Cerebral Cavernous Malformation: From Mechanism to Therapy von Snellings, Daniel A., Hong, Courtney C., Ren, Aileen A., Lopez-Ramirez, Miguel A., Girard, Romuald, Srinath, Abhinav, Marchuk, Douglas A., Ginsberg, Mark H., Awad, Issam A., Kahn, Mark L.

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Cerebral cavernous malformations proteins inhibit Rho kinase to stabilize vascular integrity von Stockton, Rebecca A, Shenkar, Robert, Awad, Issam A, Ginsberg, Mark H

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PIK3CA and CCM mutations fuel cavernomas through a cancer-like mechanism von Ren, Aileen A., Snellings, Daniel A., Su, Yourong S., Hong, Courtney C., Castro, Marco, Tang, Alan T., Detter, Matthew R., Hobson, Nicholas, Girard, Romuald, Romanos, Sharbel, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Benavides, Christian, Beaman, M. Makenzie, Müller-Fielitz, Helge, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Sung, Derek C., Lawton, Michael T., Ruppert, J. Michael, Schwaninger, Markus, Körbelin, Jakob, Potente, Michael, Awad, Issam A., Marchuk, Douglas A., Kahn, Mark L.

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Endothelial TLR4 and the microbiome drive cerebral cavernous malformations von Tang, Alan T., Choi, Jaesung P., Kotzin, Jonathan J., Yang, Yiqing, Hong, Courtney C., Hobson, Nicholas, Girard, Romuald, Zeineddine, Hussein A., Lightle, Rhonda, Moore, Thomas, Cao, Ying, Shenkar, Robert, Chen, Mei, Mericko, Patricia, Yang, Jisheng, Li, Li, Tanes, Ceylan, Kobuley, Dmytro, Võsa, Urmo, Whitehead, Kevin J., Li, Dean Y., Franke, Lude, Hart, Blaine, Schwaninger, Markus, Henao-Mejia, Jorge, Morrison, Leslie, Kim, Helen, Awad, Issam A., Zheng, Xiangjian, Kahn, Mark L.

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Cerebral cavernous malformations form an anticoagulant vascular domain in humans and mice von Lopez-Ramirez, Miguel Alejandro, Pham, Angela, Girard, Romuald, Wyseure, Tine, Hale, Preston, Yamashita, Atsuki, Koskimäki, Janne, Polster, Sean, Saadat, Laleh, Romero, Ignacio A., Esmon, Charles T., Lagarrigue, Frederic, Awad, Issam A., Mosnier, Laurent O., Ginsberg, Mark H.

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Thrombospondin1 (TSP1) replacement prevents cerebral cavernous malformations von Lopez-Ramirez, Miguel Alejandro, Fonseca, Gregory, Zeineddine, Hussein A, Girard, Romuald, Moore, Thomas, Pham, Angela, Cao, Ying, Shenkar, Robert, de Kreuk, Bart-Jan, Lagarrigue, Frederic, Lawler, Jack, Glass, Christopher K, Awad, Issam A, Ginsberg, Mark H

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Biology of vascular malformations of the brain von Leblanc, Gabrielle G, Golanov, Eugene, Awad, Issam A, Young, William L

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Cerebral Cavernous Malformation Proteins in Barrier Maintenance and Regulation von Wei, Shu, Li, Ye, Polster, Sean P., Weber, Christopher R., Awad, Issam A., Shen, Le

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Single-nucleus DNA sequencing reveals hidden somatic loss-of-heterozygosity in Cerebral Cavernous Malformations von Ressler, Andrew K., Snellings, Daniel A., Girard, Romuald, Gallione, Carol J., Lightle, Rhonda, Allen, Andrew S., Awad, Issam A., Marchuk, Douglas A.

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Fasudil Decreases Lesion Burden in a Murine Model of Cerebral Cavernous Malformation Disease von MCDONALD, David A, SHI, Changbin, SHENKAR, Robert, STOCKTON, Rebecca A, FEIFEI LIU, GINSBERG, Mark H, MARCHUK, Douglas A, AWAD, Issam A

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Evaluation of Iron Content in Human Cerebral Cavernous Malformation Using Quantitative Susceptibility Mapping von Tan, Huan, Liu, Tian, Wu, Ying, Thacker, Jon, Shenkar, Robert, Mikati, Abdul Ghani, Shi, Changbin, Dykstra, Conner, Wang, Yi, Prasad, Pottumarthi V, Edelman, Robert R, Awad, Issam A

