Selective inhibition of tropomyosin-receptor-kinase A (TrkA) reduces pain and joint damage in two rat models of inflammatory arthritis von Ashraf, Sadaf, Bouhana, Karyn S, Pheneger, Jed, Andrews, Steven W, Walsh, David A

Volltext

Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227) von Seiwert, Scott D, Andrews, Steven W, Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P T Ravi, Misialek, Shawn, Stevens, Sarah K, Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R, Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R, Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P, Hartley, Dylan P, Josey, John A, Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M

Volltext

Inhibition and Binding Kinetics of the Hepatitis C Virus NS3 Protease Inhibitor ITMN-191 Reveals Tight Binding and Slow Dissociative Behavior von Rajagopalan, Ravi, Misialek, Shawn, Stevens, Sarah K, Myszka, David G, Brandhuber, Barbara J, Ballard, Joshua A, Andrews, Steven W, Seiwert, Scott D, Kossen, Karl

Volltext

Oncogenic and drug-sensitive NTRK1 rearrangements in lung cancer von Vaishnavi, Aria, Capelletti, Marzia, Le, Anh T, Kako, Severine, Butaney, Mohit, Ercan, Dalia, Mahale, Sakshi, Davies, Kurtis D, Aisner, Dara L, Pilling, Amanda B, Berge, Eamon M, Kim, Jhingook, Sasaki, Hidefumi, Park, Seung-il, Kryukov, Gregory, Garraway, Levi A, Hammerman, Peter S, Haas, Julia, Andrews, Steven W, Lipson, Doron, Stephens, Philip J, Miller, Vince A, Varella-Garcia, Marileila, Jänne, Pasi A, Doebele, Robert C

Volltext

Discovery of (1S,2R,3R)-2,3-Dimethyl-2-phenyl-1-sulfamidocyclopropanecarboxylates: Novel and Highly Selective Aggrecanase Inhibitors von Shiozaki, Makoto, Maeda, Katsuya, Miura, Tomoya, Kotoku, Masayuki, Yamasaki, Takayuki, Matsuda, Isamu, Aoki, Kenta, Yasue, Katsutaka, Imai, Hiroto, Ubukata, Minoru, Suma, Akira, Yokota, Masahiro, Hotta, Takahiro, Tanaka, Masahiro, Hase, Yasunori, Haas, Julia, Fryer, Andrew M, Laird, Ellen R, Littmann, Nicole M, Andrews, Steven W, Josey, John A, Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi

Volltext

Discovery of Danoprevir (ITMN-191/R7227), a Highly Selective and Potent Inhibitor of Hepatitis C Virus (HCV) NS3/4A Protease von Jiang, Yutong, Andrews, Steven W., Condroski, Kevin R., Buckman, Brad, Serebryany, Vlad, Wenglowsky, Steve, Kennedy, April L., Madduru, Machender R., Wang, Bin, Lyon, Michael, Doherty, George A., Woodard, Benjamin T., Lemieux, Christine, Do, Mary Geck, Zhang, Hailong, Ballard, Joshua, Vigers, Guy, Brandhuber, Barbra J., Stengel, Peter, Josey, John A., Beigelman, Leonid, Blatt, Lawrence, Seiwert, Scott D.

Volltext

Novel N-substituted 2-phenyl-1-sulfonylamino-cyclopropane carboxylates as selective ADAMTS-5 (Aggrecanase-2) inhibitors von SHIOZAKI, Makoto, MAEDA, Katsuya, MIMURA, Takayuki, SHINOZAKI, Yuichi, YOSHIUCHI, Hiromi, INABA, Takashi, MIURA, Tomoya, OGOSHI, Yosuke, HAAS, Julia, FRYER, Andrew M, LAIRD, Ellen R, LITTMANN, Nicole M, ANDREWS, Steven W, JOSEY, John A

Volltext

Sustained blockade of neurotrophin receptors TrkA, TrkB and TrkC reduces non-malignant skeletal pain but not the maintenance of sensory and sympathetic nerve fibers von Ghilardi, Joseph R, Freeman, Katie T, Jimenez-Andrade, Juan M, Mantyh, William G, Bloom, Aaron P, Bouhana, Karyn S, Trollinger, David, Winkler, James, Lee, Patrice, Andrews, Steven W, Kuskowski, Michael A, Mantyh, Patrick W

