Molecular tuning of farnesoid X receptor partial agonism von Merk, Daniel, Sreeramulu, Sridhar, Kudlinzki, Denis, Saxena, Krishna, Linhard, Verena, Gande, Santosh L., Hiller, Fabian, Lamers, Christina, Nilsson, Ewa, Aagaard, Anna, Wissler, Lisa, Dekker, Niek, Bamberg, Krister, Schubert-Zsilavecz, Manfred, Schwalbe, Harald

Volltext

Preclinical pharmacology of AZD9977: A novel mineralocorticoid receptor modulator separating organ protection from effects on electrolyte excretion von Bamberg, Krister, Johansson, Ulrika, Edman, Karl, William-Olsson, Lena, Myhre, Susanna, Gunnarsson, Anders, Geschwindner, Stefan, Aagaard, Anna, Björnson Granqvist, Anna, Jaisser, Frédéric, Huang, Yufeng, Granberg, Kenneth L, Jansson-Löfmark, Rasmus, Hartleib-Geschwindner, Judith

Volltext

Ligand Binding Mechanism in Steroid Receptors: From Conserved Plasticity to Differential Evolutionary Constraints von Edman, Karl, Hosseini, Ali, Bjursell, Magnus K., Aagaard, Anna, Wissler, Lisa, Gunnarsson, Anders, Kaminski, Tim, Köhler, Christian, Bäckström, Stefan, Jensen, Tina J., Cavallin, Anders, Karlsson, Ulla, Nilsson, Ewa, Lecina, Daniel, Takahashi, Ryoji, Grebner, Christoph, Geschwindner, Stefan, Lepistö, Matti, Hogner, Anders C., Guallar, Victor

Volltext

Intramolecular Proton-Transfer Reactions in a Membrane-Bound Proton Pump:  The Effect of pH on the Peroxy to Ferryl Transition in Cytochrome c Oxidase von Namslauer, Andreas, Aagaard, Anna, Katsonouri, Andromachi, Brzezinski, Peter

Volltext

An Inflammatory Role for the Mammalian Carboxypeptidase Inhibitor Latexin: Relationship to Cystatins and the Tumor Suppressor TIG1 von Aagaard, Anna, Listwan, Pawel, Cowieson, Nathan, Huber, Thomas, Ravasi, Timothy, Wells, Christine A., Flanagan, Jack U., Kellie, Stuart, Hume, David A., Kobe, Bostjan, Martin, Jennifer L.

Volltext

Macular hole Delphi consensus statement (MHOST) von Confalonieri, Filippo, Haave, Hanna, Binder, Susanne, Bober, Agnieszka Monika, Bragadottir, Ragnheidur, Baerland, Thomas, Faber, Rowan, Forsaa, Vegard, Gonzalez-Lopez, Julio J, Govetto, Andrea, Haugstad, Marta, Ivastinovic, Domagoj, Jenko, Neža Čokl, Nicoară, Simona Delia, Kaljurand, Kuldar, Kozak, Igor, Kvanta, Anders, Lytvynchuk, Lyubomyr, Nawrocka, Zofia Anna, Pajic, Sanja Petrovic, Petrovič, Mojca Globočnik, Radecka, Liga, Rehak, Matus, Romano, Mario R, Ruban, Andrii, Speckauskas, Martynas, Stene-Johansen, Ingar, Stranak, Zbynek, Thaler, Angela, Thein, Anna Sophie Aagaard, Theocharis, Ioannis, Tomic, Zoran, Yan, Xiaohe, Zekolli, Muhamet, Zhuri, Burim, Znaor, Ljubo, Petrovski, Beata Eva, Kolko, Miriam, Lumi, Xhevat, Petrovski, Goran

Volltext

Inhibition of proton transfer in cytochrome c oxidase by zinc ions: delayed proton uptake during oxygen reduction von Aagaard, Anna, Namslauer, Andreas, Brzezinski, Peter

Volltext

Subunit III of Cytochrome c Oxidase of Rhodobacter sphaeroides Is Required To Maintain Rapid Proton Uptake through the D Pathway at Physiologic pH von Gilderson, Gwen, Salomonsson, Lina, Aagaard, Anna, Gray, Jimmy, Brzezinski, Peter, Hosler, Jonathan

Volltext

The Proton Collecting Function of the Inner Surface of Cytochrome c Oxidase from Rhodobacter sphaeroides von Marantz, Yael, Nachliel, Esther, Aagaard, Anna, Brzezinski, Peter, Gutman, Menachem

Volltext

Engineering the surface properties of a human monoclonal antibody prevents self-association and rapid clearance in vivo von Dobson, Claire L., Devine, Paul W. A., Phillips, Jonathan J., Higazi, Daniel R., Lloyd, Christopher, Popovic, Bojana, Arnold, Joanne, Buchanan, Andrew, Lewis, Arthur, Goodman, Joanne, van der Walle, Christopher F., Thornton, Peter, Vinall, Lisa, Lowne, David, Aagaard, Anna, Olsson, Lise-Lotte, Ridderstad Wollberg, Anna, Welsh, Fraser, Karamanos, Theodoros K., Pashley, Clare L., Iadanza, Matthew G., Ranson, Neil A., Ashcroft, Alison E., Kippen, Alistair D., Vaughan, Tristan J., Radford, Sheena E., Lowe, David C.

Volltext

Structure and biophysical characterization of the human full-length neurturin–GFRa2 complex: A role for heparan sulfate in signaling von Sandmark, Jenny, Dahl, Göran, Öster, Linda, Xu, Bingze, Johansson, Patrik, Akerud, Tomas, Aagaard, Anna, Davidsson, Pia, Bigalke, Janna M., Winzell, Maria Sörhede, Rainey, G. Jonah, Roth, Robert G.

