Pharmacological targeting of the unfolded protein response for disease intervention von Hetz, Claudio, Axten, Jeffrey M., Patterson, John B.

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Targeting PERK signaling with the small molecule GSK2606414 prevents neurodegeneration in a model of Parkinson's disease von Mercado, Gabriela, Castillo, Valentina, Soto, Paulina, López, Nélida, Axten, Jeffrey M., Sardi, Sergio P., Hoozemans, Jeroen J.M., Hetz, Claudio

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Discovery of 7‑Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro‑1H‑indol-5-yl)‑7H‑pyrrolo[2,3‑d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inh... von Axten, Jeffrey M, Medina, Jesús R, Feng, Yanhong, Shu, Arthur, Romeril, Stuart P, Grant, Seth W, Li, William Hoi Hong, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Atkins, Charity, Liu, Qi, Rabindran, Sridhar, Kumar, Rakesh, Hong, Xuan, Goetz, Aaron, Stanley, Thomas, Taylor, J. David, Sigethy, Scott D, Tomberlin, Ginger H, Hassell, Annie M, Kahler, Kirsten M, Shewchuk, Lisa M, Gampe, Robert T

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Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1 von Najafov, Ayaz, Sommer, Eeva M, Axten, Jeffrey M, Deyoung, M Phillip, Alessi, Dario R

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Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development von Axten, Jeffrey M, Romeril, Stuart P, Shu, Arthur, Ralph, Jeffrey, Medina, Jesús R, Feng, Yanhong, Li, William Hoi Hong, Grant, Seth W, Heerding, Dirk A, Minthorn, Elisabeth, Mencken, Thomas, Gaul, Nathan, Goetz, Aaron, Stanley, Thomas, Hassell, Annie M, Gampe, Robert T, Atkins, Charity, Kumar, Rakesh

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Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity von ATKINS, Charity, QI LIU, CHOUDHRY, Anthony E, ALSAID, Hasan, JUCKER, Beat M, AXTEN, Jeffrey M, KUMAR, Rakesh, MINTHORN, Elisabeth, ZHANG, Shu-Yun, FIGUEROA, David J, MOSS, Katherine, STANLEY, Thomas B, SANDERS, Brent, GOETZ, Aaron, GAUL, Nathan

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Publisher Correction: Pharmacological targeting of the unfolded protein response for disease intervention von Hetz, Claudio, Axten, Jeffrey M., Patterson, John B.

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PERK inhibition delays neurodegeneration and improves motor function in a mouse model of Marinesco-Sjögren syndrome von Grande, Valentina, Ornaghi, Francesca, Comerio, Liliana, Restelli, Elena, Masone, Antonio, Corbelli, Alessandro, Tolomeo, Daniele, Capone, Vanessa, Axten, Jeffrey M, Laping, Nicholas J, Fiordaliso, Fabio, Sallese, Michele, Chiesa, Roberto

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A highly selective, cell-permeable furin inhibitor BOS-318 rescues key features of cystic fibrosis airway disease von Douglas, Lisa E.J., Reihill, James A., Ho, Melisa W.Y., Axten, Jeffrey M., Campobasso, Nino, Schneck, Jessica L., Rendina, Alan R., Wilcoxen, Keith M., Martin, S. Lorraine

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The First Total Syntheses of Ircinol A, Ircinal A, and Manzamines A and D von Winkler, Jeffrey D, Axten, Jeffrey M

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TLR2 agonism reverses chemotherapy-induced neutropenia in Macaca fascicularis von Laping, Nicholas J., DeMartino, Michael P., Cottom, Joshua E., Axten, Jeffrey M., Emery, John G., Guss, Jeffrey H., Burman, Miriam, Foley, James J., Cheung, Mui, Oliff, Allen, Kumar, Sanjay

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Enantioselective Synthesis of d -threo-Methylphenidate von Axten, Jeffrey M, Ivy, Robert, Krim, Lori, Winkler, Jeffrey D

