A Stereoselective Oxidative Polycyclization Process Mediated by a Hypervalent Iodine Reagent von Desjardins, Samuel, Andrez, Jean-Christophe, Canesi, Sylvain

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The contribution of NaV1.6 to the efficacy of voltage‐gated sodium channel inhibitors in wild type and NaV1.6 gain‐of‐function (GOF) mouse seizure control von Johnson, James P., Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J., Andrez, Jean‐Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L., Cutts, Alison J., Sherrington, Robin P., Winquist, Raymond, Cohen, Charles J., Empfield, James R.

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Selective NaV1.7 Antagonists with Long Residence Time Show Improved Efficacy against Inflammatory and Neuropathic Pain von Bankar, Girish, Goodchild, Samuel J., Howard, Sarah, Nelkenbrecher, Karen, Waldbrook, Matthew, Dourado, Michelle, Shuart, Noah G., Lin, Sophia, Young, Clint, Xie, Zhiwei, Khakh, Kuldip, Chang, Elaine, Sojo, Luis E., Lindgren, Andrea, Chowdhury, Sultan, Decker, Shannon, Grimwood, Michael, Andrez, Jean-Christophe, Dehnhardt, Christoph M., Pang, Jodie, Chang, Jae H., Safina, Brian S., Sutherlin, Daniel P., Johnson, James P., Hackos, David H., Robinette, C. Lee, Cohen, Charles J.

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Mitomycins syntheses: a recent update von Andrez, Jean-Christophe

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Rapid Formation of Hindered Cores Using an Oxidative Prins Process von Andrez, Jean-Christophe, Giroux, Marc-André, Lucien, Jessica, Canesi, Sylvain

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Structural basis of Nav1.7 inhibition by an isoform-selective small-molecule antagonist von Ahuja, Shivani, Mukund, Susmith, Deng, Lunbin, Khakh, Kuldip, Chang, Elaine, Ho, Hoangdung, Shriver, Stephanie, Young, Clint, Lin, Sophia, Johnson, J. P., Wu, Ping, Li, Jun, Coons, Mary, Tam, Christine, Brillantes, Bobby, Sampang, Honorio, Mortara, Kyle, Bowman, Krista K., Clark, Kevin R., Estevez, Alberto, Xie, Zhiwei, Verschoof, Henry, Grimwood, Michael, Dehnhardt, Christoph, Andrez, Jean–Christophe, Focken, Thilo, Sutherlin, Daniel P., Safina, Brian S., Starovasnik, Melissa A., Ortwine, Daniel F., Franke, Yvonne, Cohen, Charles J., Hackos, David H., Koth, Christopher M., Payandeh, Jian

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The contribution of Na V 1.6 to the efficacy of voltage-gated sodium channel inhibitors in wild type and Na V 1.6 gain-of-function (GOF) mouse seizure control von Johnson, Jr, James P, Focken, Thilo, Karimi Tari, Parisa, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Christabel, Jessica, Dean, Richard, de Boer, Gina, Dehnhardt, Christoph, Gong, Wei, Grimwood, Michael, Hussainkhel, Angela, Jia, Qi, Khakh, Kuldip, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Waldbrook, Matthew, Wesolowski, Steven, Wilson, Michael, Xie, Zhiwei, Zenova, Alla, Zhang, Wei, Scott, Fiona L, Cutts, Alison J, Sherrington, Robin P, Winquist, Raymond, Cohen, Charles J, Empfield, James R

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective NaV1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy von Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, J. P, Dehnhardt, Christoph M, Empfield, James R

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Identification of Selective Acyl Sulfonamide–Cycloalkylether Inhibitors of the Voltage-Gated Sodium Channel (NaV) 1.7 with Potent Analgesic Activity von Sun, Shaoyi, Jia, Qi, Zenova, Alla Y, Wilson, Michael S, Chowdhury, Sultan, Focken, Thilo, Li, Jun, Decker, Shannon, Grimwood, Michael E, Andrez, Jean-Christophe, Hemeon, Ivan, Sheng, Tao, Chen, Chien-An, White, Andy, Hackos, David H, Deng, Lunbin, Bankar, Girish, Khakh, Kuldip, Chang, Elaine, Kwan, Rainbow, Lin, Sophia, Nelkenbrecher, Karen, Sellers, Benjamin D, DiPasquale, Antonio G, Chang, Jae, Pang, Jodie, Sojo, Luis, Lindgren, Andrea, Waldbrook, Matthew, Xie, Zhiwei, Young, Clint, Johnson, James P, Robinette, C. Lee, Cohen, Charles J, Safina, Brian S, Sutherlin, Daniel P, Ortwine, Daniel F, Dehnhardt, Christoph M

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NBI-921352, a first-in-class, NaV1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats von Johnson, JP, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R

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Discovery of Acyl-sulfonamide Nav1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, J.P, Robinette, C. Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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Synthesis of 2-amino-imidazoles, purines, and benzoxazolamines through DIB oxidation von Andrez, Jean-Christophe

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Aromatic oxidative decompositions of copper Schiff base complexes von Andrez, Jean-Christophe

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New methodology for acridine synthesis using a rhodium-catalyzed benzannulation von Belmont, Philippe, Andrez, Jean-Christophe, Allan, Charlotte S.M.

