4‑Methyl-6,7-dihydro‑4H‑triazolo[4,5‑c]­pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidate... von Letavic, Michael A, Savall, Brad M, Allison, Brett D, Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A, Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I, Ceusters, Marc, Coe, Kevin J, Dvorak, Curt A, Fraser, Ian C, Gelin, Christine F, Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W, Otieno, Monicah A, Schoetens, Freddy, Swanson, Devin M, Wang, Qi, Wickenden, Alan D, Bhattacharya, Anindya

Volltext

Allyl-Assisted, Cu(I)-Catalyzed Azide–Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo-4,5,6,7-tetrahydropyridine Core Structure von Deng, Xiaohu, Liang, Jimmy, Allison, Brett B, Dvorak, Curt, McAllister, Heather, Savall, Brad M, Mani, Neelakandha S

Volltext

The synthesis of 2-amino-4(3H)-quinazolinones and related heterocycles via a mild electrocyclization of aryl guanidines von Sales, Zachary S., Mani, Neelakandha S., Allison, Brett D.

Volltext

Gram-Scale Synthesis of a β‑Secretase 1 (BACE 1) Inhibitor von Allison, Brett D, Mani, Neelakandha S

Volltext

The Exceptional Chelating Ability of Dimethylaluminum Chloride and Methylaluminum Dichloride. The Merged Stereochemical Impact of α- and β-Stereocenters in Chelate-Controlled Carbo... von Evans, David A, Allison, Brett D, Yang, Michael G, Masse, Craig E

Volltext

Tetrahydroindazole inhibitors of bacterial type II topoisomerases. Part 2: SAR development and potency against multidrug-resistant strains von Wiener, John J.M., Gomez, Laurent, Venkatesan, Hariharan, Santillán, Alejandro, Allison, Brett D., Schwarz, Kimberly L., Shinde, Shirin, Tang, Liu, Hack, Michael D., Morrow, Brian J., Motley, S. Timothy, Goldschmidt, Raul M., Shaw, Karen Joy, Jones, Todd K., Grice, Cheryl A.

Volltext

Indole- and benzothiophene-based histamine H3 antagonists von SANTILLAN, Alejandro, MCCLURE, Kelly J, LOVENBERG, Timothy W, CARRUTHERS, Nicholas I, GRICE, Cheryl A, ALLISON, Brett D, LORD, Brian, BOGGS, Jamin D, MORTON, Kirsten L, EVERSON, Anita M, NEPOMUCENO, Diane, LETAVIC, Michael A, LEE-DUTRA, Alice

Volltext

Anthranilic sulfonamide CCK1/CCK2 dual receptor antagonists I: Discovery of CCKR1 selectivity in a previously CCKR2-selective lead series von Pippel, Marna, Allison, Brett D., Phuong, Victor K., Li, Lina, Morton, Magda F., Prendergast, Clodagh, Wu, Xiaodong, Shankley, Nigel P., Rabinowitz, Michael H.

Volltext

Identification and Optimization of Anthranilic Sulfonamides as Novel, Selective Cholecystokinin-2 Receptor Antagonists von Allison, Brett D, Phuong, Victor K, McAtee, Laura C, Rosen, Mark, Morton, Magda, Prendergast, Clodagh, Barrett, Terry, Lagaud, Guy, Freedman, Jamie, Li, Lina, Wu, Xiaodong, Venkatesan, Hariharan, Pippel, Marna, Woods, Craig, Rizzolio, Michèle C, Hack, Michael, Hoey, Kenway, Deng, Xiaohu, King, Christopher, Shankley, Nigel P, Rabinowitz, Michael H

Volltext

Selective Metalation of Functionalized Quinazolines to Enable Discovery and Advancement of Covalent KRAS Inhibitors von Allison, Brett D., Deng, Xiaohu, Li, Lian-Sheng, Liang, Jimmy, Mani, Neelakandha S., Ren, Pingda, Sales, Zachary S.

Volltext

Synthesis and solid-phase purification of anthranilic sulfonamides as CCK-2 ligands von Woods, Craig R., Hack, Michael D., Allison, Brett D., Phuong, Victor K., Rosen, Mark D., Morton, Magda F., Prendergast, Clodagh E., Barrett, Terrance D., Shankley, Nigel P., Rabinowitz, Michael H.

