High-Throughput Screening: today’s biochemical and cell-based approaches von Blay, Vincent, Tolani, Bhairavi, Ho, Sunita P., Arkin, Michelle R.

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Molecular glues for protein-protein interactions: Progressing toward a new dream von Konstantinidou, Markella, Arkin, Michelle R.

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Meet the authors: Markella Konstantinidou and Michelle R. Arkin von Konstantinidou, Markella, Arkin, Michelle R.

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Small-molecule inhibitors of protein-protein interactions: progressing towards the dream von Arkin, Michelle R, Wells, James A

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Autophagy Receptor-Inspired Antibody-Fusion Proteins for Targeted Intracellular Degradation von Jiang, Ziwen, Kuo, Yu-Hsuan, Arkin, Michelle R.

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Covalent targeting of acquired cysteines in cancer von Visscher, Marieke, Arkin, Michelle R, Dansen, Tobias B

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A screen against Leishmania intracellular amastigotes: comparison to a promastigote screen and identification of a host cell-specific hit von De Muylder, Geraldine, Ang, Kenny K H, Chen, Steven, Arkin, Michelle R, Engel, Juan C, McKerrow, James H

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Screening for noise in gene expression identifies drug synergies von Dar, Roy D., Hosmane, Nina N., Arkin, Michelle R., Siliciano, Robert F., Weinberger, Leor S.

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The road less traveled: modulating signal transduction enzymes by inhibiting their protein–protein interactions von Arkin, Michelle R, Whitty, Adrian

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LC3B Binds to the Autophagy Protease ATG4b with High Affinity Using a Bipartite Interface von Tang, Yinyan, Kay, Amber, Jiang, Ziwen, Arkin, Michelle R.

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Modulating protein–protein interaction networks in protein homeostasis von Zhong, Mengqi, Lee, Gregory M, Sijbesma, Eline, Ottmann, Christian, Arkin, Michelle R

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Fragment-based Differential Targeting of PPI Stabilizer Interfaces von Guillory, Xavier, Wolter, Madita, Leysen, Seppe, Neves, João Filipe, Kuusk, Ave, Genet, Sylvia, Somsen, Bente, Morrow, John Kenneth, Rivers, Emma, van Beek, Lotte, Patel, Joe, Goodnow, Robert, Schoenherr, Heike, Fuller, Nathan, Cao, Qing, Doveston, Richard G, Brunsveld, Luc, Arkin, Michelle R, Castaldi, Paola, Boyd, Helen, Landrieu, Isabelle, Chen, Hongming, Ottmann, Christian

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Pharmacological brake-release of mRNA translation enhances cognitive memory von Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter

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Deep phenotypic profiling of neuroactive drugs in larval zebrafish von Gendelev, Leo, Taylor, Jack, Myers-Turnbull, Douglas, Chen, Steven, McCarroll, Matthew N., Arkin, Michelle R., Kokel, David, Keiser, Michael J.

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2.3 Å resolution cryo-EM structure of human p97 and mechanism of allosteric inhibition von Banerjee, Soojay, Bartesaghi, Alberto, Merk, Alan, Rao, Prashant, Bulfer, Stacie L., Yan, Yongzhao, Green, Neal, Mroczkowski, Barbara, Neitz, R. Jeffrey, Wipf, Peter, Falconieri, Veronica, Deshaies, Raymond J., Milne, Jacqueline L. S., Huryn, Donna, Arkin, Michelle, Subramaniam, Sriram

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Reversible Dual-Covalent Molecular Locking of the 14-3-3/ERRγ Protein–Protein Interaction as a Molecular Glue Drug Discovery Approach von Somsen, Bente A., Schellekens, Rick J.C., Verhoef, Carlo J.A., Arkin, Michelle R., Ottmann, Christian, Cossar, Peter J., Brunsveld, Luc

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USP7 small-molecule inhibitors interfere with ubiquitin binding von Kategaya, Lorna, Di Lello, Paola, Rougé, Lionel, Pastor, Richard, Clark, Kevin R., Drummond, Jason, Kleinheinz, Tracy, Lin, Eva, Upton, John-Paul, Prakash, Sumit, Heideker, Johanna, McCleland, Mark, Ritorto, Maria Stella, Alessi, Dario R., Trost, Matthias, Bainbridge, Travis W., Kwok, Michael C. M., Ma, Taylur P., Stiffler, Zachary, Brasher, Bradley, Tang, Yinyan, Jaishankar, Priyadarshini, Hearn, Brian R., Renslo, Adam R., Arkin, Michelle R., Cohen, Frederick, Yu, Kebing, Peale, Frank, Gnad, Florian, Chang, Matthew T., Klijn, Christiaan, Blackwood, Elizabeth, Martin, Scott E., Forrest, William F., Ernst, James A., Ndubaku, Chudi, Wang, Xiaojing, Beresini, Maureen H., Tsui, Vickie, Schwerdtfeger, Carsten, Blake, Robert A., Murray, Jeremy, Maurer, Till, Wertz, Ingrid E.

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A high-throughput drug screen for Entamoeba histolytica identifies a new lead and target von Debnath, Anjan, Parsonage, Derek, Andrade, Rosa M, He, Chen, Cobo, Eduardo R, Hirata, Ken, Chen, Steven, García-Rivera, Guillermina, Orozco, Esther, Martínez, Máximo B, Gunatilleke, Shamila S, Barrios, Amy M, Arkin, Michelle R, Poole, Leslie B, McKerrow, James H, Reed, Sharon L

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Structure-Based Optimization of Covalent, Small-Molecule Stabilizers of the 14-3-3σ/ERα Protein–Protein Interaction from Nonselective Fragments von Konstantinidou, Markella, Visser, Emira J., Vandenboorn, Edmee, Chen, Sheng, Jaishankar, Priyadarshini, Overmans, Maurits, Dutta, Shubhankar, Neitz, R. Jeffrey, Renslo, Adam R., Ottmann, Christian, Brunsveld, Luc, Arkin, Michelle R.

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Ceapins are a new class of unfolded protein response inhibitors, selectively targeting the ATF6α branch von Gallagher, Ciara M, Garri, Carolina, Cain, Erica L, Ang, Kenny Kean-Hooi, Wilson, Christopher G, Chen, Steven, Hearn, Brian R, Jaishankar, Priyadarshini, Aranda-Diaz, Andres, Arkin, Michelle R, Renslo, Adam R, Walter, Peter

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