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Broad Kinase Inhibition Mitigates Early Neuronal Dysfunction in Tauopathy von Koren, Shon A, Hamm, Matthew J, Cloyd, Ryan, Fontaine, Sarah N, Chishti, Emad, Lanzillotta, Chiara, Rodriguez-Rivera, Jennifer, Ingram, Alexandria, Bell, Michelle, Galvis-Escobar, Sara M, Zulia, Nicholas, Di Domenico, Fabio, Duong, Duc, Seyfried, Nicholas T, Powell, David, Vandsburger, Moriel, Frolinger, Tal, Hartz, Anika M S, Koren, 3rd, John, Axten, Jeffrey M, Laping, Nicholas J, Abisambra, Jose F

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Novel amino-piperidines as potent antibacterials targeting bacterial type IIA topoisomerases von Miles, Timothy J., Axten, Jeffrey M., Barfoot, Christopher, Brooks, Gerald, Brown, Pamela, Chen, Dongzhao, Dabbs, Steven, Davies, David T., Downie, David L., Eyrisch, Susanne, Gallagher, Timothy, Giordano, Ilaria, Gwynn, Michael N., Hennessy, Alan, Hoover, Jennifer, Huang, Jianzhong, Jones, Graham, Markwell, Roger, Miller, William H., Minthorn, Elizabeth A., Rittenhouse, Stephen, Seefeld, Mark, Pearson, Neil

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Structure-Based Design of Potent and Selective 3-Phosphoinositide-Dependent Kinase-1 (PDK1) Inhibitors von Medina, Jesús R, Becker, Christopher J, Blackledge, Charles W, Duquenne, Celine, Feng, Yanhong, Grant, Seth W, Heerding, Dirk, Li, William H, Miller, William H, Romeril, Stuart P, Scherzer, Daryl, Shu, Arthur, Bobko, Mark A, Chadderton, Antony R, Dumble, Melissa, Gardiner, Christine M, Gilbert, Seth, Liu, Qi, Rabindran, Sridhar K, Sudakin, Valery, Xiang, Hong, Brady, Pat G, Campobasso, Nino, Ward, Paris, Axten, Jeffrey M

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Conversion of 2-deoxyglucose-induced growth inhibition to cell death in normoxic tumor cells von Liu, Huaping, Kurtoglu, Metin, Cao, Yenong, Xi, Haibin, Kumar, Rakesh, Axten, Jeffrey M., Lampidis, Theodore J.

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Rapid synthesis of diversely functionalized 3,4,7-trisubstituted indoles von Grant, Seth W., Gallagher, Timothy F., Bobko, Mark A., Duquenne, Celine, Axten, Jeffrey M.

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Aminoindazole PDK1 Inhibitors: A Case Study in Fragment-Based Drug Discovery von Medina, Jesús R, Blackledge, Charles W, Heerding, Dirk A, Campobasso, Nino, Ward, Paris, Briand, Jacques, Wright, Lois, Axten, Jeffrey M

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Acylprolinamides: A new class of peptide deformylase inhibitors with in vivo antibacterial activity von Axten, Jeffrey M., Medina, Jesús R., Blackledge, Charles W., Duquenne, Céline, Grant, Seth W., Bobko, Mark A., Peng, Tony, Miller, William H., Pinckney, Theresa, Gallagher, Timothy F., Kulkarni, Swarupa, Lewandowski, Thomas, Van Aller, Glenn S., Zonis, Rimma, Ward, Paris, Campobasso, Nino

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Discovery of a new series of Aurora inhibitors through truncation of GSK1070916 von Medina, Jesus R., Grant, Seth W., Axten, Jeffrey M., Miller, William H., Donatelli, Carla A., Hardwicke, Mary Ann, Oleykowski, Catherine A., Liao, Qiaoyin, Plant, Ramona, Xiang, Hong

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