Foxo1 directly regulates the transcription of recombination-activating genes during B cell development von Schlissel, Mark S, Amin, Rupesh H

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Series of Novel and Highly Potent Cyclic Peptide PCSK9 Inhibitors Derived from an mRNA Display Screen and Optimized via Structure-Based Design von Alleyne, Candice, Amin, Rupesh P, Bhatt, Bhavana, Bianchi, Elisabetta, Blain, J. Craig, Boyer, Nicolas, Branca, Danila, Embrey, Mark W, Ha, Sookhee N, Jette, Kelli, Johns, Douglas G, Kerekes, Angela D, Koeplinger, Kenneth A, LaPlaca, Derek, Li, Nianyu, Murphy, Beth, Orth, Peter, Ricardo, Alonso, Salowe, Scott, Seyb, Kathleen, Shahripour, Aurash, Stringer, Joseph R, Sun, Yili, Tracy, Rodger, Wu, Chengwei, Xiong, Yusheng, Youm, Hyewon, Zokian, Hratch J, Tucker, Thomas J

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A Series of Novel, Highly Potent, and Orally Bioavailable Next-Generation Tricyclic Peptide PCSK9 Inhibitors von Tucker, Thomas J, Embrey, Mark W, Alleyne, Candice, Amin, Rupesh P, Bass, Alan, Bhatt, Bhavana, Bianchi, Elisabetta, Branca, Danila, Bueters, Tjerk, Buist, Nicole, Ha, Sookhee N, Hafey, Mike, He, Huaibing, Higgins, John, Johns, Douglas G, Kerekes, Angela D, Koeplinger, Kenneth A, Kuethe, Jeffrey T, Li, Nianyu, Murphy, BethAnn, Orth, Peter, Salowe, Scott, Shahripour, Aurash, Tracy, Rodger, Wang, Weixun, Wu, Chengwei, Xiong, Yusheng, Zokian, Hratch J, Wood, Harold B, Walji, Abbas

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Nonclinical Cardiovascular Assessment of the Soluble Guanylate Cyclase Stimulator Vericiguat von Himmel, Herbert, Lagrutta, Armando, Vömel, Matthias, Amin, Rupesh P., Imredy, John P., Johnson, Timothy, Vinzing, Maya, Prescott, Judith, Blaustein, Robert O.

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Comprehensive genotoxicity and carcinogenicity assessment of molnupiravir von Escobar, Patricia A, Sobol, Zhanna, Miller, Randy R, Ferry-Martin, Sandrine, Stermer, Angela, Jacob, Binod, Muniappa, Nagaraja, Sanchez, Rosa I, Blanchard, Kerry T, Galijatovic-Idrizbegovic, Alema, Amin, Rupesh P, Troth, Sean P

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Discovery of sulfone containing metallo-β-lactamase inhibitors with reduced bacterial cell efflux and histamine release issues von Bennett, Frank, Huang, Yuhua, Dong, Shuzhi, Jiang, Jinlong, Hunter, David, Zhao, Zhiqiang, Gu, Xin, Scott, Jack D., Tang, Haiqun, Yang, Dexi, Xiao, Li, Scapin, Giovanna, Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Chen, Feifei, Bhatt, Bhavana, Regan, Christopher P., Regan, Hilary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Young, Katherine, Pasternak, Alexander

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Invention of MK-8262, a Cholesteryl Ester Transfer Protein (CETP) Inhibitor Backup to Anacetrapib with Best-in-Class Properties von Vachal, Petr, Duffy, Joseph L, Campeau, Louis-Charles, Amin, Rupesh P, Mitra, Kaushik, Murphy, Beth Ann, Shao, Pengcheng P, Sinclair, Peter J, Ye, Feng, Katipally, Revathi, Lu, Zhijian, Ondeyka, Debra, Chen, Yi-Heng, Zhao, Kake, Sun, Wanying, Tyagarajan, Sriram, Bao, Jianming, Wang, Sheng-Ping, Cote, Josee, Lipardi, Concetta, Metzger, Daniel, Leung, Dennis, Hartmann, Georgy, Wollenberg, Gordon K, Liu, Jian, Tan, Lushi, Xu, Yingju, Chen, Qinghao, Liu, Guiquan, Blaustein, Robert O, Johns, Douglas G

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Early-Onset albuminuria and Associated Renal Pathology in Leucine-Rich Repeat Kinase 2 Knockout Rats von Gu, Yi-Zhong, Vlasakova, Katerina, Miller, Glen, Gatto, Nicholas T., Ciaccio, Paul J., Kuruvilla, Sabu, Besteman, Elizabeth G., Smith, Roger, Reynolds, Spencer J., Amin, Rupesh P., Glaab, Warren E., Wollenberg, Gordon, Lebron, Jose, Sistare, Frank D.

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Structure Guided Discovery of Novel Pan Metallo-β-Lactamase Inhibitors with Improved Gram-Negative Bacterial Cell Penetration von Dong, Shuzhi, Zhao, Zhiqiang, Tang, Haiqun, Li, Guoqing, Pan, Jianping, Gu, Xin, Jiang, Jinlong, Xiao, Li, Scapin, Giovanna, Hunter, David N., Yang, Dexi, Huang, Yuhua, Bennett, Frank, Yang, Shu-Wei, Mandal, Mihirbaran, Tang, Haifeng, Su, Jing, Tudge, Clare, deJesus, Reynalda Keh, Ding, Fa-Xiang, Lombardo, Matthew, Hicks, Jacqueline D., Fischmann, Thierry, Mirza, Asra, Dayananth, Priya, Painter, Ronald E., Villafania, Artjohn, Garlisi, Charles G., Zhang, Rumin, Mayhood, Todd W., Si, Qian, Li, Nianyu, Amin, Rupesh P., Bhatt, Bhavana, Chen, Feifei, Regan, Christopher P., Regan, Hillary, Lin, Xinjie, Wu, Jin, Leithead, Andrew, Pollack, Scott R., Scott, Jack D., Nargund, Ravi P., Therien, Alex G., Black, Todd, Young, Katherine, Pasternak, Alexander

