Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics von Avery, Lindsay B, Wade, Jason, Wang, Mengmeng, Tam, Amy, King, Amy, Piche-Nicholas, Nicole, Kavosi, Mania S, Penn, Steve, Cirelli, David, Kurz, Jeffrey C, Zhang, Minlei, Cunningham, Orla, Jones, Rhys, Fennell, Brian J, McDonnell, Barry, Sakorafas, Paul, Apgar, James, Finlay, William J, Lin, Laura, Bloom, Laird, O'Hara, Denise M

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A Physiologically‐Based Pharmacokinetic Model for the Prediction of Monoclonal Antibody Pharmacokinetics From In Vitro Data von Jones, Hannah M., Zhang, Zhiwei, Jasper, Paul, Luo, Haobin, Avery, Lindsay B., King, Lindsay E., Neubert, Hendrik, Barton, Hugh A., Betts, Alison M., Webster, Robert

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Utility of a human FcRn transgenic mouse model in drug discovery for early assessment and prediction of human pharmacokinetics of monoclonal antibodies von Avery, Lindsay B, Wang, Mengmeng, Kavosi, Mania S, Joyce, Alison, Kurz, Jeffrey C, Fan, Yao-Yun, Dowty, Martin E, Zhang, Minlei, Zhang, Yiqun, Cheng, Aili, Hua, Fei, Jones, Hannah M, Neubert, Hendrik, Polzer, Robert J, O'Hara, Denise M

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Pharmacological activation of myosin II paralogs to correct cell mechanics defects von Surcel, Alexandra, Ng, Win Pin, West-Foyle, Hoku, Zhu, Qingfeng, Ren, Yixin, Avery, Lindsay B., Krenc, Agata K., Meyers, David J., Rock, Ronald S., Anders, Robert A., Meyers, Caren L. Freel, Robinson, Douglas N.

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Human Biotransformation of the Nonnucleoside Reverse Transcriptase Inhibitor Rilpivirine and a Cross-Species Metabolism Comparison von LADE, Julie M, AVERY, Lindsay B, BUMPUS, Namandjé N

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A highly sensitive ultra performance liquid chromatography–tandem mass spectrometric (UPLC–MS/MS) technique for quantitation of protein free and bound efavirenz (EFV) in human semi... von Avery, Lindsay B., Parsons, Teresa L., Meyers, David J., Hubbard, Walter C.

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A minimal physiologically based pharmacokinetic model to study the combined effect of antibody size, charge, and binding affinity to FcRn/antigen on antibody pharmacokinetics von Patidar, Krutika, Pillai, Nikhil, Dhakal, Saroj, Avery, Lindsay B., Mavroudis, Panteleimon D.

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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey... von Betts, Alison, Keunecke, Anne, van Steeg, Tamara J, van der Graaf, Piet H, Avery, Lindsay B, Jones, Hannah, Berkhout, Jan

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Valproic Acid Is a Novel Activator of AMP-Activated Protein Kinase and Decreases Liver Mass, Hepatic Fat Accumulation, and Serum Glucose in Obese Mice von Avery, Lindsay B., Bumpus, Namandjé N.

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Dendritic Spine Injury Induced by the 8-Hydroxy Metabolite of Efavirenz von Tovar-y-Romo, Luis B., Bumpus, Namandjé N., Pomerantz, Daniel, Avery, Lindsay B., Sacktor, Ned, McArthur, Justin C., Haughey, Norman J.

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Changes in complementarity-determining regions significantly alter IgG binding to the neonatal Fc receptor (FcRn) and pharmacokinetics von Piche-Nicholas, Nicole M, Avery, Lindsay B, King, Amy C, Kavosi, Mania, Wang, Mengmeng, O'Hara, Denise M, Tchistiakova, Lioudmila, Katragadda, Madan

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Mechanistic incorporation of FcRn binding in plasma and endosomes in a whole body PBPK model for large molecules von de Witte, Wilhelmus E. A., Avery, Lindsay B., Mackness, Brian C., Van Bogaert, Tom, Park, Anna, Sargentini-Maier, Maria Laura

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A Selective Phenelzine Analogue Inhibitor of Histone Demethylase LSD1 von Prusevich, Polina, Kalin, Jay H, Ming, Shonoi A, Basso, Manuela, Givens, Jeffrey, Li, Xin, Hu, Jianfei, Taylor, Martin S, Cieniewicz, Anne M, Hsiao, Po-Yuan, Huang, Rong, Roberson, Heather, Adejola, Nkosi, Avery, Lindsay B, Casero, Robert A, Taverna, Sean D, Qian, Jiang, Tackett, Alan J, Ratan, Rajiv R, McDonald, Oliver G, Feinberg, Andrew P, Cole, Philip A

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Tissue expression profile of human neonatal Fc receptor (FcRn) in Tg32 transgenic mice von Fan, Yao-Yun, Avery, Lindsay B., Wang, Mengmeng, O'Hara, Denise M., Leung, Sheldon, Neubert, Hendrik

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Neuroprotective maraviroc monotherapy in simian immunodeficiency virus-infected macaques: reduced replicating and latent SIV in the brain von KELLY, Kathleen M, BECK, Sarah E, METCALF PATE, Kelly A, QUEEN, Suzanne E, DORSEY, Jamie L, ADAMS, Robert J, AVERY, Lindsay B, HUBBARD, Walter, TARWATER, Patrick M, MANKOWSKI, Joseph L

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Compartmentalization and antiviral effect of efavirenz metabolites in blood plasma, seminal plasma, and cerebrospinal fluid von Avery, Lindsay B, VanAusdall, Jennifer L, Hendrix, Craig W, Bumpus, Namandjé N

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Increasing extracellular protein concentration reduces intracellular antiretroviral drug concentration and antiviral effect von Avery, Lindsay B, Zarr, Melissa A, Bakshi, Rahul P, Siliciano, Robert F, Hendrix, Craig W

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Development of an mPBPK machine learning framework for early target pharmacology assessment of biotherapeutics von Patidar, Krutika, Pillai, Nikhil, Dhakal, Saroj, Avery, Lindsay B., Mavroudis, Panteleimon D.

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Compartmental distribution and antiviral effect of efavirenz metabolites von Avery, Lindsay B, VanAusdall, Jennifer L, Hendrix, Craig W, Bumpus, Namandje N

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Linear pharmacokinetic parameters for monoclonal antibodies are similar within a species and across different pharmacological targets: A comparison between human, cynomolgus monkey... von Betts, Alison, Keunecke, Anne, van Steeg, Tamara J., van der Graaf, Piet H., Avery, Lindsay B., Jones, Hannah, Berkhout, Jan

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