Specificity in Transition State Binding: The Pauling Model Revisited von Amyes, Tina L, Richard, John P

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Orotidine 5′-Monophosphate Decarboxylase: Probing the Limits of the Possible for Enzyme Catalysis von Richard, John P, Amyes, Tina L, Reyes, Archie C

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Enzymatic Catalysis of Proton Transfer at Carbon:  Activation of Triosephosphate Isomerase by Phosphite Dianion von Amyes, Tina L, Richard, John P

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Proton Transfer from C‑6 of Uridine 5′-Monophosphate Catalyzed by Orotidine 5′-Monophosphate Decarboxylase: Formation and Stability of a Vinyl Carbanion Intermediate and the Effect... von Tsang, Wing-Yin, Wood, B. McKay, Wong, Freeman M, Wu, Weiming, Gerlt, John A, Amyes, Tina L, Richard, John P

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OMP Decarboxylase: Phosphodianion Binding Energy Is Used To Stabilize a Vinyl Carbanion Intermediate von Goryanova, Bogdana, Amyes, Tina L, Gerlt, John A, Richard, John P

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Orotidine 5′-Monophosphate Decarboxylase: Transition State Stabilization from Remote Protein–Phosphodianion Interactions von Amyes, Tina L, Ming, Shonoi A, Goldman, Lawrence M, Wood, B. McKay, Desai, Bijoy J, Gerlt, John A, Richard, John P

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Enzyme architecture: on the importance of being in a protein cage von Richard, John P, Amyes, Tina L, Goryanova, Bogdana, Zhai, Xiang

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Formation and Stability of a Vinyl Carbanion at the Active Site of Orotidine 5‘-Monophosphate Decarboxylase:  pKa of the C-6 Proton of Enzyme-Bound UMP von AMYES, Tina L., WOOD, Bryant M., CHAN, Kui, GERLT, John A., RICHARD, John P.

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Activation of Orotidine 5‘-Monophosphate Decarboxylase by Phosphite Dianion:  The Whole Substrate is the Sum of Two Parts von Amyes, Tina L, Richard, John P, Tait, James J

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Linear Free Energy Relationships for Enzymatic Reactions: Fresh Insight from a Venerable Probe von Richard, John P., Cristobal, Judith R., Amyes, Tina L.

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A role for flexible loops in enzyme catalysis von Malabanan, M Merced, Amyes, Tina L, Richard, John P

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Role of the Carboxylate in Enzyme-Catalyzed Decarboxylation of Orotidine 5′-Monophosphate: Transition State Stabilization Dominates Over Ground State Destabilization von Goryanova, Bogdana, Amyes, Tina L, Richard, John P

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Mechanism of the Orotidine 5′-Monophosphate Decarboxylase-Catalyzed Reaction: Evidence for Substrate Destabilization von Chan, Kui K, Wood, B. McKay, Fedorov, Alexander A, Fedorov, Elena V, Imker, Heidi J, Amyes, Tina L, Richard, John P, Almo, Steven C, Gerlt, John A

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Role of Loop-Clamping Side Chains in Catalysis by Triosephosphate Isomerase von Zhai, Xiang, Amyes, Tina L, Richard, John P

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Enzyme Architecture: The Role of a Flexible Loop in Activation of Glycerol-3-phosphate Dehydrogenase for Catalysis of Hydride Transfer von He, Rui, Reyes, Archie C, Amyes, Tina L, Richard, John P

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Activation of R235A Mutant Orotidine 5′-Monophosphate Decarboxylase by the Guanidinium Cation: Effective Molarity of the Cationic Side Chain of Arg-235 von Barnett, Shonoi A, Amyes, Tina L, McKay Wood, B, Gerlt, John A, Richard, John P

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Enzyme Architecture: Amino Acid Side-Chains That Function To Optimize the Basicity of the Active Site Glutamate of Triosephosphate Isomerase von Zhai, Xiang, Reinhardt, Christopher J, Malabanan, M. Merced, Amyes, Tina L, Richard, John P

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Phosphodianion Activation of Enzymes for Catalysis of Central Metabolic Reactions von Fernandez, Patrick L, Nagorski, Richard W, Cristobal, Judith R, Amyes, Tina L, Richard, John P

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Primary Deuterium Kinetic Isotope Effects: A Probe for the Origin of the Rate Acceleration for Hydride Transfer Catalyzed by Glycerol-3-Phosphate Dehydrogenase von Reyes, Archie C, Amyes, Tina L, Richard, John P

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Conformational Changes in Orotidine 5′-Monophosphate Decarboxylase: A Structure-Based Explanation for How the 5′-Phosphate Group Activates the Enzyme von Desai, Bijoy J, Wood, B. McKay, Fedorov, Alexander A, Fedorov, Elena V, Goryanova, Bogdana, Amyes, Tina L, Richard, John P, Almo, Steven C, Gerlt, John A

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