Acute Respiratory Distress Syndrome Neutrophils Have a Distinct Phenotype and Are Resistant to Phosphoinositide 3-Kinase Inhibition von Juss, Jatinder K, House, David, Amour, Augustin, Begg, Malcolm, Herre, Jurgen, Storisteanu, Daniel M L, Hoenderdos, Kim, Bradley, Glyn, Lennon, Mark, Summers, Charlotte, Hessel, Edith M, Condliffe, Alison, Chilvers, Edwin R

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The 5-Phosphatase SHIP2 Promotes Neutrophil Chemotaxis and Recruitment von Michael, Melina, McCormick, Barry, Anderson, Karen E, Karmakar, Utsa, Vermeren, Matthieu, Schurmans, Stéphane, Amour, Augustin, Vermeren, Sonja

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PI3Kδ inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation von Uddin, Sorif, Amour, Augustin, Lewis, David J, Edwards, Chris D, Williamson, Matthew G, Hall, Simon, Lione, Lisa A, Hessel, Edith M

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The in vitro activity of ADAM-10 is inhibited by TIMP-1 and TIMP-3 von Amour, Augustin, Knight, C.Graham, Webster, Ailsa, Slocombe, Patrick M., Stephens, Paul E., Knäuper, Vera, Docherty, Andrew J.P., Murphy, Gillian

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Genome-wide transcription profiling in neutrophils in acute respiratory distress syndrome von Juss, JatinderK, MBBChir, Herre, Jurgen, PhD, Begg, Malcolm, PhD, Bradley, Glyn, Lennon, Mark, Amour, Augustin, PhD, House, David, PhD, Hessel, Edith M, PhD, Summers, Charlotte, PhD, Condliffe, Alison M, MBBChir, Chilvers, Edwin R, Prof

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TIMP-3 Inhibition of ADAMTS-4 (Aggrecanase-1) Is Modulated by Interactions between Aggrecan and the C-terminal Domain of ADAMTS-4 von Wayne, Gareth J., Deng, Su-Jun, Amour, Augustin, Borman, Satty, Matico, Rosalie, Carter, H. Luke, Murphy, Gillian

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Functional capacity of alveolar neutrophils in acute respiratory distress syndrome von Juss, Jatinder K, PhD, Herre, Jurgen, PhD, Amour, Augustin, PhD, Begg, Malcolm, PhD, House, David, PhD, Hessel, Edith M, PhD, Summers, Charlotte, PhD, Condliffe, Alison M, PhD, Chilvers, Edwin R, Prof

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Organ-on-chip applications in drug discovery: an end user perspective von Clapp, Naomi, Amour, Augustin, Rowan, Wendy C, Candarlioglu, Pelin L

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A broad-spectrum fluorescence-based peptide library for the rapid identification of protease substrates von Thomas, Daniel A., Francis, Peter, Smith, Carla, Ratcliffe, Steven, Ede, Nicholas J., Kay, Corinne, Wayne, Gareth, Martin, Steve L., Moore, Keith, Amour, Augustin, Hooper, Nigel M.

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The identification of β-hydroxy carboxylic acids as selective MMP-12 inhibitors von Holmes, Ian P., Gaines, Simon, Watson, Steve P., Lorthioir, Olivier, Walker, Adam, Baddeley, Suzanne J., Herbert, Shane, Egan, Danielle, Convery, Máire A., Singh, Onkar M.P., Gross, Jeffrey W., Strelow, John M., Smith, Robert H., Amour, Augustin J., Brown, David, Martin, Stephen L.

