Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy von Cristescu, Razvan, Mogg, Robin, Ayers, Mark, Albright, Andrew, Murphy, Erin, Yearley, Jennifer, Sher, Xinwei, Liu, Xiao Qiao, Lu, Hongchao, Nebozhyn, Michael, Zhang, Chunsheng, Lunceford, Jared K, Joe, Andrew, Cheng, Jonathan, Webber, Andrea L, Ibrahim, Nageatte, Plimack, Elizabeth R, Ott, Patrick A, Seiwert, Tanguy Y, Ribas, Antoni, McClanahan, Terrill K, Tomassini, Joanne E, Loboda, Andrey, Kaufman, David

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Comprehensive molecular characterization of clinical responses to PD-1 inhibition in metastatic gastric cancer von Kim, Seung Tae, Cristescu, Razvan, Bass, Adam J., Kim, Kyoung-Mee, Odegaard, Justin I., Kim, Kyung, Liu, Xiao Qiao, Sher, Xinwei, Jung, Hun, Lee, Mijin, Lee, Sujin, Park, Se Hoon, Park, Joon Oh, Park, Young Suk, Lim, Ho Yeong, Lee, Hyuk, Choi, Mingew, Talasaz, AmirAli, Kang, Peter Soonmo, Cheng, Jonathan, Loboda, Andrey, Lee, Jeeyun, Kang, Won Ki

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Cancer-Associated Fibroblasts Neutralize the Anti-tumor Effect of CSF1 Receptor Blockade by Inducing PMN-MDSC Infiltration of Tumors von Kumar, Vinit, Donthireddy, Laxminarasimha, Marvel, Douglas, Condamine, Thomas, Wang, Fang, Lavilla-Alonso, Sergio, Hashimoto, Ayumi, Vonteddu, Prashanthi, Behera, Reeti, Goins, Marlee A., Mulligan, Charles, Nam, Brian, Hockstein, Neil, Denstman, Fred, Shakamuri, Shanti, Speicher, David W., Weeraratna, Ashani T., Chao, Timothy, Vonderheide, Robert H., Languino, Lucia R., Ordentlich, Peter, Liu, Qin, Xu, Xiaowei, Lo, Albert, Puré, Ellen, Zhang, Chunsheng, Loboda, Andrey, Sepulveda, Manuel A., Snyder, Linda A., Gabrilovich, Dmitry I.

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An Unbiased Oncology Compound Screen to Identify Novel Combination Strategies von O'Neil, Jennifer, Benita, Yair, Feldman, Igor, Chenard, Melissa, Roberts, Brian, Liu, Yaping, Li, Jing, Kral, Astrid, Lejnine, Serguei, Loboda, Andrey, Arthur, William, Cristescu, Razvan, Haines, Brian B, Winter, Christopher, Zhang, Theresa, Bloecher, Andrew, Shumway, Stuart D

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Molecular insights into the pathogenesis of Alzheimer's disease and its relationship to normal aging von Podtelezhnikov, Alexei A, Tanis, Keith Q, Nebozhyn, Michael, Ray, William J, Stone, David J, Loboda, Andrey P

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A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC von Schell, Michael J., Yang, Mingli, Teer, Jamie K., Lo, Fang Yin, Madan, Anup, Coppola, Domenico, Monteiro, Alvaro N. A., Nebozhyn, Michael V., Yue, Binglin, Loboda, Andrey, Bien-Willner, Gabriel A., Greenawalt, Danielle M., Yeatman, Timothy J.

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Cancer-Associated Fibroblasts Promote Immunosuppression by Inducing ROS-Generating Monocytic MDSCs in Lung Squamous Cell Carcinoma von Xiang, Handan, Ramil, Carlo P., Hai, Josephine, Zhang, Chunsheng, Wang, Huijun, Watkins, Amanda A., Afshar, Roshi, Georgiev, Peter, Sze, Marc A., Song, Xuelei S., Curran, Patrick J., Cheng, Mangeng, Miller, J. Richard, Sun, Dongyu, Loboda, Andrey, Jia, Yanlin, Moy, Lily Y., Chi, An, Brandish, Philip E.

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Tumor mutational burden predicts the efficacy of pembrolizumab monotherapy: a pan-tumor retrospective analysis of participants with advanced solid tumors von Cristescu, Razvan, Aurora-Garg, Deepti, Albright, Andrew, Xu, Lei, Liu, Xiao Qiao, Loboda, Andrey, Lang, Lixin, Jin, Fan, Rubin, Eric H, Snyder, Alexandra, Lunceford, Jared

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Whole-genome sequencing identifies recurrent mutations in hepatocellular carcinoma von Kan, Zhengyan, Zheng, Hancheng, Liu, Xiao, Li, Shuyu, Barber, Thomas D, Gong, Zhuolin, Gao, Huan, Hao, Ke, Willard, Melinda D, Xu, Jiangchun, Hauptschein, Robert, Rejto, Paul A, Fernandez, Julio, Wang, Guan, Zhang, Qinghui, Wang, Bo, Chen, Ronghua, Wang, Jian, Lee, Nikki P, Zhou, Wei, Lin, Zhao, Peng, Zhiyu, Yi, Kang, Chen, Shengpei, Li, Lin, Fan, Xiaomei, Yang, Jie, Ye, Rui, Ju, Jia, Wang, Kai, Estrella, Heather, Deng, Shibing, Wei, Ping, Qiu, Ming, Wulur, Isabella H, Liu, Jiangang, Ehsani, Mariam E, Zhang, Chunsheng, Loboda, Andrey, Sung, Wing Kin, Aggarwal, Amit, Poon, Ronnie T, Fan, Sheung Tat, Wang, Jun, Hardwick, James, Reinhard, Christoph, Dai, Hongyue, Li, Yingrui, Luk, John M, Mao, Mao