Volltext

AZD0284, a Potent, Selective, and Orally Bioavailable Inverse Agonist of Retinoic Acid Receptor-Related Orphan Receptor C2 von Narjes, Frank, Llinas, Antonio, von Berg, Stefan, Jirholt, Johan, Lever, Sarah, Pehrson, Rikard, Collins, Mia, Malmberg, Anna, Svanberg, Petter, Xue, Yafeng, Olsson, Roine I, Malmberg, Jesper, Hughes, Glyn, Hossain, Nafizal, Grindebacke, Hanna, Leffler, Agnes, Krutrök, Nina, Bäck, Elisabeth, Ramnegård, Marie, Lepistö, Matti, Thunberg, Linda, Aagaard, Anna, McPheat, Jane, Hansson, Eva L, Chen, Rongfeng, Xiong, Yao, Hansson, Thomas G

Volltext

Potent and Orally Bioavailable Inverse Agonists of RORγt Resulting from Structure-Based Design von Narjes, Frank, Xue, Yafeng, von Berg, Stefan, Malmberg, Jesper, Llinas, Antonio, Olsson, Roine I, Jirholt, Johan, Grindebacke, Hanna, Leffler, Agnes, Hossain, Nafizal, Lepistö, Matti, Thunberg, Linda, Leek, Hanna, Aagaard, Anna, McPheat, Jane, Hansson, Eva L, Bäck, Elisabeth, Tångefjord, Stefan, Chen, Rongfeng, Xiong, Yao, Hongbin, Ge, Hansson, Thomas G

Volltext

Relocation of an internal proton donor in cytochrome c oxidase results in an altered pKa and a non-integer pumping stoichiometry von Gilderson, Gwen, Aagaard, Anna, Brzezinski, Peter

Volltext

The Structure of Murine N 1‑Acetylspermine Oxidase Reveals Molecular Details of Vertebrate Polyamine Catabolism von Sjögren, Tove, Wassvik, Carola M, Snijder, Arjan, Aagaard, Anna, Kumanomidou, Taichi, Barlind, Louise, Kaminski, Tim P, Kashima, Akiko, Yokota, Takehiro, Fjellström, Ola

Volltext

Benzoxazepines Achieve Potent Suppression of IL-17 Release in Human T-Helper 17 (TH17) Cells through an Induced-Fit Binding Mode to the Nuclear Receptor RORγ von Olsson, Roine I., Xue, Yafeng, von Berg, Stefan, Aagaard, Anna, McPheat, Jane, Hansson, Eva L., Bernström, Jenny, Hansson, Pia, Jirholt, Johan, Grindebacke, Hanna, Leffler, Agnes, Chen, Rongfeng, Xiong, Yao, Ge, Hongbin, Hansson, Thomas G., Narjes, Frank

Volltext

Identification and optimisation of a pyrimidopyridone series of IRAK4 inhibitors von Cumming, Iain A., Degorce, Sébastien L., Aagaard, Anna, Braybrooke, Erin L., Davies, Nichola L., Diène, Coura R., Eatherton, Andrew J., Felstead, Hannah R., Groombridge, Sam D., Lenz, Eva M., Li, Yunxia, Nai, Youfeng, Pearson, Stuart, Robb, Graeme R., Scott, James S., Steward, Oliver R., Wu, Chengyan, Xue, Yafeng, Zhang, Lanping, Zhang, Yanxiu

Volltext

Identification of Mineralocorticoid Receptor Modulators with Low Impact on Electrolyte Homeostasis but Maintained Organ Protection von Granberg, Kenneth L, Yuan, Zhong-Qing, Lindmark, Bo, Edman, Karl, Kajanus, Johan, Hogner, Anders, Malmgren, Marcus, O’Mahony, Gavin, Nordqvist, Anneli, Lindberg, Jan, Tångefjord, Stefan, Kossenjans, Michael, Löfberg, Christian, Brånalt, Jonas, Liu, Dongmei, Selmi, Nidhal, Nikitidis, Grigorios, Nordberg, Peter, Hayen, Ahlke, Aagaard, Anna, Hansson, Eva, Hermansson, Majlis, Ivarsson, Ida, Jansson-Löfmark, Rasmus, Karlsson, Ulla, Johansson, Ulrika, William-Olsson, Lena, Hartleib-Geschwindner, Judith, Bamberg, Krister

Volltext

Improving metabolic stability and removing aldehyde oxidase liability in a 5-azaquinazoline series of IRAK4 inhibitors von Degorce, Sébastien L., Aagaard, Anna, Anjum, Rana, Cumming, Iain A., Diène, Coura R., Fallan, Charlene, Johnson, Tony, Leuchowius, Karl-Johan, Orton, Alexandra L., Pearson, Stuart, Robb, Graeme R., Rosen, Alan, Scarfe, Graeme B., Scott, James S., Smith, James M., Steward, Oliver R., Terstiege, Ina, Tucker, Michael J., Turner, Paul, Wilkinson, Stephen D., Wrigley, Gail L., Xue, Yafeng

Volltext

Fragment-Based Discovery of Novel Allosteric MEK1 Binders von Di Fruscia, Paolo, Edfeldt, Fredrik, Shamovsky, Igor, Collie, Gavin W, Aagaard, Anna, Barlind, Louise, Börjesson, Ulf, Hansson, Eva L, Lewis, Richard J, Nilsson, Magnus K, Öster, Linda, Pemberton, Josefine, Ripa, Lena, Storer, R. Ian, Käck, Helena

Volltext