Ultrasmall Folate Receptor Alpha Targeted Enzymatically Cleavable Silica Nanoparticle Drug Conjugates Augment Penetration and Therapeutic Efficacy in Models of Cancer von Wu, Fei, Chen, Pei-Ming, Gardinier, Thomas C., Turker, Melik Z., Venkatesan, Aranapakam M., Patel, Vaibhav, Khor, Tin, Bradbury, Michelle S., Wiesner, Ulrich B., Adams, Gregory P., Germano, Geno, Chen, Feng, Ma, Kai

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Bis(morpholino-1,3,5-triazine) Derivatives: Potent Adenosine 5′-Triphosphate Competitive Phosphatidylinositol-3-kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of Compou... von Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Delos Santos, Efren, Chen, Zecheng, Dos Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, James, Abraham, Robert T, Chaudhary, Inder, Mansour, Tarek S

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Antitumor Efficacy of PKI-587, a Highly Potent Dual PI3K/mTOR Kinase Inhibitor von MALLON, Robert, FELDBERG, Larry R, HOLLANDER, Irwin, LUCAS, Judy, CHAUDHARY, Inder, DEHNHARDT, Christoph, DELOS SANTOS, Efren, ZECHENG CHEN, DOS SANTOS, Osvaldo, AYRAL-KALOUSTIAN, Semiramis, VENKATESAN, Aranapakam

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Synthetic Study toward Total Synthesis of (±)-Germine: Synthesis of (±)-4-Methylenegermine von Stork, Gilbert, Yamashita, Ayako, Hanson, Robert M, Phan, Ly, Phillips, Eifion, Dubé, Daniel, Bos, Pieter H, Clark, Andrew J, Gough, Maxwell, Greenlee, Mark L, Jiang, Yimin, Jones, Keith, Kitamura, Masato, Leonard, John, Liu, Tongzhu, Parsons, Philip J, Venkatesan, Aranapakam M

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Synthesis and SAR of Novel 4-Morpholinopyrrolopyrimidine Derivatives as Potent Phosphatidylinositol 3-Kinase Inhibitors von Chen, Zecheng, Venkatesan, Aranapakam M, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Feldberg, Larry, Hollander, Irwin, Lucas, Judy, Yu, Ker, Kong, Fangming, Mansour, Tarek S

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Lead Optimization of N-3-Substituted 7-Morpholinotriazolopyrimidines as Dual Phosphoinositide 3-Kinase/Mammalian Target of Rapamycin Inhibitors: Discovery of PKI-402 von Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Delos Santos, Efren, Chen, Zecheng, Santos, Osvaldo, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Chaudhary, Inder, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S

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PKI-179: An orally efficacious dual phosphatidylinositol-3-kinase (PI3K)/mammalian target of rapamycin (mTOR) inhibitor von Venkatesan, Aranapakam M., Chen, Zecheng, Santos, Osvaldo Dos, Dehnhardt, Christoph, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Chaudhary, Inder, Mansour, Tarek S.

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2,4-Diamino-quinazolines as inhibitors of β-catenin/Tcf-4 pathway: Potential treatment for colorectal cancer von Chen, Zecheng, Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Santos, Osvaldo Dos, Santos, Efren Delos, Ayral-Kaloustian, Semiramis, Chen, Lei, Geng, Yi, Arndt, Kim T., Lucas, Judy, Chaudhary, Inder, Mansour, Tarek S.

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Identification of 2-oxatriazines as highly potent pan-PI3K/mTOR dual inhibitors von Dehnhardt, Christoph M., Venkatesan, Aranapakam M., Chen, Zecheng, Delos-Santos, Efren, Ayral-Kaloustian, Semiramis, Brooijmans, Natasja, Yu, Ker, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Mallon, Robert

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Efficacy of Piperacillin Combined with the Penem β-Lactamase Inhibitor BLI-489 in Murine Models of Systemic Infection von PETERSEN, Peter J, HAL JONES, C, VENKATESAN, Aranapakam M, BRADFORD, Patricia A

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5-Ureidobenzofuranone indoles as potent and efficacious inhibitors of PI3 kinase-α and mTOR for the treatment of breast cancer von Zhang, Nan, Ayral-Kaloustian, Semiramis, Anderson, James T., Nguyen, Thai, Das, Sasmita, Venkatesan, Aranapakam M., Brooijmans, Natasja, Lucas, Judy, Yu, Ker, Hollander, Irwin, Mallon, Robert

