Characterizing the role of the dark kinome in neurodegenerative disease – A mini review von Axtman, Alison D.

Volltext

Progress towards a public chemogenomic set for protein kinases and a call for contributions von Drewry, David H, Wells, Carrow I, Andrews, David M, Angell, Richard, Al-Ali, Hassan, Axtman, Alison D, Capuzzi, Stephen J, Elkins, Jonathan M, Ettmayer, Peter, Frederiksen, Mathias, Gileadi, Opher, Gray, Nathanael, Hooper, Alice, Knapp, Stefan, Laufer, Stefan, Luecking, Ulrich, Michaelides, Michael, Müller, Susanne, Muratov, Eugene, Denny, R Aldrin, Saikatendu, Kumar S, Treiber, Daniel K, Zuercher, William J, Willson, Timothy M

Volltext

Development of a potent and selective chemical probe for the pleiotropic kinase CK2 von Wells, Carrow I., Drewry, David H., Pickett, Julie E., Tjaden, Amelie, Krämer, Andreas, Müller, Susanne, Gyenis, Laszlo, Menyhart, Daniel, Litchfield, David W., Knapp, Stefan, Axtman, Alison D.

Volltext

CDK16: the pick of the understudied PCTAIRE kinases von Axtman, Alison, Drewry, David, Wells, Carrow

Volltext

Exploration of Aberrant E3 Ligases Implicated in Alzheimer's Disease and Development of Chemical Tools to Modulate Their Function von Potjewyd, Frances M, Axtman, Alison D

Volltext

Modulation of tau tubulin kinases (TTBK1 and TTBK2) impacts ciliogenesis von Bashore, Frances M., Marquez, Ariana B., Chaikuad, Apirat, Howell, Stefanie, Dunn, Andrea S., Beltran, Alvaro A., Smith, Jeffery L., Drewry, David H., Beltran, Adriana S., Axtman, Alison D.

Volltext

Editorial: The next generation of tools and technologies for studying human neurons in a dish von Durcan, Thomas M, Axtman, Alison D

Volltext

Identification of Pyrimidine-Based Lead Compounds for Understudied Kinases Implicated in Driving Neurodegeneration von Drewry, David H, Annor-Gyamfi, Joel K, Wells, Carrow I, Pickett, Julie E, Dederer, Verena, Preuss, Franziska, Mathea, Sebastian, Axtman, Alison D

Volltext

Substrate binding allosterically relieves autoinhibition of the pseudokinase TRIB1 von Jamieson, Sam A, Ruan, Zheng, Burgess, Abigail E, Curry, Jack R, McMillan, Hamish D, Brewster, Jodi L, Dunbier, Anita K, Axtman, Alison D, Kannan, Natarajan, Mace, Peter D

Volltext

Characterization of covalent inhibitors that disrupt the interaction between the tandem SH2 domains of SYK and FCER1G phospho-ITAM von Bashore, Frances M, Katis, Vittorio L, Du, Yuhong, Sikdar, Arunima, Wang, Dongxue, Bradshaw, William J, Rygiel, Karolina A, Leisner, Tina M, Chalk, Rod, Mishra, Swati, Williams, C Andrew, Gileadi, Opher, Brennan, Paul E, Wiley, Jesse C, Gockley, Jake, Cary, Gregory A, Carter, Gregory W, Young, Jessica E, Pearce, Kenneth H, Fu, Haian, Axtman, Alison D

Volltext

Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Mircroglial Model von Mishra, Swati, Kinoshita, Chizuru, Axtman, Alison D, Young, Jessica E

Volltext

Identification and Utilization of a Chemical Probe to Interrogate the Roles of PIKfyve in the Lifecycle of β‑Coronaviruses von Drewry, David H., Potjewyd, Frances M., Bayati, Armin, Smith, Jeffery L., Dickmander, Rebekah J., Howell, Stefanie, Taft-Benz, Sharon, Min, Sophia M., Hossain, Mohammad Anwar, Heise, Mark, McPherson, Peter S., Moorman, Nathaniel J., Axtman, Alison D.

