Generation of systemic antitumour immunity via the in situ modulation of the gut microbiome by an orally administered inulin gel von Han, Kai, Nam, Jutaek, Xu, Jin, Sun, Xiaoqi, Huang, Xuehui, Animasahun, Olamide, Achreja, Abhinav, Jeon, Jin Heon, Pursley, Benjamin, Kamada, Nobuhiko, Chen, Grace Y., Nagrath, Deepak, Moon, James J.

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Exploiting metabolic vulnerabilities after anti-VEGF antibody therapy in ovarian cancer von Glassman, Deanna, Kim, Mark S., Spradlin, Meredith, Badal, Sunil, Taki, Mana, Bhattacharya, Pratip, Dutta, Prasanta, Kingsley, Charles V., Foster, Katherine I., Animasahun, Olamide, Jeon, Jin Heon, Achreja, Abhinav, Jayaraman, Anusha, Kumar, Praveen, Nenwani, Minal, Wuchu, Fulei, Bayraktar, Emine, Wu, Yutuan, Stur, Elaine, Mangala, Lingegowda, Lee, Sanghoon, Yap, Timothy A., Westin, Shannon N., Eberlin, Livia S., Nagrath, Deepak, Sood, Anil K.

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Cellular Location of HNF4α is Linked With Terminal Liver Failure in Humans von Florentino, Rodrigo M., Fraunhoffer, Nicolas A., Morita, Kazutoyo, Takeishi, Kazuki, Ostrowska, Alina, Achreja, Abhinav, Animasahun, Olamide, Haep, Nils, Arazov, Shohrat, Agarwal, Nandini, Collin de l'Hortet, Alexandra, Guzman‐Lepe, Jorge, Tafaleng, Edgar N., Mukherjee, Amitava, Troy, Kris, Banerjee, Swati, Paranjpe, Shirish, Michalopoulos, George K., Bell, Aaron, Nagrath, Deepak, Hainer, Sarah J., Fox, Ira J., Soto‐Gutierrez, Alejandro

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Tumour-reprogrammed stromal BCAT1 fuels branched-chain ketoacid dependency in stromal-rich PDAC tumours von Zhu, Ziwen, Achreja, Abhinav, Meurs, Noah, Animasahun, Olamide, Owen, Sarah, Mittal, Anjali, Parikh, Pooja, Lo, Ting-Wen, Franco-Barraza, Janusz, Shi, Jiaqi, Gunchick, Valerie, Sherman, Mara H., Cukierman, Edna, Pickering, Andrew M., Maitra, Anirban, Sahai, Vaibhav, Morgan, Meredith A., Nagrath, Sunitha, Lawrence, Theodore S., Nagrath, Deepak

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Devimistat in combination with gemcitabine and cisplatin in biliary tract cancer: Pre-clinical evaluation and phase 1b multicenter clinical trial (BilT-04) von Mohan, Arathi, Griffith, Kent A., Wuchu, Fulei, Zhen, David B., Kumar-Sinha, Chandan, Crysler, Oxana, Hsiehchen, David, Enzler, Thomas, Dippman, Dominique, Gunchick, Valerie, Achreja, Abhinav, Animasahun, Olamide, Choppara, Srinadh, Nenwani, Minal, Chinnaiyan, Arul M., Nagrath, Deepak, Zalupski, Mark M., Sahai, Vaibhav

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Devimistat in Combination with Gemcitabine and Cisplatin in Biliary Tract Cancer: Preclinical Evaluation and Phase Ib Multicenter Clinical Trial (BilT-04) von Mohan, Arathi, Griffith, Kent A, Wuchu, Fulei, Zhen, David B, Kumar-Sinha, Chandan, Crysler, Oxana, Hsiehchen, David, Enzler, Thomas, Dippman, Dominique, Gunchick, Valerie, Achreja, Abhinav, Animasahun, Olamide, Choppara, Srinadh, Nenwani, Minal, Chinnaiyan, Arul M, Nagrath, Deepak, Zalupski, Mark M, Sahai, Vaibhav

