Impact of the Natural Compound Urolithin A on Health, Disease, and Aging von D’Amico, Davide, Andreux, Pénélope A., Valdés, Pamela, Singh, Anurag, Rinsch, Chris, Auwerx, Johan

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents von Ryu, Dongryeol, Mouchiroud, Laurent, Andreux, Pénélope A, Katsyuba, Elena, Moullan, Norman, Nicolet-dit-Félix, Amandine A, Williams, Evan G, Jha, Pooja, Lo Sasso, Giuseppe, Huzard, Damien, Aebischer, Patrick, Sandi, Carmen, Rinsch, Chris, Auwerx, Johan

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Urolithin A improves mitochondrial health, reduces cartilage degeneration, and alleviates pain in osteoarthritis von D'Amico, Davide, Olmer, Merissa, Fouassier, Andréane M., Valdés, Pamela, Andreux, Pénélope A., Rinsch, Chris, Lotz, Martin

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The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans von Andreux, Pénélope A., Blanco-Bose, William, Ryu, Dongryeol, Burdet, Frédéric, Ibberson, Mark, Aebischer, Patrick, Auwerx, Johan, Singh, Anurag, Rinsch, Chris

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Direct supplementation with Urolithin A overcomes limitations of dietary exposure and gut microbiome variability in healthy adults to achieve consistent levels across the populatio... von Singh, Anurag, D’Amico, Davide, Andreux, Pénélope A., Dunngalvin, Gillian, Kern, Timo, Blanco-Bose, William, Auwerx, Johan, Aebischer, Patrick, Rinsch, Chris

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Expansion of T memory stem cells with superior anti-tumor immunity by Urolithin A-induced mitophagy von Denk, Dominic, Petrocelli, Valentina, Conche, Claire, Drachsler, Moritz, Ziegler, Paul K., Braun, Angela, Kress, Alena, Nicolas, Adele M., Mohs, Kathleen, Becker, Christoph, Neurath, Markus F., Farin, Henner F., Buchholz, Christian J., Andreux, Pénélope A., Rinsch, Chris, Greten, Florian R.

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Urolithin A improves muscle strength, exercise performance, and biomarkers of mitochondrial health in a randomized trial in middle-aged adults von Singh, Anurag, D’Amico, Davide, Andreux, Pénélope A., Fouassier, Andréane M., Blanco-Bose, William, Evans, Mal, Aebischer, Patrick, Auwerx, Johan, Rinsch, Chris

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Pharmacological approaches to restore mitochondrial function von Andreux, Pénélope A., Houtkooper, Riekelt H., Auwerx, Johan

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The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity von Cantó, Carles, Houtkooper, Riekelt H., Pirinen, Eija, Youn, Dou Y., Oosterveer, Maaike H., Cen, Yana, Fernandez-Marcos, Pablo J., Yamamoto, Hiroyasu, Andreux, Pénélope A., Cettour-Rose, Philippe, Gademann, Karl, Rinsch, Chris, Schoonjans, Kristina, Sauve, Anthony A., Auwerx, Johan

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Systems Genetics of Metabolism: The Use of the BXD Murine Reference Panel for Multiscalar Integration of Traits von Andreux, Pénélope A., Williams, Evan G., Koutnikova, Hana, Houtkooper, Riekelt H., Champy, Marie-France, Henry, Hugues, Schoonjans, Kristina, Williams, Robert W., Auwerx, Johan

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Bioavailable copper modulates oxidative phosphorylation and growth of tumors von Ishida, Seiko, Andreux, Pénélope, Poitry-Yamate, Carole, Auwerx, Johan, Hanahan, Douglas

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MicroRNA‐382 silencing induces a mitonuclear protein imbalance and activates the mitochondrial unfolded protein response in muscle cells von Dahlmans, Dennis, Houzelle, Alexandre, Andreux, Pénélope, Wang, Xu, Jörgensen, Johanna A., Moullan, Norman, Daemen, Sabine, Kersten, Sander, Auwerx, Johan, Hoeks, Joris

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Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial proteins without affecting global metabolic homeostasis von Fernandez-Marcos, Pablo J., Jeninga, Ellen H., Canto, Carles, Harach, Taoufiq, de Boer, Vincent C. J., Andreux, Penelope, Moullan, Norman, Pirinen, Eija, Yamamoto, Hiroyasu, Houten, Sander M., Schoonjans, Kristina, Auwerx, Johan

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The metabolic footprint of aging in mice von Houtkooper, Riekelt H., Argmann, Carmen, Houten, Sander M., Cantó, Carles, Jeninga, Ellen H., Andreux, Pénélope A., Thomas, Charles, Doenlen, Raphaël, Schoonjans, Kristina, Auwerx, Johan

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Safety assessment of Urolithin A, a metabolite produced by the human gut microbiota upon dietary intake of plant derived ellagitannins and ellagic acid von Heilman, Jacqueline, Andreux, Pénélope, Tran, Nga, Rinsch, Chris, Blanco-Bose, William

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Genetically altering organismal metabolism by leptin-deficiency benefits a mouse model of amyotrophic lateral sclerosis von Lim, Maria A, Bence, Kendra K, Sandesara, Ishani, Andreux, Pénélope, Auwerx, Johan, Ishibashi, Jeff, Seale, Patrick, Kalb, Robert G

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An evolutionarily conserved role for the aryl hydrocarbon receptor in the regulation of movement von Williams, Evan G, Mouchiroud, Laurent, Frochaux, Michael, Pandey, Ashutosh, Andreux, Pénélope A, Deplancke, Bart, Auwerx, Johan

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Murine gut microbiota is defined by host genetics and modulates variation of metabolic traits von McKnite, Autumn M, Perez-Munoz, Maria Elisa, Lu, Lu, Williams, Evan G, Brewer, Simon, Andreux, Pénélope A, Bastiaansen, John W M, Wang, Xusheng, Kachman, Stephen D, Auwerx, Johan, Williams, Robert W, Benson, Andrew K, Peterson, Daniel A, Ciobanu, Daniel C

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Mitochondrial function is impaired in the skeletal muscle of pre-frail elderly von Andreux, Pénélope A., van Diemen, Marcus P. J., Heezen, Maxime R., Auwerx, Johan, Rinsch, Chris, Groeneveld, Geert Jan, Singh, Anurag

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A method to identify and validate mitochondrial modulators using mammalian cells and the worm C. elegans von Andreux, Pénélope A., Mouchiroud, Laurent, Wang, Xu, Jovaisaite, Virginija, Mottis, Adrienne, Bichet, Sabrina, Moullan, Norman, Houtkooper, Riekelt H., Auwerx, Johan

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