Randomized phase 2 trial of pevonedistat plus azacitidine versus azacitidine for higher-risk MDS/CMML or low-blast AML von Sekeres, Mikkael A., Watts, Justin, Radinoff, Atanas, Sangerman, Montserrat Arnan, Cerrano, Marco, Lopez, Patricia Font, Zeidner, Joshua F., Campelo, Maria Diez, Graux, Carlos, Liesveld, Jane, Selleslag, Dominik, Tzvetkov, Nikolay, Fram, Robert J., Zhao, Dan, Bell, Jill, Friedlander, Sharon, Faller, Douglas V., Adès, Lionel

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Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome–positive leukemia von Porkka, Kimmo, Koskenvesa, Perttu, Lundán, Tuija, Rimpiläinen, Johanna, Mustjoki, Satu, Smykla, Richard, Wild, Robert, Luo, Roger, Arnan, Montserrat, Brethon, Benoit, Eccersley, Lydia, Hjorth-Hansen, Henrik, Höglund, Martin, Klamova, Hana, Knutsen, Håvar, Parikh, Suhag, Raffoux, Emmanuel, Gruber, Franz, Brito-Babapulle, Finella, Dombret, Hervé, Duarte, Rafael F., Elonen, Erkki, Paquette, Ron, Zwaan, C.Michel, Lee, Francis Y.F.

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A phase 2, multicenter, clinical trial of CPX-351 in older patients with secondary or high-risk acute myeloid leukemia: PETHEMA-LAMVYX von Rodríguez-Arbolí, Eduardo, Rodríguez-Veiga, Rebeca, Soria-Saldise, Elena, Bergua, Juan M, Caballero-Velázquez, Teresa, Arnán, Montserrat, Vives, Susana, Serrano, Josefina, Bernal, Teresa, Martínez-Sánchez, Pilar, Tormo, Mar, Rodríguez-Medina, Carlos, Herrera-Puente, Pilar, Lavilla-Rubira, Esperanza, Boluda, Blanca, Acuña-Cruz, Evelyn, Cano, Isabel, Cáceres, Sara, Ballesteros, Juan, Falantes, José, Martínez-Cuadrón, David, Pérez-Simón, José A, Montesinos, Pau

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Biological basis of extensive pleiotropy between blood traits and cancer risk von Pardo-Cea, Miguel Angel, Farré, Xavier, Esteve, Anna, Palade, Joanna, Espín, Roderic, Mateo, Francesca, Alsop, Eric, Alorda, Marc, Blay, Natalia, Baiges, Alexandra, Shabbir, Arzoo, Comellas, Francesc, Gómez, Antonio, Arnan, Montserrat, Teulé, Alex, Salinas, Monica, Berrocal, Laura, Brunet, Joan, Rofes, Paula, Lázaro, Conxi, Conesa, Miquel, Rojas, Juan Jose, Velten, Lars, Fendler, Wojciech, Smyczynska, Urszula, Chowdhury, Dipanjan, Zeng, Yong, He, Housheng Hansen, Li, Rong, Van Keuren-Jensen, Kendall, de Cid, Rafael, Pujana, Miquel Angel

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Survival improvement of patients with FLT3 mutated acute myeloid leukemia: results from a prospective 9 years cohort von Oñate, Guadalupe, Pratcorona, Marta, Garrido, Ana, Artigas-Baleri, Alicia, Bataller, Alex, Tormo, Mar, Arnan, Montserrat, Vives, Susana, Coll, Rosa, Salamero, Olga, Vall-Llovera, Ferran, Sampol, Antònia, Garcia, Antoni, Cervera, Marta, Avila, Sara Garcia, Bargay, Joan, Ortín, Xavier, Nomdedéu, Josep F., Esteve, Jordi, Sierra, Jorge

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DNA methylation profile in chronic myelomonocytic leukemia associates with distinct clinical, biological and genetic features von Palomo, Laura, Malinverni, Roberto, Cabezón, Marta, Xicoy, Blanca, Arnan, Montserrat, Coll, Rosa, Pomares, Helena, García, Olga, Fuster-Tormo, Francisco, Grau, Javier, Feliu, Evarist, Solé, Francesc, Buschbeck, Marcus, Zamora, Lurdes

