Defining tumor resistance to PD-1 pathway blockade: recommendations from the first meeting of the SITC Immunotherapy Resistance Taskforce von Kluger, Harriet M., Tawbi, Hussein A., Ascierto, Maria L., Bowden, Michaela, Callahan, Margaret K., Cha, Edward, Chen, Helen X., Drake, Charles G., Feltquate, David M., Ferris, Robert L., Gulley, James L., Gupta, Shilpa, Humphrey, Rachel W., LaVallee, Theresa M., Le, Dung T., Hubbard-Lucey, Vanessa M., Papadimitrakopoulou, Vassiliki A., Postow, Michael A., Rubin, Eric H., Sharon, Elad, Taube, Janis M., Topalian, Suzanne L., Zappasodi, Roberta, Sznol, Mario, Sullivan, Ryan J.

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Transcriptional Mechanisms of Resistance to Anti-PD-1 Therapy von Ascierto, Maria L, Makohon-Moore, Alvin, Lipson, Evan J, Taube, Janis M, McMiller, Tracee L, Berger, Alan E, Fan, Jinshui, Kaunitz, Genevieve J, Cottrell, Tricia R, Kohutek, Zachary A, Favorov, Alexander, Makarov, Vladimir, Riaz, Nadeem, Chan, Timothy A, Cope, Leslie, Hruban, Ralph H, Pardoll, Drew M, Taylor, Barry S, Solit, David B, Iacobuzio-Donahue, Christine A, Topalian, Suzanne L

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Phase 1/2 study of monalizumab plus durvalumab in patients with advanced solid tumors von Patel, Sandip P, Alonso-Gordoa, Teresa, Banerjee, Susana, Wang, Ding, Naidoo, Jarushka, Standifer, Nathan E, Palmer, Doug C, Cheng, Lin-Yang, Kourtesis, Panagiotis, Ascierto, Maria L, Das, Mayukh, Diamond, Jennifer R, Hellmann, Matthew D, Carneiro, Benedito A

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TNRC9 Downregulates BRCA1 Expression and Promotes Breast Cancer Aggressiveness von JINGXUAN SHAN, DSOUZA, Shoba P, AL-BOZOM, Issam, GEHANI, Salah, FURTADO, Stacia, MATHIOWITZ, Edith, WANG, Ena, MARINCOLA, Francesco M, CHOUCHANE, Lotfi, BAKHRU, Sasha, AL-AZWANI, Eman K, ASCIERTO, Maria L, SASTRY, Konduru S, BEDRI, Shahinaz, KIZHAKAYIL, Dhanya, AIGHA, Idil I, MALEK, Joel

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Multi-omic profiling reveals discrepant immunogenic properties and a unique tumor microenvironment among melanoma brain metastases von In, Gino K., Ribeiro, Jennifer R., Yin, Jun, Xiu, Joanne, Bustos, Matias A., Ito, Fumito, Chow, Frances, Zada, Gabriel, Hwang, Lindsay, Salama, April K. S., Park, Soo J., Moser, Justin C., Darabi, Sourat, Domingo-Musibay, Evidio, Ascierto, Maria L., Margolin, Kim, Lutzky, Jose, Gibney, Geoffrey T., Atkins, Michael B., Izar, Benjamin, Hoon, Dave S. B., VanderWalde, Ari M.

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Brief Report: Safety and Antitumor Activity of Durvalumab Plus Tremelimumab in Programmed Cell Death-(Ligand)1–Monotherapy Pretreated, Advanced NSCLC: Results From a Phase 1b Clini... von Garon, Edward B., Spira, Alexander I., Goldberg, Sarah B., Chaft, Jamie E., Papadimitrakopoulou, Vassiliki, Cascone, Tina, Antonia, Scott J., Brahmer, Julie R., Camidge, D. Ross, Powderly, John D., Wozniak, Antoinette J., Felip, Enriqueta, Wu, Song, Ascierto, Maria L., Elgeioushi, Nairouz, Awad, Mark M.

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Regression of melanoma metastases after immunotherapy is associated with activation of antigen presentation and interferon-mediated rejection genes von Carretero, Rafael, Wang, Ena, Rodriguez, Ana I., Reinboth, Jennifer, Ascierto, Maria L., Engle, Alyson M., Liu, Hui, Camacho, Francisco M., Marincola, Francesco M., Garrido, Federico, Cabrera, Teresa

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Immunogenomics and spatial proteomic mapping highlight distinct neuro-immune architectures in melanoma vs. non-melanoma-derived brain metastasis von Mendoza-Valderrey, Alberto, Dettmann, Ethan, Hanes, Douglas, Kessler, Daria M., Danilova, Ludmila, Rau, Kai, Quan, Yueqin, Stern, Stacey, Barkhoudarian, Garni, Bifulco, Carlo, Margolin, Kim, Kolker, Steven, Ascierto, Maria L.

