A Highly Durable RNAi Therapeutic Inhibitor of PCSK9 von Fitzgerald, Kevin, White, Suellen, Borodovsky, Anna, Bettencourt, Brian R, Strahs, Andrew, Clausen, Valerie, Wijngaard, Peter, Horton, Jay D, Taubel, Jorg, Brooks, Ashley, Fernando, Chamikara, Kauffman, Robert S, Kallend, David, Vaishnaw, Akshay, Simon, Amy

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In Vivo Silencing of the Transcription Factor IRF5 Reprograms the Macrophage Phenotype and Improves Infarct Healing von Courties, Gabriel, PhD, Heidt, Timo, MD, Sebas, Matthew, BS, Iwamoto, Yoshiko, BS, Jeon, Derrick, MS, Truelove, Jessica, BS, Tricot, Benoit, MS, Wojtkiewicz, Greg, MS, Dutta, Partha, PhD, Sager, Hendrik B., MD, Borodovsky, Anna, PhD, Novobrantseva, Tatiana, PhD, Klebanov, Boris, PhD, Fitzgerald, Kevin, PhD, Anderson, Daniel G., PhD, Libby, Peter, MD, Swirski, Filip K., PhD, Weissleder, Ralph, MD, PhD, Nahrendorf, Matthias, MD, PhD

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Proliferation and Recruitment Contribute to Myocardial Macrophage Expansion in Chronic Heart Failure von Sager, Hendrik B, Hulsmans, Maarten, Lavine, Kory J, Moreira, Marina B, Heidt, Timo, Courties, Gabriel, Sun, Yuan, Iwamoto, Yoshiko, Tricot, Benoit, Khan, Omar F, Dahlman, James E, Borodovsky, Anna, Fitzgerald, Kevin, Anderson, Daniel G, Weissleder, Ralph, Libby, Peter, Swirski, Filip K, Nahrendorf, Matthias

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Image-based analysis of lipid nanoparticle–mediated siRNA delivery, intracellular trafficking and endosomal escape von Gilleron, Jerome, Querbes, William, Zeigerer, Anja, Borodovsky, Anna, Marsico, Giovanni, Schubert, Undine, Manygoats, Kevin, Seifert, Sarah, Andree, Cordula, Stöter, Martin, Epstein-Barash, Hila, Zhang, Ligang, Koteliansky, Victor, Fitzgerald, Kevin, Fava, Eugenio, Bickle, Marc, Kalaidzidis, Yannis, Akinc, Akin, Maier, Martin, Zerial, Marino

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The classical pathway triggers pathogenic complement activation in membranous nephropathy von Seifert, Larissa, Zahner, Gunther, Meyer-Schwesinger, Catherine, Hickstein, Naemi, Dehde, Silke, Wulf, Sonia, Köllner, Sarah M. S., Lucas, Renke, Kylies, Dominik, Froembling, Sarah, Zielinski, Stephanie, Kretz, Oliver, Borodovsky, Anna, Biniaminov, Sergey, Wang, Yanyan, Cheng, Hong, Koch-Nolte, Friedrich, Zipfel, Peter F., Hopfer, Helmut, Puelles, Victor G., Panzer, Ulf, Huber, Tobias B., Wiech, Thorsten, Tomas, Nicola M.

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Monocyte-Directed RNAi Targeting CCR2 Improves Infarct Healing in Atherosclerosis-Prone Mice von Majmudar, Maulik D, Keliher, Edmund J, Heidt, Timo, Leuschner, Florian, Truelove, Jessica, Sena, Brena F, Gorbatov, Rostic, Iwamoto, Yoshiko, Dutta, Partha, Wojtkiewicz, Gregory, Courties, Gabriel, Sebas, Matt, Borodovsky, Anna, Fitzgerald, Kevin, Nolte, Marc W, Dickneite, Gerhard, Chen, John W, Anderson, Daniel G, Swirski, Filip K, Weissleder, Ralph, Nahrendorf, Matthias

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Macrophages retain hematopoietic stem cells in the spleen via VCAM-1 von Dutta, Partha, Hoyer, Friedrich Felix, Grigoryeva, Lubov S, Sager, Hendrik B, Leuschner, Florian, Courties, Gabriel, Borodovsky, Anna, Novobrantseva, Tatiana, Ruda, Vera M, Fitzgerald, Kevin, Iwamoto, Yoshiko, Wojtkiewicz, Gregory, Sun, Yuan, Da Silva, Nicolas, Libby, Peter, Anderson, Daniel G, Swirski, Filip K, Weissleder, Ralph, Nahrendorf, Matthias

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Myocardial Infarction Activates CCR2+ Hematopoietic Stem and Progenitor Cells von Dutta, Partha, Sager, Hendrik B., Stengel, Kristy R., Naxerova, Kamila, Courties, Gabriel, Saez, Borja, Silberstein, Lev, Heidt, Timo, Sebas, Matthew, Sun, Yuan, Wojtkiewicz, Gregory, Feruglio, Paolo Fumene, King, Kevin, Baker, Joshua N., van der Laan, Anja M., Borodovsky, Anna, Fitzgerald, Kevin, Hulsmans, Maarten, Hoyer, Friedrich, Iwamoto, Yoshiko, Vinegoni, Claudio, Brown, Dennis, Di Carli, Marcelo, Libby, Peter, Hiebert, Scott W., Scadden, David T., Swirski, Filip K., Weissleder, Ralph, Nahrendorf, Matthias

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Pharmacokinetics and pharmacodynamics of pozelimab alone or in combination with cemdisiran in non-human primates von Devalaraja-Narashimha, Kishor, Huang, Cong, Cao, Marc, Chen, Ya Ping, Borodovsky, Anna, Olson, William C, Morton, Lori G, Retter, Marc W

