ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets von Souers, Andrew J, Leverson, Joel D, Boghaert, Erwin R, Ackler, Scott L, Catron, Nathaniel D, Chen, Jun, Dayton, Brian D, Ding, Hong, Enschede, Sari H, Fairbrother, Wayne J, Huang, David C S, Hymowitz, Sarah G, Jin, Sha, Khaw, Seong Lin, Kovar, Peter J, Lam, Lloyd T, Lee, Jackie, Maecker, Heather L, Marsh, Kennan C, Mason, Kylie D, Mitten, Michael J, Nimmer, Paul M, Oleksijew, Anatol, Park, Chang H, Park, Cheol-Min, Phillips, Darren C, Roberts, Andrew W, Sampath, Deepak, Seymour, John F, Smith, Morey L, Sullivan, Gerard M, Tahir, Stephen K, Tse, Chris, Wendt, Michael D, Xiao, Yu, Xue, John C, Zhang, Haichao, Humerickhouse, Rod A, Rosenberg, Saul H, Elmore, Steven W

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MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor von Xiao, Yu, Nimmer, Paul, Sheppard, George S, Bruncko, Milan, Hessler, Paul, Lu, Xin, Roberts-Rapp, Lisa, Pappano, William N, Elmore, Steven W, Souers, Andrew J, Leverson, Joel D, Phillips, Darren C

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Clearance of therapy-induced senescent tumor cells by the senolytic ABT-263 via interference with BCL-X-L-BAX interaction von Saleh, Tareq, Carpenter, Valerie J., Tyutyunyk-Massey, Liliya, Murray, Graeme, Leverson, Joel D., Souers, Andrew J., Alotaibi, Moureq R., Faber, Anthony C., Reed, Jason, Harada, Hisashi, Gewirtz, David A.

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Found in Translation: How Preclinical Research Is Guiding the Clinical Development of the BCL2-Selective Inhibitor Venetoclax von Leverson, Joel D, Sampath, Deepak, Souers, Andrew J, Rosenberg, Saul H, Fairbrother, Wayne J, Amiot, Martine, Konopleva, Marina, Letai, Anthony

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New era for myelofibrosis treatment with novel agents beyond Janus kinase‐inhibitor monotherapy: Focus on clinical development of BCL‐XL/BCL‐2 inhibition with navitoclax von Pemmaraju, Naveen, Garcia, Jacqueline S, Perkins, Andrew, Harb, Jason G, Souers, Andrew J, Werner, Michael E, Brown, Christopher M, Passamonti, Francesco

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Increased Synthesis of MCL-1 Protein Underlies Initial Survival of EGFR -Mutant Lung Cancer to EGFR Inhibitors and Provides a Novel Drug Target von Song, Kyung-A, Hosono, Yasuyuki, Turner, Crystal, Jacob, Sheeba, Lochmann, Timothy L, Murakami, Yoshiko, Patel, Neha U, Ham, Jungoh, Hu, Bin, Powell, Krista M, Coon, Colin M, Windle, Brad E, Oya, Yuko, Koblinski, Jennifer E, Harada, Hisashi, Leverson, Joel D, Souers, Andrew J, Hata, Aaron N, Boikos, Sosipatros, Yatabe, Yasushi, Ebi, Hiromichi, Faber, Anthony C

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Integrated molecular and functional characterization of the intrinsic apoptotic machinery identifies therapeutic vulnerabilities in glioma von Fernandez, Elizabeth G., Mai, Wilson X., Song, Kai, Bayley, Nicholas A., Kim, Jiyoon, Zhu, Henan, Pioso, Marissa, Young, Pauline, Andrasz, Cassidy L., Cadet, Dimitri, Liau, Linda M., Li, Gang, Yong, William H., Rodriguez, Fausto J., Dixon, Scott J., Souers, Andrew J., Li, Jingyi Jessica, Graeber, Thomas G., Cloughesy, Timothy F., Nathanson, David A.