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Inulin-gel-based oral immunotherapy remodels the small intestinal microbiome and suppresses food allergy von Han, Kai, Xie, Fang, Animasahun, Olamide, Nenwani, Minal, Kitamoto, Sho, Kim, Yeji, Phoo, May Thazin, Xu, Jin, Wuchu, Fulei, Omoloja, Kehinde, Achreja, Abhinav, Choppara, Srinadh, Li, Zhaoheng, Gong, Wang, Cho, Young Seok, Dobson, Hannah, Ahn, Jinsung, Zhou, Xingwu, Huang, Xuehui, An, Xinran, Kim, Alexander, Xu, Yao, Wu, Qi, Lee, Soo-Hong, O’Konek, Jessica J., Xie, Yuying, Lei, Yu Leo, Kamada, Nobuhiko, Nagrath, Deepak, Moon, James J.

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Abstract 236: Genomic loss in cancers enable discovery of metabolic targets for precision cancer therapy via multiobjective flux analysis and machine learning von Achreja, Abhinav, Yu, Tao, Mittal, Anjali, Choppara, Srinadh, Meurs, Noah, Animasahun, Olamide, Jeon, Jin Heon, Mohan, Aradhana, Jayaraman, Anusha, Kulkarni, Reva, Reinhold, Justin, Cusato, Michele, Difeo, Analisa, Lu, Xiongbin, Nagrath, Deepak

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MDB-78. ISOCITRATE DEHYDROGENASE 1 INHIBITION PRIMES GROUP-3 MEDULLOBLASTOMAS FOR CUPROPTOSIS von Dang, Derek, McKolay, John, Smith, Kyle, Panwalkar, Pooja, Sweha, Stefan, Natarajan, Siva Kumar, Pun, Matthew J, Ji, Sunjong, Patel, Diya, Animasahun, Olamide, Achreja, Abhinav, Ogrodzinski, Martin P, Cotter, Jennifer, Hawes, Debra, Yang, Fusheng, Doherty, Robert, Franson, Andrea T, Hanaford, Allison R, Eberhart, Charles G, Raabe, Eric H, Chen, Brandon, Lyssiotis, Costas A, Shah, Yatrik, Lunt, Sophia Y, Judkins, Alexander R, Prensner, John, Koschmann, Carl J, Waszak, Sebastian, Nagrath, Deepak, Northcott, Paul, Venneti, Sriram

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What’s next after bevaciumab resistance? Targeting metabolic vulnerabilities in ovarian cancer (022) von Glassman, Deanna, Kim, Mark, Badal, Sunil, Spradlin, Meredith, Animasahun, Olamide, Jeon, Jin Heon, Achreja, Abhinav, Jayaraman, Anusha, Kumar, Praveen, Nenwani, Minal, Wuchu, Fulei, Bayraktar, Emine, Wu, Yutuan, Stur, Elaine, Mangala, Lingegowda, Lee, Sanghoon, Yap, Timothy, Westin, Shannon, Eberlin, Livia Schiavinato, Nagrath, Deepak, Sood, Anil

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Mitochondrial Electron Transport Chain Inhibition Promotes Resistance to Proteasome Inhibitors in Multiple Myeloma von Sharma, Aditi, Achreja, Abhinav, Nair, Remya, Gupta, Pulkit, Edgar, Claudia L, Animasahun, Olamide, Mittal, Anjali, Dwivedi, Bhakti, Bhasin, Manoj, Gupta, Vikas A, Barwick, Benjamin G, Matulis, Shannon M, Lonial, Sagar, Boise, Lawrence H., Jaye, David L, Wiita, Arun P, Nooka, Ajay K., Nagrath, Deepak, Shanmugam, Mala

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Abstract 2236: The role of CPI-613 in cholangiocarcinoma treatment von Wuchu, Fulei, Animasahun, Olamide, Choppara, Srinadh, Gunchick, Valerie, Nenwani, Minal, Roy, Jyotirmoy, Paserba, Miya, Achreja, Abhinav, Sahai, Vaibhav, Nagrath, Deepak