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Guiding Chemically Synthesized Peptide Drug Lead Optimization by Derisking Mast Cell Degranulation-Related Toxicities of a NaV1.7 Peptide Inhibitor von Morissette, Pierre, Li, Nianyu, Ballard, Jeanine E, Vavrek, Marissa, Adams, Gregory L, Regan, Chris, Regan, Hillary, Lee, K J, Wang, Weixun, Burton, Aimee, Chen, Feifei, Gerenser, Pamela, Li, Yuxing, Kraus, Richard L, Tellers, David, Palani, Anand, Zhu, Yuping, Sun, Chengzao, Bianchi, Elisabetta, Colarusso, Stefania, De Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Amin, Rupesh P

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Lead Optimization to Advance Protease-Activated Receptor‑1 Antagonists in Early Discovery von Mandal, Mihirbaran, Madeira, Maria, Amin, Rupesh P, Buevich, Alexei V, Cheng, Alan, Labroli, Marc, Liu, Xiaoxiang, Acton, John, Pio, Barbara, Basso, Andrea, Chobanian, Harry, Dong, Grace, Dropinski, Jamie, Guo, Yan, Guo, Zhuyan, Kurowski, Stan, Korfmacher, Walter, Lee, Sandra, Meng, Dongfang, Ondeyka, Debra, Yang, Zhiqiang, Zhang, Rumin, Wei, Huijun, Wu, Zhicai, Zhang, Fengqi, Wollenberg, Gordon, Biftu, Tesfaye, Greenlee, William J, Chintala, Madhu, Maletic, Milana, Zhu, Zhaoning

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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Nav1.7 for the Treatment of Pain von Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo’ Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M

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Translational Safety Biomarkers of Kidney Injury von Troth, Sean P., Vlasakova, Katerina, Amur, Shashi, Amin, Rupesh P., Glaab, Warren E.

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RAG-induced DNA double-strand breaks signal through Pim2 to promote pre-B cell survival and limit proliferation von Bednarski, Jeffrey J, Nickless, Andrew, Bhattacharya, Deepta, Amin, Rupesh H, Schlissel, Mark S, Sleckman, Barry P

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Development of ProTx-II Analogues as Highly Selective Peptide Blockers of Na v 1.7 for the Treatment of Pain von Adams, Gregory L, Pall, Parul S, Grauer, Steven M, Zhou, Xiaoping, Ballard, Jeanine E, Vavrek, Marissa, Kraus, Richard L, Morissette, Pierre, Li, Nianyu, Colarusso, Stefania, Bianchi, Elisabetta, Palani, Anandan, Klein, Rebecca, John, Christopher T, Wang, Deping, Tudor, Matthew, Nolting, Andrew F, Biba, Mirlinda, Nowak, Timothy, Makarov, Alexey A, Reibarkh, Mikhail, Buevich, Alexei V, Zhong, Wendy, Regalado, Erik L, Wang, Xiao, Gao, Qi, Shahripour, Aurash, Zhu, Yuping, de Simone, Daniele, Frattarelli, Tommaso, Pasquini, Nicolo' Maria, Magotti, Paola, Iaccarino, Roberto, Li, Yuxing, Solly, Kelli, Lee, Keun-Joong, Wang, Weixun, Chen, Feifei, Zeng, Haoyu, Wang, Jixin, Regan, Hilary, Amin, Rupesh P, Regan, Christopher P, Burgey, Christopher S, Henze, Darrell A, Sun, Chengzao, Tellers, David M

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A T-cell-dependent antibody response study using a murine surrogate anti-PD-1 monoclonal antibody as an alternative to a non-human primate model von Plitnick, Lisa M., Hutchins, Beth, Dubey, Sheri, Li, Nianyu, Amin, Rupesh P., Born, Stephanie, Mangadu, Ruban, Phillips, Joseph H., Sriram, Venkataraman, Herzyk, Danuta J.

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Identification of Putative Gene-Based Markers of Renal Toxicity von Amin, Rupesh P., Vickers, Alison E., Sistare, Frank, Thompson, Karol L., Roman, Richard J., Lawton, Michael, Kramer, Jeffrey, Hamadeh, Hisham K., Collins, Jennifer, Grissom, Sherry, Bennett, Lee, Tucker, C. Jeffrey, Wild, Stacie, Kind, Clive, Oreffo, Victor, Davis, John W., Curtiss, Sandra, Naciff, Jorge M., Cunningham, Michael, Tennant, Raymond, Stevens, James, Car, Bruce, Bertram, Timothy A., Afshari, Cynthia A.

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Gfi1b negatively regulates Rag expression directly and via the repression of FoxO1 von Schulz, Danae, Vassen, Lothar, Chow, Kwan T, McWhirter, Sarah M, Amin, Rupesh H, Möröy, Tarik, Schlissel, Mark S

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Oxidative stress and its role in skin disease von Trouba, Kevin J, Hamadeh, Hisham K, Amin, Rupesh P, Germolec, Dori R

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Biallelic, ubiquitous transcription from the distal germline Igκ locus promoter during B cell development von Amin, Rupesh H, Cado, Dragana, Nolla, Hector, Huang, Dan, Shinton, Susan A, Zhou, Yan, Hardy, Richard R, Schlissel, Mark S

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