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A sex-informed approach to improve the personalised decision making process in myelodysplastic syndromes: a multicentre, observational cohort study von Maggioni, Giulia, Bersanelli, Matteo, Travaglino, Erica, Alfonso Piérola, Ana, Kasprzak, Annika, Sangerman Montserrat, Arnan, Sauta, Elisabetta, Sala, Claudia, Matteuzzi, Tommaso, Meggendorfer, Manja, Gnocchi, Matteo, Zhao, Lin-Pierre, Tentori, Cristina Astrid, Nachtkamp, Kathrin, Dall'Olio, Daniele, Mosca, Ettore, Ubezio, Marta, Campagna, Alessia, Russo, Antonio, Rivoli, Giulia, Bernardi, Massimo, Borin, Lorenza, Voso, Maria Teresa, Riva, Marta, Oliva, Esther, Zampini, Matteo, Riva, Elena, Saba, Elena, D'Amico, Saverio, Lanino, Luca, Tinterri, Benedetta, Re, Francesca, Bicchieri, Marilena, Giordano, Laura, Angelotti, Giovanni, Morandini, Pierandrea, Kubasch, Anne Sophie, Passamonti, Francesco, Rambaldi, Alessandro, Savevski, Victor, Santoro, Armando, van de Loosdrecht, Arjan A., Brogi, Alice, Santini, Valeria, Kordasti, Shahram, Sanz, Guillermo, Sole, Francesc, Gattermann, Norbert, Kern, Wolfgang, Platzbecker, Uwe, Ades, Lionel, Fenaux, Pierre, Haferlach, Torsten, Castellani, Gastone, Germing, Ulrich, Diez-Campelo, Maria, Della Porta, Matteo G.

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P714: DISSECTING THE CLINICAL HETEROGENEITY OF ISOLATED TRISOMY 8 MYELODYSPLASTIC SYNDROMES THROUGH MUTATIONAL PROFILE von María Toribio Castelló, Sofía, Castaño, Sandra, Villaverde‐Ramiro, Angela, Such, Esperanza, Arnan, Montserrat, Solé, Francesc, Díaz Beyá, Marina, Díez‐Campelo, María, Rey, Mónica, González, Teresa, Hernández Rivas, Jesus

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The division of chronic myelomonocytic leukemia (CMML)-1 into CMML-0 and CMML-1 according to 2016 World Health Organization (WHO) classification has no impact in outcome in a large... von Xicoy, Blanca, Triguero, Ana, Such, Esperanza, García, Olga, Jiménez, María-José, Arnán, Montserrat, Bernal, Teresa, Diaz-Beya, Marina, Valcárcel, David, Pedro, Carme, Ramos, Fernando, Amigo, María-Luz, Collado, Rosa, Palomo, Laura, Ardanaz, María-Teresa, Cedena, María-Teresa, Grau, Javier, Zamora, Lurdes, Sanz, Guillermo

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Trisomy 8, a Cytogenetic Abnormality in Myelodysplastic Syndromes, Is Constitutional or Not? von Saumell, Sílvia, Solé, Francesc, Arenillas, Leonor, Montoro, Julia, Valcárcel, David, Pedro, Carme, Sanzo, Carmen, Luño, Elisa, Giménez, Teresa, Arnan, Montserrat, Pomares, Helena, De Paz, Raquel, Arrizabalaga, Beatriz, Jerez, Andrés, Martínez, Ana B, Sánchez-Castro, Judith, Rodríguez-Gambarte, Juan D, Raya, José M, Ríos, Eduardo, Rodríguez-Rivera, María, Espinet, Blanca, Florensa, Lourdes

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Effect of Posaconazole on Cyclosporine Blood Levels and Dose Adjustment in Allogeneic Blood and Marrow Transplant Recipients von SANCHEZ-ORTEGA, Isabel, VAZQUEZ, Lourdes, MONTES, Carmen, PATINO, Beatriz, ARNAN, Montserrat, BERMUDEZ, Arancha, YANEZ, Lucrecia, CABALLERO, Teresa, DUARTE, Rafael F

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P531: MIDOSTAURIN PLUS 7 + 3 OR QUIZARTINIB PLUS 7 + 3 IN FLT3-ITD MUTATED AML von Tormo, Mar, Diaz-Beya, Marina, Beneit, Paola, Fernández Moreno, Ainhoa, Arnan, Montserrat, Garrido Diaz, Ana, Vives, Susana, García Fortes, Maria, Sampol, Antonia, Labrador, Jorge, Garcia-Guiñon, Antonio, Botella, Carmen, Miguel Bergua Burgues, Juan, Olave, Mayte, Luz Amigo, Maria, Ortín, Xavier, Ferran Vall-Llovera, Ferrand, Pereiro, Maria, Serrano, Josefina, Jose Sayas Lloris, Maria, De Laiglesia Lorenzo, Almudena, Jose Bargay Lleonart, Juan, Luisa Calabuig Muñoz, Maria, De La Fuente, Adolfo

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The direct and indirect effects of COVID‐19 pandemic in a real‐life hematological setting von Condom, Maria, Mussetti, Alberto, Maluquer, Clara, Parody, Rocío, González‐Barca, Eva, Arnan, Montserrat, Albasanz‐Puig, Adaia, Pomares, Helena, Salas, Maria Queralt, Carro, Itziar, Peña, Marta, Clapes, Victòria, Baca Cano, Cristina, Oliveira Ramos, Ana Carla, Sanz‐Linares, Gabriela, Moreno‐González, Gabriel, Mercadal, Santiago, Boqué, Concepcion, Gudiol, Carlota, Domingo‐Domènech, Eva, Sureda, Anna

