Itaconate and itaconate derivatives target JAK1 to suppress alternative activation of macrophages von Runtsch, Marah C., Angiari, Stefano, Hooftman, Alexander, Wadhwa, Ridhima, Zhang, Yanling, Zheng, Yunan, Spina, Joseph S., Ruzek, Melanie C., Argiriadi, Maria A., McGettrick, Anne F., Mendez, Rui Santalla, Zotta, Alessia, Peace, Christian G., Walsh, Aoife, Chirillo, Roberta, Hams, Emily, Fallon, Padraic G., Jayaraman, Ranjith, Dua, Kamal, Brown, Alexandra C., Kim, Richard Y., Horvat, Jay C., Hansbro, Philip M., Wang, Chu, O’Neill, Luke A.J.

Volltext

In vitro and in vivo characterization of the JAK1 selectivity of upadacitinib (ABT-494) von Parmentier, Julie M, Voss, Jeff, Graff, Candace, Schwartz, Annette, Argiriadi, Maria, Friedman, Michael, Camp, Heidi S, Padley, Robert J, George, Jonathan S, Hyland, Deborah, Rosebraugh, Matthew, Wishart, Neil, Olson, Lisa, Long, Andrew J

Volltext

Tricyclic Covalent Inhibitors Selectively Target Jak3 through an Active Site Thiol von Goedken, Eric R., Argiriadi, Maria A., Banach, David L., Fiamengo, Bryan A., Foley, Sage E., Frank, Kristine E., George, Jonathan S., Harris, Christopher M., Hobson, Adrian D., Ihle, David C., Marcotte, Douglas, Merta, Philip J., Michalak, Mark E., Murdock, Sara E., Tomlinson, Medha J., Voss, Jeffrey W.

Volltext

Small Molecule IL-36γ Antagonist as a Novel Therapeutic Approach for Plaque Psoriasis von Todorović, Viktor, Su, Zhi, Putman, C. Brent, Kakavas, Stevan J., Salte, Katherine M., McDonald, Heath A., Wetter, Joseph B., Paulsboe, Stephanie E., Sun, Qi, Gerstein, Clare E., Medina, Limary, Sielaff, Bernhard, Sadhukhan, Ramkrishna, Stockmann, Henning, Richardson, Paul L., Qiu, Wei, Argiriadi, Maria A., Henry, Rodger F., Herold, J. Martin, Shotwell, J. Brad, McGaraughty, Steve P., Honore, Prisca, Gopalakrishnan, Sujatha M., Sun, Chaohong C., Scott, Victoria E.

Volltext

Identification and structure-based drug design of cell-active inhibitors of interleukin 17A at a novel C-terminal site von Goedken, Eric R., Argiriadi, Maria A., Dietrich, Justin D., Petros, Andrew M., Krishnan, Navasona, Panchal, Sanjay C., Qiu, Wei, Wu, Haihong, Zhu, Haizhong, Adams, Ashley M., Bodelle, Pierre M., Goguen, Lucas, Richardson, Paul L., Slivka, Peter F., Srikumaran, Myron, Upadhyay, Anup K., Wu, Bainan, Judge, Russell A., Vasudevan, Anil, Gopalakrishnan, Sujatha M., Cox, Philip B., Stoll, Vincent S., Sun, Chaohong

Volltext

Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds von Ramos, Ashley L., Goedken, Eric R., Frank, Kristine E., Argiriadi, Maria A., Bazzaz, Sana, Bian, Zhiguo, Brown, Jesse T. C., Centrella, Paolo A., Chen, Hui-Ju, Disch, Jeremy S., Donner, Pamela L., Duignan, David B., Gikunju, Diana, Greszler, Stephen N., Guié, Marie-Aude, Habeshian, Sevan, Hartl, Hajnalka E., Hein, Christopher D., Hutchins, Charles W., Jetson, Rachael, Keefe, Anthony D., Khan, Hasan, Li, Huan-Qiu, Olszewski, Allison, Ortiz Cardona, Benjamin J., Osuma, Augustine, Panchal, Sanjay C., Phelan, Ryan, Qiu, Wei, Shotwell, J. Brad, Shrestha, Anurupa, Srikumaran, Myron, Su, Zhi, Sun, Chaohong, Upadhyay, Anup K., Wood, Michael D., Wu, Haihong, Zhang, Ruijie, Zhang, Ying, Zhao, Gang, Zhu, Haizhong, Webster, Matthew P.

Volltext

Inhibition of Interleukin-23–Mediated Inflammation with a Novel Small Molecule Inverse Agonist of RORγt von Gauld, Stephen B., Jacquet, Sebastien, Gauvin, Donna, Wallace, Craig, Wang, Yibing, McCarthy, Richard, Goess, Christian, Leys, Laura, Huang, Susan, Su, Zhi, Edelmayer, Rebecca, Wetter, Joseph, Salte, Katherine, McGaraughty, Steven P., Argiriadi, Maria A., Honore, Prisca, Luccarini, Jean-Michel, Bressac, Didier, Desino, Kelly, Breinlinger, Eric, Cusack, Kevin, Potin, Dominique, Kort, Michael E., Masson, Philippe J

Volltext

Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active RORγ inverse agonists von Amaudrut, Jérôme, Argiriadi, Maria A., Barth, Martine, Breinlinger, Eric C., Bressac, Didier, Broqua, Pierre, Calderwood, David J., Chatar, Mohamed, Cusack, Kevin P., Gauld, Stephen B., Jacquet, Sébastien, Kamath, Rajesh V., Kort, Michael E., Lepais, Valérie, Luccarini, Jean-Michel, Masson, Philippe, Montalbetti, Christian, Mounier, Laurent, Potin, Dominique, Poupardin, Olivia, Rouaud, Sylvie, Spitzer, Luc, Wallace, Craig D.

