Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition von Schneidman-Duhovny, Dina, Khuri, Natalia, Dong, Guang Qiang, Winter, Michael B, Shifrut, Eric, Friedman, Nir, Craik, Charles S, Pratt, Kathleen P, Paz, Pedro, Aswad, Fred, Sali, Andrej

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Evaluation of in vitro Assays to Assess the Modulation of Dendritic Cells Functions by Therapeutic Antibodies and Aggregates von Morgan, Hannah, Tseng, Su-Yi, Gallais, Yann, Leineweber, Margret, Buchmann, Pascale, Riccardi, Sabrina, Nabhan, Myriam, Lo, Jeannette, Gani, Zaahira, Szely, Natacha, Zhu, Cornelia S, Yang, Ming, Kiessling, Andrea, Vohr, Hans-Werner, Pallardy, Marc, Aswad, Fred, Turbica, Isabelle

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P2X7 Receptors Regulate NKT Cells in Autoimmune Hepatitis von Kawamura, Hiroki, Aswad, Fred, Minagawa, Masahiro, Govindarajan, Sugantha, Dennert, Gunther

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Identification of the KIF18A alpha-4 helix as a therapeutic target for chromosomally unstable tumor cells von Schutt, Katherine L, Queen, Katelyn A, Fisher, Kira, Budington, Olivia, Mao, Weifeng, Liu, Wei, Gu, Xiaohui, Xiao, Yisong, Aswad, Fred, Joseph, James, Stumpff, Jason

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The Role of NKT Cells in Animal Models of Autoimmune Hepatitis von Dennert, G, Aswad, F

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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19 von Wong, Lok-Yin Roy, Zheng, Jian, Wilhelmsen, Kevin, Li, Kun, Ortiz, Miguel E., Schnicker, Nicholas J., Thurman, Andrew, Pezzulo, Alejandro A., Szachowicz, Peter J., Li, Pengfei, Pan, Ruangang, Klumpp, Klaus, Aswad, Fred, Rebo, Justin, Narumiya, Shuh, Murakami, Makoto, Zuniga, Sonia, Sola, Isabel, Enjuanes, Luis, Meyerholz, David K., Fortney, Kristen, McCray, Paul B., Perlman, Stanley

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Antibody Engineering of Anti-TFPI Bypass Therapeutic BAY 1093884: Isotype Selection and Sequence Optimization von Paz, Pedro, Xie, Jinger, Aswad, Fred

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The prostaglandin D2 antagonist asapiprant ameliorates clinical severity in young hosts infected with invasive Streptococcus pneumoniae von Bhalla, Manmeet, Herring, Sydney, Lenhard, Alexsandra, Wheeler, Joshua R, Aswad, Fred, Klumpp, Klaus, Rebo, Justin, Wang, Yan, Wilhelmsen, Kevin, Fortney, Kristen, Bou Ghanem, Elsa N

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P2X7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes von Aswad, Fred, Dennert, Gunther

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Abstract 3255: A novel small molecule inhibitor of AhR suppresses the polarization and activity of M2 macrophages von Garcia, Candy, Lemar, Hadia, Galang, Christina, Joseph, James, Gonzalez-Lopez, Marcos, Hager, Jeffrey, Dillon, Michael P., Aswad, Fred J.

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Mapping T-Cell Peptide Epitopes on Activated Recombinant Factor VII (rFVIIa) Contributing to Inhibitor Antibody Response von Paz, Pedro, Schroeder, Jens, Mathew, Prasad, Hardtke, Marion, Aswad, Fred

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Eicosanoid signaling as a therapeutic target in middle-aged mice with severe COVID-19 von Zheng, Jian, Wong, Lok-Yin Roy, Wilhelmsen, Kevin, Li, Kun, Ortiz, Miguel E, Schnicker, Nicholas J, Thurman, Andrew, Pezzulo, Alejandro A, Szachowicz, Peter J, Li, Pengfei, Pan, Ruangang, Klumpp, Klaus, Aswad, Fred, Rebo, Justin, Narumiya, Shuh, Murakami, Makoto, Zuniga, Sonia, Sola, Isabel, Enjuanes, Luis, Meyerholz, David K, Fortney, Kristen, McCray, Paul B, Perlman, Stanley

