EGFR/Src/Akt signaling modulates Sox2 expression and self-renewal of stem-like side-population cells in non-small cell lung cancer von Singh, Sandeep, Trevino, Jose, Bora-Singhal, Namrata, Coppola, Domenico, Haura, Eric, Altiok, Soner, Chellappan, Srikumar P

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Chemotherapy enhances tumor cell susceptibility to CTL-mediated killing during cancer immunotherapy in mice von Ramakrishnan, Rupal, Assudani, Deepak, Nagaraj, Srinivas, Hunter, Terri, Cho, Hyun-Il, Antonia, Scott, Altiok, Soner, Celis, Esteban, Gabrilovich, Dmitry I

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Antitumor Efficacy of the Anti-Interleukin-6 (IL-6) Antibody Siltuximab in Mouse Xenograft Models of Lung Cancer von Song, Lanxi, Smith, Matthew A., Doshi, Parul, Sasser, Kate, Fulp, William, Altiok, Soner, Haura, Eric B.

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MK1775, a selective Wee1 inhibitor, shows single-agent antitumor activity against sarcoma cells von Kreahling, Jenny M, Gemmer, Jennifer Y, Reed, Damon, Letson, Douglas, Bui, Marilyn, Altiok, Soner

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Phosphoproteomics Identifies Driver Tyrosine Kinases in Sarcoma Cell Lines and Tumors von YUN BAI, JIANNONG LI, BIN FANG, EDWARDS, Arthur, GUOLIN ZHANG, BUI, Marilyn, ESCHRICH, Steven, ALTIOK, Soner, KOOMEN, John, HAURA, Eric B

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Autophagy Induced by Conventional Chemotherapy Mediates Tumor Cell Sensitivity to Immunotherapy von RAMAKRISHNAN, Rupal, HUANG, Chun, GABRILOVICH, Dmitry I, CHO, Hyun-Ii, LLOYD, Mark, JOHNSON, Joseph, XIUBAO REN, ALTIOK, Soner, SULLIVAN, Daniel, WEBER, Jeffrey, CELIS, Esteban

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Microfluidic Biopsy Trapping Device for the Real-Time Monitoring of Tumor Microenvironment von Holton, Angela Babetski, Sinatra, Francy L, Kreahling, Jenny, Conway, Amy J, Landis, David A, Altiok, Soner

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An In vivo Platform for Translational Drug Development in Pancreatic Cancer von Rubio-Viqueira, Belen, Jimeno, Antonio, Cusatis, George, Zhang, Xianfeng, Iacobuzio-Donahue, Christine, Karikari, Collins, Shi, Chanjusn, Danenberg, Kathleen, Danenberg, Peter V, Kuramochi, Hidekazu, Tanaka, Koji, Singh, Sharat, Salimi-Moosavi, Hossein, Bouraoud, Nadia, Amador, Maria L, Altiok, Soner, Kulesza, Piotr, Yeo, Charles, Messersmith, Wells, Eshleman, James, Hruban, Ralph H, Maitra, Anirban, Hidalgo, Manuel

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Wee1 inhibition by MK-1775 leads to tumor inhibition and enhances efficacy of gemcitabine in human sarcomas von Kreahling, Jenny M, Foroutan, Parastou, Reed, Damon, Martinez, Gary, Razabdouski, Tiffany, Bui, Marilyn M, Raghavan, Meera, Letson, Douglas, Gillies, Robert J, Altiok, Soner

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Anti-PD1 treatment to induce M1 polarization of tumor infiltrating macrophages in a 3D ex vivo system of lung cancer patients von Mediavilla-Varela, Melanie, Page, Melba Marie, Kreahling, Jenny, Antonia, Scott Joseph, Altiok, Soner

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The cyclin-dependent kinase inhibitor SCH 727965 (dinacliclib) induces the apoptosis of osteosarcoma cells von Fu, Wei, Ma, Le, Chu, Baoky, Wang, Xue, Bui, Marilyn M, Gemmer, Jennifer, Altiok, Soner, Pledger, W Jackson

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586 Monitoring the impact of MDSC targeting drugs in combination with nivolumab on activation and proliferation of tumor resident effector immune cells in patient-derived 3D-EXplor... von Ehrhart, Jared, Bunch, Brittany, Sussman, Kelly, Guzman, Kelly, Altiok, Soner

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Diffusion MRI and novel texture analysis in osteosarcoma xenotransplants predicts response to anti-checkpoint therapy von Foroutan, Parastou, Kreahling, Jenny M, Morse, David L, Grove, Olya, Lloyd, Mark C, Reed, Damon, Raghavan, Meera, Altiok, Soner, Martinez, Gary V, Gillies, Robert J

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Histone deacetylase inhibitors downregulate checkpoint kinase 1 expression to induce cell death in non-small cell lung cancer cells von Brazelle, William, Kreahling, Jenny M, Gemmer, Jennifer, Ma, Yihong, Cress, W Douglas, Haura, Eric, Altiok, Soner

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681 An ex vivo 3D tumoroid model of fresh patient tissue (3D-EXplore) to assess the phagocytic activity of tumor resident innate immune cells von Guzman, Kelly, McIntosh, Olivia, Bunch, Brittany, Yarinsky, Jacob, Ehrhart, Jared, Altiok, Soner

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759 Single-Cell Proteogenomics (Cite-seq) analysis of cGAS-STING pathway activation alone and in combination with nivolumab using a patient-derived 3D ex vivo tumoroid platform von Bunch, Brittany, Joerger, Autumn, Mtchedlidze, Nino, Hoff, Olivia, Guzman, Kelly, Ehrhart, Jared, Altiok, Soner

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619 Evaluating the effectiveness of targeted ADC therapy in a patient-derived ex vivo tumoroid model, 3D-EX, for quantitative tumor cell killing von Kreahling, Jenny, Ehrhart, Jared, Pabon, Mibel, Iwanowycz, Stephen, Pastoor, Tina, Altiok, Soner

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Mass Spectrometry Mapping of Epidermal Growth Factor Receptor Phosphorylation Related to Oncogenic Mutations and Tyrosine Kinase Inhibitor Sensitivity von Zhang, Guolin, Fang, Bin, Liu, Richard Z, Lin, Huiyi, Kinose, Fumi, Bai, Yun, Oguz, Umut, Remily-Wood, Elizabeth R, Li, Jiannong, Altiok, Soner, Eschrich, Steven, Koomen, John, Haura, Eric B

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A Miniaturized Chemical Proteomic Approach for Target Profiling of Clinical Kinase Inhibitors in Tumor Biopsies von Chamrád, Ivo, Rix, Uwe, Stukalov, Alexey, Gridling, Manuela, Parapatics, Katja, Müller, André C, Altiok, Soner, Colinge, Jacques, Superti-Furga, Giulio, Haura, Eric B, Bennett, Keiryn L

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Phase 2 randomized study of enzastaurin (LY317615) for lung cancer prevention in former smokers von Gray, Jhanelle E., Altiok, Soner, Alexandrow, Mark G., Walsh, Frank W., Chen, Jian, Schell, Michael J., Tai, Datchen Fritz, Bepler, Gerold

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