Targeting the WNT Signaling Pathway in Cancer Therapeutics von Tai, David, Wells, Keith, Arcaroli, John, Vanderbilt, Chad, Aisner, Dara L., Messersmith, Wells A., Lieu, Christopher H.

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Lipid catabolism inhibition sensitizes prostate cancer cells to antiandrogen blockade von Flaig, Thomas W, Salzmann-Sullivan, Maren, Su, Lih-Jen, Zhang, Zhiyong, Joshi, Molishree, Gijón, Miguel A, Kim, Jihye, Arcaroli, John J, Van Bokhoven, Adrie, Lucia, M Scott, La Rosa, Francisco G, Schlaepfer, Isabel R

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Dual pharmacological targeting of the MAP kinase and PI3K/mTOR pathway in preclinical models of colorectal cancer von Pitts, Todd M, Newton, Timothy P, Bradshaw-Pierce, Erica L, Addison, Rebecca, Arcaroli, John J, Klauck, Peter J, Bagby, Stacey M, Hyatt, Stephanie L, Purkey, Alicia, Tentler, John J, Tan, Aik Choon, Messersmith, Wells A, Eckhardt, S Gail, Leong, Stephen

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ALDH1B1 Is Crucial for Colon Tumorigenesis by Modulating Wnt/β-Catenin, Notch and PI3K/Akt Signaling Pathways von Singh, Surendra, Arcaroli, John, Chen, Ying, Thompson, David C, Messersmith, Wells, Jimeno, Antonio, Vasiliou, Vasilis

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An improved high yield total synthesis and cytotoxicity study of the marine alkaloid neoamphimedine: an ATP-competitive inhibitor of topoisomerase IIα and potent anticancer agent von Li, Linfeng, Abraham, Adedoyin D, Zhou, Qiong, Ali, Hadi, O'Brien, Jeremy V, Hamill, Brayden D, Arcaroli, John J, Messersmith, Wells A, LaBarbera, Daniel V

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Association between IL-32 genotypes and outcome in infection-associated acute lung injury von Arcaroli, John J, Liu, Nianjun, Yi, Nengjun, Abraham, Edward

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CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma von Ravindran Menon, Dinoop, Luo, Yuchun, Arcaroli, John J, Liu, Sucai, KrishnanKutty, Lekha Nair, Osborne, Douglas G, Li, Yang, Samson, Jenny Mae, Bagby, Stacey, Tan, Aik-Choon, Robinson, William A, Messersmith, Wells A, Fujita, Mayumi

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Regulation of Head and Neck Squamous Cancer Stem Cells by PI3K and SOX2 von Keysar, Stephen B, Le, Phuong N, Miller, Bettina, Jackson, Brian C, Eagles, Justin R, Nieto, Cera, Kim, Jihye, Tang, Binwu, Glogowska, Magdalena J, Morton, J Jason, Padilla-Just, Nuria, Gomez, Karina, Warnock, Emily, Reisinger, Julie, Arcaroli, John J, Messersmith, Wells A, Wakefield, Lalage M, Gao, Dexiang, Tan, Aik-Choon, Serracino, Hilary, Vasiliou, Vasilis, Roop, Dennis R, Wang, Xiao-Jing, Jimeno, Antonio

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Dual compartmental targeting of cell cycle and angiogenic kinases in colorectal cancer models von Capasso, Anna, Pitts, Todd M, Klauck, Peter J, Bagby, Stacey M, Westbrook, Lindsey, Kaplan, Jeffrey, Soleimani, Milad, Spreafico, Anna, Tentler, John J, Diamond, Jennifer R, Arcaroli, John J, Messersmith, Wells A, Eckhardt, Sue G, Leong, Stephen

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Examination of Wnt signaling as a therapeutic target for pancreatic ductal adenocarcinoma (PDAC) using a pancreatic tumor organoid library (PTOL) von Hawkins, Hayley J, Yacob, Betelehem W, Brown, Monica E, Goldstein, Brandon R, Arcaroli, John J, Bagby, Stacey M, Hartman, Sarah J, Macbeth, Morgan, Goodspeed, Andrew, Danhorn, Thomas, Lentz, Robert W, Lieu, Christopher H, Leal, Alexis D, Messersmith, Wells A, Dempsey, Peter J, Pitts, Todd M

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Cabozantinib Exhibits Potent Antitumor Activity in Colorectal Cancer Patient-Derived Tumor Xenograft Models via Autophagy and Signaling Mechanisms von Scott, Aaron J, Arcaroli, John J, Bagby, Stacey M, Yahn, Rachel, Huber, Kendra M, Serkova, Natalie J, Nguyen, Anna, Kim, Jihye, Thorburn, Andrew, Vogel, Jon, Quackenbush, Kevin S, Capasso, Anna, Schreiber, Anna, Blatchford, Patrick, Klauck, Peter J, Pitts, Todd M, Eckhardt, S Gail, Messersmith, Wells A

