Mechanistic implications for LDL receptor degradation from the PCSK9/LDLR structure at neutral pH von Surdo, Paola Lo, Bottomley, Matthew J, Calzetta, Alessandra, Settembre, Ethan C, Cirillo, Agostino, Pandit, Shilpa, Ni, Yan G, Hubbard, Brian, Sitlani, Ayesha, Carfí, Andrea

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Effects of pH and Low Density Lipoprotein (LDL) on PCSK9-dependent LDL Receptor Regulation von Fisher, Timothy S., Surdo, Paola Lo, Pandit, Shilpa, Mattu, Marco, Santoro, Joseph C., Wisniewski, Doug, Cummings, Richard T., Calzetta, Alessandra, Cubbon, Rose M., Fischer, Paul A., Tarachandani, Anil, De Francesco, Raffaele, Wright, Samuel D., Sparrow, Carl P., Carfi, Andrea, Sitlani, Ayesha

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Biochemical characterization of cholesteryl ester transfer protein inhibitors von Ranalletta, Mollie, Bierilo, Kathleen K., Chen, Ying, Milot, Denise, Chen, Qing, Tung, Elaine, Houde, Caroline, Elowe, Nadine H., Garcia-Calvo, Margarita, Porter, Gene, Eveland, Suzanne, Frantz-Wattley, Betsy, Kavana, Mike, Addona, George, Sinclair, Peter, Sparrow, Carl, O'Neill, Edward A., Koblan, Ken S., Sitlani, Ayesha, Hubbard, Brian, Fisher, Timothy S.

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Structural and Biochemical Characterization of the Wild Type PCSK9-EGF(AB) Complex and Natural Familial Hypercholesterolemia Mutants von Bottomley, Matthew J., Cirillo, Agostino, Orsatti, Laura, Ruggeri, Lionello, Fisher, Timothy S., Santoro, Joseph C., Cummings, Richard T., Cubbon, Rose M., Lo Surdo, Paola, Calzetta, Alessandra, Noto, Alessia, Baysarowich, Jennifer, Mattu, Marco, Talamo, Fabio, De Francesco, Raffaele, Sparrow, Carl P., Sitlani, Ayesha, Carfí, Andrea

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PCSK9 is not involved in the degradation of LDL receptors and BACE1 in the adult mouse brain von Liu, Mali, Wu, Guoxin, Baysarowich, Jennifer, Kavana, Michael, Addona, George H., Bierilo, Kathleen K., Mudgett, John S., Pavlovic, Guillaume, Sitlani, Ayesha, Renger, John J., Hubbard, Brian K., Fisher, Timothy S., Zerbinatti, Celina V.

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Identification of a potent synthetic FXR agonist with an unexpected mode of binding and activation von Soisson, Stephen M, Parthasarathy, Gopalakrishnan, Adams, Alan D, Sahoo, Soumya, Sitlani, Ayesha, Sparrow, Carl, Cui, Jisong, Becker, Joseph W

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Immunization against proprotein convertase subtilisin-like/kexin type 9 lowers plasma LDL-cholesterol levels in mice von Fattori, Elena, Cappelletti, Manuela, Lo Surdo, Paola, Calzetta, Alessandra, Bendtsen, Claus, Ni, Yan G., Pandit, Shilpa, Sitlani, Ayesha, Mesiti, Giuseppe, Carfí, Andrea, Monaci, Paolo

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Nicotinic acid and DP1 blockade: studies in mouse models of atherosclerosis[S] von Strack, Alison M., Carballo-Jane, Ester, Wang, Sheng-ping, Xue, Jiyan, Ping, Xiaoli, McNamara, Lesley Ann, Thankappan, Anil, Price, Olga, Wolff, Michael, Wu, T.J., Kawka, Douglas, Mariano, Michele, Burton, Charlotte, Chang, Ching H., Chen, Jing, Menke, John, Luell, Silvi, Zycband, Emanuel I., Tong, Xinchun, Raubertas, Richard, Sparrow, Carl P., Hubbard, Brian, Woods, John, O'Neill, Gary, Waters, M. Gerard, Sitlani, Ayesha

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Clinical and Regulatory Challenges and Opportunities for Monoclonal Antibodies in Low- and Middle-Income Countries: Lessons from COVID-19 and Beyond von Gieber, Lisa, Muturi-Kioi, Vincent, Malhotra, Shelly, Sitlani, Ayesha

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Allosteric Effects of Dexamethasone and RU486 on Glucocorticoid Receptor-DNA Interactions von Pandit, Shilpa, Geissler, Wayne, Harris, Georgianna, Sitlani, Ayesha

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DNA photocleavage by phenanthrenequinone diimine complexes of rhodium(III): shape-selective recognition and reaction von Sitlani, Ayesha, Long, Eric C, Pyle, Anna M, Barton, Jacqueline K

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A PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo1[S] von Ni, Yan G., Di Marco, Stefania, Condra, Jon H., Peterson, Laurence B., Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A., Rosa, Ray, Cummings, Richard T., Wood, Dana D., Liu, Xiaomei, Bottomley, Matthew J., Shen, Xun, Cubbon, Rose M., Wang, Sheng-ping, Johns, Douglas G., Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J., Sparrow, Carl P., Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

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Functional analysis of sites within PCSK9 responsible for hypercholesterolemias von Pandit, Shilpa, Wisniewski, Doug, Santoro, Joseph C., Ha, Sookhee, Ramakrishnan, Vijayalakshmi, Cubbon, Rose M., Cummings, Richard T., Wright, Samuel D., Sparrow, Carl P., Sitlani, Ayesha, Fisher, Timothy S.