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Hepatocyte-Specific Delivery of siRNAs Conjugated to Novel Non-nucleosidic Trivalent N-Acetylgalactosamine Elicits Robust Gene Silencing in Vivo von Rajeev, Kallanthottathil G., Nair, Jayaprakash K., Jayaraman, Muthusamy, Charisse, Klaus, Taneja, Nate, O'Shea, Jonathan, Willoughby, Jennifer L. S., Yucius, Kristina, Nguyen, Tuyen, Shulga-Morskaya, Svetlana, Milstein, Stuart, Liebow, Abigail, Querbes, William, Borodovsky, Anna, Fitzgerald, Kevin, Maier, Martin A., Manoharan, Muthiah

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A combinatorial library of lipid-like materials for delivery of RNAi therapeutics von Anderson, Daniel G, Akinc, Akin, Zumbuehl, Andreas, Goldberg, Michael, Leshchiner, Elizaveta S, Busini, Valentina, Hossain, Naushad, Bacallado, Sergio A, Nguyen, David N, Fuller, Jason, Alvarez, Rene, Borodovsky, Anna, Borland, Todd, Constien, Rainer, de Fougerolles, Antonin, Dorkin, J Robert, Narayanannair Jayaprakash, K, Jayaraman, Muthusamy, John, Matthias, Koteliansky, Victor, Manoharan, Muthiah, Nechev, Lubomir, Qin, June, Racie, Timothy, Raitcheva, Denitza, Rajeev, Kallanthottathil G, Sah, Dinah W Y, Soutschek, Jürgen, Toudjarska, Ivanka, Vornlocher, Hans-Peter, Zimmermann, Tracy S, Langer, Robert

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Polymeric Nanoparticle PET/MR Imaging Allows Macrophage Detection in Atherosclerotic Plaques von Majmudar, Maulik D, Yoo, Jeongsoo, Keliher, Edmund J, Truelove, Jessica J, Iwamoto, Yoshiko, Sena, Brena, Dutta, Partha, Borodovsky, Anna, Fitzgerald, Kevin, Di Carli, Marcelo F, Libby, Peter, Anderson, Daniel G, Swirski, Filip K, Weissleder, Ralph, Nahrendorf, Matthias

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Multiple Associated Proteins Regulate Proteasome Structure and Function von Leggett, David S., Hanna, John, Borodovsky, Anna, Crosas, Bernat, Schmidt, Marion, Baker, Rohan T., Walz, Thomas, Ploegh, Hidde, Finley, Daniel

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TL1A-DR3 interaction regulates Th17 cell function and Th17-mediated autoimmune disease von Pappu, Bhanu P, Borodovsky, Anna, Zheng, Timothy S, Yang, Xuexian, Wu, Ping, Dong, Xingwen, Weng, Shawn, Browning, Beth, Scott, Martin L, Ma, Li, Su, Lihe, Tian, Qiang, Schneider, Pascal, Flavell, Richard A, Dong, Chen, Burkly, Linda C

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Investigational RNAi Therapeutic Targeting C5 Is Efficacious in Pre-clinical Models of Myasthenia Gravis von Kusner, Linda L., Yucius, Kristina, Sengupta, Manjistha, Sprague, Andrew G., Desai, Dhruv, Nguyen, Tuyen, Charisse, Klaus, Kuchimanchi, Satya, Kallanthottathil, Rajeev, Fitzgerald, Kevin, Kaminski, Henry J., Borodovsky, Anna

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Results of a phase 1/2 study of cemdisiran in healthy subjects and patients with paroxysmal nocturnal hemoglobinuria von Gaya, Anna, Munir, Talha, Urbano‐Ispizua, Alvaro, Griffin, Morag, Taubel, Jorg, Bush, Jim, Bhan, Ishir, Borodovsky, Anna, Wang, Yue, Badri, Prajakta, Garg, Pushkal

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Molecularly self-assembled nucleic acid nanoparticles for targeted in vivo siRNA delivery von Lee, Hyukjin, Lytton-Jean, Abigail K. R., Chen, Yi, Love, Kevin T., Park, Angela I., Karagiannis, Emmanouil D., Sehgal, Alfica, Querbes, William, Zurenko, Christopher S., Jayaraman, Muthusamy, Peng, Chang G., Charisse, Klaus, Borodovsky, Anna, Manoharan, Muthiah, Donahoe, Jessica S., Truelove, Jessica, Nahrendorf, Matthias, Langer, Robert, Anderson, Daniel G.

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A novel active site-directed probe specific for deubiquitylating enzymes reveals proteasome association of USP14 von Borodovsky, Anna, Kessler, Benedikt M., Casagrande, Rocco, Overkleeft, Herman S., Wilkinson, Keith D., Ploegh, Hidde L.

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Key Components of the Complement Lectin Pathway Are Not Only Required for the Development of Inflammatory Arthritis but Also Regulate the Transcription of Factor D von Holers, V Michael, Borodovsky, Anna, Scheinman, Robert I, Ho, Nhu, Ramirez, Joseline Ramos, Dobó, József, Gál, Péter, Lindenberger, Jared, Hansen, Annette G, Desai, Dhruv, Pihl, Rasmus, Thiel, Steffen, Banda, Nirmal K

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Specific and Covalent Targeting of Conjugating and Deconjugating Enzymes of Ubiquitin-Like Proteins von Hemelaar, Joris, Borodovsky, Anna, Kessler, Benedikt M., Reverter, David, Cook, Julie, Kolli, Nagamallesawari, Gan-Erdene, Tudev, Wilkinson, Keith D., Gill, Grace, Lima, Christopher D., Ploegh, Hidde L., Ovaa, Huib

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