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Serum Galactomannan–Based Early Detection of Invasive Aspergillosis in Hematology Patients Receiving Effective Antimold Prophylaxis von Duarte, Rafael F., Sánchez-Ortega, Isabel, Cuesta, Isabel, Arnan, Montserrat, Patiño, Beatriz, de Sevilla, Alberto Fernández, Gudiol, Carlota, Ayats, Josefina, Estrella, Manuel Cuenca

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Allogeneic STEM Cell Transplantation in 45 Patients with Myelodysplastic Syndrome: Single-Center Analysis von Pomares, Helena, Parody Porras, Rocio, Mussetti, Alberto, Galiano, Mercedes, Maluquer, Clara, Sureda, Anna, Arnan, Montserrat

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Efficacy of extended infusion of β-lactam antibiotics for the treatment of febrile neutropenia in haematologic patients (BEATLE): a randomized, multicentre, open-label, superiority... von Laporte-Amargos, Julia, Carmona-Torre, Francisco, Huguet, Maria, Puerta-Alcalde, Pedro, Rigo-Bonnin, Raul, Ulldemolins, Marta, Arnan, Montserrat, del Pozo, Jose Luis, Torrent, Anna, Garcia-Vidal, Carolina, Pallarès, Natàlia, Tebé, Cristian, Muñoz, Carme, Tubau, Fe, Padullés, Ariadna, Sureda, Ana-Maria, Carratalà, Jordi, Gudiol, Carlota

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Durable Clinical Benefit with Ker-050 Treatment: Findings from an Ongoing Phase 2 Study in Participants with Lower-Risk MDS von Diez-Campelo, Maria, Ross, David M., Giagounidis, Aristoteles, Tan, Shuhying, Cluzeau, Thomas, Chee, Lynette C.Y., Valcarcel, David, Arnan, Montserrat, Graham, Christine, McGinty, Allie, Ross, Miranda, Feng, Wei, Jiang, Ying, Bobba, Suresh, Hankin, Montagu, Rovaldi, Christopher, Grayson, Dena, Cooper, Simon, Salstrom, Jen L.

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Ker-050 Treatment Reduced Iron Overload and Increased Bone Specific Alkaline Phosphatase in Participants with Lower-Risk MDS Supporting Potential to Restore Balance to the Osteohem... von Chee, Lynette C.Y., Ross, David M., Cluzeau, Thomas, Tan, Shuhying, Giagounidis, Aristoteles, Valcarcel, David, Arnan, Montserrat, Diez-Campelo, Maria, Graham, Christine, McGinty, Allie, Ross, Miranda, Bobba, Suresh, Feng, Wei, Jiang, Ying, Hankin, Montagu, Rovaldi, Christopher, Cooper, Simon, Grayson, Dena, Salstrom, Jen L.

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Acute myeloid leukemia with NPM1 mutation and favorable European LeukemiaNet category: outcome after preemptive intervention based on measurable residual disease von Bataller, Alex, Oñate, Guadalupe, Diaz‐Beyá, Marina, Guijarro, Francesca, Garrido, Ana, Vives, Susana, Tormo, Mar, Arnan, Montserrat, Salamero, Olga, Sampol, Antònia, Coll, Rosa, Vall‐Llovera, Ferran, Oliver‐Caldés, Aina, López‐Guerra, Mònica, Pratcorona, Marta, Zamora, Lurdes, Villamon, Eva, Roué, Gaël, Blanco, Adoración, Nomdedeu, Josep F., Colomer, Dolors, Brunet, Salut, Sierra, Jorge, Esteve, Jordi

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Olutasidenib alone or with azacitidine in IDH1-mutated acute myeloid leukaemia and myelodysplastic syndrome: phase 1 results of a phase 1/2 trial von Watts, Justin M, Baer, Maria R, Yang, Jay, Prebet, Thomas, Lee, Sangmin, Schiller, Gary J, Dinner, Shira N, Pigneux, Arnaud, Montesinos, Pau, Wang, Eunice S, Seiter, Karen P, Wei, Andrew H, De Botton, Stephane, Arnan, Montserrat, Donnellan, Will, Schwarer, Anthony P, Récher, Christian, Jonas, Brian A, Ferrell, P Brent, Marzac, Christophe, Kelly, Patrick, Sweeney, Jennifer, Forsyth, Sanjeev, Guichard, Sylvie M, Brevard, Julie, Henrick, Patrick, Mohamed, Hesham, Cortes, Jorge E

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