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Antithrombotic Potential of GW813893: A Novel, Orally Active, Active-site Directed Factor Xa Inhibitor von Abboud, Melanie A, Needle, Saul J, Burns-Kurtis, Cynthia L, Valocik, Richard E, Koster, Paul F, Amour, Augustin J, Chan, Chuen, Brown, David, Chaudry, Laiq, Zhou, Ping, Patikis, Angela, Patel, Champa, Pateman, Anthony J, Young, Rob J, Watson, Nigel S, Toomey, John R

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Optimization of Novel Indazoles as Highly Potent and Selective Inhibitors of Phosphoinositide 3‑Kinase δ for the Treatment of Respiratory Disease von Down, Kenneth, Amour, Augustin, Baldwin, Ian R, Cooper, Anthony W. J, Deakin, Angela M, Felton, Leigh M, Guntrip, Stephen B, Hardy, Charlotte, Harrison, Zoë A, Jones, Katherine L, Jones, Paul, Keeling, Suzanne E, Le, Joelle, Livia, Stefano, Lucas, Fiona, Lunniss, Christopher J, Parr, Nigel J, Robinson, Ed, Rowland, Paul, Smith, Sarah, Thomas, Daniel A, Vitulli, Giovanni, Washio, Yoshiaki, Hamblin, J. Nicole

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An open label trial of nemiralisib, an inhaled PI3 kinase delta inhibitor for the treatment of Activated PI3 kinase Delta Syndrome von Begg, Malcolm, Amour, Augustin, Jarvis, Emily, Tang, Teresa, Franco, Sara Santos, Want, Andrew, Beerahee, Misba, Fernando, Disala, Karkera, Yakshitha, Sander, Clare, Southworth, Thomas, Singh, Dave, Clark, Jonathan, Nejentsev, Sergey, Okkenhaug, Klaus, Condliffe, Alison, Chandra, Anita, Cahn, Anthony, Hall, Edward Banham

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Physiologically Based Pharmacokinetic Modelling of Inhaled Nemiralisib: Mechanistic Components for Pulmonary Absorption, Systemic Distribution, and Oral Absorption von Miller, Neil A., Graves, Rebecca H., Edwards, Chris D., Amour, Augustin, Taylor, Ed, Robb, Olivia, O’Brien, Brett, Patel, Aarti, Harrell, Andrew W., Hessel, Edith M.

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Targeting phosphoinositide 3-kinase δ for the treatment of respiratory diseases von Sriskantharajah, Srividya, Hamblin, Nicole, Worsley, Sally, Calver, Andrew R., Hessel, Edith M., Amour, Augustin

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An investigation of the anti-inflammatory effects and a potential biomarker of PI3K[delta] inhibition in COPD T cells von Khan, Abid, Southworth, Thomas, Worsley, Sally, Sriskantharajah, Srividya, Amour, Augustin, Hessel, Edith M, Singh, Dave

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An investigation of the anti‐inflammatory effects and a potential biomarker of PI3Kδ inhibition in COPD T cells von Khan, Abid, Southworth, Thomas, Worsley, Sally, Sriskantharajah, Srividya, Amour, Augustin, Hessel, Edith M, Singh, Dave

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Optimization of Orally Bioavailable PI3Kδ Inhibitors and Identification of Vps34 as a Key Selectivity Target von Henley, Zoë A, Amour, Augustin, Barton, Nick, Bantscheff, Marcus, Bergamini, Giovanna, Bertrand, Sophie M, Convery, Máire, Down, Kenneth, Dümpelfeld, Birgit, Edwards, Chris D, Grandi, Paola, Gore, Paul M, Keeling, Steve, Livia, Stefano, Mallett, David, Maxwell, Aoife, Price, Mark, Rau, Christina, Reinhard, Friedrich B. M, Rowedder, James, Rowland, Paul, Taylor, Jonathan A, Thomas, Daniel A, Hessel, Edith M, Hamblin, J. Nicole

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PI3K[delta] inhibition prevents IL33, ILC2s and inflammatory eosinophils in persistent airway inflammation von Uddin, Sorif, Amour, Augustin, Lewis, David J, Edwards, Chris D, Williamson, Matthew G, Hall, Simon, Lione, Lisa A, Hessel, Edith M

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An investigation of the anti‐inflammatory effects and a potential biomarker of PI 3Kδ inhibition in COPD T cells von Khan, Abid, Southworth, Thomas, Worsley, Sally, Sriskantharajah, Srividya, Amour, Augustin, Hessel, Edith M, Singh, Dave

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