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Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of NaV1.7 von Sun, Shaoyi, Chowdhury, Sultan, Hemeon, Ivan, Hasan, Abid, Wilson, Michael S., Bergeron, Phillipe, Jia, Qi, Zenova, Alla Y., Grimwood, Mike E., Gong, Wei, Decker, Shannon M., Bichler, Paul, Andrez, Jean-Christophe, Focken, Thilo, Ngyuen, Theresa, Zhu, Jiuxiang, White, Andrew D., Bankar, Girish, Howard, Sarah, Chang, Elaine, Khakh, Kuldip, Lin, Sophia, Dean, Richard, Johnson, J.P., Chang, Jae H., Hackos, David H., McKerrall, Steve J., Sellers, Ben, Ortwine, Dan F., Cohen, Charles J., Safina, Brian S., Sutherlin, Daniel P., Dehnhardt, Christoph M.

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Discovery of Acyl-sulfonamide Na v 1.7 Inhibitors GDC-0276 and GDC-0310 von Safina, Brian S, McKerrall, Steven J, Sun, Shaoyi, Chen, Chien-An, Chowdhury, Sultan, Jia, Qi, Li, Jun, Zenova, Alla Y, Andrez, Jean-Christophe, Bankar, Girish, Bergeron, Philippe, Chang, Jae H, Chang, Elaine, Chen, Jun, Dean, Richard, Decker, Shannon M, DiPasquale, Antonio, Focken, Thilo, Hemeon, Ivan, Khakh, Kuldip, Kim, Amy, Kwan, Rainbow, Lindgren, Andrea, Lin, Sophia, Maher, Jonathan, Mezeyova, Janette, Misner, Dinah, Nelkenbrecher, Karen, Pang, Jodie, Reese, Rebecca, Shields, Shannon D, Sojo, Luis, Sheng, Tao, Verschoof, Henry, Waldbrook, Matthew, Wilson, Michael S, Xie, Zhiwei, Young, Clint, Zabka, Tanja S, Hackos, David H, Ortwine, Daniel F, White, Andrew D, Johnson, Jr, J P, Robinette, C Lee, Dehnhardt, Christoph M, Cohen, Charles J, Sutherlin, Daniel P

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Identification of CNS-Penetrant Aryl Sulfonamides as Isoform-Selective Na V 1.6 Inhibitors with Efficacy in Mouse Models of Epilepsy von Focken, Thilo, Burford, Kristen, Grimwood, Michael E, Zenova, Alla, Andrez, Jean-Christophe, Gong, Wei, Wilson, Michael, Taron, Matt, Decker, Shannon, Lofstrand, Verner, Chowdhury, Sultan, Shuart, Noah, Lin, Sophia, Goodchild, Samuel J, Young, Clint, Soriano, Maegan, Tari, Parisa K, Waldbrook, Matthew, Nelkenbrecher, Karen, Kwan, Rainbow, Lindgren, Andrea, de Boer, Gina, Lee, Stephanie, Sojo, Luis, DeVita, Robert J, Cohen, Charles J, Wesolowski, Steven S, Johnson, Jr, J P, Dehnhardt, Christoph M, Empfield, James R

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Discovery of novel cyclopentane carboxylic acids as potent and selective inhibitors of Na V 1.7 von Sun, Shaoyi, Chowdhury, Sultan, Hemeon, Ivan, Hasan, Abid, Wilson, Michael S, Bergeron, Phillipe, Jia, Qi, Zenova, Alla Y, Grimwood, Mike E, Gong, Wei, Decker, Shannon M, Bichler, Paul, Andrez, Jean-Christophe, Focken, Thilo, Ngyuen, Theresa, Zhu, Jiuxiang, White, Andrew D, Bankar, Girish, Howard, Sarah, Chang, Elaine, Khakh, Kuldip, Lin, Sophia, Dean, Richard, Johnson, Jr, J P, Chang, Jae H, Hackos, David H, McKerrall, Steve J, Sellers, Ben, Ortwine, Dan F, Cohen, Charles J, Safina, Brian S, Sutherlin, Daniel P, Dehnhardt, Christoph M

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NBI-921352, a first-in-class, Na V 1.6 selective, sodium channel inhibitor that prevents seizures in Scn8a gain-of-function mice, and wild-type mice and rats von Johnson, J P, Focken, Thilo, Khakh, Kuldip, Tari, Parisa Karimi, Dube, Celine, Goodchild, Samuel J, Andrez, Jean-Christophe, Bankar, Girish, Bogucki, David, Burford, Kristen, Chang, Elaine, Chowdhury, Sultan, Dean, Richard, de Boer, Gina, Decker, Shannon, Dehnhardt, Christoph, Feng, Mandy, Gong, Wei, Grimwood, Michael, Hasan, Abid, Hussainkhel, Angela, Jia, Qi, Lee, Stephanie, Li, Jenny, Lin, Sophia, Lindgren, Andrea, Lofstrand, Verner, Mezeyova, Janette, Namdari, Rostam, Nelkenbrecher, Karen, Shuart, Noah Gregory, Sojo, Luis, Sun, Shaoyi, Taron, Matthew, Waldbrook, Matthew, Weeratunge, Diana, Wesolowski, Steven, Williams, Aaron, Wilson, Michael, Xie, Zhiwei, Yoo, Rhena, Young, Clint, Zenova, Alla, Zhang, Wei, Cutts, Alison J, Sherrington, Robin P, Pimstone, Simon N, Winquist, Raymond, Cohen, Charles J, Empfield, James R

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ChemInform Abstract: A Stereoselective Oxidative Polycyclization Process Mediated by a Hypervalent Iodine Reagent von Desjardins, Samuel, Andrez, Jean-Christophe, Canesi, Sylvain

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