Volltext

Synthesis and SAR of 2-phenyl-1-sulfonylaminocyclopropane carboxylates as ADAMTS-5 (Aggrecanase-2) inhibitors von Shiozaki, Makoto, Imai, Hiroto, Maeda, Katsuya, Miura, Tomoya, Yasue, Katsutaka, Suma, Akira, Yokota, Masahiro, Ogoshi, Yosuke, Haas, Julia, Fryer, Andrew M., Laird, Ellen R., Littmann, Nicole M., Andrews, Steven W., Josey, John A., Mimura, Takayuki, Shinozaki, Yuichi, Yoshiuchi, Hiromi, Inaba, Takashi

Volltext

Loxo-305, a Highly Selective and Non-Covalent Next Generation BTK Inhibitor, Inhibits Diverse BTK C481 Substitution Mutations von Gomez, Eliana B., Isabel, Lippincott, Rosendahal, Mary S., Rothenberg, Stephen M., Andrews, Steven W., Brandhuber, Barb J.

Volltext

Abstract 1464: Pre-clinical characterization of potent and selective next-generation RET inhibitors von Kolakowski, Gabrielle R., Anderson, Erin D., Ballard, Joshua A., Brandhuber, Barbara J., Condroski, Kevin R., Gomez, Eliana B., Irvin, Thomas C., Kumar, Manoj, Patel, Nisha A., Watson, Faith D., Andrews, Steven W.

Volltext

Abstract P141: Preclinical characterization of LOX-24350, a highly potent and isoform-selective FGFR3 inhibitor von Ballard, Joshua A., Kercher, Timothy, Abraham, David, Brecht, Ryan, Brooks, Nathan A., Buckles, Thomas, Bume, Desta, Busha, David, Cedervall, Ernst Peder, Condroski, Kevin, Ebata, Kevin, Gharbi, Severine Isabelle, Hazlitt, Robert, Morales, Tony, Patel, Nisha, Podoll, Jessica, Urkalan, Kaveri, Villalain, Sandra Gomez, Walls, Shane, Watson, Faith, Yang, Peiyi, Brandhuber, Barbara J., Andrews, Steven W.

Volltext

Regiochemical control in the intramolecular addition of allylstannanes and allylsilanes to 2,3-epoxy ethers: preparation of functionalized oxepanes von Molander, Gary A, Andrews, Steven W

Volltext

Abstract P142: Preclinical characterization of LOX-22783, a highly potent, mutant-selective and brain-penetrant allosteric PI3Kα H1047R inhibitor von Klippel, Anke, Wang, Rui, Puca, Loredana, Faber, Andrew Lee, Shen, Weihua, Bhagwat, Shripad V., Karukurichi, Kannan, Zhang, Feiyu Fred, Perez, Carmen, Rama, Ramon, Ramos, Ana, Zheng, Yi, Bonday, Zahid, Thomas, James, Brooks, Harold B., Kindler, Lisa J., Bogner, Sarah M., Zolfaghari, Parisa, II, Mark Hicks, Callies, Sophie, Mattioni, Brian, LeBrun, Laurie, Durbin, Jim, Anderson, Erin, Mayne, Chris, Kesicki, Edward, Kolakowski, Gabrielle, Andrews, Steven W., Brandhuber, Barbara J.

Volltext

NTRK1 gene fusions as a novel oncogene target in lung cancer von Doebele, Robert Charles, Vaishnavi, Aria, Capelletti, Marzia, Le, Anh T., Kako, Severine, Butaney, Mohit, Mahale, Sakshi, Aisner, Dara L., Haas, Julia, Andrews, Steven W., Lipson, Doron, Stephens, Philip J., Varella-Garcia, Marileila, Janne, Pasi Antero, Miller, Vincent A.

Volltext

METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS von Zhang, Gan, Andrews, Steven W, Jiang, Yutong, Haas, Julia

Volltext bestellen

Chelation control in the intramolecular addition of allylsilanes to carbonyl electrophiles von Molander, Gary A., Andrews, Steven W.

Volltext

METHOD OF TREATMENT USING SUBSTITUTED PYRAZOLO[1,5-A] PYRIMIDINE COMPOUNDS von Zhang, Gan, Andrews, Steven W, Jiang, Yutong, Haas, Julia

Volltext bestellen

PREPARATION OF (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)PYRROLIDIN-1-YL)PYRAZOLO[1,5-A]PYRIMIDIN-3-Y L)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE von YUTONG JIANG, BRUNO HACHE, STEVEN W ANDREWS, MARK REYNOLDS, STACEY SPENCER, DERRICK JUENGST, JULIA HAAS

Volltext bestellen

Chelation-controlled cyclization of β-ketoester-substituted and β-ketoamide-substituted allylsilanes von Molander, Gary A, Andrews, Steven W

Volltext