High-Throughput Screening: today’s biochemical and cell-based approaches von Blay, Vincent, Tolani, Bhairavi, Ho, Sunita P., Arkin, Michelle R.

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream von Arkin, Michelle R, Wells, James A

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Screening for noise in gene expression identifies drug synergies von Dar, Roy D., Hosmane, Nina N., Arkin, Michelle R., Siliciano, Robert F., Weinberger, Leor S.

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A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit von De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H

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Pharmacological brake-release of mRNA translation enhances cognitive memory von Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch von Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target von Debnath, Anjan, Parsonage, Derek, Andrade, Rosa M, He, Chen, Cobo, Eduardo R, Hirata, Ken, Chen, Steven, García-Rivera, Guillermina, Orozco, Esther, Martínez, Máximo B, Gunatilleke, Shamila S, Barrios, Amy M, Arkin, Michelle R, Poole, Leslie B, McKerrow, James H, Reed, Sharon L

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Deep phenotypic profiling of neuroactive drugs in larval zebrafish von Gendelev, Leo, Taylor, Jack, Myers-Turnbull, Douglas, Chen, Steven, McCarroll, Matthew N., Arkin, Michelle R., Kokel, David, Keiser, Michael J.

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A small-molecule mimic of a peptide docking motif inhibits the protein kinase PDK1 von Rettenmaier, T. Justin, Sadowsky, Jack D., Thomsen, Nathan D., Chen, Steven C., Doak, Allison K., Arkin, Michelle R., Wells, James A.

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Altered cofactor regulation with disease-associated p97/VCP mutations von Zhang, Xiaoyi, Gui, Lin, Zhang, Xiaoyan, Bulfer, Stacie L., Sanghez, Valentina, Wong, Daniel E., Lee, YouJin, Lehmann, Lynn, Lee, James Siho, Shih, Pei-Yin, Lin, Henry J., Iacovino, Michelina, Weihl, Conrad C., Arkin, Michelle R., Wang, Yanzhuang, Chou, Tsui-Fen

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Binding of Small Molecules to an Adaptive Protein-Protein Interface von Arkin, Michelle R., Randal, Mike, DeLano, Warren L., Hyde, Jennifer, Luong, Tinh N., Oslob, Johan D., Raphael, Darren R., Taylor, Lisa, Wang, Jun, McDowell, Robert S., Wells, James A., Braisted, Andrew C.

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Molecular glues for protein-protein interactions: Progressing toward a new dream von Konstantinidou, Markella, Arkin, Michelle R.

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A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons von Kim, Gha-Hyun J, Mo, Han, Liu, Harrison, Wu, Zhihao, Chen, Steven, Zheng, Jiashun, Zhao, Xiang, Nucum, Daryl, Shortland, James, Peng, Longping, Elepano, Mannuel, Tang, Benjamin, Olson, Steven, Paras, Nick, Li, Hao, Renslo, Adam R, Arkin, Michelle R, Huang, Bo, Lu, Bingwei, Sirota, Marina, Guo, Su

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Venetoclax and dinaciclib elicit synergistic preclinical efficacy against hypodiploid acute lymphoblastic leukemia von Pariury, Holly, Fandel, Joshua, Bachl, Stefanie, Ang, Kenny K, Markossian, Sarine, Wilson, Chris G, Braun, Benjamin S, Popescu, Bogdan, Wohlfeil, Margo, Beckman, Kyle, Xirenayi, Simayijiang, Roy, Ritu P, Olshen, Adam B, Smith, Catherine, Arkin, Michelle R, Loh, Mignon L, Diaz-Flores, Ernesto

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Utilizing Chemical Genomics to Identify Cytochrome b as a Novel Drug Target for Chagas Disease von Khare, Shilpi, Roach, Steven L, Barnes, S Whitney, Hoepfner, Dominic, Walker, John R, Chatterjee, Arnab K, Neitz, R Jeffrey, Arkin, Michelle R, McNamara, Case W, Ballard, Jaime, Lai, Yin, Fu, Yue, Molteni, Valentina, Yeh, Vince, McKerrow, James H, Glynne, Richard J, Supek, Frantisek

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A High-Throughput Functional Screen Identifies Small Molecule Regulators of Temperature- and Mechano-Sensitive K2P Channels von Bagriantsev, Sviatoslav N, Ang, Kean-Hooi, Gallardo-Godoy, Alejandra, Clark, Kimberly A, Arkin, Michelle R, Renslo, Adam R, Minor, Daniel L

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Small-Molecule Inhibitors of Protein-Protein Interactions: Progressing toward the Reality von Arkin, Michelle R., Tang, Yinyan, Wells, James A.

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Identification of Plasmodium dipeptidyl aminopeptidase allosteric inhibitors by high throughput screening von Sanchez, Mateo I, de Vries, Laura E, Lehmann, Christine, Lee, Jeong T, Ang, Kenny K, Wilson, Christopher, Chen, Steven, Arkin, Michelle R, Bogyo, Matthew, Deu, Edgar

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Voreloxin is an anticancer quinolone derivative that intercalates DNA and poisons topoisomerase II von Hawtin, Rachael E, Stockett, David E, Byl, Jo Ann W, McDowell, Robert S, Nguyen, Tan, Arkin, Michelle R, Conroy, Andrew, Yang, Wenjin, Osheroff, Neil, Fox, Judith A

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Meet the authors: Markella Konstantinidou and Michelle R. Arkin von Konstantinidou, Markella, Arkin, Michelle R.

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