Volltext

Optimized Protein Kinase Cθ (PKCθ) Inhibitors Reveal Only Modest Anti-inflammatory Efficacy in a Rodent Model of Arthritis von George, Dawn M., Breinlinger, Eric C., Argiriadi, Maria A., Zhang, Yang, Wang, Jianfei, Bansal-Pakala, Pratima, Duignan, David B., Honore, Prisca, Lang, QingYu, Mittelstadt, Scott, Rundell, Lian, Schwartz, Annette, Sun, Jiakang, Edmunds, Jeremy J.

Volltext

CD40/anti-CD40 antibody complexes which illustrate agonist and antagonist structural switches von Argiriadi, Maria A, Benatuil, Lorenzo, Dubrovska, Ievgeniia, Egan, David A, Gao, Lei, Greischar, Amy, Hardman, Jennifer, Harlan, John, Iyer, Ramesh B, Judge, Russell A, Lake, Marc, Perron, Denise C, Sadhukhan, Ramkrishna, Sielaff, Bernhard, Sousa, Silvino, Wang, Rui, McRae, Bradford L

Volltext

Structure activity optimization of 6H-pyrrolo[2,3-e][1,2,4]triazolo[4,3-a]pyrazines as Jak1 kinase inhibitors von Friedman, Michael, Frank, Kristine E., Aguirre, Ana, Argiriadi, Maria A., Davis, Heather, Edmunds, Jeremy J., George, Dawn M., George, Jonathan S., Goedken, Eric, Fiamengo, Bryan, Hyland, Deborah, Li, Bin, Murtaza, Anwar, Morytko, Michael, Somal, Gagandeep, Stewart, Kent, Tarcsa, Edit, Van Epps, Stacy, Voss, Jeffrey, Wang, Lu, Woller, Kevin, Wishart, Neil

Volltext

Detoxification of Environmental Mutagens and Carcinogens: Structure, Mechanism, and Evolution of Liver Epoxide Hydrolase von Argiriadi, Maria A., Morisseau, Christophe, Hammock, Bruce D., Christianson, David W.

Volltext

Creation of a S1P Lyase bacterial surrogate for structure-based drug design von Argiriadi, Maria A., Banach, David, Radziejewska, Elzbieta, Marchie, Susan, DiMauro, Jennifer, Dinges, Jurgen, Dominguez, Eric, Hutchins, Charles, Judge, Russell A., Queeney, Kara, Wallace, Grier, Harris, Christopher M.

Volltext

Hit-to-lead evaluation of a novel class of sphingosine 1-phosphate lyase inhibitors von Dinges, Jurgen, Harris, Christopher M., Wallace, Grier A., Argiriadi, Maria A., Queeney, Kara L., Perron, Denise C., Dominguez, Eric, Kebede, Tegest, Desino, Kelly E., Patel, Hetal, Vasudevan, Anil

Volltext

Unusual Water-mediated Antigenic Recognition of the Proinflammatory Cytokine Interleukin-18 von Argiriadi, Maria A., Xiang, Tao, Wu, Chengbin, Ghayur, Tariq, Borhani, David W.

Volltext

Enabling structure-based drug design of Tyk2 through co-crystallization with a stabilizing aminoindazole inhibitor von Argiriadi, Maria A, Goedken, Eric R, Banach, David, Borhani, David W, Burchat, Andrew, Dixon, Richard W, Marcotte, Doug, Overmeyer, Gary, Pivorunas, Valerie, Sadhukhan, Ramkrishna, Sousa, Silvino, Moore, Nigel St John, Tomlinson, Medha, Voss, Jeffrey, Wang, Lu, Wishart, Neil, Woller, Kevin, Talanian, Robert V

Volltext

The use of cyclic peptide antigens to generate LRP8 specific antibodies von Argiriadi, Maria A., Deng, Kangwen, Egan, David, Gao, Lei, Gizatullin, Farid, Harlan, John, Karaoglu Hanzatian, Denise, Qiu, Wei, Villanueva, Ruth, Goodearl, Andrew

Volltext

Crystal structure of a DNA polymerase sliding clamp from a Gram-positive bacterium von Argiriadi, Maria A, Goedken, Eric R, Bruck, Irina, O'Donnell, Mike, Kuriyan, John

Volltext

2,4-Diaminopyrimidine MK2 inhibitors. Part I: Observation of an unexpected inhibitor binding mode von Argiriadi, Maria A., Ericsson, Anna M., Harris, Christopher M., Banach, David L., Borhani, David W., Calderwood, David J., Demers, Megan D., DiMauro, Jennifer, Dixon, Richard W., Hardman, Jennifer, Kwak, Silvia, Li, Biqin, Mankovich, John A., Marcotte, Douglas, Mullen, Kelly D., Ni, Baofu, Pietras, M., Sadhukhan, Ramkrishna, Sousa, Silvino, Tomlinson, Medha J., Wang, Lu, Xiang, Tao, Talanian, Robert V.

Volltext

2,4-Diaminopyrimidine MK2 inhibitors. Part II: Structure-based inhibitor optimization von Harris, Christopher M., Ericsson, Anna M., Argiriadi, Maria A., Barberis, Claude, Borhani, David W., Burchat, Andrew, Calderwood, David J., Cunha, George A., Dixon, Richard W., Frank, Kristine E., Johnson, Eric F., Kamens, Joanne, Kwak, Silvia, Li, Biqin, Mullen, Kelly D., Perron, Denise C., Wang, Lu, Wishart, Neil, Wu, Xiaoyun, Zhang, Xiaolei, Zmetra, Tami R., Talanian, Robert V.

Volltext