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Stereoselective Synthesis of an Active Metabolite of the Potent PI3 Kinase Inhibitor PKI-179 von Chen, Zecheng, Venkatesan, Aranapakam M, Dos Santos, Osvaldo, Delos Santos, Efren, Dehnhardt, Christoph M, Ayral-Kaloustian, Semiramis, Ashcroft, Joseph, McDonald, Leonard A, Mansour, Tarek S

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5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases von Venkatesan, Aranapakam M., Agarwal, Atul, Abe, Takao, Ushirogochi, Hideki, Ado, Mihira, Tsuyoshi, Takasaki, Dos Santos, Osvaldo, Li, Zhong, Francisco, Gerry, Lin, Yang I., Petersen, Peter J., Yang, Youjun, Weiss, William J., Shlaes, David M., Mansour, Tarek S.

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Novel purine and pyrazolo[3,4- d]pyrimidine inhibitors of PI3 kinase-α: Hit to lead studies von Gilbert, Adam M., Nowak, Pawel, Brooijmans, Natasja, Bursavich, Matthew G., Dehnhardt, Christoph, Santos, Efren Delos, Feldberg, Larry R., Hollander, Irwin, Kim, Stephen, Lombardi, Sabrina, Park, Kaapjoo, Venkatesan, Aranapakam M., Mallon, Robert

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Design and Synthesis of Novel Diaminoquinazolines with in Vivo Efficacy for β-Catenin/T-Cell Transcriptional Factor 4 Pathway Inhibition von Dehnhardt, Christoph M, Venkatesan, Aranapakam M, Chen, Zecheng, Ayral-Kaloustian, Semiramis, Dos Santos, Osvaldo, Delos Santos, Efren, Curran, Kevin, Follettie, Max T, Diesl, Veronica, Lucas, Judy, Geng, Yi, DeJoy, Susan Quinn, Petersen, Rosanne, Chaudhary, Inder, Brooijmans, Natasja, Mansour, Tarek S, Arndt, Kim, Chen, Lei

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Establishment of In Vitro Susceptibility Testing Methodologies and Comparative Activities of Piperacillin in Combination with the Penem β-Lactamase Inhibitor BLI-489 von PETERSEN, Peter J, HAL JONES, C, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, PROJAN, Steven J, BRADFORD, Patricia A

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Novel imidazolopyrimidines as dual PI3-Kinase/mTOR inhibitors von Venkatesan, Aranapakam M., Dehnhardt, Christoph M., Chen, Zecheng, Santos, Efren Delos, Dos Santos, Osvaldo, Bursavich, Matthew, Gilbert, Adam M., Ellingboe, John W., Ayral-Kaloustian, Semiramis, Khafizova, Gulnaz, Brooijmans, Natasja, Mallon, Robert, Hollander, Irwin, Feldberg, Larry, Lucas, Judy, Yu, Ker, Gibbons, Jay, Abraham, Robert, Mansour, Tarek S.

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Inhibition of OXA-1 β-Lactamase by Penems von BETHEL, Christopher R, DISTLER, Anne M, ANDERSON, Vernon E, LEONARD, David A, HUJER, Kristine M, ABE, Takao, VENKATESAN, Aranapakam M, MANSOUR, Tarek S, BONOMO, Robert A, RUSZCZYCKY, Mark W, CAREY, Marianne P, CAREY, Paul R, HUJER, Andrea M, TARACILA, Magda, HELFAND, Marion S, THOMSON, Jodi M, KALP, Matthew

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Novel benzofuran derivatives with dual 5-HT1A receptor and serotonin transporter affinity von Venkatesan, Aranapakam M, Dos Santos, O, Ellingboe, John, Evrard, Deborah A, Harrison, Boyd L, Smith, Deborah L, Scerni, Rosemary, Hornby, Geoffrey A, Schechter, Lee E, Andree, Terrence H

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Structure−Activity Relationship of 6-Methylidene Penems Bearing Tricyclic Heterocycles as Broad-Spectrum β-Lactamase Inhibitors:  Crystallographic Structures Show Unexpected Bindin... von Venkatesan, Aranapakam M, Gu, Yansong, Santos, Osvaldo Dos, Abe, Takao, Agarwal, Atul, Yang, Youjun, Petersen, Peter J, Weiss, William J, Mansour, Tarek S, Nukaga, Michiyoshi, Hujer, Andrea M, Bonomo, Robert A, Knox, James R

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