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DNA-Binding Domains of Fos and Jun do not Induce DNA Curvature: An Investigation with Solution and Gel Methods von Sitlani, Ayesha, Crothers, Donald M.

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PCSK9-binding antibody that structurally mimics the EGF(A) domain of LDL-receptor reduces LDL cholesterol in vivo von Ni, Yan G, Di Marco, Stefania, Condra, Jon H, Peterson, Laurence B, Wang, Weirong, Wang, Fubao, Pandit, Shilpa, Hammond, Holly A, Rosa, Ray, Cummings, Richard T, Wood, Dana D, Liu, Xiaomei, Bottomley, Matthew J, Shen, Xun, Cubbon, Rose M, Wang, Sheng-ping, Johns, Douglas G, Volpari, Cinzia, Hamuro, Lora, Chin, Jayne, Huang, Lingyi, Zhao, Jing Zhang, Vitelli, Salvatore, Haytko, Peter, Wisniewski, Douglas, Mitnaul, Lyndon J, Sparrow, Carl P, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

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Enantiospecific palindromic recognition of 5'-d(CTCTAGAG)-3' by a novel rhodium intercalator: analogies to a DNA-binding protein von Sitlani, Ayesha, Dupureur, Cynthia M, Barton, Jacqueline K

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An anti-PCSK9 antibody reduces LDL-cholesterol on top of a statin and suppresses hepatocyte SREBP-regulated genes von Zhang, Liwen, McCabe, Timothy, Condra, Jon H, Ni, Yan G, Peterson, Laurence B, Wang, Weirong, Strack, Alison M, Wang, Fubao, Pandit, Shilpa, Hammond, Holly, Wood, Dana, Lewis, Dale, Rosa, Ray, Mendoza, Vivienne, Cumiskey, Anne Marie, Johns, Douglas G, Hansen, Barbara C, Shen, Xun, Geoghagen, Neil, Jensen, Kristian, Zhu, Lei, Wietecha, Karol, Wisniewski, Douglas, Huang, Lingyi, Zhao, Jing Zhang, Ernst, Robin, Hampton, Richard, Haytko, Peter, Ansbro, Frances, Chilewski, Shannon, Chin, Jayne, Mitnaul, Lyndon J, Pellacani, Andrea, Sparrow, Carl P, An, Zhiqiang, Strohl, William, Hubbard, Brian, Plump, Andrew S, Blom, Daniel, Sitlani, Ayesha

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Functional analysis of sites within PCSK9 responsible for hypercholesterolemia von Pandit, Shilpa, Wisniewski, Doug, Santoro, Joseph C, Ha, Sookhee, Ramakrishnan, Vijayalakshmi, Cubbon, Rose M, Cummings, Richard T, Wright, Samuel D, Sparrow, Carl P, Sitlani, Ayesha, Fisher, Timothy S

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A Proprotein Convertase Subtilisin-like/Kexin Type 9 (PCSK9) C-terminal Domain Antibody Antigen-binding Fragment Inhibits PCSK9 Internalization and Restores Low Density Lipoprotein... von Ni, Yan G., Condra, Jon H., Orsatti, Laura, Shen, Xun, Di Marco, Stefania, Pandit, Shilpa, Bottomley, Matthew J., Ruggeri, Lionello, Cummings, Richard T., Cubbon, Rose M., Santoro, Joseph C., Ehrhardt, Anka, Lewis, Dale, Fisher, Timothy S., Ha, Sookhee, Njimoluh, Leila, Wood, Dana D., Hammond, Holly A., Wisniewski, Douglas, Volpari, Cinzia, Noto, Alessia, Lo Surdo, Paola, Hubbard, Brian, Carfí, Andrea, Sitlani, Ayesha

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Novel N-Arylpyrazolo[3,2-c]-Based Ligands for the Glucocorticoid Receptor:  Receptor Binding and in Vivo Activity von Ali, Amjad, Thompson, Christopher F, Balkovec, James M, Graham, Donald W, Hammond, Milton L, Quraishi, Nazia, Tata, James R, Einstein, Monica, Ge, Lan, Harris, Georgianna, Kelly, Terri M, Mazur, Paul, Pandit, Shilpa, Santoro, Joseph, Sitlani, Ayesha, Wang, Chuanlin, Williamson, Joanne, Miller, Douglas K, Thompson, Chris M, Zaller, Dennis M, Forrest, Michael J, Carballo-Jane, Ester, Luell, Silvi

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