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Permissive microbiome characterizes human subjects with a neurovascular disease cavernous angioma von Polster, Sean P., Sharma, Anukriti, Tanes, Ceylan, Tang, Alan T., Mericko, Patricia, Cao, Ying, Carrión-Penagos, Julián, Girard, Romuald, Koskimäki, Janne, Zhang, Dongdong, Stadnik, Agnieszka, Romanos, Sharbel G., Lyne, Seán B., Shenkar, Robert, Yan, Kimberly, Lee, Cornelia, Akers, Amy, Morrison, Leslie, Robinson, Myranda, Zafar, Atif, Bittinger, Kyle, Kim, Helen, Gilbert, Jack A., Kahn, Mark L., Shen, Le, Awad, Issam A.

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CSF and serum inflammatory response and association with outcomes in spontaneous intracerebral hemorrhage with intraventricular extension: an analysis of the CLEAR-III Trial von Gusdon, Aaron M., Thompson, Carol B., Quirk, Kendel, Mayasi, Yunis M., Avadhani, Radhika, Awad, Issam A., Hanley, Daniel F., Ziai, Wendy C.

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Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican von Hong, Courtney C., Tang, Alan T., Detter, Matthew R., Choi, Jaesung P., Wang, Rui, Yang, Xi, Guerrero, Andrea A., Wittig, Carl F., Hobson, Nicholas, Girard, Romuald, Lightle, Rhonda, Moore, Thomas, Shenkar, Robert, Polster, Sean P., Goddard, Lauren M., Ren, Aileen A., Leu, N. Adrian, Sterling, Stephanie, Yang, Jisheng, Li, Li, Chen, Mei, Mericko-Ishizuka, Patricia, Dow, Lukas E., Watanabe, Hideto, Schwaninger, Markus, Min, Wang, Marchuk, Douglas A., Zheng, Xiangjian, Awad, Issam A., Kahn, Mark L.

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A conserved CCM complex promotes apoptosis non-autonomously by regulating zinc homeostasis von Chapman, Eric M., Lant, Benjamin, Ohashi, Yota, Yu, Bin, Schertzberg, Michael, Go, Christopher, Dogra, Deepika, Koskimäki, Janne, Girard, Romuald, Li, Yan, Fraser, Andrew G., Awad, Issam A., Abdelilah-Seyfried, Salim, Gingras, Anne-Claude, Derry, W. Brent

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Cerebral Hemorrhage: Pathophysiology, Treatment, and Future Directions von Magid-Bernstein, Jessica, Girard, Romuald, Polster, Sean, Srinath, Abhinav, Romanos, Sharbel, Awad, Issam A., Sansing, Lauren H.

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Emerging clinical imaging techniques for cerebral cavernous malformations: a systematic review von Campbell, Peter G, Jabbour, Pascal, Yadla, Sanjay, Awad, Issam A

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Propranolol as therapy for cerebral cavernous malformations: a cautionary note von Shenkar, Robert, Moore, Thomas, Benavides, Christian, Lightle, Rhonda, Detter, Matthew R, Hobson, Nicholas, Girard, Romuald, DeBiasse, Dorothy, Patrucco, Mary, Gallione, Carol, Zabramski, Joseph M, Marchuk, Douglas A, Awad, Issam A

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Abortive intussusceptive angiogenesis causes multi-cavernous vascular malformations von Li, Wenqing, Tran, Virginia, Shaked, Iftach, Xue, Belinda, Moore, Thomas, Lightle, Rhonda, Kleinfeld, David, Awad, Issam A., Ginsberg, Mark H.

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Epigenetic regulation by polycomb repressive complex 1 promotes cerebral cavernous malformations von Pham, Van-Cuong, Rödel, Claudia Jasmin, Valentino, Mariaelena, Malinverno, Matteo, Paolini, Alessio, Münch, Juliane, Pasquier, Candice, Onyeogaziri, Favour C, Lazovic, Bojana, Girard, Romuald, Koskimäki, Janne, Hußmann, Melina, Keith, Benjamin, Jachimowicz, Daniel, Kohl, Franziska, Hagelkruys, Astrid, Penninger, Josef M, Schulte-Merker, Stefan, Awad, Issam A, Hicks, Ryan, Magnusson, Peetra U, Faurobert, Eva, Pagani, Massimiliano, Abdelilah-Seyfried, Salim

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