BET bromodomain inhibition suppresses TH17-mediated pathology von Mele, Deanna A, Salmeron, Andres, Ghosh, Srimoyee, Huang, Hon-Ren, Bryant, Barbara M, Lora, Jose M

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1059 Spatial analysis of tumor infiltrating lymphocyte populations in syngeneic mouse tumor models after treatment with IL-12 (mWTX-330) and IL-2 (WTX-124) INDUKINETM molecules von Nirschl, Christopher J, Brodkin, Heather R, Hicklin, Daniel J, Seidel-Dugan, Cynthia, Steuert, Zoe, Winston, William M, Salmeron, Andres

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1058 Optimal antitumor immunity triggered by WTX-124, a clinical stage conditionally activated INDUKINETM molecule that releases fully potent IL-2 in the tumor microenvironment von Nirschl, Christopher J, Brodkin, Heather R, Hicklin, Daniel J, Ismail, Nesreen, Lewis, Yuka, Seidel-Dugan, Cynthia, Steuert, Zoe, Sullivan, Jenna M, Winston, William M, Salmeron, Andres

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1075 Development of WTX-712, a conditionally active IL-21 INDUKINETM molecule for the treatment of cancer von Sullivan, Jenna M, Aderhold, Pam, Brodkin, Heather R, Nagy-Domonkos, Celesztina, Economides, Kyriakos, Hicklin, Daniel J, Ismail, Nesreen, Seidel-Dugan, Cynthia, Winston, William M, Salmeron, Andres

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1074 PK/RO modeling of WTX-124, a tumor-activated IL-2 prodrug, highlights the potential for a substantially improved therapeutic index compared to other IL-2 molecules von Subramanian, Kulandayan K, Chopra, Sameer, Morris, Kristin, Nirschl, Christopher J, Domonkos, Celesztina, Economides, Kyriakos, Salmeron, Andres, Seidel-Dugan, Cynthia, Isaacs, Randi, Hicklin, Daniel J

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252 The combination of ACT and INDUKINE therapy leads to improved antitumor immunity in solid tumors von Dwyer, Connor J, Brodkin, Heather R, Donovan, Olivia G, Economides, Kyriakos, Hicklin, Daniel J, LePrevost, Julie, Morris, Kristin, Seidel-Dugan, Cynthia, Winston, William M, Salmeron, Andres

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715 WTX-330 is an IL-12 pro-drug that is conditionally activated within the tumor microenvironment and induces regressions in mouse tumor models von Morris, Kristin, Brodkin, Heather, Hicklin, Daniel, Ismail, Nesreen, Nirschl, Christopher, Salmeron, Andres, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna, Winston, William

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Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody von Shirasuna, Kenna, Koelsch, Gerald, Seidel-Dugan, Cynthia, Salmeron, Andres, Steiner, Philipp, Winston, William M, Brodkin, Heather R, Nirschl, Christopher J, Abbott, Sandra, Kinugasa, Fumitaka, Sugahara, Shingo, Ohori, Makoto, Takeuchi, Masahiro, Hicklin, Daniel J, Yoshida, Taku

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718 WTX-124 is a novel IL-2 pro-drug that is conditionally activated in tumors and drives antitumor immunity in murine syngeneic cancer models von Nirschl, Christopher, Brodkin, Heather, Hicklin, Daniel, Ismail, Nesreen, Morris, Kristin, Salmeron, Andres, Seidel-Dugan, Cindy, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna, Winston, William

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723 WTX-613, a conditionally activated IFNα INDUKINE™ molecule, induces anti-tumor immune responses resulting in strong tumor growth control in syngeneic mouse tumor models von Tyagi, Ethika, Brodkin, Heather, Canales, Josue, Hicklin, Dan, Ismail, Nesreen, Morris, Kristin, Nirschl, Christopher, Salmeron, Andres, Seidel-Dugan, Cindy, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna, Winston, William

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βTrCP-Mediated Proteolysis of NF-κB1 p105 Requires Phosphorylation of p105 Serines 927 and 932 von Lang, Valerie, Janzen, Julia, Fischer, Gregory Zvi, Soneji, Yasmina, Beinke, Sören, Salmeron, Andres, Allen, Hamish, Hay, Ronald T., Ben-Neriah, Yinon, Ley, Steven C.

