Gram-Scale Synthesis of a β‑Secretase 1 (BACE 1) Inhibitor von Allison, Brett D, Mani, Neelakandha S

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The synthesis of 2-amino-4(3H)-quinazolinones and related heterocycles via a mild electrocyclization of aryl guanidines von Sales, Zachary S., Mani, Neelakandha S., Allison, Brett D.

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4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]­pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate... von Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya

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The Exceptional Chelating Ability of Dimethylaluminum Chloride and Methylaluminum Dichloride. The Merged Stereochemical Impact of α- and β-Stereocenters in Chelate-Controlled Carbo... von Evans, David A, Allison, Brett D, Yang, Michael G, Masse, Craig E

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Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains von Wiener, John J.M., Gomez, Laurent, Venkatesan, Hariharan, Santillán, Alejandro, Allison, Brett D., Schwarz, Kimberly L., Shinde, Shirin, Tang, Liu, Hack, Michael D., Morrow, Brian J., Motley, S. Timothy, Goldschmidt, Raul M., Shaw, Karen Joy, Jones, Todd K., Grice, Cheryl A.

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Indole- and benzothiophene-based histamine H3 antagonists von SANTILLAN, Alejandro, MCCLURE, Kelly J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, GRICE, Cheryl A, ALLISON, Brett D, LORD, Brian, BOGGS, Jamin D, MORTON, Kirsten L, EVERSON, Anita M, NEPOMUCENO, Diane, LETAVIC, Michael A, LEE-DUTRA, Alice

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Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: Discovery of CCKR1 selectivity in a previously CCKR2-selective lead series von Pippel, Marna, Allison, Brett D., Phuong, Victor K., Li, Lina, Morton, Magda F., Prendergast, Clodagh, Wu, Xiaodong, Shankley, Nigel P., Rabinowitz, Michael H.

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Identification and Optimization of Anthranilic Sulfonamides as Novel, Selective Cholecystokinin-2 Receptor Antagonists von Allison, Brett D, Phuong, Victor K, McAtee, Laura C, Rosen, Mark, Morton, Magda, Prendergast, Clodagh, Barrett, Terry, Lagaud, Guy, Freedman, Jamie, Li, Lina, Wu, Xiaodong, Venkatesan, Hariharan, Pippel, Marna, Woods, Craig, Rizzolio, Michèle C, Hack, Michael, Hoey, Kenway, Deng, Xiaohu, King, Christopher, Shankley, Nigel P, Rabinowitz, Michael H

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Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands von Woods, Craig R., Hack, Michael D., Allison, Brett D., Phuong, Victor K., Rosen, Mark D., Morton, Magda F., Prendergast, Clodagh E., Barrett, Terrance D., Shankley, Nigel P., Rabinowitz, Michael H.

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Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors von Allison, Brett D., Deng, Xiaohu, Li, Lian-Sheng, Liang, Jimmy, Mani, Neelakandha S., Ren, Pingda, Sales, Zachary S.

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Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis von Rosen, Mark D., Hack, Michael D., Allison, Brett D., Phuong, Victor K., Woods, Craig R., Morton, Magda F., Prendergast, Clodagh E., Barrett, Terrance D., Schubert, Carsten, Li, Lina, Wu, Xiaodong, Wu, Jiejun, Freedman, Jamie M., Shankley, Nigel P., Rabinowitz, Michael H.

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4-Methyl-6,7-dihydro-4 H -triazolo[4,5- c ]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidat... von Letavic, Michael A., Savall, Brad M., Allison, Brett D., Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A., Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I., Ceusters, Marc, Coe, Kevin J., Dvorak, Curt A., Fraser, Ian C., Gelin, Christine F., Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W., Otieno, Monicah A., Schoetens, Freddy, Swanson, Devin M., Wang, Qi, Wickenden, Alan D., Bhattacharya, Anindya

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Chelate-controlled carbonyl addition reactions. The exceptional chelating abilityof dimethylaluminum chloride and methylaluminum dichloride von Evans, David A., Allison, Brett D., Yang, Michael G.

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Indole- and benzothiophene-based histamine H 3 antagonists von Santillan, Alejandro, McClure, Kelly J., Allison, Brett D., Lord, Brian, Boggs, Jamin D., Morton, Kirsten L., Everson, Anita M., Nepomuceno, Diane, Letavic, Michael A., Lee-Dutra, Alice, Lovenberg, Timothy W., Carruthers, Nicholas I., Grice, Cheryl A.

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Indole- and benzothiophene-based histamine H sub(3 antagonists) von Santillan, Alejandro, McClure, Kelly J, Allison, Brett D, Lord, Brian, Boggs, Jamin D, Morton, Kirsten L, Everson, Anita M, Nepomuceno, Diane, Letavic, Michael A, Lee-Dutra, Alice, Lovenberg, Timothy W, Carruthers, Nicholas I, Grice, Cheryl A

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Chelation-controlled stannylacetylene additions to β-alkoxy aldehydes promoted by alkylaluminum halide Lewis acids von Evans, David A., Halstead, David P., Allison, Brett D.

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P2X7 modulators von ANDRES GIL, Jose Ignacio, ALCAZAR VACA, Manuel Jesus, SAVALL, Brad M, CHROVIAN, Christa C, DENG, Xiaohu, SWANSON, Devin M, ALLISON, Brett D, DVORAK, Curt A, LETAVIC, Michael A, COATE, Heather R, STENNE, Brice M, MANI, Neelakandha S, SOYODE-JOHNSON, Akinola, WALL, Jessica L, GELIN, Christine F, DE ANGELIS, Meri, RECH, Jason C, LIANG, Jimmy T

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P2X7 MODULATORS von ANDRES GIL, Jose Ignacio, ALCAZAR VACA, Manuel Jesus, SAVALL, Brad M, CHROVIAN, Christa C, DENG, Xiaohu, SWANSON, Devin M, ALLISON, Brett D, DVORAK, Curt A, LETAVIC, Michael A, COATE, Heather R, STENNE, Brice M, MANI, Neelakandha S, SOYODE-JOHNSON, Akinola, WALL, Jessica L, GELIN, Christine F, DE ANGELIS, Meri, RECH, Jason C, LIANG, Jimmy T

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P2X7 modulators von Alcazar Vaca, Manuel Jesus, Allison, Brett D, Wall, Jessica L, Deng, Xiaohu, Andres Gil, Jose Ignacio, Mani, Neelakandha S, Chrovian, Christa C, Swanson, Devin M, Coate, Heather R, Rech, Jason C, Dvorak, Curt A, Stenne, Brice M, Letavic, Michael A, De Angelis, Meri, Liang, Jimmy T, Soyode-Johnson, Akinola, Gelin, Christine F, Savall, Brad M

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P2X7 MODULATORS von LIANG, JIMMY T, MANI, NEELAKANDHA S, SWANSON, DEVIN M, DENG, XIAOHU, WALL, JESSICA L, ALCAZAR VACA, MANUEL JESUS, GELIN, CHRISTINE F, STENNE, BRICE M, CHROVIAN, CHRISTA C, DE ANGELIS, MERI, COATE, HEATHER R, RECH, JASON C, ALLISON, BRETT D, DVORAK, CURT A, ANDRES GIL, JOSE IGNACIO, LETAVIC, MICHAEL A, SAVALL, BRAD M, SOYODE-JOHNSON, AKINOLA

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