Volltext

Discovery of potent cholecystokinin-2 receptor antagonists: Elucidation of key pharmacophore elements by X-ray crystallographic and NMR conformational analysis von Rosen, Mark D., Hack, Michael D., Allison, Brett D., Phuong, Victor K., Woods, Craig R., Morton, Magda F., Prendergast, Clodagh E., Barrett, Terrance D., Schubert, Carsten, Li, Lina, Wu, Xiaodong, Wu, Jiejun, Freedman, Jamie M., Shankley, Nigel P., Rabinowitz, Michael H.

Volltext

Substituted Azabicyclo[2.2.1]heptanes as Selective Orexin‑1 Antagonists: Discovery of JNJ-54717793 von Préville, Cathy, Bonaventure, Pascal, Koudriakova, Tatiana, Lord, Brian, Nepomuceno, Diane, Rizzolio, Michele, Mani, Neelakandha, Coe, Kevin J, Ndifor, Anthony, Dugovic, Christine, Dvorak, Curt A, Coate, Heather, Pippel, Daniel J, Fitzgerald, Anne, Allison, Brett, Lovenberg, Timothy W, Carruthers, Nicholas I, Shireman, Brock T

Volltext

4-Methyl-6,7-dihydro-4 H -triazolo[4,5- c ]pyridine-Based P2X7 Receptor Antagonists: Optimization of Pharmacokinetic Properties Leading to the Identification of a Clinical Candidat... von Letavic, Michael A., Savall, Brad M., Allison, Brett D., Aluisio, Leah, Andres, Jose Ignacio, De Angelis, Meri, Ao, Hong, Beauchamp, Derek A., Bonaventure, Pascal, Bryant, Stewart, Carruthers, Nicholas I., Ceusters, Marc, Coe, Kevin J., Dvorak, Curt A., Fraser, Ian C., Gelin, Christine F., Koudriakova, Tatiana, Liang, Jimmy, Lord, Brian, Lovenberg, Timothy W., Otieno, Monicah A., Schoetens, Freddy, Swanson, Devin M., Wang, Qi, Wickenden, Alan D., Bhattacharya, Anindya

Volltext

Discovery of a novel series of selective HCN1 blockers von McClure, Kelly J., Maher, Michael, Wu, Nancy, Chaplan, Sandra R., Eckert, William A., Lee, Dong H., Wickenden, Alan D., Hermann, Michelle, Allison, Brett, Hawryluk, Natalie, Breitenbucher, J. Guy, Grice, Cheryl A.

Volltext

ChemInform Abstract: Allyl‐Assisted, Cu(I)‐Catalyzed Azide—Alkyne Cycloaddition/Allylation Reaction: Assembly of the [1,2,3]Triazolo‐4,5,6,7‐tetrahydropyridine Core Structure... von Deng, Xiaohu, Liang, Jimmy, Allison, Brett B., Dvorak, Curt, McAllister, Heather, Savall, Brad M., Mani, Neelakandha S.

Volltext

Indole- and benzothiophene-based histamine H 3 antagonists von Santillan, Alejandro, McClure, Kelly J., Allison, Brett D., Lord, Brian, Boggs, Jamin D., Morton, Kirsten L., Everson, Anita M., Nepomuceno, Diane, Letavic, Michael A., Lee-Dutra, Alice, Lovenberg, Timothy W., Carruthers, Nicholas I., Grice, Cheryl A.

Volltext

JNJ-26070109 [(R)4-Bromo-N-[1-(2,4-difluoro-phenyl)-ethyl]-2-(quinoxaline-5-sulfonylamino)-benzamide]: A Novel, Potent, and Selective Cholecystokinin 2 Receptor Antagonist with Goo... von Morton, Magda F., Barrett, Terrance D., Freedman, Jamie, Li, Lina, Rizzolio, Michele C., Prendergast, Clodagh E., Wu, Xiaodong, Moreno, Veronica, Pyati, Jayashree, Figueroa, Katherine, Cagnon, Laurence, Lagaud, Guy, Ver Donck, Luc, Ghoos, Etienne, Allison, Brett, Rabinowitz, Michael H., Shankley, Nigel P.

Volltext

Chelate-controlled carbonyl addition reactions. The exceptional chelating abilityof dimethylaluminum chloride and methylaluminum dichloride von Evans, David A., Allison, Brett D., Yang, Michael G.

Volltext

Indole- and benzothiophene-based histamine H sub(3 antagonists) von Santillan, Alejandro, McClure, Kelly J, Allison, Brett D, Lord, Brian, Boggs, Jamin D, Morton, Kirsten L, Everson, Anita M, Nepomuceno, Diane, Letavic, Michael A, Lee-Dutra, Alice, Lovenberg, Timothy W, Carruthers, Nicholas I, Grice, Cheryl A

Volltext