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Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination von Fourati, Slim, Cristescu, Razvan, Loboda, Andrey, Talla, Aarthi, Filali, Ali, Railkar, Radha, Schaeffer, Andrea K., Favre, David, Gagnon, Dominic, Peretz, Yoav, Wang, I-Ming, Beals, Chan R., Casimiro, Danilo R., Carayannopoulos, Leonidas N., Sékaly, Rafick-Pierre

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Phase I Pharmacologic and Pharmacodynamic Study of the Gamma Secretase (Notch) Inhibitor MK-0752 in Adult Patients With Advanced Solid Tumors von KROP, Ian, DEMUTH, Tim, BLACKMAN, Samuel, WATTERS, James, LOBODA, Andrey, PODTELEZHNIKOV, Alexei, LUNCEFORD, Jared, CONG CHEN, GIANNOTTI, Maxine, HING, Jeremy, BECKMAN, Robert, LORUSSO, Patricia, GUTHRIE, Tina, WEN, Patrick Y, MASON, Warren P, CHINNAIYAN, Prakash, BUTOWSKI, Nicholas, GROVES, Morris D, KESARI, Santosh, FREEDMAN, Steven J

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ILT3 (LILRB4) Promotes the Immunosuppressive Function of Tumor-Educated Human Monocytic Myeloid-Derived Suppressor Cells von Singh, Latika, Muise, Eric S., Bhattacharya, Anannya, Grein, Jeff, Javaid, Sarah, Stivers, Peter, Zhang, Jun, Qu, Yujie, Joyce-Shaikh, Barbara, Loboda, Andrey, Zhang, Chunsheng, Meehl, Michael, Chiang, Derek Y., Ranganath, Sheila H., Rosenzweig, Michael, Brandish, Philip E.

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Functional genomics identifies therapeutic targets for MYC-driven cancer von Toyoshima, Masafumi, Howie, Heather L, Imakura, Maki, Walsh, Ryan M, Annis, James E, Chang, Aaron N, Frazier, Jason, Chau, B. Nelson, Loboda, Andrey, Linsley, Peter S, Cleary, Michele A, Park, Julie R, Grandori, Carla

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Quantitative Transcriptional Biomarkers of Xenobiotic Receptor Activation in Rat Liver for the Early Assessment of Drug Safety Liabilities von Podtelezhnikov, Alexei A, Monroe, James J, Aslamkhan, Amy G, Pearson, Kara, Qin, Chunhua, Tamburino, Alex M, Loboda, Andrey P, Glaab, Warren E, Sistare, Frank D, Tanis, Keith Q

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A gene expression signature of RAS pathway dependence predicts response to PI3K and RAS pathway inhibitors and expands the population of RAS pathway activated tumors von Loboda, Andrey, Nebozhyn, Michael, Klinghoffer, Rich, Frazier, Jason, Chastain, Michael, Arthur, William, Roberts, Brian, Zhang, Theresa, Chenard, Melissa, Haines, Brian, Andersen, Jannik, Nagashima, Kumiko, Paweletz, Cloud, Lynch, Bethany, Feldman, Igor, Dai, Hongyue, Huang, Pearl, Watters, James

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Comparative expression pathway analysis of human and canine mammary tumors von Uva, Paolo, Aurisicchio, Luigi, Watters, James, Loboda, Andrey, Kulkarni, Amit, Castle, John, Palombo, Fabio, Viti, Valentina, Mesiti, Giuseppe, Zappulli, Valentina, Marconato, Laura, Abramo, Francesca, Ciliberto, Gennaro, Lahm, Armin, La Monica, Nicola, de Rinaldis, Emanuele

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An integrative gene expression signature analysis identifies CMS4 KRAS-mutated colorectal cancers sensitive to combined MEK and SRC targeted therapy von Yang, Mingli, Davis, Thomas B, Pflieger, Lance, Nebozhyn, Michael V, Loboda, Andrey, Wang, Heiman, Schell, Michael J, Thota, Ramya, Pledger, W Jack, Yeatman, Timothy J

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Phase II Trial of Vorinostat in Recurrent Glioblastoma Multiforme: A North Central Cancer Treatment Group Study von GALANIS, Evanthia, JAECKLE, Kurt A, RICHON, Victoria M, SCHEITHAUER, Bernd, GIANNINI, Caterina, FLYNN, Patrick J, MOORE, Dennis F, ZWIEBEL, James, BUCKNER, Jan C, MAURER, Matthew J, REID, Joel M, AMES, Matthew M, HARDWICK, James S, REILLY, John F, LOBODA, Andrey, NEBOZHYN, Michael, FANTIN, Valeria R

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STUB1 is an intracellular checkpoint for interferon gamma sensing von Ng, Simon, Lim, Shuhui, Sim, Adrian Chong Nyi, Mangadu, Ruban, Lau, Ally, Zhang, Chunsheng, Martinez, Sarah Bollinger, Chandramohan, Arun, Lim, U-Ming, Ho, Samantha Shu Wen, Chang, Shih Chieh, Gopal, Pooja, Hong, Lewis Z., Schwaid, Adam, Fernandis, Aaron Zefrin, Loboda, Andrey, Li, Cai, Phan, Uyen, Henry, Brian, Partridge, Anthony W.

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Analysis of genomic targets reveals complex functions of MYC von McMahon, Steven B, Patel, Jagruti H, Loboda, Andrey P, Showe, Michael K, Showe, Louise C

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