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A novel CDK9 inhibitor increases the efficacy of venetoclax (ABT-199) in multiple models of hematologic malignancies von Phillips, Darren C., Jin, Sha, Gregory, Gareth P., Zhang, Qi, Xue, John, Zhao, Xiaoxian, Chen, Jun, Tong, Yunsong, Zhang, Haichao, Smith, Morey, Tahir, Stephen K., Clark, Rick F., Penning, Thomas D., Devlin, Jennifer R., Shortt, Jake, Hsi, Eric D., Albert, Daniel H., Konopleva, Marina, Johnstone, Ricky W., Leverson, Joel D., Souers, Andrew J.

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Structure-Guided Design of a Series of MCL‑1 Inhibitors with High Affinity and Selectivity von Bruncko, Milan, Wang, Le, Sheppard, George S, Phillips, Darren C, Tahir, Stephen K, Xue, John, Erickson, Scott, Fidanze, Steve, Fry, Elizabeth, Hasvold, Lisa, Jenkins, Gary J, Jin, Sha, Judge, Russell A, Kovar, Peter J, Madar, David, Nimmer, Paul, Park, Chang, Petros, Andrew M, Rosenberg, Saul H, Smith, Morey L, Song, Xiaohong, Sun, Chaohong, Tao, Zhi-Fu, Wang, Xilu, Xiao, Yu, Zhang, Haichao, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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MCL1 nuclear translocation induces chemoresistance in colorectal carcinoma von Fu, Dechen, Pfannenstiel, Luke, Demelash, Abeba, Phoon, Yee Peng, Mayell, Cameron, Cabrera, Claudia, Liu, Caini, Zhao, Junjie, Dermawan, Josephine, Patil, Deepa, DeVecchio, Jennifer, Kalady, Matthew, Souers, Andrew J., Phillips, Darren C., Li, Xiaoxia, Gastman, Brian

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Acquired resistance to venetoclax (ABT-199) in t(14;18) positive lymphoma cells von Bodo, Juraj, Zhao, Xiaoxian, Durkin, Lisa, Souers, Andrew J, Phillips, Darren C, Smith, Mitchell R, Hsi, Eric D

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Enabling, Decagram-Scale Synthesis of Macrocyclic MCL‑1 Inhibitor ABBV-467 von Brady, Patrick B., Sorensen, Bryan K., Risi, Roberto M., Curtin, Michael L., Mantei, Robert A., Florjancic, Alan S., Mastracchio, Anthony, Ji, Cheng, Kunzer, Aaron R., Lai, Chunqiu, Storer, Gregory E., Chan, Vincent S., Henry, Rodger F., Souers, Andrew J., Michaelides, Michael R., Judd, Andrew S., Hansen, T. Matthew

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Discovery of a Potent and Selective BCL‑XL Inhibitor with in Vivo Activity von Tao, Zhi-Fu, Hasvold, Lisa, Wang, Le, Wang, Xilu, Petros, Andrew M, Park, Chang H, Boghaert, Erwin R, Catron, Nathaniel D, Chen, Jun, Colman, Peter M, Czabotar, Peter E, Deshayes, Kurt, Fairbrother, Wayne J, Flygare, John A, Hymowitz, Sarah G, Jin, Sha, Judge, Russell A, Koehler, Michael F. T, Kovar, Peter J, Lessene, Guillaume, Mitten, Michael J, Ndubaku, Chudi O, Nimmer, Paul, Purkey, Hans E, Oleksijew, Anatol, Phillips, Darren C, Sleebs, Brad E, Smith, Brian J, Smith, Morey L, Tahir, Stephen K, Watson, Keith G, Xiao, Yu, Xue, John, Zhang, Haichao, Zobel, Kerry, Rosenberg, Saul H, Tse, Chris, Leverson, Joel D, Elmore, Steven W, Souers, Andrew J

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Venetoclax-based Rational Combinations are Effective in Models of MYCN-amplified Neuroblastoma von Dalton, Krista M., Krytska, Kateryna, Lochmann, Timothy L., Sano, Renata, Casey, Colleen, D'Aulerio, Alessia, Khan, Qasim A., Crowther, Giovanna Stein, Coon, Colin, Cai, Jinyang, Jacob, Sheeba, Kurupi, Richard, Hu, Bin, Dozmorov, Mikhail, Greninger, Patricia, Souers, Andrew J., Benes, Cyril H., Mosse, Yael P., Faber, Anthony C.