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Abstract 1716: WTX-330, a conditionally activated IL-12 INDUKINE, releases IL-12 selectively in the tumor microenvironment to activate anti-tumor immune responses and induce regres... von Steiner, Philipp, Brodkin, Heather, Hicklin, Dan, Ismail, Nesreen, Morris, Kristin, Nirschl, Christopher, Salmeron, Andres, Seidel-Dugan, Cindy, Steuert, Zoe, Sullivan, Jenna, Winston, William

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Abstract 1723: WTX-124 is an IL-2 pro-drug conditionally activated in tumors and able to induce complete regressions in mouse tumor models von Salmeron, Andres, Brodkin, Heather, Hicklin, Daniel, Ismail, Nesreen, Morris, Kristin, Nirschl, Christopher, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna, Winston, William

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Conditionally Activated IL-12 or IFNα Indukine™ Molecules Inhibit Syngeneic Lymphoma Tumor Growth in Mice, Induce Anti-Tumor Immune Responses and Are Tolerated in Non-Human Primate... von Steiner, Philipp, Brodkin, Heather, Canales, Josue, Hicklin, Daniel, Isaacs, Randi, Ismail, Nesreen, Morris, Kristin, Nirschl, Christopher, Salmeron, Andres, Seidel-Dugan, Cindy, Steuert, Zoe, Sullivan, Jenna, Tyagi, Ethika, Winston, William

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Discovery of a Conditionally Activated IL-2 that Promotes Antitumor Immunity and Induces Tumor Regression von Nirschl, Christopher J, Brodkin, Heather R, Hicklin, Daniel J, Ismail, Nesreen, Morris, Kristin, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna M, Tyagi, Ethika, Winston, William M, Salmeron, Andres

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Regulatory T Cell Modulation by CBP/EP300 Bromodomain Inhibition von Ghosh, Srimoyee, Taylor, Alexander, Chin, Melissa, Huang, Hon-Ren, Conery, Andrew R., Mertz, Jennifer A., Salmeron, Andres, Dakle, Pranal J., Mele, Deanna, Cote, Alexandre, Jayaram, Hari, Setser, Jeremy W., Poy, Florence, Hatzivassiliou, Georgia, DeAlmeida-Nagata, Denise, Sandy, Peter, Hatton, Charlie, Romero, F. Anthony, Chiang, Eugene, Reimer, Thornik, Crawford, Terry, Pardo, Eneida, Watson, Venita G., Tsui, Vickie, Cochran, Andrea G., Zawadzke, Laura, Harmange, Jean-Christophe, Audia, James E., Bryant, Barbara M., Cummings, Richard T., Magnuson, Steven R., Grogan, Jane L., Bellon, Steve F., Albrecht, Brian K., Sims, Robert J., Lora, Jose M.

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Abstract 2727: The discovery and characterization of PTZ-201, a fully-human, high affinity, antagonistic anti-TIGIT monoclonal antibody von Abbott, Sandra, Anderson, Ana C., Brodkin, Heather, Hicklin, Daniel J., Ismail, Nesreen, Nielson, Nels, Nirschl, Christopher, Salmeron, Andres, Seidel-Dugan, Cynthia, Steiner, Philipp, Winston, William

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Bromodomain and Extra-Terminal Protein Inhibition Attenuates Neutrophil-dominant Allergic Airway Disease von Manni, Michelle L., Mandalapu, Sivanarayana, Salmeron, Andres, Lora, Jose M., Kolls, Jay K., Alcorn, John F.

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mWTX-330, an IL-12 INDUKINE Molecule, Activates and Reshapes Tumor-Infiltrating CD8+ T and NK Cells to Generate Antitumor Immunity von Nirschl, Christopher J, Brodkin, Heather R, Domonkos, Celesztina, Dwyer, Connor J, Hicklin, Daniel J, Ismail, Nesreen, Seidel-Dugan, Cynthia, Steiner, Philipp, Steuert, Zoe, Sullivan, Jenna M, Winston, William M, Salmeron, Andres

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Abstract 1829: Generation of IL-21 INDUKINETM molecules for the treatment of cancer von Sullivan, Jenna M., Aderhold, Pamela A., Brodkin, Heather R., Economides, Kyriakos, Hicklin, Daniel J., Ismail, Nesreen, Lewis, Yuka, Seidel-Dugan, Cynthia, Spencer, Cierra, Winston, William M., Salmeron, Andres

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