Volltext

WNT Activates the AAK1 Kinase to Promote Clathrin-Mediated Endocytosis of LRP6 and Establish a Negative Feedback Loop von Agajanian, Megan J., Walker, Matthew P., Axtman, Alison D., Ruela-de-Sousa, Roberta R., Serafin, D. Stephen, Rabinowitz, Alex D., Graham, David M., Ryan, Meagan B., Tamir, Tigist, Nakamichi, Yuko, Gammons, Melissa V., Bennett, James M., Couñago, Rafael M., Drewry, David H., Elkins, Jonathan M., Gileadi, Carina, Gileadi, Opher, Godoi, Paulo H., Kapadia, Nirav, Müller, Susanne, Santiago, André S., Sorrell, Fiona J., Wells, Carrow I., Fedorov, Oleg, Willson, Timothy M., Zuercher, William J., Major, Michael B.

Volltext

Strategic Fluorination to Achieve a Potent, Selective, Metabolically Stable, and Orally Bioavailable Inhibitor of CSNK2 von Ong, Han Wee, Yang, Xuan, Smith, Jeffery L, Taft-Benz, Sharon, Howell, Stefanie, Dickmander, Rebekah J, Havener, Tammy M, Sanders, Marcia K, Brown, Jason W, Couñago, Rafael M, Chang, Edcon, Krämer, Andreas, Moorman, Nathaniel J, Heise, Mark, Axtman, Alison D, Drewry, David H, Willson, Timothy M

Volltext

Fused Tetrahydroquinolines Are Interfering with Your Assay von Bashore, Frances M, Annor-Gyamfi, Joel, Du, Yuhong, Katis, Vittorio, Nwogbo, Felix, Flax, Raymond G, Frye, Stephen V, Pearce, Kenneth H, Fu, Haian, Willson, Timothy M, Drewry, David H, Axtman, Alison D

Volltext

Defining the Neural Kinome: Strategies and Opportunities for Small Molecule Drug Discovery to Target Neurodegenerative Diseases von Krahn, Andrea I, Wells, Carrow, Drewry, David H, Beitel, Lenore K, Durcan, Thomas M, Axtman, Alison D

Volltext

Evaluation of a Selective Chemical Probe Validates That CK2 Mediates Neuroinflammation in a Human Induced Pluripotent Stem Cell-Derived Microglial Model von Mishra, Swati, Kinoshita, Chizuru, Axtman, Alison D, Young, Jessica E

Volltext

Synthesis of 5-Benzylamino and 5-Alkylamino-Substituted Pyrimido[4,5-c]quinoline Derivatives as CSNK2A Inhibitors with Antiviral Activity von Asressu, Kesatebrhan Haile, Smith, Jeffery L, Dickmander, Rebekah J, Moorman, Nathaniel J, Wellnitz, James, Popov, Konstantin I, Axtman, Alison D, Willson, Timothy M

Volltext

The Kinase Chemogenomic Set (KCGS): An Open Science Resource for Kinase Vulnerability Identification von Wells, Carrow I, Al-Ali, Hassan, Andrews, David M, Asquith, Christopher R M, Axtman, Alison D, Dikic, Ivan, Ebner, Daniel, Ettmayer, Peter, Fischer, Christian, Frederiksen, Mathias, Futrell, Robert E, Gray, Nathanael S, Hatch, Stephanie B, Knapp, Stefan, Lücking, Ulrich, Michaelides, Michael, Mills, Caitlin E, Müller, Susanne, Owen, Dafydd, Picado, Alfredo, Saikatendu, Kumar S, Schröder, Martin, Stolz, Alexandra, Tellechea, Mariana, Turunen, Brandon J, Vilar, Santiago, Wang, Jinhua, Zuercher, William J, Willson, Timothy M, Drewry, David H

Volltext

PKIS deep dive yields a chemical starting point for dark kinases and a cell active BRSK2 inhibitor von Tamir, Tigist Y., Drewry, David H., Wells, Carrow, Major, M. Ben, Axtman, Alison D.

Volltext