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The role of lymphatic transport on the systemic bioavailability of the Bcl-2 protein family inhibitors navitoclax (ABT-263) and ABT-199 von Choo, Edna F, Boggs, Jason, Zhu, Chunqiang, Lubach, Joseph W, Catron, Nathaniel D, Jenkins, Gary, Souers, Andrew J, Voorman, Richard

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Coamplification of miR-4728 protects HER2-amplified breast cancers from targeted therapy von Floros, Konstantinos V., Lochmann, Timothy L., Hu, Bin, Monterrubio, Carles, Hughes, Mark T., Wells, Jason D., Morales, Cristina Bernadó, Ghotra, Maninderjit S., Costa, Carlotta, Souers, Andrew J., Boikos, Sosipatros A., Leverson, Joel D., Tan, Ming, Serra, Violeta, Koblinski, Jennifer E., Arribas, Joaquin, Prat, Aleix, Paré, Laia, Miller, Todd W., Dozmorov, Mikhail G., Harada, Hisashi, Windle, Brad E., Scaltriti, Maurizio, Faber, Anthony C.

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Selective MCL-1 inhibitor ABBV-467 is efficacious in tumor models but is associated with cardiac troponin increases in patients von Yuda, Junichiro, Will, Christine, Phillips, Darren C., Abraham, Linu, Alvey, Cory, Avigdor, Abraham, Buck, Wayne, Besenhofer, Lauren, Boghaert, Erwin, Cheng, Dong, Cojocari, Dan, Doyle, Kelly, Hansen, T. Matthew, Huang, Kevin, Johnson, Eric F., Judd, Andrew S., Judge, Russell A., Kalvass, John C., Kunzer, Aaron, Lam, Lloyd T., Li, Rachel, Martin, Ruth L., Mastracchio, Anthony, Mitten, Mike, Petrich, Adam, Wang, Jin, Ward, James E., Zhang, Haichao, Wang, Xilu, Wolff, Johannes E., Bell-McGuinn, Katherine M., Souers, Andrew J.

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Expanding the Repertoire for "Large Small Molecules": Prodrug ABBV-167 Efficiently Converts to Venetoclax with Reduced Food Effect in Healthy Volunteers von Salem, Ahmed Hamed, Tao, Zhi-Fu, Bueno, Orlando F., Chen, Jie, Chen, Shuang, Edalji, Rohinton, Elmore, Steven W., Fournier, Keith M., Harper, Kaid C., Hong, Richard, Jenkins, Gary J., Ji, Jianguo, Judge, Russell A., Kalvass, John C., Klix, Russell C., Ku, Yi-Yin, Leverson, Joel D., Marks, Richard A., Marsh, Kennan C., Menon, Rajeev M., Park, Chang H., Phillips, Darren C., Pu, Yu-Ming, Rosenberg, Saul H., Sanzgiri, Yeshwant D., Sheikh, Ahmad Y., Shi, Yi, Stolarik, Deanne, Suleiman, Ahmed A., Wang, Xilu, Zhang, Geoff G. Z., Catron, Nathaniel D., Souers, Andrew J.

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Structure-Based Design of A-1293102, a Potent and Selective BCL-X-L Inhibitor von Tao, Zhi-Fu, Wang, Xilu, Chen, Jun, Ingram, Justin P., Jin, Sha, Judge, Russell A., Kovar, Peter J., Park, Chang, Sun, Chaohong, Wakefield, Brian D., Zhou, Li, Zhang, Haichao, Elmore, Steven W., Phillips, Darren C., Judd, Andrew S., Leverson, Joel D., Souers, Andrew J.

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Unmasking BCL-2 Addiction in Synovial Sarcoma by Overcoming Low NOXA von Fairchild, Carter K., Floros, Konstantinos V., Jacob, Sheeba, Coon, Colin M., Puchalapalli, Madhavi, Hu, Bin, Harada, Hisashi, Dozmorov, Mikhail G., Koblinski, Jennifer E., Smith, Steven C., Domson, Gregory, Leverson, Joel D., Souers, Andrew J., Takebe, Naoko, Ebi, Hiromichi, Faber, Anthony C., Boikos, Sosipatros A.

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