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1484 An interplay between innate/adaptive/humoral immunity leads to increased immunogenicity of melanoma vs. non-melanoma derived brain metastases von Valderrey, Alberto Mendoza, Kessler, Daria M, Hanes, Douglas A, Danilova, Ludmila, Dettmann, Ethan, Rau, Kai, Quan, Yueqin, Stern, Stacey, Rockne, Russell C, Kelly, Daniel F, Barkhoudarian, Garni, Margolin, Kim, Kolker, Steven E, Ascierto, Maria L

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Main roads to melanoma von Palmieri, Giuseppe, Capone, Mariaelena, Ascierto, Maria Libera, Gentilcore, Giusy, Stroncek, David F, Casula, Milena, Sini, Maria Cristina, Palla, Marco, Mozzillo, Nicola, Ascierto, Paolo A

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An immunologic portrait of cancer von Ascierto, Maria Libera, De Giorgi, Valeria, Liu, Qiuzhen, Bedognetti, Davide, Spivey, Tara L, Murtas, Daniela, Uccellini, Lorenzo, Ayotte, Ben D, Stroncek, David F, Chouchane, Lotfi, Manjili, Masoud H, Wang, Ena, Marincola, Francesco M

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Gene expression profiling in acute allograft rejection: challenging the immunologic constant of rejection hypothesis von Spivey, Tara L, Uccellini, Lorenzo, Ascierto, Maria Libera, Zoppoli, Gabriele, De Giorgi, Valeria, Delogu, Lucia Gemma, Engle, Alyson M, Thomas, Jaime M, Wang, Ena, Marincola, Francesco M, Bedognetti, Davide

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Correlates Between Host and Viral Transcriptional Program Associated with Different Oncolytic Vaccinia Virus Isolates von REINBOTH, Jennifer, ASCIERTO, Maria L, MARINCOLA, Francesco M, SZALAY, Aladar A, CHEN, Nanhai G, QIAN ZHANG, YU, Yong A, AGUILAR, Richard J, CARRETERO, Rafael, WORSCHECH, Andrea, YINGDONG ZHAO, WANG, Ena

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Abstract 2167: Immune-related biomarkers associated with pathologic complete response (pCR) to neoadjuvant cisplatin-based chemotherapy in patients with muscle-invasive bladder can... von Ascierto, Maria L., Mendoza-Valderrey, Alberto, Choe, Jane, Kessler, Daria M., Li, Xinmin, Linehan, Jennifer A., Twardowski, Przemyslaw W.

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The stable traits of melanoma genetics: an alternate approach to target discovery von Spivey, Tara L, De Giorgi, Valeria, Zhao, Yingdong, Bedognetti, Davide, Pos, Zoltan, Liu, Qiuzhen, Tomei, Sara, Ascierto, Maria Libera, Uccellini, Lorenzo, Reinboth, Jennifer, Chouchane, Lotfi, Stroncek, David F, Wang, Ena, Marincola, Francesco M

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Abstract 6777: Digital Spatial Profiler highlights a T and B cells inflamed tumor microenvironment in brain metastases derived from melanoma vs. non-melanoma solid tumors von Mendoza-Valderrey, Alberto, Kessler, Daria M., Dettmann, Ethan, Li, Xinmin, Thompson, Sierra, Kolker, Steven E., Margolin, Kim A., Ascierto, Maria L.

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Permissivity of the NCI-60 cancer cell lines to oncolytic Vaccinia Virus GLV-1h68 von Ascierto, Maria Libera, Worschech, Andrea, Yu, Zhiya, Adams, Sharon, Reinboth, Jennifer, Chen, Nanhai G, Pos, Zoltan, Roychoudhuri, Rahul, Di Pasquale, Giovanni, Bedognetti, Davide, Uccellini, Lorenzo, Rossano, Fabio, Ascierto, Paolo A, Stroncek, David F, Restifo, Nicholas P, Wang, Ena, Szalay, Aladar A, Marincola, Francesco M

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IRF5 gene polymorphisms in melanoma von Uccellini, Lorenzo, De Giorgi, Valeria, Zhao, Yingdong, Tumaini, Barbara, Erdenebileg, Narnygerel, Dudley, Mark E, Tomei, Sara, Bedognetti, Davide, Ascierto, Maria Libera, Liu, Qiuzhen, Simon, Richard, Kottyan, Leah, Kaufman, Kenneth M, Harley, John B, Wang, Ena, Rosenberg, Steven A, Marincola, Francesco M

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Genomic scale analysis of NK cells impact on response to IFN-α von Ascierto, Maria L, Alter, Harvey, Bozzano, Federica, Picciotto, Antonio, Marenco, Simona, Marras, Francesco, Schechterly, Cathy, Bedognetti, Davide, De Giorgi, Valeria, Sommariva, Michele, Ascierto, Paolo A, Moretta, Lorenzo, Wang, Ena, Marincola, Francesco M, De Maria, Andrea

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Genetic inference of immune responsiveness of melanoma cancer patients to TIL therapy von Sommariva, Michele, Cheung, Foo, Chen, Jinguo, Shi, Rongye, Zhang, Ling, Morgan, Richard, Bedognetti, Davide, De Giorgi, Valeria, Ascierto, Maria L, Rosenberg, Steven A, Marincola, Francesco M, Wang, Ena

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