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Abstract 6041: Investigating metabolic dependencies of group 3 medulloblastoma von Dang, Derek, Smith, Kyle S., Panwalkar, Pooja, McKolay, John, Animasahun, Olamide, Achreja, Abhinav, Nagrath, Deepak, Northcott, Paul A., Venneti, Sriram

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Abstract 2026: Comprehensive metabolic flux analysis on triple-negative breast cancer shows potential collaterally lethal targets related to the serine pathway von Jeon, Jin Heon, Achreja, Abhinav, Slayton, Mark, Animasahun, Olamide, Paserba, Miya, Roy, Jyotirmoy, Nagrath, Deepak, Merajver, Sofia D.

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Abstract 6037: Identification of collateral lethal targets in cancers using integrated machine learning and flux analysis platform for personalized metabolic therapy von Achreja, Abhinav, Jeon, Jin Heon, Slayton, Mark, Yu, Tao, Animasahun, Olamide, Nenwani, Minal, Wuchu, Fulei, Mittal, Anjali, Lu, Xiongbin, Merajver, Sofia D., Nagrath, Deepak

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Metabolic collateral lethal target identification reveals MTHFD2 paralogue dependency in ovarian cancer von Achreja, Abhinav, Yu, Tao, Mittal, Anjali, Choppara, Srinadh, Animasahun, Olamide, Nenwani, Minal, Wuchu, Fulei, Meurs, Noah, Mohan, Aradhana, Jeon, Jin Heon, Sarangi, Itisam, Jayaraman, Anusha, Owen, Sarah, Kulkarni, Reva, Cusato, Michele, Weinberg, Frank, Kweon, Hye Kyong, Subramanian, Chitra, Wicha, Max S., Merajver, Sofia D., Nagrath, Sunitha, Cho, Kathleen R., DiFeo, Analisa, Lu, Xiongbin, Nagrath, Deepak

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Therapeutic implications of mitochondrial stress-induced proteasome inhibitor resistance in multiple myeloma von Sharma, Aditi, Nair, Remya, Achreja, Abhinav, Mittal, Anjali, Gupta, Pulkit, Balakrishnan, Kamakshi, Edgar, Claudia L, Animasahun, Olamide, Dwivedi, Bhakti, Barwick, Benjamin G, Gupta, Vikas A, Matulis, Shannon M, Bhasin, Manoj, Lonial, Sagar, Nooka, Ajay K, Wiita, Arun P, Boise, Lawrence H, Nagrath, Deepak, Shanmugam, Mala

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Abstract 1092: Targeting one-carbon metabolism radiosensitizes pancreatic ductal adenocarcinoma cells (PDAC) von Nenwani, Minal, Achreja, Abhinav, Animasahun, Olamide, Sarangi, Itisam, Roy, Jyotirmoy, Choppara, Srinadh, Wuchu, Fulei, Paserba, Miya, Mittal, Anjali, Quispe, Sergio, Mohan, Aradhana, Morgan, Meredith, Lawrence, Theodore S., Nagrath, Deepak

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Porous PDMS‐Based Microsystem (ExoSponge) for Rapid Cost‐Effective Tumor Extracellular Vesicle Isolation and Mass Spectrometry‐Based Metabolic Biomarker Screening von Marvar, Joseph, Kumari, Abha, Onukwugha, Nna‐Emeka, Achreja, Abhinav, Meurs, Noah, Animasahun, Olamide, Roy, Jyotirmoy, Paserba, Miya, Raju, Kruthi Srinivasa, Fortna, Shawn, Ramnath, Nithya, Nagrath, Deepak, Kang, Yoon‐Tae, Nagrath, Sunitha

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SYSTEMS AND METHODS FOR IDENTIFYING AND TARGETING COLLATERAL LETHAL GENES von WUCHU, Fulei, ANIMASAHUN, Olamide, ACHREJA, Abhinav, NAGRATH, Deepak, NENWANI, Minal

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