Miriam J., Evans, D. Gareth R., Pöyhönen, Minna, Kiuru, Anne, Auvinen, Anssi, Aaltonen, Lauri A., Taipale, Jussi, Vahteristo, Pia

Volltext

Oncogenic exon 2 mutations in Mediator subunit MED12 disrupt allosteric activation of cyclin C-CDK8/19 von Park, Min Ju, Shen, Hailian, Spaeth, Jason M., Tolvanen, Jaana H., Failor, Courtney, Knudtson, Jennifer F., McLaughlin, Jessica, Halder, Sunil K., Yang, Qiwei, Bulun, Serdar E., Al-Hendy, Ayman, Schenken, Robert S., Aaltonen, Lauri A., Boyer, Thomas G.

Volltext

Genomic profile of pseudomyxoma peritonei analyzed using next‐generation sequencing and immunohistochemistry von Nummela, Pirjo, Saarinen, Lilli, Thiel, Alexandra, Järvinen, Petrus, Lehtonen, Rainer, Lepistö, Anna, Järvinen, Heikki, Aaltonen, Lauri A, Hautaniemi, Sampsa, Ristimäki, Ari

Volltext

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer von Fang, Hu, Barbour, Jayne A., Poulos, Rebecca C., Katainen, Riku, Aaltonen, Lauri A., Wong, Jason W. H.

Volltext

A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function von Moutinho, Catia, Yamamoto, Hiroyuki, Capella, Gabriel, Ferreira, Bibiana, Liu, Chang-Gong, Esteller, Manel, Aaltonen, Lauri A, Shiekhattar, Ramin, Oliveira, Carla, Schwartz Jr, Simo, Ropero, Santiago, Rossi, Simona, Villanueva, Alberto, Calin, George A, Melo, Sonia A, Fernandez, Agustin F, Carneiro, Fatima

Volltext

Genetic and Epigenetic Characterization of Growth Hormone-Secreting Pituitary Tumors von Välimäki, Niko, Schalin-Jäntti, Camilla, Karppinen, Atte, Paetau, Anders, Kivipelto, Leena, Aaltonen, Lauri A, Karhu, Auli

Volltext