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T cells from hemophilia A subjects recognize the same HLA-restricted FVIII epitope with a narrow TCR repertoire von Ettinger, Ruth A., Paz, Pedro, James, Eddie A., Gunasekera, Devi, Aswad, Fred, Thompson, Arthur R., Matthews, Dana C., Pratt, Kathleen P.

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Abstract 4719: Small-molecule antagonists of the Aryl Hydrocarbon Receptor (AhR) promote activation of human PBMCs in vitro and demonstrate significant impact on tumor growth and i... von Joseph, James, Gonzalez-Lopez, Marcos, Galang, Christina, Garcia, Candy, Lemar, Hadia, Lu, Jing, Vaidya, Kedar, Fischer, Marcus, Frey, Christian, Alam, Muzaffar, Yao, Bing, Dillon, Michael, Hager, Jeffrey H., Venetsanakos, Eleni, Aswad, Fred

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Abstract 4965: Targeting the mitotic kinesin, KIF18A, in chromosomally unstable cancers von Joseph, James D., Schutt, Katherine, Fisher, Kira, Queen, Katelyn, Budington, Olivia, Mao, Weifeng, Liu, Wei, Zhu, Zhengqing, Zhang, Xiangping, Xiao, Yisong, Lai, Kunmin, Gu, Xiaohui, Stumpff, Jason, Aswad, Fred

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Abstract 3930: AI-driven discovery and profiling of GTAEXS-617, a selective and highly potent inhibitor of CDK7 von Besnard, Jérémy, Joseph, James, Bai, Haiyun, Paveley, Ross A., Wang, Tao, Barbeau, Olivier R., Gu, Xiao-Hui, Bell, Andrew S., Somlyay, Mate, Taubert, Christina, Boudesco, Christophe, Vladimer, Gregory, Aswad, Fred

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TGF-β1 potentiates Vγ9Vδ2 T cell adoptive immunotherapy of cancer von Beatson, Richard E., Parente-Pereira, Ana C., Halim, Leena, Cozzetto, Domenico, Hull, Caroline, Whilding, Lynsey M., Martinez, Olivier, Taylor, Chelsea A., Obajdin, Jana, Luu Hoang, Kim Ngan, Draper, Benjamin, Iqbal, Ayesha, Hardiman, Tom, Zabinski, Tomasz, Man, Francis, de Rosales, Rafael T.M., Xie, Jinger, Aswad, Fred, Achkova, Daniela, Joseph, Chung-Yang Ricardo, Ciprut, Sara, Adami, Antonella, Roider, Helge G., Hess-Stumpp, Holger, Győrffy, Balázs, Quist, Jelmar, Grigoriadis, Anita, Sommer, Anette, Tutt, Andrew N.J., Davies, David M., Maher, John

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P2X 7 receptor expression levels determine lethal effects of a purine based danger signal in T lymphocytes von Aswad, Fred, Dennert, Gunther

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P2X7 Receptor-Dependent and -Independent T Cell Death Is Induced by Nicotinamide Adenine Dinucleotide von Kawamura, Hiroki, Aswad, Fred, Minagawa, Masahiro, Malone, Karen, Kaslow, Harvey, Koch-Nolte, Friederich, Schott, William H, Leiter, Edward H, Dennert, Gunther

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High Sensitivity of CD4 super(+)CD25 super(+) Regulatory T Cells to Extracellular Metabolites Nicotinamide Adenine Dinucleotide and ATP: A Role for P2X sub(7) Receptors von Aswad, Fred, Kawamura, Hiroki, Dennert, Gunther

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