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Aldehyde Dehydrogenase 1B1 as a Modulator of Pancreatic Adenocarcinoma von Singh, Surendra, Arcaroli, John J., Orlicky, David J., Chen, Ying, Messersmith, Wells A., Bagby, Stacey, Purkey, Alicia, Quackenbush, Kevin S., Thompson, David C., Vasiliou, Vasilis

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A patient tumor transplant model of squamous cell cancer identifies PI3K inhibitors as candidate therapeutics in defined molecular bins von Keysar, Stephen B., Astling, David P., Anderson, Ryan T., Vogler, Brian W., Bowles, Daniel W., Morton, J. Jason, Paylor, Jeramiah J., Glogowska, Magdalena J., Le, Phuong N., Eagles-Soukup, Justin R., Kako, Severine L., Takimoto, Sarah M., Sehrt, Daniel B., Umpierrez, Adrian, Pittman, Morgan A., Macfadden, Sarah M., Helber, Ryan M., Peterson, Scott, Hausman, Diana F., Said, Sherif, Leem, Ted H., Goddard, Julie A., Arcaroli, John J., Messersmith, Wells A., Robinson, William A., Hirsch, Fred R., Varella-Garcia, Marileila, Raben, David, Wang, Xiao-Jing, Song, John I., Tan, Aik-Choon, Jimeno, Antonio

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Rational Combination of a MEK Inhibitor, Selumetinib, and the Wnt/Calcium Pathway Modulator, Cyclosporin A, in Preclinical Models of Colorectal Cancer von SPREAFICO, Anna, TENTLER, John J, MICEL, Lindsey N, SELBY, Heather M, NEWTON, Timothy P, MCPHILLIPS, Kelly L, GUSTAFSON, Daniel L, DEGREGORI, James V, MESSERSMITH, Wells A, WINN, Robert A, ECKHARDT, S. Gail, PITTS, Todd M, AIK CHOON TAN, GREGORY, Mark A, ARCAROLI, John J, KLAUCK, Peter J, MCMANUS, Martine C, HANSEN, Ryan J, JIHYE KIM

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Potent antitumor activity of cabozantinib, a c‐MET and VEGFR2 inhibitor, in a colorectal cancer patient‐derived tumor explant model von Song, Eun‐Kee, Tai, WM, Messersmith, Wells A., Bagby, Stacey, Purkey, Alicia, Quackenbush, Kevin S., Pitts, Todd M., Wang, Guoliang, Blatchford, Patrick, Yahn, Rachel, Kaplan, Jeffrey, Tan, Aik Choon, Atreya, Chloe E., Eckhardt, Gail, Kelley, Robin K., Venook, Alan, Kwak, Eunice L., Ryan, David, Arcaroli, John J.

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Antitumor activity of the polo-like kinase inhibitor, TAK-960, against preclinical models of colorectal cancer von Klauck, Peter J, Bagby, Stacey M, Capasso, Anna, Bradshaw-Pierce, Erica L, Selby, Heather M, Spreafico, Anna, Tentler, John J, Tan, Aik Choon, Kim, Jihye, Arcaroli, John J, Purkey, Alicia, Messersmith, Wells A, Kuida, Keisuke, Eckhardt, S Gail, Pitts, Todd M

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Cutting Edge: HMG-1 as a Mediator of Acute Lung Inflammation von Abraham, Edward, Arcaroli, John, Carmody, Aaron, Wang, Haichao, Tracey, Kevin J

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A NOTCH1 gene copy number gain is a prognostic indicator of worse survival and a predictive biomarker to a Notch1 targeting antibody in colorectal cancer von Arcaroli, John J., Tai, W.M., McWilliams, Ryan, Bagby, Stacey, Blatchford, Patrick J., Varella‐Garcia, Marileila, Purkey, Alicia, Quackenbush, Kevin S., Song, Eun‐Kee, Pitts, Todd M., Gao, Dexiang, Lieu, Chris, McManus, Martine, Tan, Aik Choon, Zheng, Xianxian, Zhang, Qin, Ozeck, Mark, Olson, Peter, Jiang, Zhi‐Qin, Kopetz, Scott, Jimeno, Antonio, Keysar, Stephen, Eckhardt, Gail, Messersmith, Wells A.

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Neutrophils as early immunologic effectors in hemorrhage- or endotoxemia-induced acute lung injury von Abraham, Edward, Carmody, Aaron, Shenkar, Robert, Arcaroli, John

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Evaluation of the efficacy of dasatinib, a Src/Abl inhibitor, in colorectal cancer cell lines and explant mouse model von Scott, Aaron J, Song, Eun-Kee, Bagby, Stacey, Purkey, Alicia, McCarter, Martin, Gajdos, Csaba, Quackenbush, Kevin S, Cross, Benjamin, Pitts, Todd M, Tan, Aik Choon, Eckhardt, S Gail, Fenton, Hubert, Arcaroli, John, Messersmith, Wells A

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